U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Undifferentiated Neuroblastoma

MedGen UID:
274348
•Concept ID:
C1519787
•
Neoplastic Process

Definition

A neuroblastoma characterized by the absence of differentiating neuroblasts. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUndifferentiated Neuroblastoma

Professional guidelines

PubMed

Polysialylated neural cell adhesion molecule as a marker for differential diagnosis in pediatric tumors.
Glüer S, Schelp C, Gerardy-Schahn R, von Schweinitz D
J Pediatr Surg 1998 Oct;33(10):1516-20. doi: 10.1016/s0022-3468(98)90488-2. PMID: 9802804

Recent clinical studies

Etiology

Five Years Follow-up of Opsoclonus-Myoclonus-Ataxia Syndrome-Associated Neurogenic Tumors in Children.
Aktekin EH, Gezer HÖ, Yazıcı N, Erol İ, Erbay A, Sarıalioğlu F
Neuropediatrics 2024 Feb;55(1):57-62. Epub 2023 Apr 5 doi: 10.1055/s-0043-1768143. PMID: 37019145
Metastatic neuroblastoma in fertility preservation biopsy of clinically normal testis: a case report.
Ahler A, Gook D, Moussaoui D, Archer J, Zacharin M, D'Arcy CE, Sullivan M, Jayasinghe Y
Reprod Biomed Online 2023 Aug;47(2):103232. Epub 2023 May 9 doi: 10.1016/j.rbmo.2023.05.004. PMID: 37301710
Avocado oil (Persea americana) protects SH-SY5Y cells against cytotoxicity triggered by cortisol by the modulation of BDNF, oxidative stress, and apoptosis molecules.
Motta JR, Jung IEDC, Azzolin VF, Teixeira CF, Braun LE, De Oliveira Nerys DA, Motano MAE, Duarte MMMF, Maia-Ribeiro EA, da Cruz IBM, Barbisan F
J Food Biochem 2021 Feb;45(2):e13596. Epub 2021 Jan 22 doi: 10.1111/jfbc.13596. PMID: 33480081
Pediatric neuroblastic tumors: A critical evaluation of cytomorphological features for risk stratification on aspiration cytology.
Behera G, Chhabra G, Mishra P, Sable M
Diagn Cytopathol 2020 May;48(5):464-474. Epub 2020 Feb 11 doi: 10.1002/dc.24389. PMID: 32043835
Intraventricular cerebral neuroblastoma. Analysis of subtypes and comparison with hemispheric neuroblastoma.
Rhodes RH, Cole M, Takaoka Y, Roessmann U, Cotes EE, Simon J
Arch Pathol Lab Med 1994 Sep;118(9):897-911. PMID: 8080360

Diagnosis

Five Years Follow-up of Opsoclonus-Myoclonus-Ataxia Syndrome-Associated Neurogenic Tumors in Children.
Aktekin EH, Gezer HÖ, Yazıcı N, Erol İ, Erbay A, Sarıalioğlu F
Neuropediatrics 2024 Feb;55(1):57-62. Epub 2023 Apr 5 doi: 10.1055/s-0043-1768143. PMID: 37019145
Pediatric neuroblastic tumors: A critical evaluation of cytomorphological features for risk stratification on aspiration cytology.
Behera G, Chhabra G, Mishra P, Sable M
Diagn Cytopathol 2020 May;48(5):464-474. Epub 2020 Feb 11 doi: 10.1002/dc.24389. PMID: 32043835
Undifferentiated Neuroblastoma Cells Are More Sensitive to Photogenerated Oxidative Stress Than Differentiated Cells.
Lee CI, Perng JH, Chen HY, Hong YR, Wang JJ
J Cell Biochem 2015 Sep;116(9):2074-85. doi: 10.1002/jcb.25165. PMID: 25919890
PHOX2B immunolabeling: a novel tool for the diagnosis of undifferentiated neuroblastomas among childhood small round blue-cell tumors.
Bielle F, Fréneaux P, Jeanne-Pasquier C, Maran-Gonzalez A, Rousseau A, Lamant L, Paris R, Pierron G, Nicolas AV, Sastre-Garau X, Delattre O, Bourdeaut F, Peuchmaur M
Am J Surg Pathol 2012 Aug;36(8):1141-9. doi: 10.1097/PAS.0b013e31825a6895. PMID: 22790854
Polysialylated neural cell adhesion molecule in childhood ganglioneuroma and neuroblastoma of different histological grade and clinical stage.
Glüer S, Zense M, Radtke E, von Schweinitz D
Langenbecks Arch Surg 1998 Oct;383(5):340-4. doi: 10.1007/s004230050145. PMID: 9860228

Therapy

Five Years Follow-up of Opsoclonus-Myoclonus-Ataxia Syndrome-Associated Neurogenic Tumors in Children.
Aktekin EH, Gezer HÖ, Yazıcı N, Erol İ, Erbay A, Sarıalioğlu F
Neuropediatrics 2024 Feb;55(1):57-62. Epub 2023 Apr 5 doi: 10.1055/s-0043-1768143. PMID: 37019145
Pigment epithelium-derived factor (PEDF) in neuroblastoma: a multifunctional mediator of Schwann cell antitumor activity.
Crawford SE, Stellmach V, Ranalli M, Huang X, Huang L, Volpert O, De Vries GH, Abramson LP, Bouck N
J Cell Sci 2001 Dec;114(Pt 24):4421-8. doi: 10.1242/jcs.114.24.4421. PMID: 11792807
Polysialylated neural cell adhesion molecule in childhood ganglioneuroma and neuroblastoma of different histological grade and clinical stage.
Glüer S, Zense M, Radtke E, von Schweinitz D
Langenbecks Arch Surg 1998 Oct;383(5):340-4. doi: 10.1007/s004230050145. PMID: 9860228
Chemotherapy for neuroendocrine tumors: the Beatson Oncology Centre experience.
Hatton MQ, Reed NS
Clin Oncol (R Coll Radiol) 1997;9(6):385-9. doi: 10.1016/s0936-6555(97)80132-x. PMID: 9448967

Prognosis

Five Years Follow-up of Opsoclonus-Myoclonus-Ataxia Syndrome-Associated Neurogenic Tumors in Children.
Aktekin EH, Gezer HÖ, Yazıcı N, Erol İ, Erbay A, Sarıalioğlu F
Neuropediatrics 2024 Feb;55(1):57-62. Epub 2023 Apr 5 doi: 10.1055/s-0043-1768143. PMID: 37019145
Pediatric neuroblastic tumors: A critical evaluation of cytomorphological features for risk stratification on aspiration cytology.
Behera G, Chhabra G, Mishra P, Sable M
Diagn Cytopathol 2020 May;48(5):464-474. Epub 2020 Feb 11 doi: 10.1002/dc.24389. PMID: 32043835
Caspase 8L, a novel inhibitory isoform of caspase 8, is associated with undifferentiated neuroblastoma.
Miller MA, Karacay B, Zhu X, O'Dorisio MS, Sandler AD
Apoptosis 2006 Jan;11(1):15-24. doi: 10.1007/s10495-005-3258-0. PMID: 16374545
Polysialylated neural cell adhesion molecule in childhood ganglioneuroma and neuroblastoma of different histological grade and clinical stage.
Glüer S, Zense M, Radtke E, von Schweinitz D
Langenbecks Arch Surg 1998 Oct;383(5):340-4. doi: 10.1007/s004230050145. PMID: 9860228
Stage-specific expression of integrin alphaVbeta3 in neuroblastic tumors.
Gladson CL, Hancock S, Arnold MM, Faye-Petersen OM, Castleberry RP, Kelly DR
Am J Pathol 1996 May;148(5):1423-34. PMID: 8623914Free PMC Article

Clinical prediction guides

Investigation of mechanisms underlying the inhibitory effects of metformin against proliferation and growth of neuroblastoma SH-SY5Y cells.
Binlateh T, Reudhabibadh R, Prommeenate P, Hutamekalin P
Toxicol In Vitro 2022 Sep;83:105410. Epub 2022 Jun 5 doi: 10.1016/j.tiv.2022.105410. PMID: 35675846
Pediatric neuroblastic tumors: A critical evaluation of cytomorphological features for risk stratification on aspiration cytology.
Behera G, Chhabra G, Mishra P, Sable M
Diagn Cytopathol 2020 May;48(5):464-474. Epub 2020 Feb 11 doi: 10.1002/dc.24389. PMID: 32043835
Binding, internalization and fate of Huntingtin Exon1 fibrillar assemblies in mitotic and nonmitotic neuroblastoma cells.
Ruiz-Arlandis G, Pieri L, Bousset L, Melki R
Neuropathol Appl Neurobiol 2016 Feb;42(2):137-52. Epub 2015 Jul 20 doi: 10.1111/nan.12258. PMID: 26111612
The neurogene BTG2TIS21/PC3 is transactivated by DeltaNp73alpha via p53 specifically in neuroblastoma cells.
Goldschneider D, Million K, Meiller A, Haddada H, Puisieux A, Bénard J, May E, Douc-Rasy S
J Cell Sci 2005 Mar 15;118(Pt 6):1245-53. Epub 2005 Mar 1 doi: 10.1242/jcs.01704. PMID: 15741235
Induction of apoptosis and differentiation in neuroblastoma and astrocytoma cells by the overexpression of Bin1, a novel Myc interacting protein.
Galderisi U, Di Bernardo G, Cipollaro M, Jori FP, Piegari E, Cascino A, Peluso G, Melone MA
J Cell Biochem 1999 Sep 1;74(3):313-22. PMID: 10412034

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...