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Fallopian tube germ cell tumor

MedGen UID:
274487
•Concept ID:
C1517114
•
Neoplastic Process
Synonyms: fallopian tube germ cell cancer; Fallopian Tube Germ Cell Neoplasm; fallopian tube germ cell neoplasm; Fallopian Tube Germ Cell Tumor; fallopian tube germ cell tumor
 
Monarch Initiative: MONDO:0003392

Definition

A rare germ cell tumor that affects the fallopian tube. The vast majority of cases are teratomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFallopian tube germ cell tumor

Professional guidelines

PubMed

The 2020 Japan Society of Gynecologic Oncology guidelines for the treatment of ovarian cancer, fallopian tube cancer, and primary peritoneal cancer.
Tokunaga H, Mikami M, Nagase S, Kobayashi Y, Tabata T, Kaneuchi M, Satoh T, Hirashima Y, Matsumura N, Yokoyama Y, Kawana K, Kyo S, Aoki D, Katabuchi H
J Gynecol Oncol 2021 Mar;32(2):e49. doi: 10.3802/jgo.2021.32.e49. PMID: 33650343Free PMC Article
Treatment of ovarian cancer in young women.
Gershenson DM
Clin Obstet Gynecol 2012 Mar;55(1):65-74. doi: 10.1097/GRF.0b013e318248045b. PMID: 22343230
The clinical presentation, treatment, and outcome of patients diagnosed with possible ectopic molar gestation.
Gillespie AM, Lidbury EA, Tidy JA, Hancock BW
Int J Gynecol Cancer 2004 Mar-Apr;14(2):366-9. doi: 10.1111/j.1048-891X.2004.014223.x. PMID: 15086739

Recent clinical studies

Etiology

BRCA1/2 reversion mutations in a pan-cancer cohort.
Nakamura K, Hayashi H, Kawano R, Ishikawa M, Aimono E, Mizuno T, Kuroda H, Kojima Y, Niikura N, Kawanishi A, Takeshita K, Suzuki S, Ueno S, Okuwaki K, Sasaki J, Yamaguchi M, Masuda K, Chiyoda T, Yamagami W, Okada C, Nohara S, Tanishima S, Nishihara H
Cancer Sci 2024 Feb;115(2):635-647. Epub 2023 Dec 1 doi: 10.1111/cas.16033. PMID: 38041241Free PMC Article
Neuroendocrine Tumor of the Fallopian Tube and Serous Adenocarcinoma of the Ovary: Multicentric Primary Tumors.
Hyriavenko N, Lуndіn M, Sikora V, Chyzhma R, Lуndіna Y, Sikora K, Awuah WA, Romaniuk A
Turk Patoloji Derg 2023;39(2):161-166. doi: 10.5146/tjpath.2022.01589. PMID: 36178284Free PMC Article
Biomarkers of Targeted Therapy and Immuno-Oncology in Cancers Metastatic to the Breast.
Vranic S, Senarathne W, Stafford P, Poorman K, Pockaj BA, Gatalica Z
Appl Immunohistochem Mol Morphol 2020 Oct;28(9):661-668. doi: 10.1097/PAI.0000000000000808. PMID: 31517642Free PMC Article
Choriocarcinoma in Women: Analysis of a Case Series With Genotyping.
Savage J, Adams E, Veras E, Murphy KM, Ronnett BM
Am J Surg Pathol 2017 Dec;41(12):1593-1606. doi: 10.1097/PAS.0000000000000937. PMID: 28877059
Fertility control and the risk of gynecological malignancies.
Sivanesaratnam V
Obstet Gynecol Surv 1991 Mar;46(3):131-7. doi: 10.1097/00006254-199103000-00002. PMID: 1849623

Diagnosis

BRCA1/2 reversion mutations in a pan-cancer cohort.
Nakamura K, Hayashi H, Kawano R, Ishikawa M, Aimono E, Mizuno T, Kuroda H, Kojima Y, Niikura N, Kawanishi A, Takeshita K, Suzuki S, Ueno S, Okuwaki K, Sasaki J, Yamaguchi M, Masuda K, Chiyoda T, Yamagami W, Okada C, Nohara S, Tanishima S, Nishihara H
Cancer Sci 2024 Feb;115(2):635-647. Epub 2023 Dec 1 doi: 10.1111/cas.16033. PMID: 38041241Free PMC Article
Fallopian Tube Dermoid Tumor.
Horton T, Dinh T
J Minim Invasive Gynecol 2024 Jan;31(1):3-4. Epub 2023 Sep 22 doi: 10.1016/j.jmig.2023.09.008. PMID: 37741436
Malignant germ cell tumor of fallopian tube with rhabdomyosarcoma: a case report and literature review.
Zhao L, Li Y, Wang F, Zheng X, He L, Zhang L
Diagn Pathol 2023 Sep 2;18(1):99. doi: 10.1186/s13000-023-01388-8. PMID: 37660086Free PMC Article
Primary Gestational Trophoblastic Disease of the Fallopian Tube: A Case Series Analysis and Literature Review.
Lu J, Yue X, Xu C, Lu X
J Reprod Med 2017 Mar-Apr;62(3-4):147-52. PMID: 30230306
Adnexal masses in children and adolescents.
Kelleher CM, Goldstein AM
Clin Obstet Gynecol 2015 Mar;58(1):76-92. doi: 10.1097/GRF.0000000000000084. PMID: 25551698

Therapy

BRCA1/2 reversion mutations in a pan-cancer cohort.
Nakamura K, Hayashi H, Kawano R, Ishikawa M, Aimono E, Mizuno T, Kuroda H, Kojima Y, Niikura N, Kawanishi A, Takeshita K, Suzuki S, Ueno S, Okuwaki K, Sasaki J, Yamaguchi M, Masuda K, Chiyoda T, Yamagami W, Okada C, Nohara S, Tanishima S, Nishihara H
Cancer Sci 2024 Feb;115(2):635-647. Epub 2023 Dec 1 doi: 10.1111/cas.16033. PMID: 38041241Free PMC Article
Safety and anti-tumor activity of lisavanbulin administered as 48-hour infusion in patients with ovarian cancer or recurrent glioblastoma: a phase 2a study.
Joerger M, Hundsberger T, Haefliger S, von Moos R, Hottinger AF, Kaindl T, Engelhardt M, Marszewska M, Lane H, Roth P, Stathis A
Invest New Drugs 2023 Apr;41(2):267-275. Epub 2023 Feb 16 doi: 10.1007/s10637-023-01336-9. PMID: 36792805Free PMC Article
What is the success of ultrasonography of benign adnexal masses?
Bayoğlu Tekin Y, Dede FS
J Obstet Gynaecol Res 2014 Feb;40(2):473-8. Epub 2013 Oct 22 doi: 10.1111/jog.12208. PMID: 24147915
Malignant mixed müllerian tumor of the fallopian tube.
Carlson JA Jr, Ackerman BL, Wheeler JE
Cancer 1993 Jan 1;71(1):187-92. doi: 10.1002/1097-0142(19930101)71:1<187::aid-cncr2820710129>3.0.co;2-c. PMID: 8380115
Fertility control and the risk of gynecological malignancies.
Sivanesaratnam V
Obstet Gynecol Surv 1991 Mar;46(3):131-7. doi: 10.1097/00006254-199103000-00002. PMID: 1849623

Prognosis

BRCA1/2 reversion mutations in a pan-cancer cohort.
Nakamura K, Hayashi H, Kawano R, Ishikawa M, Aimono E, Mizuno T, Kuroda H, Kojima Y, Niikura N, Kawanishi A, Takeshita K, Suzuki S, Ueno S, Okuwaki K, Sasaki J, Yamaguchi M, Masuda K, Chiyoda T, Yamagami W, Okada C, Nohara S, Tanishima S, Nishihara H
Cancer Sci 2024 Feb;115(2):635-647. Epub 2023 Dec 1 doi: 10.1111/cas.16033. PMID: 38041241Free PMC Article
Malignant germ cell tumor of fallopian tube with rhabdomyosarcoma: a case report and literature review.
Zhao L, Li Y, Wang F, Zheng X, He L, Zhang L
Diagn Pathol 2023 Sep 2;18(1):99. doi: 10.1186/s13000-023-01388-8. PMID: 37660086Free PMC Article
Emerging Therapeutic Concepts and Latest Diagnostic Advancements Regarding Neuroendocrine Tumors of the Gynecologic Tract.
Georgescu TA, Bohiltea RE, Munteanu O, Furtunescu F, Lisievici AC, Grigoriu C, Gherghiceanu F, Vlădăreanu EM, Berceanu C, Ducu I, Iordache AM
Medicina (Kaunas) 2021 Dec 7;57(12) doi: 10.3390/medicina57121338. PMID: 34946283Free PMC Article
Cancer of the ovary, fallopian tube, and peritoneum: 2021 update.
Berek JS, Renz M, Kehoe S, Kumar L, Friedlander M
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):61-85. doi: 10.1002/ijgo.13878. PMID: 34669199Free PMC Article
Cancer of the ovary, fallopian tube, and peritoneum.
Berek JS, Kehoe ST, Kumar L, Friedlander M
Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:59-78. doi: 10.1002/ijgo.12614. PMID: 30306591

Clinical prediction guides

BRCA1/2 reversion mutations in a pan-cancer cohort.
Nakamura K, Hayashi H, Kawano R, Ishikawa M, Aimono E, Mizuno T, Kuroda H, Kojima Y, Niikura N, Kawanishi A, Takeshita K, Suzuki S, Ueno S, Okuwaki K, Sasaki J, Yamaguchi M, Masuda K, Chiyoda T, Yamagami W, Okada C, Nohara S, Tanishima S, Nishihara H
Cancer Sci 2024 Feb;115(2):635-647. Epub 2023 Dec 1 doi: 10.1111/cas.16033. PMID: 38041241Free PMC Article
Neuroendocrine Tumor of the Fallopian Tube and Serous Adenocarcinoma of the Ovary: Multicentric Primary Tumors.
Hyriavenko N, Lуndіn M, Sikora V, Chyzhma R, Lуndіna Y, Sikora K, Awuah WA, Romaniuk A
Turk Patoloji Derg 2023;39(2):161-166. doi: 10.5146/tjpath.2022.01589. PMID: 36178284Free PMC Article
Human iPSC-derived fallopian tube organoids with BRCA1 mutation recapitulate early-stage carcinogenesis.
Yucer N, Ahdoot R, Workman MJ, Laperle AH, Recouvreux MS, Kurowski K, Naboulsi DJ, Liang V, Qu Y, Plummer JT, Gayther SA, Orsulic S, Karlan BY, Svendsen CN
Cell Rep 2021 Dec 28;37(13):110146. doi: 10.1016/j.celrep.2021.110146. PMID: 34965417Free PMC Article
Biomarkers of Targeted Therapy and Immuno-Oncology in Cancers Metastatic to the Breast.
Vranic S, Senarathne W, Stafford P, Poorman K, Pockaj BA, Gatalica Z
Appl Immunohistochem Mol Morphol 2020 Oct;28(9):661-668. doi: 10.1097/PAI.0000000000000808. PMID: 31517642Free PMC Article
A Case of Extragonadal Teratoma in the Pouch of Douglas and Literature Review.
Kakuda M, Matsuzaki S, Kobayashi E, Yoshino K, Morii E, Kimura T
J Minim Invasive Gynecol 2015 Nov-Dec;22(7):1311-7. Epub 2015 Jul 20 doi: 10.1016/j.jmig.2015.07.008. PMID: 26205577

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