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Choroid spindle cell melanoma

MedGen UID:
272477
•Concept ID:
C1333027
•
Neoplastic Process
Synonyms: Choroid Spindle Cell Melanoma; choroid spindle cell melanoma; optic choroid spindle cell melanoma; Spindle Cell Melanoma of Choroid; spindle cell melanoma of choroid; spindle cell melanoma of optic choroid; Spindle Cell Melanoma of the Choroid; spindle cell melanoma of the choroid
 
Monarch Initiative: MONDO:0003745

Definition

A melanoma that arises from the choroid. It is characterized by the presence of spindle-shaped melanocytes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChoroid spindle cell melanoma

Professional guidelines

PubMed

Tumours of the anterior uvea. III. Oxytalan fibres in the differential diagnosis of leiomyoma and malignant melanoma of the iris.
Noor Sunba MS, Rahi AH, Garner A, Alexander RA, Morgan G
Br J Ophthalmol 1980 Nov;64(11):867-74. doi: 10.1136/bjo.64.11.867. PMID: 7426559Free PMC Article
Management of small elevated pigmented choroidal lesions.
Char DH, Hogan MJ
Br J Ophthalmol 1977 Jan;61(1):54-8. doi: 10.1136/bjo.61.1.54. PMID: 836778Free PMC Article

Recent clinical studies

Etiology

Autophagy and vesicular trafficking in human uveal melanoma: A histopathological study.
Taskaeva I, Shatruk A, Bgatova N, Yeremina A, Trunov A, Kononova N, Chernykh V
Microsc Res Tech 2024 Jan;87(1):122-132. Epub 2023 Sep 12 doi: 10.1002/jemt.24417. PMID: 37698482
Choroidal Melanoma: Our Experience.
Hamal D, Limbu B, Sthapit PR, Pradhan E, Shrestha R, Saiju R
Nepal J Ophthalmol 2019 Jan;11(21):64-73. doi: 10.3126/nepjoph.v11i1.25422. PMID: 31523069
Diagnostic Cytologic Features of Uveal Melanoma.
Medina CA, Biscotti CV, Singh N, Singh AD
Ophthalmology 2015 Aug;122(8):1580-4. Epub 2015 May 23 doi: 10.1016/j.ophtha.2015.04.013. PMID: 26012864
Epidemiological trends in uveal melanoma.
Andreoli MT, Mieler WF, Leiderman YI
Br J Ophthalmol 2015 Nov;99(11):1550-3. Epub 2015 Apr 22 doi: 10.1136/bjophthalmol-2015-306810. PMID: 25904122
Iris melanoma.
Henderson E, Margo CE
Arch Pathol Lab Med 2008 Feb;132(2):268-72. doi: 10.5858/2008-132-268-IM. PMID: 18251588

Diagnosis

Unusual presentation of a choroidal melanoma.
Jain S, Phoong KY
BMJ Case Rep 2021 May 27;14(5) doi: 10.1136/bcr-2020-240983. PMID: 34045197Free PMC Article
Choroidal Melanoma: Our Experience.
Hamal D, Limbu B, Sthapit PR, Pradhan E, Shrestha R, Saiju R
Nepal J Ophthalmol 2019 Jan;11(21):64-73. doi: 10.3126/nepjoph.v11i1.25422. PMID: 31523069
Epidemiological trends in uveal melanoma.
Andreoli MT, Mieler WF, Leiderman YI
Br J Ophthalmol 2015 Nov;99(11):1550-3. Epub 2015 Apr 22 doi: 10.1136/bjophthalmol-2015-306810. PMID: 25904122
Iris melanoma.
Henderson E, Margo CE
Arch Pathol Lab Med 2008 Feb;132(2):268-72. doi: 10.5858/2008-132-268-IM. PMID: 18251588
Cavitary choroidal melanoma.
Becerra EM, Saornil MA, Blanco G, Méndez MC, Muiños Y, Esteban MR
Can J Ophthalmol 2005 Oct;40(5):619-22. doi: 10.1016/S0008-4182(05)80057-2. PMID: 16391628

Therapy

No differences in the long-term prognosis of iris and choroidal melanomas when adjusting for tumor thickness and diameter.
Sabazade S, Herrspiegel C, Gill V, Stålhammar G
BMC Cancer 2021 Nov 24;21(1):1270. doi: 10.1186/s12885-021-09002-0. PMID: 34819035Free PMC Article
VITREOUS AND PRERETINAL SEEDING AFTER TRANSVITREAL FINE NEEDLE ASPIRATION BIOPSY OF CHOROIDAL MELANOMA.
Mashayekhi A, Shields CL, Eagle RC Jr, Shields JA
Retin Cases Brief Rep 2021 Nov 1;15(6):713-717. doi: 10.1097/ICB.0000000000000905. PMID: 31403972
Enucleation after Stereotactic Radiosurgery in Patients with Uveal Melanoma.
Zahorjanová P, Sekáč J, Babál P, Štubňa M
Cesk Slov Oftalmol 2020 Winter;76(1):46-51. doi: 10.31348/2020/6. PMID: 32917094
Bilateral uveal melanoma in an arc welder.
Turaka K, Shields CL, Shah CP, Say EA, Shields JA
Graefes Arch Clin Exp Ophthalmol 2011 Jan;249(1):141-4. Epub 2010 Sep 19 doi: 10.1007/s00417-010-1516-5. PMID: 20853114
Optic nerve invasion of uveal melanoma.
Lindegaard J, Isager P, Prause JU, Heegaard S
APMIS 2007 Jan;115(1):1-16. doi: 10.1111/j.1600-0463.2007.apm_527.x. PMID: 17223846

Prognosis

Choroidal Melanoma: Our Experience.
Hamal D, Limbu B, Sthapit PR, Pradhan E, Shrestha R, Saiju R
Nepal J Ophthalmol 2019 Jan;11(21):64-73. doi: 10.3126/nepjoph.v11i1.25422. PMID: 31523069
Diagnostic Cytologic Features of Uveal Melanoma.
Medina CA, Biscotti CV, Singh N, Singh AD
Ophthalmology 2015 Aug;122(8):1580-4. Epub 2015 May 23 doi: 10.1016/j.ophtha.2015.04.013. PMID: 26012864
Epidemiological trends in uveal melanoma.
Andreoli MT, Mieler WF, Leiderman YI
Br J Ophthalmol 2015 Nov;99(11):1550-3. Epub 2015 Apr 22 doi: 10.1136/bjophthalmol-2015-306810. PMID: 25904122
Iris melanoma.
Henderson E, Margo CE
Arch Pathol Lab Med 2008 Feb;132(2):268-72. doi: 10.5858/2008-132-268-IM. PMID: 18251588
Pathological and prognostic features of uveal melanomas.
McLean IW, Saraiva VS, Burnier MN Jr
Can J Ophthalmol 2004 Jun;39(4):343-50. doi: 10.1016/s0008-4182(04)80004-8. PMID: 15327098

Clinical prediction guides

Serum adiponectin, insulin resistance, and uveal melanoma: clinicopathological correlations.
Sevim DG, Kiratli H
Melanoma Res 2016 Apr;26(2):164-72. doi: 10.1097/CMR.0000000000000226. PMID: 26630661
Diagnostic Cytologic Features of Uveal Melanoma.
Medina CA, Biscotti CV, Singh N, Singh AD
Ophthalmology 2015 Aug;122(8):1580-4. Epub 2015 May 23 doi: 10.1016/j.ophtha.2015.04.013. PMID: 26012864
Epidemiological trends in uveal melanoma.
Andreoli MT, Mieler WF, Leiderman YI
Br J Ophthalmol 2015 Nov;99(11):1550-3. Epub 2015 Apr 22 doi: 10.1136/bjophthalmol-2015-306810. PMID: 25904122
Expression and distribution of MMPs and TIMPs in human uveal melanoma.
Lai K, Conway RM, Crouch R, Jager MJ, Madigan MC
Exp Eye Res 2008 Jun;86(6):936-41. Epub 2008 Mar 16 doi: 10.1016/j.exer.2008.03.010. PMID: 18423620
Pathological and prognostic features of uveal melanomas.
McLean IW, Saraiva VS, Burnier MN Jr
Can J Ophthalmol 2004 Jun;39(4):343-50. doi: 10.1016/s0008-4182(04)80004-8. PMID: 15327098

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