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Tumor Progression

MedGen UID:
61255
•Concept ID:
C0178874
•
Neoplastic Process
Synonym: Tumor progression
SNOMED CT: Tumor progression (419835002)

Definition

A pathologic process in which alterations at the molecular level result in a more aggressive cytologic and phenotypic profile and clinical course of a neoplasm. [from NCI]

Professional guidelines

PubMed

RANO 2.0: Update to the Response Assessment in Neuro-Oncology Criteria for High- and Low-Grade Gliomas in Adults.
Wen PY, van den Bent M, Youssef G, Cloughesy TF, Ellingson BM, Weller M, Galanis E, Barboriak DP, de Groot J, Gilbert MR, Huang R, Lassman AB, Mehta M, Molinaro AM, Preusser M, Rahman R, Shankar LK, Stupp R, Villanueva-Meyer JE, Wick W, Macdonald DR, Reardon DA, Vogelbaum MA, Chang SM
J Clin Oncol 2023 Nov 20;41(33):5187-5199. Epub 2023 Sep 29 doi: 10.1200/JCO.23.01059. PMID: 37774317Free PMC Article
Epidemiology and Management of Hepatocellular Carcinoma.
Kulik L, El-Serag HB
Gastroenterology 2019 Jan;156(2):477-491.e1. Epub 2018 Oct 24 doi: 10.1053/j.gastro.2018.08.065. PMID: 30367835Free PMC Article
Glutathione metabolism in cancer progression and treatment resistance.
Bansal A, Simon MC
J Cell Biol 2018 Jul 2;217(7):2291-2298. Epub 2018 Jun 18 doi: 10.1083/jcb.201804161. PMID: 29915025Free PMC Article

Recent clinical studies

Etiology

Breast Cancer.
Visvader JE, Rosen JM, Aparicio S
Cold Spring Harb Perspect Med 2024 Aug 1;14(8) doi: 10.1101/cshperspect.a041729. PMID: 38692741Free PMC Article
Crossroads: the role of biomarkers in the management of lumps in the breast.
Weber GF
Oncotarget 2023 Apr 24;14:358-362. doi: 10.18632/oncotarget.28402. PMID: 37096988
The Role of Androgen Receptor Signaling in Ovarian Cancer.
Mizushima T, Miyamoto H
Cells 2019 Feb 19;8(2) doi: 10.3390/cells8020176. PMID: 30791431Free PMC Article
Role of the androgen receptor in urothelial cancer.
Inoue S, Mizushima T, Miyamoto H
Mol Cell Endocrinol 2018 Apr 15;465:73-81. Epub 2017 Jun 23 doi: 10.1016/j.mce.2017.06.021. PMID: 28652170
X chromosome abnormal inactivation: a unique factor for women's diseases?
Wu C, Sun Z
Epigenomics 2016 Apr;8(4):447-50. Epub 2016 Apr 1 doi: 10.2217/epi.16.2. PMID: 27032507

Diagnosis

Cancer and the Metaorganism.
Zitvogel L, Kroemer G
Cancer Discov 2024 Apr 4;14(4):658-662. doi: 10.1158/2159-8290.CD-23-1484. PMID: 38571436
Soluble B7-H3 in Colorectal Cancer.
Kovaleva OV, Gratchev AN, Sokolov NY, Maslennikov VV, Kuzmin YB, Gershtein ES, Alferov AA, Mamedli ZZ, Stilidi IS, Kushlinskii NE
Bull Exp Biol Med 2023 Nov;176(1):87-90. Epub 2023 Dec 12 doi: 10.1007/s10517-023-05972-2. PMID: 38085395
Exosome-Associated circRNAs as Key Regulators of EMT in Cancer.
Amicone L, Marchetti A, Cicchini C
Cells 2022 May 23;11(10) doi: 10.3390/cells11101716. PMID: 35626752Free PMC Article
Extracellular vesicles in immunomodulation and tumor progression.
Marar C, Starich B, Wirtz D
Nat Immunol 2021 May;22(5):560-570. Epub 2021 Mar 22 doi: 10.1038/s41590-021-00899-0. PMID: 33753940Free PMC Article
Low-grade gliomas: the challenges of imaging.
Guillevin R, Herpe G, Verdier M, Guillevin C
Diagn Interv Imaging 2014 Oct;95(10):957-63. Epub 2014 Sep 5 doi: 10.1016/j.diii.2014.07.005. PMID: 25195186

Therapy

Glycosylation in the Era of Cancer-Targeted Therapy: Where Are We Heading?
Mereiter S, Balmaña M, Campos D, Gomes J, Reis CA
Cancer Cell 2019 Jul 8;36(1):6-16. doi: 10.1016/j.ccell.2019.06.006. PMID: 31287993
Current State of Immunotherapy for Treatment of Glioblastoma.
McGranahan T, Therkelsen KE, Ahmad S, Nagpal S
Curr Treat Options Oncol 2019 Feb 21;20(3):24. doi: 10.1007/s11864-019-0619-4. PMID: 30790064Free PMC Article
Effect of Fruquintinib vs Placebo on Overall Survival in Patients With Previously Treated Metastatic Colorectal Cancer: The FRESCO Randomized Clinical Trial.
Li J, Qin S, Xu RH, Shen L, Xu J, Bai Y, Yang L, Deng Y, Chen ZD, Zhong H, Pan H, Guo W, Shu Y, Yuan Y, Zhou J, Xu N, Liu T, Ma D, Wu C, Cheng Y, Chen D, Li W, Sun S, Yu Z, Cao P, Chen H, Wang J, Wang S, Wang H, Fan S, Hua Y, Su W
JAMA 2018 Jun 26;319(24):2486-2496. doi: 10.1001/jama.2018.7855. PMID: 29946728Free PMC Article
Coenzyme Q10 in breast cancer care.
Tafazoli A
Future Oncol 2017 May;13(11):1035-1041. doi: 10.2217/fon-2016-0547. PMID: 28481148
Anticoagulants and cancer survival.
Piccioli A, Falanga A, Prandoni P
Semin Thromb Hemost 2006 Nov;32(8):810-3. doi: 10.1055/s-2006-957326. PMID: 17171594

Prognosis

Intratumor heterogeneity inferred from targeted deep sequencing as a prognostic indicator.
Oh BY, Shin HT, Yun JW, Kim KT, Kim J, Bae JS, Cho YB, Lee WY, Yun SH, Park YA, Park YH, Im YH, Lee J, Joung JG, Kim HC, Park WY
Sci Rep 2019 Mar 14;9(1):4542. doi: 10.1038/s41598-019-41098-0. PMID: 30872730Free PMC Article
Obesity and cancer: at the crossroads of cellular metabolism and proliferation.
O'Rourke RW
Surg Obes Relat Dis 2014 Nov-Dec;10(6):1208-19. Epub 2014 Aug 27 doi: 10.1016/j.soard.2014.08.012. PMID: 25264328Free PMC Article
Prognostic factors for resectable pancreatic adenocarcinoma.
Neuzillet C, Sauvanet A, Hammel P
J Visc Surg 2011 Sep;148(4):e232-43. Epub 2011 Sep 15 doi: 10.1016/j.jviscsurg.2011.07.007. PMID: 21924695
Elective regional nodal irradiation in patients with early-stage breast cancer.
Xie L, Higginson DS, Marks LB
Semin Radiat Oncol 2011 Jan;21(1):66-78. doi: 10.1016/j.semradonc.2010.08.006. PMID: 21134656
Other skull-base tumors.
Inoue HK
Prog Neurol Surg 2009;22:112-121. doi: 10.1159/000163386. PMID: 18948723

Clinical prediction guides

Achievement in active agent structures as a power tools in tumor angiogenesis imaging.
Staszak K, Wieszczycka K, Bajek A, Staszak M, Tylkowski B, Roszkowski K
Biochim Biophys Acta Rev Cancer 2021 Aug;1876(1):188560. Epub 2021 May 10 doi: 10.1016/j.bbcan.2021.188560. PMID: 33965512
Extracellular vesicles as biomarkers and therapeutic targets for cancer.
Urabe F, Kosaka N, Ito K, Kimura T, Egawa S, Ochiya T
Am J Physiol Cell Physiol 2020 Jan 1;318(1):C29-C39. Epub 2019 Nov 6 doi: 10.1152/ajpcell.00280.2019. PMID: 31693397
Novel strategies for managing pancreatic cancer.
Loc WS, Smith JP, Matters G, Kester M, Adair JH
World J Gastroenterol 2014 Oct 28;20(40):14717-25. doi: 10.3748/wjg.v20.i40.14717. PMID: 25356034Free PMC Article
H2AX a promising biomarker for lung cancer: a review.
Matthaios D, Hountis P, Karakitsos P, Bouros D, Kakolyris S
Cancer Invest 2013 Nov;31(9):582-99. doi: 10.3109/07357907.2013.849721. PMID: 24164298
Pulmonary epithelioid hemangioendothelioma.
Mizuno Y, Iwata H, Shirahashi K, Hirose Y, Takemura H
Gen Thorac Cardiovasc Surg 2011 Apr;59(4):297-300. Epub 2011 Apr 12 doi: 10.1007/s11748-010-0651-6. PMID: 21484560

Recent systematic reviews

Targeting p53 pathways: mechanisms, structures, and advances in therapy.
Wang H, Guo M, Wei H, Chen Y
Signal Transduct Target Ther 2023 Mar 1;8(1):92. doi: 10.1038/s41392-023-01347-1. PMID: 36859359Free PMC Article
Implication of Irisin in Different Types of Cancer: A Systematic Review and Meta-Analysis.
Vliora M, Nintou E, Karligiotou E, Ioannou LG, Grillo E, Mitola S, Flouris AD
Int J Mol Sci 2022 Sep 1;23(17) doi: 10.3390/ijms23179971. PMID: 36077366Free PMC Article
Alternative splicing and cancer: a systematic review.
Zhang Y, Qian J, Gu C, Yang Y
Signal Transduct Target Ther 2021 Feb 24;6(1):78. doi: 10.1038/s41392-021-00486-7. PMID: 33623018Free PMC Article
MicroRNA-217: A regulator of human cancer.
Zhou S, Zhu C, Pang Q, Liu HC
Biomed Pharmacother 2021 Jan;133:110943. Epub 2020 Nov 27 doi: 10.1016/j.biopha.2020.110943. PMID: 33254014
mTOR inhibitors in breast cancer: a systematic review.
Zagouri F, Sergentanis TN, Chrysikos D, Filipits M, Bartsch R
Gynecol Oncol 2012 Dec;127(3):662-72. Epub 2012 Sep 9 doi: 10.1016/j.ygyno.2012.08.040. PMID: 22967800

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