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Fallopian tube germ cell tumor

MedGen UID:
274487
•Concept ID:
C1517114
•
Neoplastic Process
Synonyms: fallopian tube germ cell cancer; Fallopian Tube Germ Cell Neoplasm; fallopian tube germ cell neoplasm; Fallopian Tube Germ Cell Tumor; fallopian tube germ cell tumor
 
Monarch Initiative: MONDO:0003392

Definition

A rare germ cell tumor that affects the fallopian tube. The vast majority of cases are teratomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFallopian tube germ cell tumor

Professional guidelines

PubMed

The 2020 Japan Society of Gynecologic Oncology guidelines for the treatment of ovarian cancer, fallopian tube cancer, and primary peritoneal cancer.
Tokunaga H, Mikami M, Nagase S, Kobayashi Y, Tabata T, Kaneuchi M, Satoh T, Hirashima Y, Matsumura N, Yokoyama Y, Kawana K, Kyo S, Aoki D, Katabuchi H
J Gynecol Oncol 2021 Mar;32(2):e49. doi: 10.3802/jgo.2021.32.e49. PMID: 33650343Free PMC Article
Treatment of ovarian cancer in young women.
Gershenson DM
Clin Obstet Gynecol 2012 Mar;55(1):65-74. doi: 10.1097/GRF.0b013e318248045b. PMID: 22343230
FIGO staging classifications and clinical practice guidelines in the management of gynecologic cancers. FIGO Committee on Gynecologic Oncology.
Benedet JL, Bender H, Jones H 3rd, Ngan HY, Pecorelli S
Int J Gynaecol Obstet 2000 Aug;70(2):209-62. PMID: 11041682

Recent clinical studies

Etiology

Biomarkers of Targeted Therapy and Immuno-Oncology in Cancers Metastatic to the Breast.
Vranic S, Senarathne W, Stafford P, Poorman K, Pockaj BA, Gatalica Z
Appl Immunohistochem Mol Morphol 2020 Oct;28(9):661-668. doi: 10.1097/PAI.0000000000000808. PMID: 31517642Free PMC Article
Choriocarcinoma in Women: Analysis of a Case Series With Genotyping.
Savage J, Adams E, Veras E, Murphy KM, Ronnett BM
Am J Surg Pathol 2017 Dec;41(12):1593-1606. doi: 10.1097/PAS.0000000000000937. PMID: 28877059
Fertility control and the risk of gynecological malignancies.
Sivanesaratnam V
Obstet Gynecol Surv 1991 Mar;46(3):131-7. doi: 10.1097/00006254-199103000-00002. PMID: 1849623
The ultrastructure of selected gynecologic neoplasms.
Dickersin GR
Clin Lab Med 1987 Mar;7(1):117-56. PMID: 3030611
High-risk factors in gynecologic cancer.
Berg JW, Lampe JG
Cancer 1981 Jul 15;48(2 Suppl):429-41. doi: 10.1002/1097-0142(19810715)48:1+<429::aid-cncr2820481303>3.0.co;2-2. PMID: 7023659

Diagnosis

Emerging Therapeutic Concepts and Latest Diagnostic Advancements Regarding Neuroendocrine Tumors of the Gynecologic Tract.
Georgescu TA, Bohiltea RE, Munteanu O, Furtunescu F, Lisievici AC, Grigoriu C, Gherghiceanu F, Vlădăreanu EM, Berceanu C, Ducu I, Iordache AM
Medicina (Kaunas) 2021 Dec 7;57(12) doi: 10.3390/medicina57121338. PMID: 34946283Free PMC Article
Multimodality Imaging Approach to Ovarian Neoplasms with Pathologic Correlation.
Taylor EC, Irshaid L, Mathur M
Radiographics 2021 Jan-Feb;41(1):289-315. Epub 2020 Nov 13 doi: 10.1148/rg.2021200086. PMID: 33186060
Adnexal masses in children and adolescents.
Kelleher CM, Goldstein AM
Clin Obstet Gynecol 2015 Mar;58(1):76-92. doi: 10.1097/GRF.0000000000000084. PMID: 25551698
Treatment of ovarian cancer in young women.
Gershenson DM
Clin Obstet Gynecol 2012 Mar;55(1):65-74. doi: 10.1097/GRF.0b013e318248045b. PMID: 22343230
The ultrastructure of selected gynecologic neoplasms.
Dickersin GR
Clin Lab Med 1987 Mar;7(1):117-56. PMID: 3030611

Therapy

Primary yolk sac tumor of the omentum: a case report and review of the literature.
Kim SW, Park JH, Lim MC, Park JY, Yoo CW, Park SY
Arch Gynecol Obstet 2009 Feb;279(2):189-92. Epub 2008 Jul 22 doi: 10.1007/s00404-008-0661-0. PMID: 18648830
Primary tubal choriocarcinoma.
Gálvez CR, Fernández VC, de Los Reyes JM, Jaén MM, Teruel RG
Int J Gynecol Cancer 2004 Sep-Oct;14(5):1040-4. doi: 10.1111/j.1048-891X.2004.014550.x. PMID: 15361223
Malignant mixed müllerian tumor of the fallopian tube.
Carlson JA Jr, Ackerman BL, Wheeler JE
Cancer 1993 Jan 1;71(1):187-92. doi: 10.1002/1097-0142(19930101)71:1<187::aid-cncr2820710129>3.0.co;2-c. PMID: 8380115
Fertility control and the risk of gynecological malignancies.
Sivanesaratnam V
Obstet Gynecol Surv 1991 Mar;46(3):131-7. doi: 10.1097/00006254-199103000-00002. PMID: 1849623
Primary carcinoma of the fallopian tube.
Podratz KC, Podczaski ES, Gaffey TA, O'Brien PC, Schray MF, Malkasian GD Jr
Am J Obstet Gynecol 1986 Jun;154(6):1319-26. doi: 10.1016/0002-9378(86)90719-2. PMID: 3013008

Prognosis

Malignant germ cell tumor of fallopian tube with rhabdomyosarcoma: a case report and literature review.
Zhao L, Li Y, Wang F, Zheng X, He L, Zhang L
Diagn Pathol 2023 Sep 2;18(1):99. doi: 10.1186/s13000-023-01388-8. PMID: 37660086Free PMC Article
Emerging Therapeutic Concepts and Latest Diagnostic Advancements Regarding Neuroendocrine Tumors of the Gynecologic Tract.
Georgescu TA, Bohiltea RE, Munteanu O, Furtunescu F, Lisievici AC, Grigoriu C, Gherghiceanu F, Vlădăreanu EM, Berceanu C, Ducu I, Iordache AM
Medicina (Kaunas) 2021 Dec 7;57(12) doi: 10.3390/medicina57121338. PMID: 34946283Free PMC Article
Cancer of the ovary, fallopian tube, and peritoneum: 2021 update.
Berek JS, Renz M, Kehoe S, Kumar L, Friedlander M
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):61-85. doi: 10.1002/ijgo.13878. PMID: 34669199Free PMC Article
Cancer of the ovary, fallopian tube, and peritoneum.
Berek JS, Kehoe ST, Kumar L, Friedlander M
Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:59-78. doi: 10.1002/ijgo.12614. PMID: 30306591
Neuroendocrine tumors of the genital tract.
Eichhorn JH, Young RH
Am J Clin Pathol 2001 Jun;115 Suppl:S94-112. doi: 10.1309/64CW-WKGK-49EF-BYD1. PMID: 11993694

Clinical prediction guides

Neuroendocrine Tumor of the Fallopian Tube and Serous Adenocarcinoma of the Ovary: Multicentric Primary Tumors.
Hyriavenko N, Lуndіn M, Sikora V, Chyzhma R, Lуndіna Y, Sikora K, Awuah WA, Romaniuk A
Turk Patoloji Derg 2023;39(2):161-166. doi: 10.5146/tjpath.2022.01589. PMID: 36178284Free PMC Article
Biomarkers of Targeted Therapy and Immuno-Oncology in Cancers Metastatic to the Breast.
Vranic S, Senarathne W, Stafford P, Poorman K, Pockaj BA, Gatalica Z
Appl Immunohistochem Mol Morphol 2020 Oct;28(9):661-668. doi: 10.1097/PAI.0000000000000808. PMID: 31517642Free PMC Article
A Case of Extragonadal Teratoma in the Pouch of Douglas and Literature Review.
Kakuda M, Matsuzaki S, Kobayashi E, Yoshino K, Morii E, Kimura T
J Minim Invasive Gynecol 2015 Nov-Dec;22(7):1311-7. Epub 2015 Jul 20 doi: 10.1016/j.jmig.2015.07.008. PMID: 26205577
Pelvic pain, adnexal masses, and ultrasound.
Shwayder JM
Semin Reprod Med 2008 May;26(3):252-65. doi: 10.1055/s-2008-1076144. PMID: 18504700
Gestational choriocarcinoma of the fallopian tube.
Ober WB, Maier RC
Diagn Gynecol Obstet 1981 Fall;3(3):213-31. PMID: 7035113

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