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Childhood testicular neoplasm

MedGen UID:
272472
•Concept ID:
C1333010
•
Neoplastic Process
Synonyms: Childhood Neoplasm of Testis; childhood neoplasm of testis; Childhood Neoplasm of the Testis; childhood neoplasm of the testis; Childhood Testicular Neoplasm; childhood testicular neoplasm; neoplasm of testis of childhood; paediatric neoplasm of testis; paediatric neoplasm of the testis; paediatric testicular neoplasm; Pediatric Neoplasm of Testis; pediatric neoplasm of testis; Pediatric Neoplasm of the Testis; pediatric neoplasm of the testis; Pediatric Testicular Neoplasm; pediatric testicular neoplasm; Testicular Tumor, Childhood; testicular tumor, childhood
 
Monarch Initiative: MONDO:0037250

Definition

A neoplasm that affects the testis during childhood. [from NCI]

Professional guidelines

PubMed

Clinical characteristics and long-term management of prepubertal testicular teratomas: a retrospective, multicenter study.
Zhou G, Sun F, Yu X, Huang R, Liu X, Ouyang Y, Yang Z, Li S
Eur J Pediatr 2023 Apr;182(4):1823-1828. Epub 2023 Feb 16 doi: 10.1007/s00431-023-04859-8. PMID: 36795187Free PMC Article
Different Clinical Presentations and Management in Complete Androgen Insensitivity Syndrome (CAIS).
Lanciotti L, Cofini M, Leonardi A, Bertozzi M, Penta L, Esposito S
Int J Environ Res Public Health 2019 Apr 9;16(7) doi: 10.3390/ijerph16071268. PMID: 30970592Free PMC Article
Testicular function and fertility preservation after treatment for haematological cancer.
Jahnukainen K, Mitchell RT, Stukenborg JB
Curr Opin Endocrinol Diabetes Obes 2015 Jun;22(3):217-23. doi: 10.1097/MED.0000000000000156. PMID: 25871959

Recent clinical studies

Etiology

What should be done in terms of fertility preservation for patients with cancer? The French 2021 guidelines.
Rives N, Courbière B, Almont T, Kassab D, Berger C, Grynberg M, Papaxanthos A, Decanter C, Elefant E, Dhedin N, Barraud-Lange V, Béranger MC, Demoor-Goldschmidt C, Frédérique N, Bergère M, Gabrel L, Duperray M, Vermel C, Hoog-Labouret N, Pibarot M, Provansal M, Quéro L, Lejeune H, Methorst C, Saias J, Véronique-Baudin J, Giscard d'Estaing S, Farsi F, Poirot C, Huyghe É
Eur J Cancer 2022 Sep;173:146-166. Epub 2022 Aug 3 doi: 10.1016/j.ejca.2022.05.013. PMID: 35932626
Endocrine disruptors and the male reproductive system.
Stukenborg JB, Mitchell RT, Söder O
Best Pract Res Clin Endocrinol Metab 2021 Sep;35(5):101567. Epub 2021 Aug 14 doi: 10.1016/j.beem.2021.101567. PMID: 34426080
DICER1 and Associated Conditions: Identification of At-risk Individuals and Recommended Surveillance Strategies.
Schultz KAP, Williams GM, Kamihara J, Stewart DR, Harris AK, Bauer AJ, Turner J, Shah R, Schneider K, Schneider KW, Carr AG, Harney LA, Baldinger S, Frazier AL, Orbach D, Schneider DT, Malkin D, Dehner LP, Messinger YH, Hill DA
Clin Cancer Res 2018 May 15;24(10):2251-2261. Epub 2018 Jan 17 doi: 10.1158/1078-0432.CCR-17-3089. PMID: 29343557Free PMC Article
Therapy-related myeloid neoplasms.
Leone G, Fianchi L, Voso MT
Curr Opin Oncol 2011 Nov;23(6):672-80. doi: 10.1097/CCO.0b013e32834bcc2a. PMID: 21918440
Pediatric genitourinary tumors.
Castellino SM, McLean TW
Curr Opin Oncol 2007 May;19(3):248-53. doi: 10.1097/CCO.0b013e3280ad43ce. PMID: 17414644

Diagnosis

Prognostic factors of childhood acute lymphoblastic leukemia with TCF3::PBX1 in CCCG-ALL-2015: A multicenter study.
Zhang H, Wan Y, Wang H, Cai J, Yu J, Hu S, Fang Y, Gao J, Jiang H, Yang M, Liang C, Jin R, Tian X, Ju X, Hu Q, Jiang H, Li Z, Wang N, Sun L, Leung AWK, Wu X, Qian X, Qian M, Li CK, Yang J, Tang J, Zhu X, Shen S, Zhang L, Pui CH, Zhai X
Cancer 2023 Jun 1;129(11):1691-1703. Epub 2023 Mar 21 doi: 10.1002/cncr.34741. PMID: 36943767
Update on pediatric testicular germ cell tumors.
Aldrink JH, Glick RD, Baertschiger RM, Kulaylat AN, Lautz TB, Christison-Lagay E, Grant CN, Tracy E, Dasgupta R, Brown EG, Mattei P, Rothstein DH, Rodeberg DA, Ehrlich PF
J Pediatr Surg 2022 Apr;57(4):690-699. Epub 2021 Apr 15 doi: 10.1016/j.jpedsurg.2021.04.001. PMID: 33975708
Exposure to Chemotherapy During Childhood or Adulthood and Consequences on Spermatogenesis and Male Fertility.
Delessard M, Saulnier J, Rives A, Dumont L, Rondanino C, Rives N
Int J Mol Sci 2020 Feb 20;21(4) doi: 10.3390/ijms21041454. PMID: 32093393Free PMC Article
DICER1 and Associated Conditions: Identification of At-risk Individuals and Recommended Surveillance Strategies.
Schultz KAP, Williams GM, Kamihara J, Stewart DR, Harris AK, Bauer AJ, Turner J, Shah R, Schneider K, Schneider KW, Carr AG, Harney LA, Baldinger S, Frazier AL, Orbach D, Schneider DT, Malkin D, Dehner LP, Messinger YH, Hill DA
Clin Cancer Res 2018 May 15;24(10):2251-2261. Epub 2018 Jan 17 doi: 10.1158/1078-0432.CCR-17-3089. PMID: 29343557Free PMC Article
Pediatric genitourinary tumors.
Castellino SM, McLean TW
Curr Opin Oncol 2007 May;19(3):248-53. doi: 10.1097/CCO.0b013e3280ad43ce. PMID: 17414644

Therapy

Evolutionary determinants of curability in cancer.
Mansur MB, deSouza NM, Natrajan R, Abegglen LM, Schiffman JD, Greaves M
Nat Ecol Evol 2023 Nov;7(11):1761-1770. Epub 2023 Aug 24 doi: 10.1038/s41559-023-02159-w. PMID: 37620552
Orchidopexy for congenital cryptorchidism in childhood and adolescence and testicular cancer in adults: an updated systematic review and meta-analysis of observational studies.
Florou M, Tsilidis KK, Siomou E, Koletsa T, Syrnioti A, Spyridakis I, Kaselas C, Ntzani EE
Eur J Pediatr 2023 Jun;182(6):2499-2507. Epub 2023 Mar 29 doi: 10.1007/s00431-023-04947-9. PMID: 36988678
Prognostic factors of childhood acute lymphoblastic leukemia with TCF3::PBX1 in CCCG-ALL-2015: A multicenter study.
Zhang H, Wan Y, Wang H, Cai J, Yu J, Hu S, Fang Y, Gao J, Jiang H, Yang M, Liang C, Jin R, Tian X, Ju X, Hu Q, Jiang H, Li Z, Wang N, Sun L, Leung AWK, Wu X, Qian X, Qian M, Li CK, Yang J, Tang J, Zhu X, Shen S, Zhang L, Pui CH, Zhai X
Cancer 2023 Jun 1;129(11):1691-1703. Epub 2023 Mar 21 doi: 10.1002/cncr.34741. PMID: 36943767
Endocrine disruptors and the male reproductive system.
Stukenborg JB, Mitchell RT, Söder O
Best Pract Res Clin Endocrinol Metab 2021 Sep;35(5):101567. Epub 2021 Aug 14 doi: 10.1016/j.beem.2021.101567. PMID: 34426080
Testicular damage in children and adolescents treated for malignancy: a short review.
De Sanctis V, Soliman AT, Yassin MA, Di Maio S, Millimaggi G, Kattamis C
Acta Biomed 2018 Apr 3;89(3-S):7-17. doi: 10.23750/abm.v89i3-S.7212. PMID: 29633727Free PMC Article

Prognosis

Prognostic factors of childhood acute lymphoblastic leukemia with TCF3::PBX1 in CCCG-ALL-2015: A multicenter study.
Zhang H, Wan Y, Wang H, Cai J, Yu J, Hu S, Fang Y, Gao J, Jiang H, Yang M, Liang C, Jin R, Tian X, Ju X, Hu Q, Jiang H, Li Z, Wang N, Sun L, Leung AWK, Wu X, Qian X, Qian M, Li CK, Yang J, Tang J, Zhu X, Shen S, Zhang L, Pui CH, Zhai X
Cancer 2023 Jun 1;129(11):1691-1703. Epub 2023 Mar 21 doi: 10.1002/cncr.34741. PMID: 36943767
The prognostic value of testicular microlithiasis as an incidental finding for the risk of testicular malignancy in children and the adult population: A systematic review. On behalf of the EAU pediatric urology guidelines panel.
't Hoen LA, Bhatt NR, Radmayr C, Dogan HS, Nijman RJM, Quaedackers J, Rawashdeh YF, Silay MS, Tekgul S, Stein R, Bogaert G
J Pediatr Urol 2021 Dec;17(6):815-831. Epub 2021 Jun 13 doi: 10.1016/j.jpurol.2021.06.013. PMID: 34217588
Primary mediastinal germ cell tumors.
Rosti G, Secondino S, Necchi A, Fornarini G, Pedrazzoli P
Semin Oncol 2019 Apr;46(2):107-111. Epub 2019 Apr 24 doi: 10.1053/j.seminoncol.2019.04.001. PMID: 31076171
Male infertility: a biomarker of individual and familial cancer risk.
Hanson BM, Eisenberg ML, Hotaling JM
Fertil Steril 2018 Jan;109(1):6-19. doi: 10.1016/j.fertnstert.2017.11.005. PMID: 29307404
Pediatric genitourinary tumors.
Castellino SM, McLean TW
Curr Opin Oncol 2007 May;19(3):248-53. doi: 10.1097/CCO.0b013e3280ad43ce. PMID: 17414644

Clinical prediction guides

Orchidopexy for congenital cryptorchidism in childhood and adolescence and testicular cancer in adults: an updated systematic review and meta-analysis of observational studies.
Florou M, Tsilidis KK, Siomou E, Koletsa T, Syrnioti A, Spyridakis I, Kaselas C, Ntzani EE
Eur J Pediatr 2023 Jun;182(6):2499-2507. Epub 2023 Mar 29 doi: 10.1007/s00431-023-04947-9. PMID: 36988678
The systematic analysis and 10-year prediction on disease burden of childhood cancer in China.
Zhu B, Wu X, An W, Yao B, Liu Y
Front Public Health 2022;10:908955. Epub 2022 Sep 6 doi: 10.3389/fpubh.2022.908955. PMID: 36148350Free PMC Article
Endocrine disruptors and the male reproductive system.
Stukenborg JB, Mitchell RT, Söder O
Best Pract Res Clin Endocrinol Metab 2021 Sep;35(5):101567. Epub 2021 Aug 14 doi: 10.1016/j.beem.2021.101567. PMID: 34426080
Germ Cell Tumors in Adolescents and Young Adults.
Fonseca A, Frazier AL, Shaikh F
J Oncol Pract 2019 Aug;15(8):433-441. doi: 10.1200/JOP.19.00190. PMID: 31404512
Therapy-related myeloid neoplasms.
Leone G, Fianchi L, Voso MT
Curr Opin Oncol 2011 Nov;23(6):672-80. doi: 10.1097/CCO.0b013e32834bcc2a. PMID: 21918440

Recent systematic reviews

Orchidopexy for congenital cryptorchidism in childhood and adolescence and testicular cancer in adults: an updated systematic review and meta-analysis of observational studies.
Florou M, Tsilidis KK, Siomou E, Koletsa T, Syrnioti A, Spyridakis I, Kaselas C, Ntzani EE
Eur J Pediatr 2023 Jun;182(6):2499-2507. Epub 2023 Mar 29 doi: 10.1007/s00431-023-04947-9. PMID: 36988678
The impact of vincristine on testicular development and function in childhood cancer.
Clark I, Brougham MFH, Spears N, Mitchell RT
Hum Reprod Update 2023 Mar 1;29(2):233-245. doi: 10.1093/humupd/dmac039. PMID: 36495566Free PMC Article
Giant prolactinoma in children and adolescents: a single-center experience and systematic review.
Kumar S, Sarathi V, Lila AR, Sehemby M, Memon SS, Karlekar M, Sankhe S, Patil VA, Shah N, Bandgar T
Pituitary 2022 Dec;25(6):819-830. Epub 2022 Jul 18 doi: 10.1007/s11102-022-01250-y. PMID: 35851929
The prognostic value of testicular microlithiasis as an incidental finding for the risk of testicular malignancy in children and the adult population: A systematic review. On behalf of the EAU pediatric urology guidelines panel.
't Hoen LA, Bhatt NR, Radmayr C, Dogan HS, Nijman RJM, Quaedackers J, Rawashdeh YF, Silay MS, Tekgul S, Stein R, Bogaert G
J Pediatr Urol 2021 Dec;17(6):815-831. Epub 2021 Jun 13 doi: 10.1016/j.jpurol.2021.06.013. PMID: 34217588
Physical activity and risk of testicular cancer: a systematic review.
Huang S, Signal V, Sarfati D, Shaw C, Stanley J, McGlynn K, Gurney J
BMC Cancer 2018 Feb 14;18(1):189. doi: 10.1186/s12885-018-4093-3. PMID: 29444652Free PMC Article

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