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Childhood testicular neoplasm

MedGen UID:: 272472
•Concept ID:: C1333010
•: Neoplastic Process

Synonyms:	Childhood Neoplasm of Testis; childhood neoplasm of testis; Childhood Neoplasm of the Testis; childhood neoplasm of the testis; Childhood Testicular Neoplasm; childhood testicular neoplasm; neoplasm of testis of childhood; paediatric neoplasm of testis; paediatric neoplasm of the testis; paediatric testicular neoplasm; Pediatric Neoplasm of Testis; pediatric neoplasm of testis; Pediatric Neoplasm of the Testis; pediatric neoplasm of the testis; Pediatric Testicular Neoplasm; pediatric testicular neoplasm; Testicular Tumor, Childhood; testicular tumor, childhood

Monarch Initiative:	MONDO:0037250

Definition

A neoplasm that affects the testis during childhood. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVChildhood testicular neoplasm

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Neoplasm
      - Neoplasm by Special Category
        Childhood neoplasm
        Childhood testicular neoplasm
        Childhood testicular germ cell tumor
        Childhood Malignant Testicular Germ Cell Tumor
        Childhood embryonal testis carcinoma
        Childhood testicular choriocarcinoma
        Childhood testicular mixed germ cell cancer
        Childhood Testicular Yolk Sac Tumor
        Childhood Testicular Non-Seminomatous Germ Cell Tumor
        Childhood testicular mixed embryonal carcinoma and teratoma
        Childhood Testicular Teratoma

Professional guidelines

PubMed

Different Clinical Presentations and Management in Complete Androgen Insensitivity Syndrome (CAIS).

Lanciotti L, Cofini M, Leonardi A, Bertozzi M, Penta L, Esposito S
Int J Environ Res Public Health 2019 Apr 9;16(7) doi: 10.3390/ijerph16071268. PMID: 30970592 Free PMC Article

Testicular function and fertility preservation after treatment for haematological cancer.

Jahnukainen K, Mitchell RT, Stukenborg JB
Curr Opin Endocrinol Diabetes Obes 2015 Jun;22(3):217-23. doi: 10.1097/MED.0000000000000156. PMID: 25871959

Male fertility and strategies for fertility preservation following childhood cancer treatment.

Mitchell RT, Saunders PTK, Sharpe RM, Kelnar CJH, Wallace WHB
Endocr Dev 2009;15:101-134. Epub 2009 Mar 3 doi: 10.1159/000207612. PMID: 19293606

See all (38)

Recent clinical studies

Etiology

What should be done in terms of fertility preservation for patients with cancer? The French 2021 guidelines.

Rives N, Courbière B, Almont T, Kassab D, Berger C, Grynberg M, Papaxanthos A, Decanter C, Elefant E, Dhedin N, Barraud-Lange V, Béranger MC, Demoor-Goldschmidt C, Frédérique N, Bergère M, Gabrel L, Duperray M, Vermel C, Hoog-Labouret N, Pibarot M, Provansal M, Quéro L, Lejeune H, Methorst C, Saias J, Véronique-Baudin J, Giscard d'Estaing S, Farsi F, Poirot C, Huyghe É
Eur J Cancer 2022 Sep;173:146-166. Epub 2022 Aug 3 doi: 10.1016/j.ejca.2022.05.013. PMID: 35932626

Update on pediatric testicular germ cell tumors.

Aldrink JH, Glick RD, Baertschiger RM, Kulaylat AN, Lautz TB, Christison-Lagay E, Grant CN, Tracy E, Dasgupta R, Brown EG, Mattei P, Rothstein DH, Rodeberg DA, Ehrlich PF
J Pediatr Surg 2022 Apr;57(4):690-699. Epub 2021 Apr 15 doi: 10.1016/j.jpedsurg.2021.04.001. PMID: 33975708

Primary mediastinal germ cell tumors.

Rosti G, Secondino S, Necchi A, Fornarini G, Pedrazzoli P
Semin Oncol 2019 Apr;46(2):107-111. Epub 2019 Apr 24 doi: 10.1053/j.seminoncol.2019.04.001. PMID: 31076171

DICER1 and Associated Conditions: Identification of At-risk Individuals and Recommended Surveillance Strategies.

Schultz KAP, Williams GM, Kamihara J, Stewart DR, Harris AK, Bauer AJ, Turner J, Shah R, Schneider K, Schneider KW, Carr AG, Harney LA, Baldinger S, Frazier AL, Orbach D, Schneider DT, Malkin D, Dehner LP, Messinger YH, Hill DA
Clin Cancer Res 2018 May 15;24(10):2251-2261. Epub 2018 Jan 17 doi: 10.1158/1078-0432.CCR-17-3089. PMID: 29343557 Free PMC Article

Pediatric genitourinary tumors.

Castellino SM, McLean TW
Curr Opin Oncol 2007 May;19(3):248-53. doi: 10.1097/CCO.0b013e3280ad43ce. PMID: 17414644

See all (376)

Diagnosis

Update on pediatric testicular germ cell tumors.

DICER1 and Associated Conditions: Identification of At-risk Individuals and Recommended Surveillance Strategies.

Macroorchidism in childhood and adolescence: an update.

De Sanctis V, Marsella M, Soliman A, Yassin M
Pediatr Endocrinol Rev 2014 Feb;11 Suppl 2:263-73. PMID: 24683950

Pediatric genitourinary tumors.

Castellino SM, McLean TW
Curr Opin Oncol 2007 May;19(3):248-53. doi: 10.1097/CCO.0b013e3280ad43ce. PMID: 17414644

Acute lymphoblastic leukemia.

Miller DR
Pediatr Clin North Am 1980 May;27(2):269-91. doi: 10.1016/s0031-3955(16)33851-2. PMID: 6992074

See all (303)

Therapy

Evolutionary determinants of curability in cancer.

Mansur MB, deSouza NM, Natrajan R, Abegglen LM, Schiffman JD, Greaves M
Nat Ecol Evol 2023 Nov;7(11):1761-1770. Epub 2023 Aug 24 doi: 10.1038/s41559-023-02159-w. PMID: 37620552

Endocrine disruptors and the male reproductive system.

Stukenborg JB, Mitchell RT, Söder O
Best Pract Res Clin Endocrinol Metab 2021 Sep;35(5):101567. Epub 2021 Aug 14 doi: 10.1016/j.beem.2021.101567. PMID: 34426080

Different Clinical Presentations and Management in Complete Androgen Insensitivity Syndrome (CAIS).

Lanciotti L, Cofini M, Leonardi A, Bertozzi M, Penta L, Esposito S
Int J Environ Res Public Health 2019 Apr 9;16(7) doi: 10.3390/ijerph16071268. PMID: 30970592 Free PMC Article

Long-Term Follow-Up after Treatment of Cryptorchidism.

Thorup J, Cortes D
Eur J Pediatr Surg 2016 Oct;26(5):427-431. Epub 2016 Sep 2 doi: 10.1055/s-0036-1592138. PMID: 27589079

Acute lymphoblastic leukemia.

Miller DR
Pediatr Clin North Am 1980 May;27(2):269-91. doi: 10.1016/s0031-3955(16)33851-2. PMID: 6992074

See all (211)

Prognosis

Review of injection techniques for spermatogonial stem cell transplantation.

Gul M, Hildorf S, Dong L, Thorup J, Hoffmann ER, Jensen CFS, Sønksen J, Cortes D, Fedder J, Andersen CY, Goossens E
Hum Reprod Update 2020 Apr 15;26(3):368-391. doi: 10.1093/humupd/dmaa003. PMID: 32163572

Primary mediastinal germ cell tumors.

Rosti G, Secondino S, Necchi A, Fornarini G, Pedrazzoli P
Semin Oncol 2019 Apr;46(2):107-111. Epub 2019 Apr 24 doi: 10.1053/j.seminoncol.2019.04.001. PMID: 31076171

Long-Term Follow-Up after Treatment of Cryptorchidism.

Thorup J, Cortes D
Eur J Pediatr Surg 2016 Oct;26(5):427-431. Epub 2016 Sep 2 doi: 10.1055/s-0036-1592138. PMID: 27589079

Pediatric genitourinary tumors.

Castellino SM, McLean TW
Curr Opin Oncol 2007 May;19(3):248-53. doi: 10.1097/CCO.0b013e3280ad43ce. PMID: 17414644

Germinal testicular tumors in childhood. Report of observations and literature review.

Weissbach L, Altwein JE, Stiens R
Eur Urol 1984;10(2):73-85. doi: 10.1159/000463762. PMID: 6368238

See all (244)

Clinical prediction guides

The systematic analysis and 10-year prediction on disease burden of childhood cancer in China.

Zhu B, Wu X, An W, Yao B, Liu Y
Front Public Health 2022;10:908955. Epub 2022 Sep 6 doi: 10.3389/fpubh.2022.908955. PMID: 36148350 Free PMC Article

Endocrine disruptors and the male reproductive system.

Stukenborg JB, Mitchell RT, Söder O
Best Pract Res Clin Endocrinol Metab 2021 Sep;35(5):101567. Epub 2021 Aug 14 doi: 10.1016/j.beem.2021.101567. PMID: 34426080

Germ Cell Tumors in Adolescents and Young Adults.

Fonseca A, Frazier AL, Shaikh F
J Oncol Pract 2019 Aug;15(8):433-441. doi: 10.1200/JOP.19.00190. PMID: 31404512

Therapy-related myeloid neoplasms.

Leone G, Fianchi L, Voso MT
Curr Opin Oncol 2011 Nov;23(6):672-80. doi: 10.1097/CCO.0b013e32834bcc2a. PMID: 21918440

Germ cell tumors.

Rescorla FJ
Semin Pediatr Surg 1997 Feb;6(1):29-37. PMID: 9117272

See all (143)

Recent systematic reviews

The impact of vincristine on testicular development and function in childhood cancer.

Clark I, Brougham MFH, Spears N, Mitchell RT
Hum Reprod Update 2023 Mar 1;29(2):233-245. doi: 10.1093/humupd/dmac039. PMID: 36495566 Free PMC Article

Giant prolactinoma in children and adolescents: a single-center experience and systematic review.

Kumar S, Sarathi V, Lila AR, Sehemby M, Memon SS, Karlekar M, Sankhe S, Patil VA, Shah N, Bandgar T
Pituitary 2022 Dec;25(6):819-830. Epub 2022 Jul 18 doi: 10.1007/s11102-022-01250-y. PMID: 35851929

The prognostic value of testicular microlithiasis as an incidental finding for the risk of testicular malignancy in children and the adult population: A systematic review. On behalf of the EAU pediatric urology guidelines panel.

't Hoen LA, Bhatt NR, Radmayr C, Dogan HS, Nijman RJM, Quaedackers J, Rawashdeh YF, Silay MS, Tekgul S, Stein R, Bogaert G
J Pediatr Urol 2021 Dec;17(6):815-831. Epub 2021 Jun 13 doi: 10.1016/j.jpurol.2021.06.013. PMID: 34217588

Physical activity and risk of testicular cancer: a systematic review.

Huang S, Signal V, Sarfati D, Shaw C, Stanley J, McGlynn K, Gurney J
BMC Cancer 2018 Feb 14;18(1):189. doi: 10.1186/s12885-018-4093-3. PMID: 29444652 Free PMC Article

Fertility Preservation in Children and Adolescents With Cancer.

Long CJ, Ginsberg JP, Kolon TF
Urology 2016 May;91:190-6. Epub 2016 Jan 11 doi: 10.1016/j.urology.2015.10.047. PMID: 26790587

See all (9)

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Childhood testicular neoplasm

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

Related information

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