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Uterine Corpus Leiomyoma, Mitotically Active Variant

MedGen UID:
274365
•Concept ID:
C1519854
•
Neoplastic Process

Definition

A morphologic variant of uterine corpus leiomyoma characterized by an increased number of mitoses (up to 19 mitoses per 10 high-powered fields). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUterine Corpus Leiomyoma, Mitotically Active Variant

Professional guidelines

PubMed

Uterine fibroid-like tumors: spectrum of MR imaging findings and their differential diagnosis.
Lin Y, Wu RC, Huang YL, Chen K, Tseng SC, Wang CJ, Chao A, Lai CH, Lin G
Abdom Radiol (NY) 2022 Jun;47(6):2197-2208. Epub 2022 Mar 26 doi: 10.1007/s00261-022-03431-6. PMID: 35347386
Smooth muscle tumors of the ovary: a clinicopathologic study of 54 cases emphasizing prognostic criteria, histologic variants, and differential diagnosis.
Lerwill MF, Sung R, Oliva E, Prat J, Young RH
Am J Surg Pathol 2004 Nov;28(11):1436-51. doi: 10.1097/01.pas.0000141393.99300.d0. PMID: 15489647
Smooth muscle neoplasms of the uterus other than ordinary leiomyoma. A study of 46 cases, with emphasis on diagnostic criteria and prognostic factors.
Evans HL, Chawla SP, Simpson C, Finn KP
Cancer 1988 Nov 15;62(10):2239-47. doi: 10.1002/1097-0142(19881115)62:10<2239::aid-cncr2820621028>3.0.co;2-y. PMID: 3179938

Recent clinical studies

Etiology

POTENTIAL LIFE PROGNOSTIC MARKER FOR MESENCHYMAL TUMOR RESEMBLING UTERINE LEIOMYOSARCOMA.
Nishikawa S, Hayashi T, Uzaki T, Yaegashi N, Abiko K, Konishi I
Georgian Med News 2023 Oct;(343):119-126. PMID: 38096528
Mass lesions of the myometrium: interpretation and management of unexpected pathology.
Porter AE, Kho KA, Gwin K
Curr Opin Obstet Gynecol 2019 Oct;31(5):349-355. doi: 10.1097/GCO.0000000000000569. PMID: 31425175
Leiomyoma: Its Variants And Secondary Changes A Five-Year Study.
Naz S, Rehman A, Riyaz A, Jehangir F, Naeem S, Iqbal T
J Ayub Med Coll Abbottabad 2019 Apr-Jun;31(2):192-195. PMID: 31094115
Uterine smooth muscle tumors other than the ordinary leiomyomas and leiomyosarcomas: a review of selected variants with emphasis on recent advances and unusual morphology that may cause concern for malignancy.
Ip PP, Tse KY, Tam KF
Adv Anat Pathol 2010 Mar;17(2):91-112. doi: 10.1097/PAP.0b013e3181cfb901. PMID: 20179432
Fascin expression in uterine smooth muscle tumors.
Kefeli M, Yildiz L, Kaya FC, Aydin O, Kandemir B
Int J Gynecol Pathol 2009 Jul;28(4):328-33. doi: 10.1097/PGP.0b013e318195da9f. PMID: 19483633

Diagnosis

POTENTIAL LIFE PROGNOSTIC MARKER FOR MESENCHYMAL TUMOR RESEMBLING UTERINE LEIOMYOSARCOMA.
Nishikawa S, Hayashi T, Uzaki T, Yaegashi N, Abiko K, Konishi I
Georgian Med News 2023 Oct;(343):119-126. PMID: 38096528
Uterine fibroid-like tumors: spectrum of MR imaging findings and their differential diagnosis.
Lin Y, Wu RC, Huang YL, Chen K, Tseng SC, Wang CJ, Chao A, Lai CH, Lin G
Abdom Radiol (NY) 2022 Jun;47(6):2197-2208. Epub 2022 Mar 26 doi: 10.1007/s00261-022-03431-6. PMID: 35347386
Mass lesions of the myometrium: interpretation and management of unexpected pathology.
Porter AE, Kho KA, Gwin K
Curr Opin Obstet Gynecol 2019 Oct;31(5):349-355. doi: 10.1097/GCO.0000000000000569. PMID: 31425175
Leiomyoma: Its Variants And Secondary Changes A Five-Year Study.
Naz S, Rehman A, Riyaz A, Jehangir F, Naeem S, Iqbal T
J Ayub Med Coll Abbottabad 2019 Apr-Jun;31(2):192-195. PMID: 31094115
Uterine smooth muscle tumors other than the ordinary leiomyomas and leiomyosarcomas: a review of selected variants with emphasis on recent advances and unusual morphology that may cause concern for malignancy.
Ip PP, Tse KY, Tam KF
Adv Anat Pathol 2010 Mar;17(2):91-112. doi: 10.1097/PAP.0b013e3181cfb901. PMID: 20179432

Prognosis

POTENTIAL LIFE PROGNOSTIC MARKER FOR MESENCHYMAL TUMOR RESEMBLING UTERINE LEIOMYOSARCOMA.
Nishikawa S, Hayashi T, Uzaki T, Yaegashi N, Abiko K, Konishi I
Georgian Med News 2023 Oct;(343):119-126. PMID: 38096528
Intravascular adenomyomatosis: a morphologic variant of intravenous leiomyomatosis associated with endometriosis and potential for misdiagnosis.
Fitzpatrick MB, Hammer PM, Yang EJ, Howitt BE
Hum Pathol 2022 Feb;120:18-25. Epub 2021 Nov 29 doi: 10.1016/j.humpath.2021.11.009. PMID: 34856302
STUMP - atypowy mięśniak macicy - mimikra guza złośliwego?
Ropacka-Lesiak M, Suminska M, Jasiński P, Podkowa N, Bręborowicz GH
Ginekol Pol 2016;87(2):148-52. doi: 10.17772/gp/61712. PMID: 27306293
May Sonic Hedgehog proteins be markers for malignancy in uterine smooth muscle tumors?
Garcia N, Bozzini N, Baiocchi G, da Cunha IW, Maciel GA, Soares Junior JM, Soares FA, Baracat EC, Carvalho KC
Hum Pathol 2016 Apr;50:43-50. Epub 2015 Nov 24 doi: 10.1016/j.humpath.2015.08.026. PMID: 26997437
Cutaneous leiomyoma with cytologic atypia, akin to uterine symplastic leiomyoma.
Matthews JH, Pichardo RO, Hitchcock MG, Leshin B
Dermatol Surg 2004 Sep;30(9):1249-51; discussion 1251. doi: 10.1111/j.1524-4725.2004.30386.x. PMID: 15355371

Clinical prediction guides

POTENTIAL LIFE PROGNOSTIC MARKER FOR MESENCHYMAL TUMOR RESEMBLING UTERINE LEIOMYOSARCOMA.
Nishikawa S, Hayashi T, Uzaki T, Yaegashi N, Abiko K, Konishi I
Georgian Med News 2023 Oct;(343):119-126. PMID: 38096528
Divergent Schwannoma-Like Phenotype in a Pleomorphic Adenoma.
Chandra SR, Karim F, Rawal YB
Head Neck Pathol 2017 Dec;11(4):567-574. Epub 2017 Apr 24 doi: 10.1007/s12105-017-0817-y. PMID: 28439689Free PMC Article
May Sonic Hedgehog proteins be markers for malignancy in uterine smooth muscle tumors?
Garcia N, Bozzini N, Baiocchi G, da Cunha IW, Maciel GA, Soares Junior JM, Soares FA, Baracat EC, Carvalho KC
Hum Pathol 2016 Apr;50:43-50. Epub 2015 Nov 24 doi: 10.1016/j.humpath.2015.08.026. PMID: 26997437
Fascin expression in uterine smooth muscle tumors.
Kefeli M, Yildiz L, Kaya FC, Aydin O, Kandemir B
Int J Gynecol Pathol 2009 Jul;28(4):328-33. doi: 10.1097/PGP.0b013e318195da9f. PMID: 19483633
Cotyledonoid dissecting leiomyoma of the uterus: a case report of a benign uterine tumor with sarcomalike gross appearance and review of literature.
Saeed AS, Hanaa B, Faisal AS, Najla AM
Int J Gynecol Pathol 2006 Jul;25(3):262-7. doi: 10.1097/01.pgp.0000186542.19434.ea. PMID: 16810065

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