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t(4;11)(q21;q23)

MedGen UID:
271879
•Concept ID:
C1515769
•
Cell or Molecular Dysfunction
Synonym: t(4;11)(q21;q23.3)

Definition

A chromosomal abnormality consisting of the translocation of 4q21 with 11q23. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVt(4;11)(q21;q23)

Professional guidelines

PubMed

MLL-Rearranged Acute Leukemia with t(4;11)(q21;q23)-Current Treatment Options. Is There a Role for CAR-T Cell Therapy?
Britten O, Ragusa D, Tosi S, Kamel YM
Cells 2019 Oct 29;8(11) doi: 10.3390/cells8111341. PMID: 31671855Free PMC Article
Treatment of infants with lymphoblastic leukaemia: results of the UK Infant Protocols 1987-1999.
Chessells JM, Harrison CJ, Watson SL, Vora AJ, Richards SM; Medical Research Council Working Party on Childhood Leukaemia
Br J Haematol 2002 May;117(2):306-14. doi: 10.1046/j.1365-2141.2002.03442.x. PMID: 11972512
Panhandle PCR strategy to amplify MLL genomic breakpoints in treatment-related leukemias.
Megonigal MD, Rappaport EF, Jones DH, Kim CS, Nowell PC, Lange BJ, Felix CA
Proc Natl Acad Sci U S A 1997 Oct 14;94(21):11583-8. doi: 10.1073/pnas.94.21.11583. PMID: 9326653Free PMC Article

Recent clinical studies

Etiology

Allogeneic hematopoietic stem cell transplantation for adult patients with t(4;11)(q21;q23) KMT2A/AFF1 B-cell precursor acute lymphoblastic leukemia in first complete remission: impact of pretransplant measurable residual disease (MRD) status. An analysis from the Acute Leukemia Working Party of the EBMT.
Esteve J, Giebel S, Labopin M, Czerw T, Wu D, Volin L, Socié G, Yakoub-Agha I, Maertens J, Cornelissen JJ, Pigneux A, Shimoni A, Schwerdtfeger R, Labussière-Wallet H, Russell N, Schattenberg A, Chevallier P, Koza V, Foà R, Schmid C, Peric Z, Mohty M, Nagler A
Leukemia 2021 Aug;35(8):2232-2242. Epub 2021 Feb 4 doi: 10.1038/s41375-021-01135-2. PMID: 33542481
The clinical characteristics, therapy and outcome of 85 adults with acute lymphoblastic leukemia and t(4;11)(q21;q23)/MLL-AFF1 prospectively treated in the UKALLXII/ECOG2993 trial.
Marks DI, Moorman AV, Chilton L, Paietta E, Enshaie A, DeWald G, Harrison CJ, Fielding AK, Foroni L, Goldstone AH, Litzow MR, Luger SM, McMillan AK, Racevskis J, Rowe JM, Tallman MS, Wiernik P, Lazarus HM
Haematologica 2013 Jun;98(6):945-52. Epub 2013 Jan 24 doi: 10.3324/haematol.2012.081877. PMID: 23349309Free PMC Article
Gene expression profiling of adult t(4;11)(q21;q23)-associated acute lymphoblastic leukemia reveals a different signature from pediatric cases.
De Braekeleer E, Douet-Guilbert N, Le Bris MJ, Basinko A, Morel F, De Braekeleer M
Anticancer Res 2012 Sep;32(9):3893-9. PMID: 22993334
Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product.
Domer PH, Fakharzadeh SS, Chen CS, Jockel J, Johansen L, Silverman GA, Kersey JH, Korsmeyer SJ
Proc Natl Acad Sci U S A 1993 Aug 15;90(16):7884-8. doi: 10.1073/pnas.90.16.7884. PMID: 7689231Free PMC Article
Chromosomal abnormalities in myelodysplastic syndromes and acute myeloid leukemia.
Machnicki JL, Bloomfield CD
Clin Lab Med 1990 Dec;10(4):755-67. PMID: 2272173

Diagnosis

Lymphoma- and leukemia-associated chromosomal translocations in healthy individuals.
Janz S, Potter M, Rabkin CS
Genes Chromosomes Cancer 2003 Mar;36(3):211-23. doi: 10.1002/gcc.10178. PMID: 12557221
Acute lymphoblastic leukaemia: diagnosis and classification.
Kebriaei P, Anastasi J, Larson RA
Best Pract Res Clin Haematol 2002 Dec;15(4):597-621. doi: 10.1053/beha.2002.0224. PMID: 12617866
Human t(4;11)(q21;q23) acute lymphoblastic leukemia in mice with severe combined immunodeficiency.
Uckun FM, Downing JR, Chelstrom LM, Gunther R, Ryan M, Simon J, Carroll AJ, Tuel-Ahlgren L, Crist WM
Blood 1994 Aug 1;84(3):859-65. PMID: 8043867
Quantitative acute leukemia cytogenetics.
Mitelman F, Heim S
Genes Chromosomes Cancer 1992 Jul;5(1):57-66. doi: 10.1002/gcc.2870050109. PMID: 1384663
Chromosomal abnormalities in myelodysplastic syndromes and acute myeloid leukemia.
Machnicki JL, Bloomfield CD
Clin Lab Med 1990 Dec;10(4):755-67. PMID: 2272173

Therapy

The clinical characteristics, therapy and outcome of 85 adults with acute lymphoblastic leukemia and t(4;11)(q21;q23)/MLL-AFF1 prospectively treated in the UKALLXII/ECOG2993 trial.
Marks DI, Moorman AV, Chilton L, Paietta E, Enshaie A, DeWald G, Harrison CJ, Fielding AK, Foroni L, Goldstone AH, Litzow MR, Luger SM, McMillan AK, Racevskis J, Rowe JM, Tallman MS, Wiernik P, Lazarus HM
Haematologica 2013 Jun;98(6):945-52. Epub 2013 Jan 24 doi: 10.3324/haematol.2012.081877. PMID: 23349309Free PMC Article
Effective immunochemotherapy of human t(4;11) leukemia in mice with severe combined immunodeficiency (SCID) using B43 (anti-CD19)-pokeweed antiviral protein immunotoxin plus cyclophosphamide.
Jansen B, Kersey JH, Jaszcz WB, Gunther R, Nguyen DP, Chelstrom LM, Tuel-Ahlgren L, Uckun FM
Leukemia 1993 Feb;7(2):290-7. PMID: 7678881
Acute lymphoid leukemia with t(4;11) (q21;q23) following chemotherapy with cytostatic agents targeting at DNA-topoisomerase II.
Pedersen-Bjergaard J
Leuk Res 1992 Aug;16(8):733-5. doi: 10.1016/0145-2126(92)90150-6. PMID: 1326684
Clinical characteristics and treatment outcome of childhood acute lymphoblastic leukemia with the t(4;11)(q21;q23): a collaborative study of 40 cases.
Pui CH, Frankel LS, Carroll AJ, Raimondi SC, Shuster JJ, Head DR, Crist WM, Land VJ, Pullen DJ, Steuber CP
Blood 1991 Feb 1;77(3):440-7. PMID: 1991161
Biology and clinical significance of cytogenetic abnormalities in childhood acute lymphoblastic leukemia.
Pui CH, Crist WM, Look AT
Blood 1990 Oct 15;76(8):1449-63. PMID: 2207320

Prognosis

MLL-Rearranged Acute Leukemia with t(4;11)(q21;q23)-Current Treatment Options. Is There a Role for CAR-T Cell Therapy?
Britten O, Ragusa D, Tosi S, Kamel YM
Cells 2019 Oct 29;8(11) doi: 10.3390/cells8111341. PMID: 31671855Free PMC Article
Mixed-phenotype acute leukemia with t(4;11)(q21;q23) KMT2A-AFF1-rearranged.
Liu H
Blood 2019 Mar 14;133(11):1265. doi: 10.1182/blood-2018-12-893016. PMID: 30872272
Acute lymphoblastic leukaemia: diagnosis and classification.
Kebriaei P, Anastasi J, Larson RA
Best Pract Res Clin Haematol 2002 Dec;15(4):597-621. doi: 10.1053/beha.2002.0224. PMID: 12617866
Human t(4;11)(q21;q23) acute lymphoblastic leukemia in mice with severe combined immunodeficiency.
Uckun FM, Downing JR, Chelstrom LM, Gunther R, Ryan M, Simon J, Carroll AJ, Tuel-Ahlgren L, Crist WM
Blood 1994 Aug 1;84(3):859-65. PMID: 8043867
Acute leukemias with the t(4;11)(q21;q23).
Pui CH
Leuk Lymphoma 1992 Jun;7(3):173-9. doi: 10.3109/10428199209053620. PMID: 1477645

Clinical prediction guides

Human t(4;11)(q21;q23) acute lymphoblastic leukemia in mice with severe combined immunodeficiency.
Uckun FM, Downing JR, Chelstrom LM, Gunther R, Ryan M, Simon J, Carroll AJ, Tuel-Ahlgren L, Crist WM
Blood 1994 Aug 1;84(3):859-65. PMID: 8043867
Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product.
Domer PH, Fakharzadeh SS, Chen CS, Jockel J, Johansen L, Silverman GA, Kersey JH, Korsmeyer SJ
Proc Natl Acad Sci U S A 1993 Aug 15;90(16):7884-8. doi: 10.1073/pnas.90.16.7884. PMID: 7689231Free PMC Article
Effective immunochemotherapy of human t(4;11) leukemia in mice with severe combined immunodeficiency (SCID) using B43 (anti-CD19)-pokeweed antiviral protein immunotoxin plus cyclophosphamide.
Jansen B, Kersey JH, Jaszcz WB, Gunther R, Nguyen DP, Chelstrom LM, Tuel-Ahlgren L, Uckun FM
Leukemia 1993 Feb;7(2):290-7. PMID: 7678881
Secondary acute lymphoblastic leukemia with t (4;11): report on two cases and review of the literature.
Auxenfants E, Morel P, Lai JL, Sartiaux C, Detourmignies L, Bauters F, Fenaux P
Ann Hematol 1992 Sep;65(3):143-6. doi: 10.1007/BF01695815. PMID: 1391125
Quantitative acute leukemia cytogenetics.
Mitelman F, Heim S
Genes Chromosomes Cancer 1992 Jul;5(1):57-66. doi: 10.1002/gcc.2870050109. PMID: 1384663

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