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Cervical squamous cell carcinoma

MedGen UID:
124644
•Concept ID:
C0279671
•
Neoplastic Process
Synonyms: cervical squamous cell cancer; Cervical Squamous Cell Carcinoma; cervical squamous cell carcinoma; Cervix Squamous Cell Carcinoma; cervix squamous cell carcinoma; Cervix Uteri Squamous Cell Carcinoma; cervix uteri squamous cell carcinoma; CESC; Squamous cell carcinoma of cervix; Squamous Cell Carcinoma of Cervix; squamous cell carcinoma of cervix; Squamous Cell Carcinoma of Cervix Uteri; squamous cell carcinoma of cervix uteri; Squamous Cell Carcinoma of the Cervix; squamous cell carcinoma of the cervix; Squamous Cell Carcinoma of the Cervix Uteri; squamous cell carcinoma of the cervix uteri; Squamous cell carcinoma of the cervix uteri; Squamous Cell Carcinoma of the Uterine Cervix; squamous cell carcinoma of the uterine cervix; Squamous Cell Carcinoma of Uterine Cervix; squamous cell carcinoma of uterine cervix; squamous cervical cancer; Uterine Cervix Squamous Cell Carcinoma; uterine cervix squamous cell carcinoma
SNOMED CT: Squamous cell carcinoma of cervix (254886006)
 
Monarch Initiative: MONDO:0006143
Orphanet: ORPHA213767

Definition

A squamous cell carcinoma arising from the cervical epithelium. It usually evolves from a precancerous cervical lesion. Increased numbers of sexual partners and human papillomavirus (HPV) infection are risk factors for cervical squamous cell carcinoma. Survival is most closely related to the stage of disease at the time of diagnosis. [from NCI]

Professional guidelines

PubMed

Menopause hormone treatment after cancer.
Gompel A
Climacteric 2023 Jun;26(3):240-247. Epub 2023 Apr 3 doi: 10.1080/13697137.2023.2176216. PMID: 37011657
The multifaceted mechanisms of pristimerin in the treatment of tumors state-of-the-art.
Wang Y, Feng W, Wang X, Li X, Mou Y, Wang X, Zhang Y
Biomed Pharmacother 2022 Oct;154:113575. Epub 2022 Aug 18 doi: 10.1016/j.biopha.2022.113575. PMID: 35988422
Management of Vaginal Cancer.
Shrivastava SB, Agrawal G, Mittal M, Mishra P
Rev Recent Clin Trials 2015;10(4):289-97. doi: 10.2174/1574887110666150923112958. PMID: 26411952

Recent clinical studies

Etiology

Radiotherapy for postoperative vaginal recurrences of cervical squamous cell carcinoma: analysis of dosing and prognosis.
Zheng Z, Hu K, Hou X, Yu L, Yan J, Zhang F
J Obstet Gynaecol 2023 Dec;43(2):2213328. doi: 10.1080/01443615.2023.2213328. PMID: 37462369
Expression and Significance of MTA2 and CPNE1 in Cervical Squamous Cell Carcinoma.
Wang L, Chen G, Zhou C, Wu C, Jiang J
Appl Immunohistochem Mol Morphol 2023 Sep 1;31(8):569-573. Epub 2023 Jul 3 doi: 10.1097/PAI.0000000000001138. PMID: 37399268
Infection pattern and immunological characteristics of Epstein-Barr virus latent infection in cervical squamous cell carcinoma.
Zuo Y, Xiao H, Lv D, Huang M, Wang L, Liu J, Zhang K, Shen J, Wang Z, Wu Q, Xu Y
J Med Virol 2023 Apr;95(4):e28717. doi: 10.1002/jmv.28717. PMID: 37184049
FTO m6A Demethylase in Obesity and Cancer: Implications and Underlying Molecular Mechanisms.
Azzam SK, Alsafar H, Sajini AA
Int J Mol Sci 2022 Mar 30;23(7) doi: 10.3390/ijms23073800. PMID: 35409166Free PMC Article
Structural characteristics of small-molecule inhibitors targeting FTO demethylase.
Gao S, Li X, Zhang M, Zhang N, Wang R, Chang J
Future Med Chem 2021 Sep;13(17):1475-1489. Epub 2021 Jul 9 doi: 10.4155/fmc-2021-0132. PMID: 34240624

Diagnosis

Cervical Squamous Cell Carcinoma Diagnosis by FTIR Microspectroscopy.
Félix MM, Tavares MV, Santos IP, Batista de Carvalho ALM, Batista de Carvalho LAE, Marques MPM
Molecules 2024 Feb 20;29(5) doi: 10.3390/molecules29050922. PMID: 38474435Free PMC Article
APOBEC3C is a novel target for the immune treatment of lower-grade gliomas.
Zhao S, Li Y, Xu J, Shen L
Neurol Res 2024 Mar;46(3):227-242. Epub 2024 Jan 22 doi: 10.1080/01616412.2023.2287340. PMID: 38007705
Single-nucleus RNA sequencing reveals heterogenous microenvironments and specific drug response between cervical squamous cell carcinoma and adenocarcinoma.
Lin S, Sun Y, Cao C, Zhu Z, Xu Y, Liu B, Hu B, Peng T, Zhi W, Xu M, Ding W, Ren F, Ma D, Li G, Wu P
EBioMedicine 2023 Nov;97:104846. Epub 2023 Oct 24 doi: 10.1016/j.ebiom.2023.104846. PMID: 37879219Free PMC Article
Single-cell dissection of cellular and molecular features underlying human cervical squamous cell carcinoma initiation and progression.
Liu C, Zhang M, Yan X, Ni Y, Gong Y, Wang C, Zhang X, Wan L, Yang H, Ge C, Li Y, Zou W, Huang R, Li X, Sun B, Liu B, Yue J, Yu J
Sci Adv 2023 Jan 27;9(4):eadd8977. doi: 10.1126/sciadv.add8977. PMID: 36706185Free PMC Article
Targeting CD96 overcomes PD-1 blockade resistance by enhancing CD8+ TIL function in cervical cancer.
Wang Y, Wang C, Qiu J, Qu X, Peng J, Lu C, Zhang M, Zhang M, Qi X, Li G, Hua K
J Immunother Cancer 2022 Mar;10(3) doi: 10.1136/jitc-2021-003667. PMID: 35288463Free PMC Article

Therapy

Multiomic analysis of cervical squamous cell carcinoma identifies cellular ecosystems with biological and clinical relevance.
Fan J, Lu F, Qin T, Peng W, Zhuang X, Li Y, Hou X, Fang Z, Yang Y, Guo E, Yang B, Li X, Fu Y, Kang X, Wu Z, Han L, Mills GB, Ma X, Li K, Wu P, Ma D, Chen G, Sun C
Nat Genet 2023 Dec;55(12):2175-2188. Epub 2023 Nov 20 doi: 10.1038/s41588-023-01570-0. PMID: 37985817
Inhibition of BIRC2 Sensitizes α7-HPV-Related Cervical Squamous Cell Carcinoma to Chemotherapy.
Lin CY, Wang CC, Wu RC, Yang LY, Chang CB, Pan YB, Chao A, Lai CH
Int J Mol Sci 2021 Oct 13;22(20) doi: 10.3390/ijms222011020. PMID: 34681681Free PMC Article
Cell Therapy With TILs: Training and Taming T Cells to Fight Cancer.
Kumar A, Watkins R, Vilgelm AE
Front Immunol 2021;12:690499. Epub 2021 Jun 1 doi: 10.3389/fimmu.2021.690499. PMID: 34140957Free PMC Article
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article
Oncostatin M receptor is a novel therapeutic target in cervical squamous cell carcinoma.
Caffarel MM, Coleman N
J Pathol 2014 Mar;232(4):386-90. doi: 10.1002/path.4305. PMID: 24659184Free PMC Article

Prognosis

APOBEC3C is a novel target for the immune treatment of lower-grade gliomas.
Zhao S, Li Y, Xu J, Shen L
Neurol Res 2024 Mar;46(3):227-242. Epub 2024 Jan 22 doi: 10.1080/01616412.2023.2287340. PMID: 38007705
Single-cell dissection of cellular and molecular features underlying human cervical squamous cell carcinoma initiation and progression.
Liu C, Zhang M, Yan X, Ni Y, Gong Y, Wang C, Zhang X, Wan L, Yang H, Ge C, Li Y, Zou W, Huang R, Li X, Sun B, Liu B, Yue J, Yu J
Sci Adv 2023 Jan 27;9(4):eadd8977. doi: 10.1126/sciadv.add8977. PMID: 36706185Free PMC Article
Racial and Ethnic Disparities in Cervical Cancer Incidence, Survival, and Mortality by Histologic Subtype.
Cohen CM, Wentzensen N, Castle PE, Schiffman M, Zuna R, Arend RC, Clarke MA
J Clin Oncol 2023 Feb 10;41(5):1059-1068. Epub 2022 Dec 1 doi: 10.1200/JCO.22.01424. PMID: 36455190Free PMC Article
Single-Nucleus RNA Sequencing and Spatial Transcriptomics Reveal the Immunological Microenvironment of Cervical Squamous Cell Carcinoma.
Ou Z, Lin S, Qiu J, Ding W, Ren P, Chen D, Wang J, Tong Y, Wu D, Chen A, Deng Y, Cheng M, Peng T, Lu H, Yang H, Wang J, Jin X, Ma D, Xu X, Wang Y, Li J, Wu P
Adv Sci (Weinh) 2022 Oct;9(29):e2203040. Epub 2022 Aug 19 doi: 10.1002/advs.202203040. PMID: 35986392Free PMC Article
Pan-Cancer Analysis of the Prognostic and Immunological Role of HSF1: A Potential Target for Survival and Immunotherapy.
Chen F, Fan Y, Cao P, Liu B, Hou J, Zhang B, Tan K
Oxid Med Cell Longev 2021;2021:5551036. Epub 2021 Jun 18 doi: 10.1155/2021/5551036. PMID: 34239690Free PMC Article

Clinical prediction guides

APOBEC3C is a novel target for the immune treatment of lower-grade gliomas.
Zhao S, Li Y, Xu J, Shen L
Neurol Res 2024 Mar;46(3):227-242. Epub 2024 Jan 22 doi: 10.1080/01616412.2023.2287340. PMID: 38007705
Diverse intratumoral heterogeneity and immune microenvironment of two HPV-related cervical cancer types revealed by single-cell RNA sequencing.
Li C, Liu D, Zhao Y, Ding Y, Hua K
J Med Virol 2023 Jun;95(6):e28857. doi: 10.1002/jmv.28857. PMID: 37287196
Racial and Ethnic Disparities in Cervical Cancer Incidence, Survival, and Mortality by Histologic Subtype.
Cohen CM, Wentzensen N, Castle PE, Schiffman M, Zuna R, Arend RC, Clarke MA
J Clin Oncol 2023 Feb 10;41(5):1059-1068. Epub 2022 Dec 1 doi: 10.1200/JCO.22.01424. PMID: 36455190Free PMC Article
Single-Nucleus RNA Sequencing and Spatial Transcriptomics Reveal the Immunological Microenvironment of Cervical Squamous Cell Carcinoma.
Ou Z, Lin S, Qiu J, Ding W, Ren P, Chen D, Wang J, Tong Y, Wu D, Chen A, Deng Y, Cheng M, Peng T, Lu H, Yang H, Wang J, Jin X, Ma D, Xu X, Wang Y, Li J, Wu P
Adv Sci (Weinh) 2022 Oct;9(29):e2203040. Epub 2022 Aug 19 doi: 10.1002/advs.202203040. PMID: 35986392Free PMC Article
Pan-Cancer Analysis of the Prognostic and Immunological Role of HSF1: A Potential Target for Survival and Immunotherapy.
Chen F, Fan Y, Cao P, Liu B, Hou J, Zhang B, Tan K
Oxid Med Cell Longev 2021;2021:5551036. Epub 2021 Jun 18 doi: 10.1155/2021/5551036. PMID: 34239690Free PMC Article

Recent systematic reviews

Hormone replacement therapy and cervical cancer: a systematic review of the literature.
Vargiu V, Amar ID, Rosati A, Dinoi G, Turco LC, Capozzi VA, Scambia G, Villa P
Climacteric 2021 Apr;24(2):120-127. Epub 2020 Nov 25 doi: 10.1080/13697137.2020.1826426. PMID: 33236658
Prognostic Value of MicroRNA-15a in Human Cancers: A Meta-Analysis and Bioinformatics.
Yang FR, Li HJ, Li TT, Zhao YF, Liu ZK, Li XR
Biomed Res Int 2019;2019:2063823. Epub 2019 Apr 2 doi: 10.1155/2019/2063823. PMID: 31061821Free PMC Article
The association between serum squamous cell carcinoma antigen and recurrence and survival of patients with cervical squamous cell carcinoma: A systematic review and meta-analysis.
Charakorn C, Thadanipon K, Chaijindaratana S, Rattanasiri S, Numthavaj P, Thakkinstian A
Gynecol Oncol 2018 Jul;150(1):190-200. Epub 2018 Mar 29 doi: 10.1016/j.ygyno.2018.03.056. PMID: 29606483
Chromosomal gains and losses in human papillomavirus-associated neoplasia of the lower genital tract - a systematic review and meta-analysis.
Thomas LK, Bermejo JL, Vinokurova S, Jensen K, Bierkens M, Steenbergen R, Bergmann M, von Knebel Doeberitz M, Reuschenbach M
Eur J Cancer 2014 Jan;50(1):85-98. Epub 2013 Sep 17 doi: 10.1016/j.ejca.2013.08.022. PMID: 24054023
Mutations of the TP53 gene in adenocarcinoma and squamous cell carcinoma of the cervix: a systematic review.
Tornesello ML, Buonaguro L, Buonaguro FM
Gynecol Oncol 2013 Mar;128(3):442-8. Epub 2012 Nov 17 doi: 10.1016/j.ygyno.2012.11.017. PMID: 23168175

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