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Tumor Expansion

MedGen UID:: 275514
•Concept ID:: C1519678
•: Neoplastic Process

Definition

Growth of a tumor involving either an increase in size of a continuous tumor tissue mass or translocation of tumor cells to secondary sites. (NCI) [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVTumor Expansion

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease Attributes
    - Course of illness
      - Tumor Progression
        Tumor Expansion
        Tumor Cell Invasion
        Tumor Cell Mobility

Professional guidelines

PubMed

Primary Aldosteronism: Spatial Multiomics Mapping of Genotype-Dependent Heterogeneity and Tumor Expansion of Aldosterone-Producing Adenomas.

Gong S, Sun N, Meyer LS, Tetti M, Koupourtidou C, Krebs S, Masserdotti G, Blum H, Rainey WE, Reincke M, Walch A, Williams TA
Hypertension 2023 Jul;80(7):1555-1567. Epub 2023 May 1 doi: 10.1161/HYPERTENSIONAHA.123.20921. PMID: 37125608 Free PMC Article

Differential Diagnosis in Hypophysitis: First Report on a Spindle Cell Rhabdomyosarcoma of the Pituitary Gland.

Ahmeti H, Jüttner E, Röcken C, Jansen O, Laudes M, Synowitz M
J Neurol Surg A Cent Eur Neurosurg 2023 May;84(3):295-299. Epub 2021 Nov 15 doi: 10.1055/s-0041-1735857. PMID: 34781400

The Cancer Stem Cell Fraction in Hierarchically Organized Tumors Can Be Estimated Using Mathematical Modeling and Patient-Specific Treatment Trajectories.

Werner B, Scott JG, Sottoriva A, Anderson AR, Traulsen A, Altrock PM
Cancer Res 2016 Apr 1;76(7):1705-13. Epub 2016 Feb 1 doi: 10.1158/0008-5472.CAN-15-2069. PMID: 26833122 Free PMC Article

See all (12)

Recent clinical studies

Etiology

Vascular disrupting agents in cancer therapy.

Smolarczyk R, Czapla J, Jarosz-Biej M, Czerwinski K, Cichoń T
Eur J Pharmacol 2021 Jan 15;891:173692. Epub 2020 Oct 29 doi: 10.1016/j.ejphar.2020.173692. PMID: 33130277

Stereotactic Radiosurgery for Trigeminal Schwannomas: A 28-Year Single-Center Experience and Review of the Literature.

Snyder MH, Shepard MJ, Chen CJ, Sheehan JP
World Neurosurg 2018 Nov;119:e874-e881. Epub 2018 Aug 9 doi: 10.1016/j.wneu.2018.07.289. PMID: 30099184

Thyroid Disorders and Hemostasis.

Elbers LPB, Squizzato A, Gerdes VEA
Semin Thromb Hemost 2018 Oct;44(7):676-682. Epub 2018 Jul 25 doi: 10.1055/s-0038-1666825. PMID: 30045389

Mechanisms of HBV-induced hepatocellular carcinoma.

Levrero M, Zucman-Rossi J
J Hepatol 2016 Apr;64(1 Suppl):S84-S101. doi: 10.1016/j.jhep.2016.02.021. PMID: 27084040

Molecular mechanisms of HBV-associated hepatocarcinogenesis.

Guerrieri F, Belloni L, Pediconi N, Levrero M
Semin Liver Dis 2013 May;33(2):147-56. Epub 2013 Jun 8 doi: 10.1055/s-0033-1345721. PMID: 23749671

See all (82)

Diagnosis

Molecular Imaging of Pituitary Tumors.

Gillett D, MacFarlane J, Bashari W, Crawford R, Harper I, Mendichovszky IA, Aloj L, Cheow H, Gurnell M
Semin Nucl Med 2023 Jul;53(4):530-538. Epub 2023 Mar 23 doi: 10.1053/j.semnuclmed.2023.02.005. PMID: 36966020

Iron Induces Cell Death and Strengthens the Efficacy of Antiandrogen Therapy in Prostate Cancer Models.

Bordini J, Morisi F, Elia AR, Santambrogio P, Pagani A, Cucchiara V, Ghia P, Bellone M, Briganti A, Camaschella C, Campanella A
Clin Cancer Res 2020 Dec 1;26(23):6387-6398. Epub 2020 Sep 14 doi: 10.1158/1078-0432.CCR-20-3182. PMID: 32928793

Probing the mechanisms of extracellular vesicle biogenesis and function in cancer.

Latifkar A, Cerione RA, Antonyak MA
Biochem Soc Trans 2018 Oct 19;46(5):1137-1146. Epub 2018 Oct 8 doi: 10.1042/BST20180523. PMID: 30301841 Free PMC Article

Hepatitis B virus-induced oncogenesis.

Lupberger J, Hildt E
World J Gastroenterol 2007 Jan 7;13(1):74-81. doi: 10.3748/wjg.v13.i1.74. PMID: 17206756 Free PMC Article

Nitric oxide and angiogenesis.

Ziche M, Morbidelli L
J Neurooncol 2000 Oct-Nov;50(1-2):139-48. doi: 10.1023/a:1006431309841. PMID: 11245273

See all (62)

Therapy

Isatuximab monotherapy in patients with refractory T-acute lymphoblastic leukemia or T-lymphoblastic lymphoma: Phase 2 study.

Boissel N, Chevallier P, Doronin V, Griskevicius L, Maschan A, McCloskey J, Rambaldi A, Rossi G, Sokolov A, Wartiovaara-Kautto U, Oprea C, Abbadessa G, Gosselin A, Macé S, Thomas X
Cancer Med 2022 Mar;11(5):1292-1298. Epub 2022 Feb 2 doi: 10.1002/cam4.4478. PMID: 35106962 Free PMC Article

Vascular disrupting agents in cancer therapy.

Smolarczyk R, Czapla J, Jarosz-Biej M, Czerwinski K, Cichoń T
Eur J Pharmacol 2021 Jan 15;891:173692. Epub 2020 Oct 29 doi: 10.1016/j.ejphar.2020.173692. PMID: 33130277

Role of the tumor microenvironment in regulating apoptosis and cancer progression.

Yaacoub K, Pedeux R, Tarte K, Guillaudeux T
Cancer Lett 2016 Aug 10;378(2):150-9. Epub 2016 May 17 doi: 10.1016/j.canlet.2016.05.012. PMID: 27224890

Anti-tumor activities of lipids and lipid analogues and their development as potential anticancer drugs.

Murray M, Hraiki A, Bebawy M, Pazderka C, Rawling T
Pharmacol Ther 2015 Jun;150:109-28. Epub 2015 Jan 17 doi: 10.1016/j.pharmthera.2015.01.008. PMID: 25603423

Prolactinomas and pregnancy.

Bronstein MD
Pituitary 2005;8(1):31-8. doi: 10.1007/s11102-005-5083-4. PMID: 16411066

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Prognosis

Gastric Cancer Vascularization and the Contribution of Reactive Oxygen Species.

Biagioni A, Peri S, Versienti G, Fiorillo C, Becatti M, Magnelli L, Papucci L
Biomolecules 2023 May 25;13(6) doi: 10.3390/biom13060886. PMID: 37371466 Free PMC Article

mTOR inhibition attenuates chemosensitivity through the induction of chemotherapy resistant persisters.

Liu Y, Azizian NG, Sullivan DK, Li Y
Nat Commun 2022 Nov 17;13(1):7047. doi: 10.1038/s41467-022-34890-6. PMID: 36396656 Free PMC Article

Antitumor strategies targeting macrophages: the importance of considering the differences in differentiation/polarization processes between human and mouse macrophages.

Monnier M, Paolini L, Vinatier E, Mantovani A, Delneste Y, Jeannin P
J Immunother Cancer 2022 Oct;10(10) doi: 10.1136/jitc-2022-005560. PMID: 36270732 Free PMC Article

Isatuximab monotherapy in patients with refractory T-acute lymphoblastic leukemia or T-lymphoblastic lymphoma: Phase 2 study.

Necrotic reshaping of the glioma microenvironment drives disease progression.

Markwell SM, Ross JL, Olson CL, Brat DJ
Acta Neuropathol 2022 Mar;143(3):291-310. Epub 2022 Jan 17 doi: 10.1007/s00401-021-02401-4. PMID: 35039931

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Clinical prediction guides

mTOR inhibition attenuates chemosensitivity through the induction of chemotherapy resistant persisters.

Liu Y, Azizian NG, Sullivan DK, Li Y
Nat Commun 2022 Nov 17;13(1):7047. doi: 10.1038/s41467-022-34890-6. PMID: 36396656 Free PMC Article

A human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade.

Geuijen C, Tacken P, Wang LC, Klooster R, van Loo PF, Zhou J, Mondal A, Liu YB, Kramer A, Condamine T, Volgina A, Hendriks LJA, van der Maaden H, Rovers E, Engels S, Fransen F, den Blanken-Smit R, Zondag-van der Zande V, Basmeleh A, Bartelink W, Kulkarni A, Marissen W, Huang CY, Hall L, Harvey S, Kim S, Martinez M, O'Brien S, Moon E, Albelda S, Kanellopoulou C, Stewart S, Nastri H, Bakker ABH, Scherle P, Logtenberg T, Hollis G, de Kruif J, Huber R, Mayes PA, Throsby M
Nat Commun 2021 Jul 21;12(1):4445. doi: 10.1038/s41467-021-24767-5. PMID: 34290245 Free PMC Article

Tumor necrosis: A synergistic consequence of metabolic stress and inflammation.

Yee PP, Li W
Bioessays 2021 Jul;43(7):e2100029. Epub 2021 May 16 doi: 10.1002/bies.202100029. PMID: 33998010 Free PMC Article

Molecular epigenetics and genetics in neuro-oncology.

Nagarajan RP, Costello JF
Neurotherapeutics 2009 Jul;6(3):436-46. doi: 10.1016/j.nurt.2009.04.002. PMID: 19560734 Free PMC Article

Nitric oxide and angiogenesis.

Ziche M, Morbidelli L
J Neurooncol 2000 Oct-Nov;50(1-2):139-48. doi: 10.1023/a:1006431309841. PMID: 11245273

See all (85)