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Childhood brain germinoma

MedGen UID:
272458
•Concept ID:
C1332948
•
Neoplastic Process
Synonyms: brain germinoma of childhood; Childhood Brain Germinoma; childhood brain germinoma; Germinoma of Childhood Brain; germinoma of childhood brain; germinoma of paediatric brain; Germinoma of Pediatric Brain; germinoma of pediatric brain; Germinoma of the Childhood Brain; germinoma of the childhood brain; germinoma of the paediatric brain; Germinoma of the Pediatric Brain; germinoma of the pediatric brain; paediatric brain germ cell cancer; paediatric brain germinoma; Pediatric Brain Germ Cell Cancer; pediatric brain germ cell cancer; Pediatric Brain Germinoma; pediatric brain germinoma
 
Monarch Initiative: MONDO:0004217

Definition

A germinoma arising from the brain during childhood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood brain germinoma

Professional guidelines

PubMed

Primary central nervous system germ cell tumors in children and young adults: A review of controversies in diagnostic and treatment approach.
Yeo KK, Nagabushan S, Dhall G, Abdelbaki MS
Neoplasia 2023 Feb;36:100860. Epub 2022 Dec 13 doi: 10.1016/j.neo.2022.100860. PMID: 36521378Free PMC Article
Longitudinal evaluation of neurocognitive function after treatment for central nervous system germ cell tumors in childhood.
Mabbott DJ, Monsalves E, Spiegler BJ, Bartels U, Janzen L, Guger S, Laperriere N, Andrews N, Bouffet E
Cancer 2011 Dec 1;117(23):5402-11. Epub 2011 May 11 doi: 10.1002/cncr.26127. PMID: 21563173
Advances in biology and treatment of childhood brain tumors.
Reddy AT
Curr Neurol Neurosci Rep 2001 Mar;1(2):137-43. doi: 10.1007/s11910-001-0009-7. PMID: 11898509

Recent clinical studies

Etiology

Evaluation of the etiological and clinical characteristics of pediatric central diabetes insipidus.
Gasimova E, Berberoğlu M, Özsu E, Aycan Z, Uyanık R, Bilici E, Ceran A, Şiklar Z
J Pediatr Endocrinol Metab 2022 Aug 26;35(8):1089-1096. Epub 2022 Jul 12 doi: 10.1515/jpem-2022-0058. PMID: 35822703
Relapsing intracranial germ cell tumours warrant retreatment.
Callec L, Lardy-Cleaud A, Guerrini-Rousseau L, Alapetite C, Vignon L, Chastagner P, Frappaz D, Faure-Conter C
Eur J Cancer 2020 Sep;136:186-194. Epub 2020 Jul 22 doi: 10.1016/j.ejca.2020.06.012. PMID: 32711377
Antibodies Against Hypothalamus and Pituitary Gland in Childhood-Onset Brain Tumors and Pituitary Dysfunction.
Patti G, Calandra E, De Bellis A, Gallizia A, Crocco M, Napoli F, Allegri AME, Thiabat HF, Bellastella G, Maiorino MI, Garrè ML, Parodi S, Maghnie M, di Iorgi N
Front Endocrinol (Lausanne) 2020;11:16. Epub 2020 Feb 18 doi: 10.3389/fendo.2020.00016. PMID: 32132974Free PMC Article
Paediatric brain tumours: A review of radiotherapy, state of the art and challenges for the future regarding protontherapy and carbontherapy.
Laprie A, Hu Y, Alapetite C, Carrie C, Habrand JL, Bolle S, Bondiau PY, Ducassou A, Huchet A, Bertozzi AI, Perel Y, Moyal É, Balosso J; radiotherapy committee of SFCE and France Hadron
Cancer Radiother 2015 Dec;19(8):775-89. Epub 2015 Nov 6 doi: 10.1016/j.canrad.2015.05.028. PMID: 26548600
Long-term outcomes and late effects for childhood and young adulthood intracranial germinomas.
Acharya S, DeWees T, Shinohara ET, Perkins SM
Neuro Oncol 2015 May;17(5):741-6. Epub 2014 Nov 23 doi: 10.1093/neuonc/nou311. PMID: 25422317Free PMC Article

Diagnosis

Primary central nervous system germ cell tumors in children and young adults: A review of controversies in diagnostic and treatment approach.
Yeo KK, Nagabushan S, Dhall G, Abdelbaki MS
Neoplasia 2023 Feb;36:100860. Epub 2022 Dec 13 doi: 10.1016/j.neo.2022.100860. PMID: 36521378Free PMC Article
Evaluation of the etiological and clinical characteristics of pediatric central diabetes insipidus.
Gasimova E, Berberoğlu M, Özsu E, Aycan Z, Uyanık R, Bilici E, Ceran A, Şiklar Z
J Pediatr Endocrinol Metab 2022 Aug 26;35(8):1089-1096. Epub 2022 Jul 12 doi: 10.1515/jpem-2022-0058. PMID: 35822703
Relapsing intracranial germ cell tumours warrant retreatment.
Callec L, Lardy-Cleaud A, Guerrini-Rousseau L, Alapetite C, Vignon L, Chastagner P, Frappaz D, Faure-Conter C
Eur J Cancer 2020 Sep;136:186-194. Epub 2020 Jul 22 doi: 10.1016/j.ejca.2020.06.012. PMID: 32711377
Central nervous system germ cell tumors: an update.
Dufour C, Guerrini-Rousseau L, Grill J
Curr Opin Oncol 2014 Nov;26(6):622-6. doi: 10.1097/CCO.0000000000000140. PMID: 25233069
Pineal region tumours in childhood. A 30-year experience.
Drummond KJ, Rosenfeld JV
Childs Nerv Syst 1999 Mar;15(2-3):119-26; discussion 127. doi: 10.1007/s003810050347. PMID: 10230668

Therapy

Challenges in the Management of Childhood Intracranial Germ Cell Tumors in Middle-Income Countries: A 20-Year Retrospective Review From a Single Tertiary Center in Malaysia.
Rajagopal R, Leong SH, Jawin V, Foo JC, Ahmad Bahuri NF, Mun KS, Azman RR, Loh J, Yap TY, Ariffin H, Moreira DC, Gottardo NG, Bouffet E, Ganesan D
J Pediatr Hematol Oncol 2021 Oct 1;43(7):e913-e923. doi: 10.1097/MPH.0000000000002116. PMID: 33633029
Clinical and neuropsychological outcome of pediatric non-midline central nervous system germinoma treated with chemotherapy and reduced dose/volume irradiation: The Children's Hospital Los Angeles experience.
Yeo KK, Kayser K, Margol AS, Wong KK, Robison N, Finlay J, Dhall G
Pediatr Blood Cancer 2019 Dec;66(12):e27983. Epub 2019 Sep 10 doi: 10.1002/pbc.27983. PMID: 31502379
Advances in biology and treatment of childhood brain tumors.
Reddy AT
Curr Neurol Neurosci Rep 2001 Mar;1(2):137-43. doi: 10.1007/s11910-001-0009-7. PMID: 11898509
Childhood tumors.
Packer RJ
Curr Opin Pediatr 1997 Dec;9(6):551-7. doi: 10.1097/00008480-199712000-00001. PMID: 9425586
Carboplatin and recurrent childhood brain tumors.
Allen JC, Walker R, Luks E, Jennings M, Barfoot S, Tan C
J Clin Oncol 1987 Mar;5(3):459-63. doi: 10.1200/JCO.1987.5.3.459. PMID: 3546620

Prognosis

Relapsing intracranial germ cell tumours warrant retreatment.
Callec L, Lardy-Cleaud A, Guerrini-Rousseau L, Alapetite C, Vignon L, Chastagner P, Frappaz D, Faure-Conter C
Eur J Cancer 2020 Sep;136:186-194. Epub 2020 Jul 22 doi: 10.1016/j.ejca.2020.06.012. PMID: 32711377
Antibodies Against Hypothalamus and Pituitary Gland in Childhood-Onset Brain Tumors and Pituitary Dysfunction.
Patti G, Calandra E, De Bellis A, Gallizia A, Crocco M, Napoli F, Allegri AME, Thiabat HF, Bellastella G, Maiorino MI, Garrè ML, Parodi S, Maghnie M, di Iorgi N
Front Endocrinol (Lausanne) 2020;11:16. Epub 2020 Feb 18 doi: 10.3389/fendo.2020.00016. PMID: 32132974Free PMC Article
Long-term outcomes and late effects for childhood and young adulthood intracranial germinomas.
Acharya S, DeWees T, Shinohara ET, Perkins SM
Neuro Oncol 2015 May;17(5):741-6. Epub 2014 Nov 23 doi: 10.1093/neuonc/nou311. PMID: 25422317Free PMC Article
Central nervous system germ cell tumors: an update.
Dufour C, Guerrini-Rousseau L, Grill J
Curr Opin Oncol 2014 Nov;26(6):622-6. doi: 10.1097/CCO.0000000000000140. PMID: 25233069
Pineal region tumours in childhood. A 30-year experience.
Drummond KJ, Rosenfeld JV
Childs Nerv Syst 1999 Mar;15(2-3):119-26; discussion 127. doi: 10.1007/s003810050347. PMID: 10230668

Clinical prediction guides

Relapsing intracranial germ cell tumours warrant retreatment.
Callec L, Lardy-Cleaud A, Guerrini-Rousseau L, Alapetite C, Vignon L, Chastagner P, Frappaz D, Faure-Conter C
Eur J Cancer 2020 Sep;136:186-194. Epub 2020 Jul 22 doi: 10.1016/j.ejca.2020.06.012. PMID: 32711377
Antibodies Against Hypothalamus and Pituitary Gland in Childhood-Onset Brain Tumors and Pituitary Dysfunction.
Patti G, Calandra E, De Bellis A, Gallizia A, Crocco M, Napoli F, Allegri AME, Thiabat HF, Bellastella G, Maiorino MI, Garrè ML, Parodi S, Maghnie M, di Iorgi N
Front Endocrinol (Lausanne) 2020;11:16. Epub 2020 Feb 18 doi: 10.3389/fendo.2020.00016. PMID: 32132974Free PMC Article
Long-term outcomes and late effects for childhood and young adulthood intracranial germinomas.
Acharya S, DeWees T, Shinohara ET, Perkins SM
Neuro Oncol 2015 May;17(5):741-6. Epub 2014 Nov 23 doi: 10.1093/neuonc/nou311. PMID: 25422317Free PMC Article
Neuroendoscopic management of intraventricular germinoma at the foramen of Monro: case report and review of the literature.
Yip CM, Hsu SS, Liao WC, Chen JY, Liu SH, Chen CH
Minim Invasive Neurosurg 2011 Aug;54(4):191-5. Epub 2011 Sep 15 doi: 10.1055/s-0031-1285887. PMID: 21922450
The applicability of Collins' Law to childhood brain tumors and its usefulness as a predictor of survival.
Brown WD, Tavaré CJ, Sobel EL, Gilles FH
Neurosurgery 1995 Jun;36(6):1093-6. doi: 10.1227/00006123-199506000-00004. PMID: 7643986

Recent systematic reviews

Paediatric brain tumours: A review of radiotherapy, state of the art and challenges for the future regarding protontherapy and carbontherapy.
Laprie A, Hu Y, Alapetite C, Carrie C, Habrand JL, Bolle S, Bondiau PY, Ducassou A, Huchet A, Bertozzi AI, Perel Y, Moyal É, Balosso J; radiotherapy committee of SFCE and France Hadron
Cancer Radiother 2015 Dec;19(8):775-89. Epub 2015 Nov 6 doi: 10.1016/j.canrad.2015.05.028. PMID: 26548600

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