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Atypical Melanocytic Nevus of Genital Type

MedGen UID:
275613
•Concept ID:
C1520072
•
Neoplastic Process
Synonyms: Atypical Melanocytic Nevus of the Genital Type; Atypical Melanocytic Nevus, Genital Type; Atypical Vulvar Nevus

Definition

A small, well circumscribed melanocytic neoplasm that arises from the vulva and affects women in their reproductive years. It is characterized by the presence of junctional nests of melanocytes. Some of the superficial melanocytes show atypia. During pregnancy the atypical melanocytic changes may appear more prominent. This neoplasm is not associated with the presence of dysplastic nevi in other anatomic areas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAtypical Melanocytic Nevus of Genital Type

Recent clinical studies

Etiology

A subgroup of melanocytic nevi on the distal lower extremity (ankle) shares features of acral nevi, dysplastic nevi, and melanoma in situ: a potential misdiagnosis of melanoma in situ.
Khalifeh I, Taraif S, Reed JA, Lazar AF, Diwan AH, Prieto VG
Am J Surg Pathol 2007 Jul;31(7):1130-6. doi: 10.1097/PAS.0b013e31802e63a2. PMID: 17592281
Atypical melanocytic nevi of the genital type with a discussion of reciprocal parenchymal-stromal interactions in the biology of neoplasia.
Clark WH Jr, Hood AF, Tucker MA, Jampel RM
Hum Pathol 1998 Jan;29(1 Suppl 1):S1-24. doi: 10.1016/s0046-8177(98)80028-2. PMID: 9445124

Diagnosis

Dermoscopic and clinical features of pigmented skin lesions of the genital area.
Cengiz FP, Emiroglu N, Wellenhof RH
An Bras Dermatol 2015 Mar-Apr;90(2):178-83. doi: 10.1590/abd1806-4841.20153294. PMID: 25830986Free PMC Article
Melanocytic lesions of the genital area with attention given to atypical genital nevi.
Ribé A
J Cutan Pathol 2008 Nov;35 Suppl 2:24-7. doi: 10.1111/j.1600-0560.2008.01150.x. PMID: 18976416
My approach to atypical melanocytic lesions.
Culpepper KS, Granter SR, McKee PH
J Clin Pathol 2004 Nov;57(11):1121-31. doi: 10.1136/jcp.2003.008516. PMID: 15509670Free PMC Article
Atypical melanocytic nevi of the genital type with a discussion of reciprocal parenchymal-stromal interactions in the biology of neoplasia.
Clark WH Jr, Hood AF, Tucker MA, Jampel RM
Hum Pathol 1998 Jan;29(1 Suppl 1):S1-24. doi: 10.1016/s0046-8177(98)80028-2. PMID: 9445124
Clinical and pathological correlation of malignant melanoma.
Lopansri S, Mihm MC Jr
J Cutan Pathol 1979 Jun;6(3):180-94. doi: 10.1111/j.1600-0560.1979.tb01122.x. PMID: 479437

Prognosis

Melanocytic lesions of the genital area with attention given to atypical genital nevi.
Ribé A
J Cutan Pathol 2008 Nov;35 Suppl 2:24-7. doi: 10.1111/j.1600-0560.2008.01150.x. PMID: 18976416
Clinical and pathological correlation of malignant melanoma.
Lopansri S, Mihm MC Jr
J Cutan Pathol 1979 Jun;6(3):180-94. doi: 10.1111/j.1600-0560.1979.tb01122.x. PMID: 479437

Clinical prediction guides

Dermoscopic and clinical features of pigmented skin lesions of the genital area.
Cengiz FP, Emiroglu N, Wellenhof RH
An Bras Dermatol 2015 Mar-Apr;90(2):178-83. doi: 10.1590/abd1806-4841.20153294. PMID: 25830986Free PMC Article
Melanocytic lesions of the genital area with attention given to atypical genital nevi.
Ribé A
J Cutan Pathol 2008 Nov;35 Suppl 2:24-7. doi: 10.1111/j.1600-0560.2008.01150.x. PMID: 18976416

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