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Cervical Squamous Cell Carcinoma In Situ

MedGen UID:
272100
•Concept ID:
C1320453
•
Neoplastic Process
Synonyms: Cervical Squamous Cell Carcinoma In Situ AJCC v7; Cervical Squamous Intraepithelial Neoplasia 3; Cervix Squamous Cell Carcinoma In Situ; Cervix Uteri Squamous Cell Carcinoma In Situ; Severe Squamous Dysplasia of the Cervix; Squamous Cell Carcinoma In Situ of Cervix; Squamous Cell Carcinoma In Situ of Cervix Uteri; Squamous Cell Carcinoma In Situ of the Cervix; Squamous Cell Carcinoma In Situ of the Cervix Uteri; Squamous Cell Carcinoma In Situ of the Uterine Cervix; Squamous Cell Carcinoma In Situ of Uterine Cervix; Squamous cell carcinoma in situ of uterine cervix; Uterine Cervix Squamous Cell Carcinoma In Situ
SNOMED CT: Squamous cell carcinoma in situ of uterine cervix (406103009)

Definition

Stage 0 includes: (Tis, N0, M0). Tis: Carcinoma in situ. N0: No regional lymph node metastasis. M0: No distant metastasis. FIGO no longer includes stage 0. (AJCC 7th ed.) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCervical Squamous Cell Carcinoma In Situ

Professional guidelines

PubMed

A Physiologically Responsive Nanocomposite Hydrogel for Treatment of Head and Neck Squamous Cell Carcinoma via Proteolysis-Targeting Chimeras Enhanced Immunotherapy.
Wu Y, Chang X, Yang G, Chen L, Wu Q, Gao J, Tian R, Mu W, Gooding JJ, Chen X, Sun S
Adv Mater 2023 Mar;35(12):e2210787. Epub 2023 Feb 10 doi: 10.1002/adma.202210787. PMID: 36656993
Clinical Utility of In Situ Hybridization Assays in Head and Neck Neoplasms.
Luk PP, Selinger CI, Cooper WA, Mahar A, Palme CE, O'Toole SA, Clark JR, Gupta R
Head Neck Pathol 2019 Sep;13(3):397-414. Epub 2018 Nov 22 doi: 10.1007/s12105-018-0988-1. PMID: 30467669Free PMC Article
Oropharyngeal squamous cell carcinoma treatment: current standards and future directions.
Marur S, Burtness B
Curr Opin Oncol 2014 May;26(3):252-8. doi: 10.1097/CCO.0000000000000072. PMID: 24626127Free PMC Article

Recent clinical studies

Etiology

Superficial spreading cervical squamous cell carcinoma in situ involving the endometrium: a case report and review of the literature.
Martín-Vallejo J, Laforga JB, Molina-Bellido P, Clemente-Pérez PA
J Med Case Rep 2022 May 20;16(1):196. doi: 10.1186/s13256-022-03433-4. PMID: 35590335Free PMC Article
Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice.
Nishio M, To Y, Maehama T, Aono Y, Otani J, Hikasa H, Kitagawa A, Mimori K, Sasaki T, Nishina H, Toyokuni S, Lydon JP, Nakao K, Wah Mak T, Kiyono T, Katabuchi H, Tashiro H, Suzuki A
Cancer Sci 2020 Oct;111(10):3576-3587. Epub 2020 Aug 21 doi: 10.1111/cas.14581. PMID: 32716083Free PMC Article
Evaluation of p16INK4a in cervical lesion of premenopausal and postmenopausal women.
Bolanca IK, Ciglar S
Coll Antropol 2007 Apr;31 Suppl 2:107-11. PMID: 17600938
Primary squamous cell carcinoma of the ovary. Report of 37 cases.
Pins MR, Young RH, Daly WJ, Scully RE
Am J Surg Pathol 1996 Jul;20(7):823-33. doi: 10.1097/00000478-199607000-00005. PMID: 8669530
Koilocytosis preceding squamous cell carcinoma in situ of uterine cervix.
Mittal KR, Miller HK, Lowell DM
Am J Clin Pathol 1987 Feb;87(2):243-5. doi: 10.1093/ajcp/87.2.243. PMID: 3028122

Diagnosis

P16 immunostaining and HPV testing in histological specimens from the uterine cervix.
Capobianco G, Marras V, Wenger JM, Santeufemia DA, Ambrosini G, Lutzoni R, Dessole M, Cherchi PL
Eur J Gynaecol Oncol 2013;34(3):227-30. PMID: 23967551
Evaluation of p16INK4a in cervical lesion of premenopausal and postmenopausal women.
Bolanca IK, Ciglar S
Coll Antropol 2007 Apr;31 Suppl 2:107-11. PMID: 17600938
Squamous cell carcinoma in situ involving mesonephric remnants. A potential diagnostic pitfall.
Samaratunga H, Beresford A, Davison A
Am J Surg Pathol 1994 Dec;18(12):1265-9. doi: 10.1097/00000478-199412000-00011. PMID: 7977951
Case-control study of risk factors for cervical neoplasia in Denmark. II. Role of sexual activity, reproductive factors, and venereal infections.
Kjaer SK, Dahl C, Engholm G, Bock JE, Lynge E, Jensen OM
Cancer Causes Control 1992 Jul;3(4):339-48. doi: 10.1007/BF00146887. PMID: 1617121
Koilocytosis preceding squamous cell carcinoma in situ of uterine cervix.
Mittal KR, Miller HK, Lowell DM
Am J Clin Pathol 1987 Feb;87(2):243-5. doi: 10.1093/ajcp/87.2.243. PMID: 3028122

Therapy

Evaluation of p16INK4a in cervical lesion of premenopausal and postmenopausal women.
Bolanca IK, Ciglar S
Coll Antropol 2007 Apr;31 Suppl 2:107-11. PMID: 17600938
Case-control study of risk factors for cervical squamous cell neoplasia in Denmark. IV: role of smoking habits.
Kjaer SK, Engholm G, Dahl C, Bock JE
Eur J Cancer Prev 1996 Oct;5(5):359-65. doi: 10.1097/00008469-199610000-00008. PMID: 8972255
Case-control study of risk factors for cervical neoplasia in Denmark. II. Role of sexual activity, reproductive factors, and venereal infections.
Kjaer SK, Dahl C, Engholm G, Bock JE, Lynge E, Jensen OM
Cancer Causes Control 1992 Jul;3(4):339-48. doi: 10.1007/BF00146887. PMID: 1617121

Prognosis

Superficial spreading cervical squamous cell carcinoma in situ involving the endometrium: a case report and review of the literature.
Martín-Vallejo J, Laforga JB, Molina-Bellido P, Clemente-Pérez PA
J Med Case Rep 2022 May 20;16(1):196. doi: 10.1186/s13256-022-03433-4. PMID: 35590335Free PMC Article
Primary squamous cell carcinoma of the ovary. Report of 37 cases.
Pins MR, Young RH, Daly WJ, Scully RE
Am J Surg Pathol 1996 Jul;20(7):823-33. doi: 10.1097/00000478-199607000-00005. PMID: 8669530
Case-control study of risk factors for cervical neoplasia in Denmark. II. Role of sexual activity, reproductive factors, and venereal infections.
Kjaer SK, Dahl C, Engholm G, Bock JE, Lynge E, Jensen OM
Cancer Causes Control 1992 Jul;3(4):339-48. doi: 10.1007/BF00146887. PMID: 1617121

Clinical prediction guides

Superficial spreading cervical squamous cell carcinoma in situ involving the endometrium: a case report and review of the literature.
Martín-Vallejo J, Laforga JB, Molina-Bellido P, Clemente-Pérez PA
J Med Case Rep 2022 May 20;16(1):196. doi: 10.1186/s13256-022-03433-4. PMID: 35590335Free PMC Article
Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice.
Nishio M, To Y, Maehama T, Aono Y, Otani J, Hikasa H, Kitagawa A, Mimori K, Sasaki T, Nishina H, Toyokuni S, Lydon JP, Nakao K, Wah Mak T, Kiyono T, Katabuchi H, Tashiro H, Suzuki A
Cancer Sci 2020 Oct;111(10):3576-3587. Epub 2020 Aug 21 doi: 10.1111/cas.14581. PMID: 32716083Free PMC Article
Evaluation of p16INK4a in cervical lesion of premenopausal and postmenopausal women.
Bolanca IK, Ciglar S
Coll Antropol 2007 Apr;31 Suppl 2:107-11. PMID: 17600938
CD40 ligand-CD40 interaction induces chemokines in cervical carcinoma cells in synergism with IFN-gamma.
Altenburg A, Baldus SE, Smola H, Pfister H, Hess S
J Immunol 1999 Apr 1;162(7):4140-7. PMID: 10201939
Case-control study of risk factors for cervical neoplasia in Denmark. II. Role of sexual activity, reproductive factors, and venereal infections.
Kjaer SK, Dahl C, Engholm G, Bock JE, Lynge E, Jensen OM
Cancer Causes Control 1992 Jul;3(4):339-48. doi: 10.1007/BF00146887. PMID: 1617121

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