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Gastric adenosquamous carcinoma

MedGen UID:
272661
•Concept ID:
C1333761
•
Neoplastic Process
Synonyms: Adenosquamous Carcinoma of Stomach; adenosquamous carcinoma of stomach; Adenosquamous Carcinoma of the Stomach; adenosquamous carcinoma of the stomach; gastric (stomach) adenosquamous cancer; Gastric Adenosquamous Carcinoma; gastric adenosquamous carcinoma; STAS; stomach adenosquamous carcinoma
 
Monarch Initiative: MONDO:0006034

Definition

A carcinoma that arises from the stomach and is characterized by the presence of malignant cells with glandular and squamous differentiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGastric adenosquamous carcinoma

Professional guidelines

PubMed

Clinicopathological characteristics, diagnosis, treatment, and outcomes of primary gastric adenosquamous carcinoma.
Chen H, Shen C, Yin R, Yin Y, Chen J, Han L, Zhang B, Chen Z, Chen J
World J Surg Oncol 2015 Apr 2;13:136. doi: 10.1186/s12957-015-0554-1. PMID: 25889482Free PMC Article

Recent clinical studies

Etiology

Immunoprofile of adenosquamous carcinoma in gastric cancer.
Wu CH, Lai CL, Teng CJ, Fang WL, Huang KH, Fen-Yau Li A, Yu HY, Chiang NJ, Chao Y, Hung YP, Chen MH
J Chin Med Assoc 2023 Jun 1;86(6):542-548. Epub 2023 Mar 29 doi: 10.1097/JCMA.0000000000000922. PMID: 36989495
Increased proportion of the squamous cell carcinoma component is associated with worse survival in resected gastric adenosquamous carcinoma: A STROBE compliant cohort study.
Li HS, Chen Y, Zhang MY, Cheng K, Zhou YW, Liu JY
Medicine (Baltimore) 2020 Sep 4;99(36):e21980. doi: 10.1097/MD.0000000000021980. PMID: 32899039Free PMC Article
Clinicopathological features and prognosis of gastric adenosquamous carcinoma.
Feng F, Zheng G, Qi J, Xu G, Wang F, Wang Q, Guo M, Lian X, Zhang H
Sci Rep 2017 Jul 4;7(1):4597. doi: 10.1038/s41598-017-04563-2. PMID: 28676632Free PMC Article
Clinicopathological characteristics, diagnosis, treatment, and outcomes of primary gastric adenosquamous carcinoma.
Chen H, Shen C, Yin R, Yin Y, Chen J, Han L, Zhang B, Chen Z, Chen J
World J Surg Oncol 2015 Apr 2;13:136. doi: 10.1186/s12957-015-0554-1. PMID: 25889482Free PMC Article

Diagnosis

Case report: Gastric adenosquamous carcinoma with EBV-positive component of squamous cell carcinoma mixed with gastric carcinoma with lymphoid stroma: A novel case report and literature review.
Lu C, Feng J, Yao Z, Shi L, Li J
Pathol Oncol Res 2023;29:1610902. Epub 2023 Feb 2 doi: 10.3389/pore.2023.1610902. PMID: 36816542Free PMC Article
Epstein-Barr virus-associated gastric adenosquamous carcinoma with concurrent gastric carcinoma with lymphoid stroma: a case report and review of the literature.
Cao F, Yan Y, Niu D, Huang X, Jia L, Diao X, Li Z
BMC Gastroenterol 2022 Jul 16;22(1):346. doi: 10.1186/s12876-022-02417-4. PMID: 35842595Free PMC Article
Increased proportion of the squamous cell carcinoma component is associated with worse survival in resected gastric adenosquamous carcinoma: A STROBE compliant cohort study.
Li HS, Chen Y, Zhang MY, Cheng K, Zhou YW, Liu JY
Medicine (Baltimore) 2020 Sep 4;99(36):e21980. doi: 10.1097/MD.0000000000021980. PMID: 32899039Free PMC Article
Fatal submucosal invasive gastric adenosquamous carcinoma detected at surveillance after gastric endoscopic submucosal dissection.
Shirahige A, Suzuki H, Oda I, Sekiguchi M, Mori G, Abe S, Nonaka S, Yoshinaga S, Sekine S, Kushima R, Saito Y, Fukagawa T, Katai H
World J Gastroenterol 2015 Apr 14;21(14):4385-90. doi: 10.3748/wjg.v21.i14.4385. PMID: 25892891Free PMC Article
Clinicopathological characteristics, diagnosis, treatment, and outcomes of primary gastric adenosquamous carcinoma.
Chen H, Shen C, Yin R, Yin Y, Chen J, Han L, Zhang B, Chen Z, Chen J
World J Surg Oncol 2015 Apr 2;13:136. doi: 10.1186/s12957-015-0554-1. PMID: 25889482Free PMC Article

Therapy

Clinicopathological characteristics, diagnosis, treatment, and outcomes of primary gastric adenosquamous carcinoma.
Chen H, Shen C, Yin R, Yin Y, Chen J, Han L, Zhang B, Chen Z, Chen J
World J Surg Oncol 2015 Apr 2;13:136. doi: 10.1186/s12957-015-0554-1. PMID: 25889482Free PMC Article
A patient with gastric adenosquamous carcinoma with intraperitoneal free cancer cells who remained recurrence-free with postoperative S-1 chemotherapy.
Ebi M, Shimura T, Yamada S, Hirata Y, Tsukamoto H, Okamoto Y, Mizoshita T, Tanida S, Kataoka H, Kamiya T, Inagaki H, Joh T
Intern Med 2012;51(22):3125-9. Epub 2012 Nov 15 doi: 10.2169/internalmedicine.51.8402. PMID: 23154717
Weekly paclitaxel therapy is effective for gastric adenosquamous carcinoma: a case report.
Tohma T, Yamamoto Y, Seki Y, Takaishi S, Sakuma Y, Funami Y, Tobita K
Hepatogastroenterology 2009 Mar-Apr;56(90):568-70. PMID: 19579645

Prognosis

Clinicopathologic characteristics, survival, and treatments for gastric adenosquamous carcinoma: a population-based study.
Li HS, Liu X, Zhang MY, Cheng K, Chen Y, Zhou YW, Liu JY
Curr Oncol 2020 Dec;27(6):e527-e536. Epub 2020 Dec 1 doi: 10.3747/co.27.6337. PMID: 33380867Free PMC Article
Increased proportion of the squamous cell carcinoma component is associated with worse survival in resected gastric adenosquamous carcinoma: A STROBE compliant cohort study.
Li HS, Chen Y, Zhang MY, Cheng K, Zhou YW, Liu JY
Medicine (Baltimore) 2020 Sep 4;99(36):e21980. doi: 10.1097/MD.0000000000021980. PMID: 32899039Free PMC Article
Clinicopathological features and prognosis of gastric adenosquamous carcinoma.
Feng F, Zheng G, Qi J, Xu G, Wang F, Wang Q, Guo M, Lian X, Zhang H
Sci Rep 2017 Jul 4;7(1):4597. doi: 10.1038/s41598-017-04563-2. PMID: 28676632Free PMC Article
Fatal submucosal invasive gastric adenosquamous carcinoma detected at surveillance after gastric endoscopic submucosal dissection.
Shirahige A, Suzuki H, Oda I, Sekiguchi M, Mori G, Abe S, Nonaka S, Yoshinaga S, Sekine S, Kushima R, Saito Y, Fukagawa T, Katai H
World J Gastroenterol 2015 Apr 14;21(14):4385-90. doi: 10.3748/wjg.v21.i14.4385. PMID: 25892891Free PMC Article
Clinicopathological characteristics, diagnosis, treatment, and outcomes of primary gastric adenosquamous carcinoma.
Chen H, Shen C, Yin R, Yin Y, Chen J, Han L, Zhang B, Chen Z, Chen J
World J Surg Oncol 2015 Apr 2;13:136. doi: 10.1186/s12957-015-0554-1. PMID: 25889482Free PMC Article

Clinical prediction guides

Immunoprofile of adenosquamous carcinoma in gastric cancer.
Wu CH, Lai CL, Teng CJ, Fang WL, Huang KH, Fen-Yau Li A, Yu HY, Chiang NJ, Chao Y, Hung YP, Chen MH
J Chin Med Assoc 2023 Jun 1;86(6):542-548. Epub 2023 Mar 29 doi: 10.1097/JCMA.0000000000000922. PMID: 36989495
Clinicopathologic characteristics, survival, and treatments for gastric adenosquamous carcinoma: a population-based study.
Li HS, Liu X, Zhang MY, Cheng K, Chen Y, Zhou YW, Liu JY
Curr Oncol 2020 Dec;27(6):e527-e536. Epub 2020 Dec 1 doi: 10.3747/co.27.6337. PMID: 33380867Free PMC Article
Clinicopathological characteristics, diagnosis, treatment, and outcomes of primary gastric adenosquamous carcinoma.
Chen H, Shen C, Yin R, Yin Y, Chen J, Han L, Zhang B, Chen Z, Chen J
World J Surg Oncol 2015 Apr 2;13:136. doi: 10.1186/s12957-015-0554-1. PMID: 25889482Free PMC Article

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