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Bladder Non-Invasive Papillary Urothelial Carcinoma, Low Grade

MedGen UID:
274712
•Concept ID:
C1518006
•
Neoplastic Process
Synonym: Non-Invasive Bladder Papillary Urothelial Carcinoma, Low Grade

Definition

Bladder non-invasive papillary urothelial carcinoma characterized by minimal cytologic atypia and infrequent mitotic figures (usually limited to the lower half of the tumor). This type of carcinoma recurs frequently, may invade the bladder wall, and has a low risk of progression. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBladder Non-Invasive Papillary Urothelial Carcinoma, Low Grade

Recent clinical studies

Etiology

Multiparametric Classification of Non-Muscle Invasive Papillary Urothelial Neoplasms: Combining Morphological, Phenotypical, and Molecular Features for Improved Risk Stratification.
Montes-Mojarro IA, Hassas S, Staehle S, Sander P, Harland N, Serna-Higuita LM, Bonzheim I, Bösmüller H, Stenzl A, Fend F
Int J Mol Sci 2022 Jul 23;23(15) doi: 10.3390/ijms23158133. PMID: 35897708Free PMC Article
Heterogenous NECTIN4 expression in urothelial high-risk non-muscle-invasive bladder cancer.
Garczyk S, Degener S, Bischoff F, Schnitzler T, Salz A, Golz R, Buchner A, Schulz GB, Schneider U, Gaisa NT, Knüchel R
Virchows Arch 2022 Jul;481(1):83-92. Epub 2022 Apr 28 doi: 10.1007/s00428-022-03328-1. PMID: 35484425Free PMC Article
Reappraisal of the papillary urothelial neoplasm of low malignant potential (PUNLMP).
Jones TD, Cheng L
Histopathology 2020 Oct;77(4):525-535. Epub 2020 Sep 13 doi: 10.1111/his.14192. PMID: 32562556
HMGB1 expression in urothelial carcinoma of the bladder.
Suren D, Yildirim HT, Atalay I, Sayiner A, Yildirim M, Alikanoglu AS, Sezer C
J BUON 2018 Nov-Dec;23(6):1882-1886. PMID: 30610817
Non-invasive papillary urothelial neoplasms: the 2004 WHO/ISUP classification system.
Miyamoto H, Miller JS, Fajardo DA, Lee TK, Netto GJ, Epstein JI
Pathol Int 2010 Jan;60(1):1-8. doi: 10.1111/j.1440-1827.2009.02477.x. PMID: 20055945

Diagnosis

Multiparametric Classification of Non-Muscle Invasive Papillary Urothelial Neoplasms: Combining Morphological, Phenotypical, and Molecular Features for Improved Risk Stratification.
Montes-Mojarro IA, Hassas S, Staehle S, Sander P, Harland N, Serna-Higuita LM, Bonzheim I, Bösmüller H, Stenzl A, Fend F
Int J Mol Sci 2022 Jul 23;23(15) doi: 10.3390/ijms23158133. PMID: 35897708Free PMC Article
Validation of grading of non-invasive urothelial carcinoma by digital pathology for routine diagnosis.
Colling R, Colling H, Browning L, Verrill C
BMC Cancer 2021 Sep 6;21(1):995. doi: 10.1186/s12885-021-08698-4. PMID: 34488682Free PMC Article
Reappraisal of the papillary urothelial neoplasm of low malignant potential (PUNLMP).
Jones TD, Cheng L
Histopathology 2020 Oct;77(4):525-535. Epub 2020 Sep 13 doi: 10.1111/his.14192. PMID: 32562556
HMGB1 expression in urothelial carcinoma of the bladder.
Suren D, Yildirim HT, Atalay I, Sayiner A, Yildirim M, Alikanoglu AS, Sezer C
J BUON 2018 Nov-Dec;23(6):1882-1886. PMID: 30610817
Reduced immunohistochemical PTEN staining is associated with higher progression rate and recurrence episodes in non-invasive low-grade papillary urothelial carcinoma of the bladder.
Kulac I, Arslankoz S, Netto GJ, Ertoy Baydar D
Virchows Arch 2018 Jun;472(6):969-974. Epub 2018 Jan 24 doi: 10.1007/s00428-018-2302-8. PMID: 29368083

Therapy

Significance of a minor high-grade component in a low-grade noninvasive papillary urothelial carcinoma of bladder.
Reis LO, Taheri D, Chaux A, Guner G, Mendoza Rodriguez MA, Bivalacqua TJ, Schoenberg MP, Epstein JI, Netto GJ
Hum Pathol 2016 Jan;47(1):20-5. Epub 2015 Sep 25 doi: 10.1016/j.humpath.2015.09.007. PMID: 26520419

Prognosis

Multiparametric Classification of Non-Muscle Invasive Papillary Urothelial Neoplasms: Combining Morphological, Phenotypical, and Molecular Features for Improved Risk Stratification.
Montes-Mojarro IA, Hassas S, Staehle S, Sander P, Harland N, Serna-Higuita LM, Bonzheim I, Bösmüller H, Stenzl A, Fend F
Int J Mol Sci 2022 Jul 23;23(15) doi: 10.3390/ijms23158133. PMID: 35897708Free PMC Article
HMGB1 expression in urothelial carcinoma of the bladder.
Suren D, Yildirim HT, Atalay I, Sayiner A, Yildirim M, Alikanoglu AS, Sezer C
J BUON 2018 Nov-Dec;23(6):1882-1886. PMID: 30610817
Reduced immunohistochemical PTEN staining is associated with higher progression rate and recurrence episodes in non-invasive low-grade papillary urothelial carcinoma of the bladder.
Kulac I, Arslankoz S, Netto GJ, Ertoy Baydar D
Virchows Arch 2018 Jun;472(6):969-974. Epub 2018 Jan 24 doi: 10.1007/s00428-018-2302-8. PMID: 29368083
Non-invasive papillary urothelial neoplasms: the 2004 WHO/ISUP classification system.
Miyamoto H, Miller JS, Fajardo DA, Lee TK, Netto GJ, Epstein JI
Pathol Int 2010 Jan;60(1):1-8. doi: 10.1111/j.1440-1827.2009.02477.x. PMID: 20055945
Non-invasive urothelial neoplasms: according to the most recent WHO classification.
Lopez-Beltran A, Montironi R
Eur Urol 2004 Aug;46(2):170-6. doi: 10.1016/j.eururo.2004.03.017. PMID: 15245809

Clinical prediction guides

Heterogenous NECTIN4 expression in urothelial high-risk non-muscle-invasive bladder cancer.
Garczyk S, Degener S, Bischoff F, Schnitzler T, Salz A, Golz R, Buchner A, Schulz GB, Schneider U, Gaisa NT, Knüchel R
Virchows Arch 2022 Jul;481(1):83-92. Epub 2022 Apr 28 doi: 10.1007/s00428-022-03328-1. PMID: 35484425Free PMC Article
Validation of grading of non-invasive urothelial carcinoma by digital pathology for routine diagnosis.
Colling R, Colling H, Browning L, Verrill C
BMC Cancer 2021 Sep 6;21(1):995. doi: 10.1186/s12885-021-08698-4. PMID: 34488682Free PMC Article
The association between the histopathological features and microsatellite instability in young patients with urothelial carcinoma of the bladder.
Ekmekci S, Küçük Ü, Kaya Ö, Yörükoğlu K
Rev Assoc Med Bras (1992) 2021 Jan;67(1):64-70. doi: 10.1590/1806-9282.67.01.20200297. PMID: 34161481
Reduced immunohistochemical PTEN staining is associated with higher progression rate and recurrence episodes in non-invasive low-grade papillary urothelial carcinoma of the bladder.
Kulac I, Arslankoz S, Netto GJ, Ertoy Baydar D
Virchows Arch 2018 Jun;472(6):969-974. Epub 2018 Jan 24 doi: 10.1007/s00428-018-2302-8. PMID: 29368083
Non-invasive papillary urothelial neoplasms: the 2004 WHO/ISUP classification system.
Miyamoto H, Miller JS, Fajardo DA, Lee TK, Netto GJ, Epstein JI
Pathol Int 2010 Jan;60(1):1-8. doi: 10.1111/j.1440-1827.2009.02477.x. PMID: 20055945

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