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Vulvar Melanocytic Nevus

MedGen UID:
925536
•Concept ID:
C4288004
•
Neoplastic Process

Definition

A benign, atypical, or dysplastic melanocytic nevus that arises from the vulva. [from NCI]

Professional guidelines

PubMed

Diagnosis and treatment of premalignant lesions of the vulva: a review.
Underwood PB Jr, Hester LL Jr
Am J Obstet Gynecol 1971 Jul 15;110(6):849-57. doi: 10.1016/0002-9378(71)90582-5. PMID: 4327296

Recent clinical studies

Etiology

PRAME Immunohistochemistry for Distinguishing Vulvar and Vaginal Melanoma From Benign Melanocytic Nevi.
Martin SD, Martin KC, Gilks CB, Crawford RI, Hoang LN
Int J Gynecol Pathol 2024 Jul 1;43(4):389-396. Epub 2023 Dec 6 doi: 10.1097/PGP.0000000000001004. PMID: 38085951
Melanocytic lesions - Staying out of trouble.
Brenn T
Ann Diagn Pathol 2018 Dec;37:91-102. Epub 2018 Sep 27 doi: 10.1016/j.anndiagpath.2018.09.010. PMID: 30312883
Pigmented lesions of the vulva.
Venkatesan A
Dermatol Clin 2010 Oct;28(4):795-805. doi: 10.1016/j.det.2010.08.007. PMID: 20883921
Pigmented lesions of the vulva.
Rock B
Dermatol Clin 1992 Apr;10(2):361-70. PMID: 1606765
Prospective study of vulvar nevi.
Rock B, Hood AF, Rock JA
J Am Acad Dermatol 1990 Jan;22(1):104-6. doi: 10.1016/0190-9622(90)70017-c. PMID: 2298946

Diagnosis

Melanocytic lesions - Staying out of trouble.
Brenn T
Ann Diagn Pathol 2018 Dec;37:91-102. Epub 2018 Sep 27 doi: 10.1016/j.anndiagpath.2018.09.010. PMID: 30312883
Vulvar Neoplasms, Benign and Malignant.
Allbritton JI
Obstet Gynecol Clin North Am 2017 Sep;44(3):339-352. doi: 10.1016/j.ogc.2017.04.002. PMID: 28778635
Vulvar nevi, melanosis, and melanoma: an epidemiologic, clinical, and histopathologic review.
Murzaku EC, Penn LA, Hale CS, Pomeranz MK, Polsky D
J Am Acad Dermatol 2014 Dec;71(6):1241-9. Epub 2014 Sep 27 doi: 10.1016/j.jaad.2014.08.019. PMID: 25267379
Atypical genital nevus.
Brenn T
Arch Pathol Lab Med 2011 Mar;135(3):317-20. doi: 10.5858/2009-0382-RA.1. PMID: 21366454
Vulvar melanoma.
Panizzon RG
Semin Dermatol 1996 Mar;15(1):67-70. doi: 10.1016/s1085-5629(96)80021-6. PMID: 8723827

Therapy

Vulvar vitiligo-like depigmentation and multiple halos of hypomelanosis at the trunk following treatment with imiquimod 5% cream for vulvar condylomata: casual or related events?
Serra MC, Menicanti C, Pennacchioli E, Tosti G
An Bras Dermatol 2014 Sep-Oct;89(5):806-7. doi: 10.1590/abd1806-4841.20143058. PMID: 25184923Free PMC Article
Melanocytic proliferations associated with lichen sclerosus in adolescence.
Bussen SS
Arch Gynecol Obstet 2009 Dec;280(6):1039-40. Epub 2009 Mar 28 doi: 10.1007/s00404-009-1049-5. PMID: 19330343
Life-threatening blood loss from scratching provoked by pruritus in the bulky perineal nevocytoma variant of giant congenital melanocytic nevus in a child.
Feng J, Sethi A, Reyes-Múgica M, Antaya R
J Am Acad Dermatol 2005 Aug;53(2 Suppl 1):S139-42. doi: 10.1016/j.jaad.2004.12.040. PMID: 16021164
The Reynold L. Haas Memorial Lecture: gynecologic curiosities and concepts.
Abell MR
Univ Mich Med Cent J 1969 Jan-Mar;35(1):1-9. PMID: 4305355

Prognosis

Vulvar nevi, melanosis, and melanoma: an epidemiologic, clinical, and histopathologic review.
Murzaku EC, Penn LA, Hale CS, Pomeranz MK, Polsky D
J Am Acad Dermatol 2014 Dec;71(6):1241-9. Epub 2014 Sep 27 doi: 10.1016/j.jaad.2014.08.019. PMID: 25267379
Melanocytic lesions of the genital area with attention given to atypical genital nevi.
Ribé A
J Cutan Pathol 2008 Nov;35 Suppl 2:24-7. doi: 10.1111/j.1600-0560.2008.01150.x. PMID: 18976416
Atypical genital nevi. A clinicopathologic analysis of 56 cases.
Gleason BC, Hirsch MS, Nucci MR, Schmidt BA, Zembowicz A, Mihm MC Jr, McKee PH, Brenn T
Am J Surg Pathol 2008 Jan;32(1):51-7. doi: 10.1097/PAS.0b013e318068420c. PMID: 18162770
Vulvar melanoma.
Panizzon RG
Semin Dermatol 1996 Mar;15(1):67-70. doi: 10.1016/s1085-5629(96)80021-6. PMID: 8723827
Pigmented lesions of the vulva.
Rock B
Dermatol Clin 1992 Apr;10(2):361-70. PMID: 1606765

Clinical prediction guides

Dermoscopic and clinical features of pigmented skin lesions of the genital area.
Cengiz FP, Emiroglu N, Wellenhof RH
An Bras Dermatol 2015 Mar-Apr;90(2):178-83. doi: 10.1590/abd1806-4841.20153294. PMID: 25830986Free PMC Article
Dermatopathology updates on melanocytic lesions.
Cheung WL, Smoller BR
Dermatol Clin 2012 Oct;30(4):617-22, vi. Epub 2012 Aug 3 doi: 10.1016/j.det.2012.06.014. PMID: 23021049
Dermoscopy of pigmented lesions of the vulva: a retrospective morphological study.
Ferrari A, Zalaudek I, Argenziano G, Buccini P, De Simone P, Silipo V, Eibenschutz L, Mariani G, Covello R, Sperduti I, Mariani L, Catricalà C
Dermatology 2011;222(2):157-66. Epub 2011 Feb 9 doi: 10.1159/000323409. PMID: 21311169
Vulvar melanocytic nevi: a dermoscopic investigation.
Virgili A, Zampino MR, Marzola A, Corazza M
Dermatology 2010 Aug;221(1):55-62. Epub 2010 May 13 doi: 10.1159/000278259. PMID: 20484874
Melanocytic lesions of the genital area with attention given to atypical genital nevi.
Ribé A
J Cutan Pathol 2008 Nov;35 Suppl 2:24-7. doi: 10.1111/j.1600-0560.2008.01150.x. PMID: 18976416

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