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Childhood teratoma of the ovary

MedGen UID:
272466
•Concept ID:
C1332992
•
Neoplastic Process
Synonyms: Childhood Ovarian Teratoma; childhood ovarian teratoma; Childhood Teratoma of Ovary; childhood teratoma of ovary; Childhood Teratoma of the Ovary; childhood teratoma of the ovary; ovarian teratoma of childhood; paediatric ovarian teratoma; paediatric teratoma of ovary; paediatric teratoma of the ovary; Pediatric Ovarian Teratoma; pediatric ovarian teratoma; Pediatric Teratoma of Ovary; pediatric teratoma of ovary; Pediatric Teratoma of the Ovary; pediatric teratoma of the ovary
 
Monarch Initiative: MONDO:0003819

Definition

A teratoma that arises from the ovary and occurs in children. [from NCI]

Professional guidelines

PubMed

Childhood ovarian nonseminomatous germ cell tumors: A highly curable disease with few long-term treatment-related toxicities-Results of the French TGM95 study.
Pavone R, Pacquement H, Pasquet M, Sudour-Bonnange H, Hameury F, Sarnacki S, Chastagner P, Faure-Conter C, Poirée M, Taque S, Patte C, Fresneau B
Int J Cancer 2021 Nov 1;149(9):1705-1712. Epub 2021 Jul 5 doi: 10.1002/ijc.33710. PMID: 34146403
Current status of the treatment of gynecologic cancer by site: ovary.
Barber HR, Kwon TH
Cancer 1976 Jul;38(1 SUPPL):610-9. doi: 10.1002/1097-0142(197607)38:1<610::aid-cncr2820380186>3.0.co;2-t. PMID: 1277113

Recent clinical studies

Etiology

Associations between birth defects and childhood and adolescent germ cell tumors according to sex, histologic subtype, and site.
Schraw JM, Sok P, Desrosiers TA, Janitz AE, Langlois PH, Canfield MA, Frazier AL, Plon SE, Lupo PJ, Poynter JN
Cancer 2023 Oct 15;129(20):3300-3308. Epub 2023 Jun 27 doi: 10.1002/cncr.34906. PMID: 37366624Free PMC Article
Outcomes and prognostic variables of extracranial germ cell tumors in children and adolescents treated over a decade: A developing world perspective.
Ramanathan S, Prasad M, Vora T, Parambil BC, Kembhavi S, Ramadwar M, Khanna N, Laskar S, Kurkure P, Qureshi S, Banavali S, Chinnaswamy G
Pediatr Blood Cancer 2022 Jul;69(7):e29765. Epub 2022 May 13 doi: 10.1002/pbc.29765. PMID: 35561025
Surgical management of ovarian teratomas in childhood: a multicentric study on 110 cases and a literature review.
Spinelli C, Strambi S, Masoni B, Ghionzoli M, Bertocchini A, Sanna B, Morganti R, Messina M, Molinaro F, Tursini S, Briganti V, Lisi G, Lelli Chiesa P
Gynecol Endocrinol 2021 Oct;37(10):950-954. Epub 2021 Jul 13 doi: 10.1080/09513590.2021.1948527. PMID: 34254550
Atypical teratoid/rhabdoid tumors (ATRTs) with SMARCA4 mutation are molecularly distinct from SMARCB1-deficient cases.
Holdhof D, Johann PD, Spohn M, Bockmayr M, Safaei S, Joshi P, Masliah-Planchon J, Ho B, Andrianteranagna M, Bourdeaut F, Huang A, Kool M, Upadhyaya SA, Bendel AE, Indenbirken D, Foulkes WD, Bush JW, Creytens D, Kordes U, Frühwald MC, Hasselblatt M, Schüller U
Acta Neuropathol 2021 Feb;141(2):291-301. Epub 2020 Dec 17 doi: 10.1007/s00401-020-02250-7. PMID: 33331994Free PMC Article
Germ-cell tumors in childhood and adolescence. GPOH MAKEI and the MAHO study groups.
Göbel U, Schneider DT, Calaminus G, Haas RJ, Schmidt P, Harms D
Ann Oncol 2000 Mar;11(3):263-71. doi: 10.1023/a:1008360523160. PMID: 10811491

Diagnosis

Surgical management of ovarian teratomas in childhood: a multicentric study on 110 cases and a literature review.
Spinelli C, Strambi S, Masoni B, Ghionzoli M, Bertocchini A, Sanna B, Morganti R, Messina M, Molinaro F, Tursini S, Briganti V, Lisi G, Lelli Chiesa P
Gynecol Endocrinol 2021 Oct;37(10):950-954. Epub 2021 Jul 13 doi: 10.1080/09513590.2021.1948527. PMID: 34254550
Ovarian neoplasms of childhood.
Lala SV, Strubel N
Pediatr Radiol 2019 Oct;49(11):1463-1475. Epub 2019 Oct 16 doi: 10.1007/s00247-019-04456-8. PMID: 31620847
Adnexal masses in children and adolescents.
Kelleher CM, Goldstein AM
Clin Obstet Gynecol 2015 Mar;58(1):76-92. doi: 10.1097/GRF.0000000000000084. PMID: 25551698
Pediatric intramedullary teratomas.
Işik N, Balak N, Silav G, Elmaci I
Neuropediatrics 2008 Aug;39(4):196-9. Epub 2009 Jan 22 doi: 10.1055/s-0028-1112116. PMID: 19165706
Germ-cell tumors in childhood and adolescence. GPOH MAKEI and the MAHO study groups.
Göbel U, Schneider DT, Calaminus G, Haas RJ, Schmidt P, Harms D
Ann Oncol 2000 Mar;11(3):263-71. doi: 10.1023/a:1008360523160. PMID: 10811491

Therapy

Outcomes of relapsed/refractory extracranial germ cell tumors treated on conventional salvage chemotherapy without stem cell rescue: Experience from a tertiary cancer center.
Ramanathan S, Prasad M, Vora T, Badira CP, Kembhavi S, Ramadwar M, Khanna N, Laskar S, Muckaden MA, Qureshi S, Banavali S, Chinnaswamy G
Pediatr Blood Cancer 2023 Apr;70(4):e30179. Epub 2023 Jan 16 doi: 10.1002/pbc.30179. PMID: 36645132
Outcomes and prognostic variables of extracranial germ cell tumors in children and adolescents treated over a decade: A developing world perspective.
Ramanathan S, Prasad M, Vora T, Parambil BC, Kembhavi S, Ramadwar M, Khanna N, Laskar S, Kurkure P, Qureshi S, Banavali S, Chinnaswamy G
Pediatr Blood Cancer 2022 Jul;69(7):e29765. Epub 2022 May 13 doi: 10.1002/pbc.29765. PMID: 35561025
Childhood ovarian nonseminomatous germ cell tumors: A highly curable disease with few long-term treatment-related toxicities-Results of the French TGM95 study.
Pavone R, Pacquement H, Pasquet M, Sudour-Bonnange H, Hameury F, Sarnacki S, Chastagner P, Faure-Conter C, Poirée M, Taque S, Patte C, Fresneau B
Int J Cancer 2021 Nov 1;149(9):1705-1712. Epub 2021 Jul 5 doi: 10.1002/ijc.33710. PMID: 34146403
Teratomas in infancy and childhood.
Göbel U, Calaminus G, Engert J, Kaatsch P, Gadner H, Bökkerink JP, Hass RJ, Waag K, Blohm ME, Dippert S, Teske C, Harms D
Med Pediatr Oncol 1998 Jul;31(1):8-15. doi: 10.1002/(sici)1096-911x(199807)31:1<8::aid-mpo2>3.0.co;2-h. PMID: 9607423
Current status of the treatment of gynecologic cancer by site: ovary.
Barber HR, Kwon TH
Cancer 1976 Jul;38(1 SUPPL):610-9. doi: 10.1002/1097-0142(197607)38:1<610::aid-cncr2820380186>3.0.co;2-t. PMID: 1277113

Prognosis

Outcomes and prognostic variables of extracranial germ cell tumors in children and adolescents treated over a decade: A developing world perspective.
Ramanathan S, Prasad M, Vora T, Parambil BC, Kembhavi S, Ramadwar M, Khanna N, Laskar S, Kurkure P, Qureshi S, Banavali S, Chinnaswamy G
Pediatr Blood Cancer 2022 Jul;69(7):e29765. Epub 2022 May 13 doi: 10.1002/pbc.29765. PMID: 35561025
Atypical teratoid/rhabdoid tumors (ATRTs) with SMARCA4 mutation are molecularly distinct from SMARCB1-deficient cases.
Holdhof D, Johann PD, Spohn M, Bockmayr M, Safaei S, Joshi P, Masliah-Planchon J, Ho B, Andrianteranagna M, Bourdeaut F, Huang A, Kool M, Upadhyaya SA, Bendel AE, Indenbirken D, Foulkes WD, Bush JW, Creytens D, Kordes U, Frühwald MC, Hasselblatt M, Schüller U
Acta Neuropathol 2021 Feb;141(2):291-301. Epub 2020 Dec 17 doi: 10.1007/s00401-020-02250-7. PMID: 33331994Free PMC Article
Ovarian teratoma in children: a plea for collaborative clinical study.
Łuczak J, Bagłaj M
J Ovarian Res 2018 Aug 30;11(1):75. doi: 10.1186/s13048-018-0448-2. PMID: 30165903Free PMC Article
Pathology and molecular biology of teratomas in childhood and adolescence.
Harms D, Zahn S, Göbel U, Schneider DT
Klin Padiatr 2006 Nov-Dec;218(6):296-302. doi: 10.1055/s-2006-942271. PMID: 17080330
Germ-cell tumors in childhood and adolescence. GPOH MAKEI and the MAHO study groups.
Göbel U, Schneider DT, Calaminus G, Haas RJ, Schmidt P, Harms D
Ann Oncol 2000 Mar;11(3):263-71. doi: 10.1023/a:1008360523160. PMID: 10811491

Clinical prediction guides

Associations between birth defects and childhood and adolescent germ cell tumors according to sex, histologic subtype, and site.
Schraw JM, Sok P, Desrosiers TA, Janitz AE, Langlois PH, Canfield MA, Frazier AL, Plon SE, Lupo PJ, Poynter JN
Cancer 2023 Oct 15;129(20):3300-3308. Epub 2023 Jun 27 doi: 10.1002/cncr.34906. PMID: 37366624Free PMC Article
Single nucleotide polymorphism array and cytogenetic analyses of ovarian teratomas in children.
Shao L, Heider A, Rabah R
Genes Chromosomes Cancer 2021 Jun;60(6):418-425. Epub 2021 Jan 8 doi: 10.1002/gcc.22934. PMID: 33377559
Atypical teratoid/rhabdoid tumors (ATRTs) with SMARCA4 mutation are molecularly distinct from SMARCB1-deficient cases.
Holdhof D, Johann PD, Spohn M, Bockmayr M, Safaei S, Joshi P, Masliah-Planchon J, Ho B, Andrianteranagna M, Bourdeaut F, Huang A, Kool M, Upadhyaya SA, Bendel AE, Indenbirken D, Foulkes WD, Bush JW, Creytens D, Kordes U, Frühwald MC, Hasselblatt M, Schüller U
Acta Neuropathol 2021 Feb;141(2):291-301. Epub 2020 Dec 17 doi: 10.1007/s00401-020-02250-7. PMID: 33331994Free PMC Article
Mature and immature teratomas: results of the first paediatric Italian study.
Lo Curto M, D'Angelo P, Cecchetto G, Klersy C, Dall'Igna P, Federico A, Siracusa F, Alaggio R, Bernini G, Conte M, De Laurentis T, Di Cataldo A, Inserra A, Santoro N, Tamaro P, Indolfi P
Pediatr Surg Int 2007 Apr;23(4):315-22. Epub 2007 Feb 28 doi: 10.1007/s00383-007-1890-1. PMID: 17333214
Immature teratomas of childhood. Report of 21 cases.
Harms D, Jänig U
Pathol Res Pract 1985 Jan;179(3):388-400. doi: 10.1016/S0344-0338(85)80148-5. PMID: 3983017

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