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Cervical squamous cell carcinoma

MedGen UID:
124644
•Concept ID:
C0279671
•
Neoplastic Process
Synonyms: cervical squamous cell cancer; Cervical Squamous Cell Carcinoma; cervical squamous cell carcinoma; Cervix Squamous Cell Carcinoma; cervix squamous cell carcinoma; Cervix Uteri Squamous Cell Carcinoma; cervix uteri squamous cell carcinoma; CESC; Squamous cell carcinoma of cervix; Squamous Cell Carcinoma of Cervix; squamous cell carcinoma of cervix; Squamous Cell Carcinoma of Cervix Uteri; squamous cell carcinoma of cervix uteri; Squamous Cell Carcinoma of the Cervix; squamous cell carcinoma of the cervix; Squamous Cell Carcinoma of the Cervix Uteri; squamous cell carcinoma of the cervix uteri; Squamous cell carcinoma of the cervix uteri; Squamous Cell Carcinoma of the Uterine Cervix; squamous cell carcinoma of the uterine cervix; Squamous Cell Carcinoma of Uterine Cervix; squamous cell carcinoma of uterine cervix; squamous cervical cancer; Uterine Cervix Squamous Cell Carcinoma; uterine cervix squamous cell carcinoma
SNOMED CT: Squamous cell carcinoma of cervix (254886006)
 
Monarch Initiative: MONDO:0006143
Orphanet: ORPHA213767

Definition

A squamous cell carcinoma arising from the cervical epithelium. It usually evolves from a precancerous cervical lesion. Increased numbers of sexual partners and human papillomavirus (HPV) infection are risk factors for cervical squamous cell carcinoma. Survival is most closely related to the stage of disease at the time of diagnosis. [from NCI]

Professional guidelines

PubMed

The multifaceted mechanisms of pristimerin in the treatment of tumors state-of-the-art.
Wang Y, Feng W, Wang X, Li X, Mou Y, Wang X, Zhang Y
Biomed Pharmacother 2022 Oct;154:113575. Epub 2022 Aug 18 doi: 10.1016/j.biopha.2022.113575. PMID: 35988422
Management of Vaginal Cancer.
Shrivastava SB, Agrawal G, Mittal M, Mishra P
Rev Recent Clin Trials 2015;10(4):289-97. doi: 10.2174/1574887110666150923112958. PMID: 26411952
Patient-tailored conservative surgical treatment of invasive uterine cervical squamous cell carcinoma. A review.
Menczer J
Minerva Ginecol 2013 Aug;65(4):407-15. PMID: 24051940

Recent clinical studies

Etiology

Necroptosis-related lncRNA signature predicts prognosis and immune response for cervical squamous cell carcinoma and endocervical adenocarcinomas.
Lin Z, Zou J, Sui X, Yao S, Lin L, Wang J, Zhao J
Sci Rep 2022 Sep 29;12(1):16285. doi: 10.1038/s41598-022-20858-5. PMID: 36175606Free PMC Article
FTO m6A Demethylase in Obesity and Cancer: Implications and Underlying Molecular Mechanisms.
Azzam SK, Alsafar H, Sajini AA
Int J Mol Sci 2022 Mar 30;23(7) doi: 10.3390/ijms23073800. PMID: 35409166Free PMC Article
SNX10 and PTGDS are associated with the progression and prognosis of cervical squamous cell carcinoma.
Jiang P, Cao Y, Gao F, Sun W, Liu J, Ma Z, Xie M, Fu S
BMC Cancer 2021 Jun 11;21(1):694. doi: 10.1186/s12885-021-08212-w. PMID: 34116656Free PMC Article
Cancer-derived exosomal miR-221-3p promotes angiogenesis by targeting THBS2 in cervical squamous cell carcinoma.
Wu XG, Zhou CF, Zhang YM, Yan RM, Wei WF, Chen XJ, Yi HY, Liang LJ, Fan LS, Liang L, Wu S, Wang W
Angiogenesis 2019 Aug;22(3):397-410. Epub 2019 Apr 15 doi: 10.1007/s10456-019-09665-1. PMID: 30993566
Management of Vaginal Cancer.
Shrivastava SB, Agrawal G, Mittal M, Mishra P
Rev Recent Clin Trials 2015;10(4):289-97. doi: 10.2174/1574887110666150923112958. PMID: 26411952

Diagnosis

Single-cell dissection of cellular and molecular features underlying human cervical squamous cell carcinoma initiation and progression.
Liu C, Zhang M, Yan X, Ni Y, Gong Y, Wang C, Zhang X, Wan L, Yang H, Ge C, Li Y, Zou W, Huang R, Li X, Sun B, Liu B, Yue J, Yu J
Sci Adv 2023 Jan 27;9(4):eadd8977. doi: 10.1126/sciadv.add8977. PMID: 36706185Free PMC Article
Targeting CD96 overcomes PD-1 blockade resistance by enhancing CD8+ TIL function in cervical cancer.
Wang Y, Wang C, Qiu J, Qu X, Peng J, Lu C, Zhang M, Zhang M, Qi X, Li G, Hua K
J Immunother Cancer 2022 Mar;10(3) doi: 10.1136/jitc-2021-003667. PMID: 35288463Free PMC Article
Cancer-derived exosomal miR-221-3p promotes angiogenesis by targeting THBS2 in cervical squamous cell carcinoma.
Wu XG, Zhou CF, Zhang YM, Yan RM, Wei WF, Chen XJ, Yi HY, Liang LJ, Fan LS, Liang L, Wu S, Wang W
Angiogenesis 2019 Aug;22(3):397-410. Epub 2019 Apr 15 doi: 10.1007/s10456-019-09665-1. PMID: 30993566
Cervical squamous cell carcinoma-secreted exosomal miR-221-3p promotes lymphangiogenesis and lymphatic metastasis by targeting VASH1.
Zhou CF, Ma J, Huang L, Yi HY, Zhang YM, Wu XG, Yan RM, Liang L, Zhong M, Yu YH, Wu S, Wang W
Oncogene 2019 Feb;38(8):1256-1268. Epub 2018 Sep 25 doi: 10.1038/s41388-018-0511-x. PMID: 30254211Free PMC Article
Management of Vaginal Cancer.
Shrivastava SB, Agrawal G, Mittal M, Mishra P
Rev Recent Clin Trials 2015;10(4):289-97. doi: 10.2174/1574887110666150923112958. PMID: 26411952

Therapy

A multicenter phase 2 trial of camrelizumab plus famitinib for women with recurrent or metastatic cervical squamous cell carcinoma.
Xia L, Zhou Q, Gao Y, Hu W, Lou G, Sun H, Zhu J, Shu J, Zhou X, Sun R, Wu X
Nat Commun 2022 Dec 8;13(1):7581. doi: 10.1038/s41467-022-35133-4. PMID: 36481736Free PMC Article
Immune Determinants of the Association between Tumor Mutational Burden and Immunotherapy Response across Cancer Types.
Sinha N, Sinha S, Valero C, Schäffer AA, Aldape K, Litchfield K, Chan TA, Morris LGT, Ruppin E
Cancer Res 2022 Jun 6;82(11):2076-2083. doi: 10.1158/0008-5472.CAN-21-2542. PMID: 35385572Free PMC Article
Cell Therapy With TILs: Training and Taming T Cells to Fight Cancer.
Kumar A, Watkins R, Vilgelm AE
Front Immunol 2021;12:690499. Epub 2021 Jun 1 doi: 10.3389/fimmu.2021.690499. PMID: 34140957Free PMC Article
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article
Oncostatin M receptor is a novel therapeutic target in cervical squamous cell carcinoma.
Caffarel MM, Coleman N
J Pathol 2014 Mar;232(4):386-90. doi: 10.1002/path.4305. PMID: 24659184Free PMC Article

Prognosis

Single-cell dissection of cellular and molecular features underlying human cervical squamous cell carcinoma initiation and progression.
Liu C, Zhang M, Yan X, Ni Y, Gong Y, Wang C, Zhang X, Wan L, Yang H, Ge C, Li Y, Zou W, Huang R, Li X, Sun B, Liu B, Yue J, Yu J
Sci Adv 2023 Jan 27;9(4):eadd8977. doi: 10.1126/sciadv.add8977. PMID: 36706185Free PMC Article
Single-Nucleus RNA Sequencing and Spatial Transcriptomics Reveal the Immunological Microenvironment of Cervical Squamous Cell Carcinoma.
Ou Z, Lin S, Qiu J, Ding W, Ren P, Chen D, Wang J, Tong Y, Wu D, Chen A, Deng Y, Cheng M, Peng T, Lu H, Yang H, Wang J, Jin X, Ma D, Xu X, Wang Y, Li J, Wu P
Adv Sci (Weinh) 2022 Oct;9(29):e2203040. Epub 2022 Aug 19 doi: 10.1002/advs.202203040. PMID: 35986392Free PMC Article
Pan-Cancer Analysis of the Prognostic and Immunological Role of HSF1: A Potential Target for Survival and Immunotherapy.
Chen F, Fan Y, Cao P, Liu B, Hou J, Zhang B, Tan K
Oxid Med Cell Longev 2021;2021:5551036. Epub 2021 Jun 18 doi: 10.1155/2021/5551036. PMID: 34239690Free PMC Article
Systematic Pan-Cancer Analysis Identifies TREM2 as an Immunological and Prognostic Biomarker.
Cheng X, Wang X, Nie K, Cheng L, Zhang Z, Hu Y, Peng W
Front Immunol 2021;12:646523. Epub 2021 Feb 17 doi: 10.3389/fimmu.2021.646523. PMID: 33679809Free PMC Article
Cancer-derived exosomal miR-221-3p promotes angiogenesis by targeting THBS2 in cervical squamous cell carcinoma.
Wu XG, Zhou CF, Zhang YM, Yan RM, Wei WF, Chen XJ, Yi HY, Liang LJ, Fan LS, Liang L, Wu S, Wang W
Angiogenesis 2019 Aug;22(3):397-410. Epub 2019 Apr 15 doi: 10.1007/s10456-019-09665-1. PMID: 30993566

Clinical prediction guides

Single-Nucleus RNA Sequencing and Spatial Transcriptomics Reveal the Immunological Microenvironment of Cervical Squamous Cell Carcinoma.
Ou Z, Lin S, Qiu J, Ding W, Ren P, Chen D, Wang J, Tong Y, Wu D, Chen A, Deng Y, Cheng M, Peng T, Lu H, Yang H, Wang J, Jin X, Ma D, Xu X, Wang Y, Li J, Wu P
Adv Sci (Weinh) 2022 Oct;9(29):e2203040. Epub 2022 Aug 19 doi: 10.1002/advs.202203040. PMID: 35986392Free PMC Article
The Prognostic Value and Immunological Role of STEAP1 in Pan-Cancer: A Result of Data-Based Analysis.
Zhao C, Xiong K, Ji Z, Liu F, Li X
Oxid Med Cell Longev 2022;2022:8297011. Epub 2022 Mar 11 doi: 10.1155/2022/8297011. PMID: 35313641Free PMC Article
Pan-Cancer Analysis of the Prognostic and Immunological Role of HSF1: A Potential Target for Survival and Immunotherapy.
Chen F, Fan Y, Cao P, Liu B, Hou J, Zhang B, Tan K
Oxid Med Cell Longev 2021;2021:5551036. Epub 2021 Jun 18 doi: 10.1155/2021/5551036. PMID: 34239690Free PMC Article
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article
Cancer-derived exosomal miR-221-3p promotes angiogenesis by targeting THBS2 in cervical squamous cell carcinoma.
Wu XG, Zhou CF, Zhang YM, Yan RM, Wei WF, Chen XJ, Yi HY, Liang LJ, Fan LS, Liang L, Wu S, Wang W
Angiogenesis 2019 Aug;22(3):397-410. Epub 2019 Apr 15 doi: 10.1007/s10456-019-09665-1. PMID: 30993566

Recent systematic reviews

Hormone replacement therapy and cervical cancer: a systematic review of the literature.
Vargiu V, Amar ID, Rosati A, Dinoi G, Turco LC, Capozzi VA, Scambia G, Villa P
Climacteric 2021 Apr;24(2):120-127. Epub 2020 Nov 25 doi: 10.1080/13697137.2020.1826426. PMID: 33236658
Prognostic Value of MicroRNA-15a in Human Cancers: A Meta-Analysis and Bioinformatics.
Yang FR, Li HJ, Li TT, Zhao YF, Liu ZK, Li XR
Biomed Res Int 2019;2019:2063823. Epub 2019 Apr 2 doi: 10.1155/2019/2063823. PMID: 31061821Free PMC Article
The association between serum squamous cell carcinoma antigen and recurrence and survival of patients with cervical squamous cell carcinoma: A systematic review and meta-analysis.
Charakorn C, Thadanipon K, Chaijindaratana S, Rattanasiri S, Numthavaj P, Thakkinstian A
Gynecol Oncol 2018 Jul;150(1):190-200. Epub 2018 Mar 29 doi: 10.1016/j.ygyno.2018.03.056. PMID: 29606483
Chromosomal gains and losses in human papillomavirus-associated neoplasia of the lower genital tract - a systematic review and meta-analysis.
Thomas LK, Bermejo JL, Vinokurova S, Jensen K, Bierkens M, Steenbergen R, Bergmann M, von Knebel Doeberitz M, Reuschenbach M
Eur J Cancer 2014 Jan;50(1):85-98. Epub 2013 Sep 17 doi: 10.1016/j.ejca.2013.08.022. PMID: 24054023
Mutations of the TP53 gene in adenocarcinoma and squamous cell carcinoma of the cervix: a systematic review.
Tornesello ML, Buonaguro L, Buonaguro FM
Gynecol Oncol 2013 Mar;128(3):442-8. Epub 2012 Nov 17 doi: 10.1016/j.ygyno.2012.11.017. PMID: 23168175

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