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Columnar cell variant thyroid gland papillary carcinoma

MedGen UID:
272499
•Concept ID:
C1333120
•
Neoplastic Process
Synonyms: Columnar Cell Variant Papillary Carcinoma; columnar cell variant papillary carcinoma; Columnar Cell Variant Papillary Thyroid Gland Carcinoma; columnar cell variant papillary thyroid gland carcinoma; Columnar Cell Variant Thyroid Gland Papillary Carcinoma; columnar cell variant thyroid gland papillary carcinoma
 
Monarch Initiative: MONDO:0004102

Definition

A morphologic variant of papillary carcinoma of the thyroid gland characterized by the presence of pseudostratified malignant follicular cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColumnar cell variant thyroid gland papillary carcinoma

Professional guidelines

PubMed

Papillary Thyroid Cancer-Aggressive Variants and Impact on Management: A Narrative Review.
Coca-Pelaz A, Shah JP, Hernandez-Prera JC, Ghossein RA, Rodrigo JP, Hartl DM, Olsen KD, Shaha AR, Zafereo M, Suarez C, Nixon IJ, Randolph GW, Mäkitie AA, Kowalski LP, Vander Poorten V, Sanabria A, Guntinas-Lichius O, Simo R, Zbären P, Angelos P, Khafif A, Rinaldo A, Ferlito A
Adv Ther 2020 Jul;37(7):3112-3128. Epub 2020 Jun 1 doi: 10.1007/s12325-020-01391-1. PMID: 32488657Free PMC Article
Recombinant human thyrotropin (rhTSH) in the follow-up and treatment of patients with thyroid cancer.
Bombardieri E, Seregni E, Villano C, Aliberti G, Mattavelli F
Tumori 2003 Sep-Oct;89(5):533-6. doi: 10.1177/030089160308900515. PMID: 14870779
Differential expression of cytokeratins in follicular variant of papillary carcinoma: an immunohistochemical study and its diagnostic utility.
Baloch ZW, Abraham S, Roberts S, LiVolsi VA
Hum Pathol 1999 Oct;30(10):1166-71. doi: 10.1016/s0046-8177(99)90033-3. PMID: 10534163

Recent clinical studies

Etiology

Molecular and clinical features of papillary thyroid cancer in adult patients with a non-classical phenotype.
Zhou J, Wang WR, Zhang HF, Gao QQ, Wang WB, Zhu JH, Han YS, Chen J, Ma TH, Zhang XY, Teng XD
Front Endocrinol (Lausanne) 2023;14:1138100. Epub 2023 Apr 12 doi: 10.3389/fendo.2023.1138100. PMID: 37124750Free PMC Article
Genomic profile of columnar cell variant of papillary thyroid carcinoma.
Janovitz T, Williamson DFK, Wong KS, Dong F, Barletta JA
Histopathology 2021 Oct;79(4):491-498. Epub 2021 Jun 15 doi: 10.1111/his.14374. PMID: 33783022
Prognostic Parameters in Differentiated Thyroid Carcinomas.
Cipriani NA
Surg Pathol Clin 2019 Dec;12(4):883-900. Epub 2019 Sep 18 doi: 10.1016/j.path.2019.07.001. PMID: 31672296
Columnar Cell Variant of Papillary Thyroid Carcinoma: Ultrasonographic and Clinical Differentiation between the Indolent and Aggressive Types.
Cho J, Shin JH, Hahn SY, Oh YL
Korean J Radiol 2018 Sep-Oct;19(5):1000-1005. Epub 2018 Aug 6 doi: 10.3348/kjr.2018.19.5.1000. PMID: 30174490Free PMC Article
Aggressive variants of papillary thyroid carcinoma.
Silver CE, Owen RP, Rodrigo JP, Rinaldo A, Devaney KO, Ferlito A
Head Neck 2011 Jul;33(7):1052-9. Epub 2010 Sep 7 doi: 10.1002/hed.21494. PMID: 20824810

Diagnosis

Aggressive variants of follicular cell-derived thyroid carcinoma: an overview.
Pizzimenti C, Fiorentino V, Ieni A, Martini M, Tuccari G, Lentini M, Fadda G
Endocrine 2022 Oct;78(1):1-12. Epub 2022 Jul 21 doi: 10.1007/s12020-022-03146-0. PMID: 35864338
Papillary Thyroid Cancer-Aggressive Variants and Impact on Management: A Narrative Review.
Coca-Pelaz A, Shah JP, Hernandez-Prera JC, Ghossein RA, Rodrigo JP, Hartl DM, Olsen KD, Shaha AR, Zafereo M, Suarez C, Nixon IJ, Randolph GW, Mäkitie AA, Kowalski LP, Vander Poorten V, Sanabria A, Guntinas-Lichius O, Simo R, Zbären P, Angelos P, Khafif A, Rinaldo A, Ferlito A
Adv Ther 2020 Jul;37(7):3112-3128. Epub 2020 Jun 1 doi: 10.1007/s12325-020-01391-1. PMID: 32488657Free PMC Article
Cribriform-morular variant of papillary thyroid carcinoma.
Pradhan D, Sharma A, Mohanty SK
Pathol Res Pract 2015 Oct;211(10):712-6. Epub 2015 Jul 3 doi: 10.1016/j.prp.2015.04.011. PMID: 26293799
Sonographic and cytopathologic correlation of papillary thyroid carcinoma variants.
Lee JH, Shin JH, Lee HW, Oh YL, Hahn SY, Ko EY
J Ultrasound Med 2015 Jan;34(1):1-15. doi: 10.7863/ultra.34.1.1. PMID: 25542934
Papillary thyroid carcinoma variants.
Lloyd RV, Buehler D, Khanafshar E
Head Neck Pathol 2011 Mar;5(1):51-6. Epub 2011 Jan 8 doi: 10.1007/s12105-010-0236-9. PMID: 21221869Free PMC Article

Therapy

Clinicopathological features of recurrent papillary thyroid cancer.
Zhu J, Wang X, Zhang X, Li P, Hou H
Diagn Pathol 2015 Jul 14;10:96. doi: 10.1186/s13000-015-0346-5. PMID: 26168921Free PMC Article
Can the tall cell variant of papillary thyroid carcinoma be distinguished from the conventional type in fine needle aspirates? A cytomorphologic study with assessment of diagnostic accuracy.
Guan H, Vandenbussche CJ, Erozan YS, Rosenthal DL, Tatsas AD, Olson MT, Zheng R, Auger M, Ali SZ
Acta Cytol 2013;57(5):534-42. Epub 2013 Sep 7 doi: 10.1159/000353823. PMID: 24021475
Recombinant human thyrotropin (rhTSH) in the follow-up and treatment of patients with thyroid cancer.
Bombardieri E, Seregni E, Villano C, Aliberti G, Mattavelli F
Tumori 2003 Sep-Oct;89(5):533-6. doi: 10.1177/030089160308900515. PMID: 14870779
Clinical experience with recombinant human thyrotrophin (rhTSH) in the management of patients with differentiated thyroid cancer.
Mariani G, Ferdeghini M, Augeri C, Villa G, Taddei GZ, Scopinaro G, Boni G, Bodei L, Rabitti C, Molinari E, Bianchi R
Cancer Biother Radiopharm 2000 Apr;15(2):211-7. doi: 10.1089/cbr.2000.15.211. PMID: 10803328

Prognosis

Aggressive variants of follicular cell-derived thyroid carcinoma: an overview.
Pizzimenti C, Fiorentino V, Ieni A, Martini M, Tuccari G, Lentini M, Fadda G
Endocrine 2022 Oct;78(1):1-12. Epub 2022 Jul 21 doi: 10.1007/s12020-022-03146-0. PMID: 35864338
Papillary Thyroid Cancer-Aggressive Variants and Impact on Management: A Narrative Review.
Coca-Pelaz A, Shah JP, Hernandez-Prera JC, Ghossein RA, Rodrigo JP, Hartl DM, Olsen KD, Shaha AR, Zafereo M, Suarez C, Nixon IJ, Randolph GW, Mäkitie AA, Kowalski LP, Vander Poorten V, Sanabria A, Guntinas-Lichius O, Simo R, Zbären P, Angelos P, Khafif A, Rinaldo A, Ferlito A
Adv Ther 2020 Jul;37(7):3112-3128. Epub 2020 Jun 1 doi: 10.1007/s12325-020-01391-1. PMID: 32488657Free PMC Article
Prognostic Parameters in Differentiated Thyroid Carcinomas.
Cipriani NA
Surg Pathol Clin 2019 Dec;12(4):883-900. Epub 2019 Sep 18 doi: 10.1016/j.path.2019.07.001. PMID: 31672296
Hobnail Variant of Papillary Thyroid Carcinoma: a Literature Review.
Ambrosi F, Righi A, Ricci C, Erickson LA, Lloyd RV, Asioli S
Endocr Pathol 2017 Dec;28(4):293-301. doi: 10.1007/s12022-017-9502-7. PMID: 29019044
Cribriform-morular variant of papillary thyroid carcinoma.
Pradhan D, Sharma A, Mohanty SK
Pathol Res Pract 2015 Oct;211(10):712-6. Epub 2015 Jul 3 doi: 10.1016/j.prp.2015.04.011. PMID: 26293799

Clinical prediction guides

Relevance of rosette patterns in variants of papillary thyroid carcinoma.
Dell'Aquila M, Musarra T, Fiorentino V, Brunelli C, De Marco C, Raffaelli M, Traini E, Pio Lombardi C, Fadda G, Larocca LM, Pantanowitz L, Rossi ED
Cytopathology 2020 Nov;31(6):533-540. Epub 2020 Aug 10 doi: 10.1111/cyt.12885. PMID: 32654236
Prognostic Parameters in Differentiated Thyroid Carcinomas.
Cipriani NA
Surg Pathol Clin 2019 Dec;12(4):883-900. Epub 2019 Sep 18 doi: 10.1016/j.path.2019.07.001. PMID: 31672296
Columnar cell variant of papillary thyroid carcinoma: Cytomorphological characteristics of 11 cases with histological correlation and literature review.
Bongiovanni M, Mermod M, Canberk S, Saglietti C, Sykiotis GP, Pusztaszeri M, Ragazzi M, Mazzucchelli L, Giovanella L, Piana S
Cancer Cytopathol 2017 Jun;125(6):389-397. Epub 2017 Apr 3 doi: 10.1002/cncy.21860. PMID: 28374549
Variants of Papillary Thyroid Carcinoma: Multiple Faces of a Familiar Tumor.
Sak SD
Turk Patoloji Derg 2015;31 Suppl 1:34-47. doi: 10.5146/tjpath.2015.01313. PMID: 26177316
Aggressive variants of papillary thyroid carcinoma.
Silver CE, Owen RP, Rodrigo JP, Rinaldo A, Devaney KO, Ferlito A
Head Neck 2011 Jul;33(7):1052-9. Epub 2010 Sep 7 doi: 10.1002/hed.21494. PMID: 20824810

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