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Signet ring cell intrahepatic cholangiocarcinoma

MedGen UID:
276815
•Concept ID:
C1519321
•
Neoplastic Process
Synonyms: Signet Ring Cell Intrahepatic Cholangiocarcinoma; signet ring cell intrahepatic cholangiocarcinoma; signet Ring cell intrahepatic cholangiocarcinoma; Signet-Ring Cell Intrahepatic Cholangiocarcinoma
 
Monarch Initiative: MONDO:0004346

Definition

An intrahepatic cholangiocarcinoma characterized by the presence of signet ring adenocarcinoma cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSignet ring cell intrahepatic cholangiocarcinoma

Professional guidelines

PubMed

Hep par 1 antibody stain for the differential diagnosis of hepatocellular carcinoma: 676 tumors tested using tissue microarrays and conventional tissue sections.
Fan Z, van de Rijn M, Montgomery K, Rouse RV
Mod Pathol 2003 Feb;16(2):137-44. doi: 10.1097/01.MP.0000052103.13730.20. PMID: 12591966

Recent clinical studies

Etiology

Digestive tract neoplasms in young individuals: Demographics, staging and risk factors.
Tasneem AA, Luck NH
Cancer Rep (Hoboken) 2021 Apr;4(2):e1319. Epub 2020 Dec 9 doi: 10.1002/cnr2.1319. PMID: 33295088Free PMC Article
Occurrence of signet-ring cell carcinoma with cholangiocarcinoma 25 years after choledochal cyst excision: A case report.
Zhang C, Zhou J, Kou K, Liu S, We F, Wang G
Medicine (Baltimore) 2018 Feb;97(8):e9956. doi: 10.1097/MD.0000000000009956. PMID: 29465585Free PMC Article
Carcinoma of extrahepatic bile ducts and gallbladder metastatic to the ovary: a report of 16 cases.
Khunamornpong S, Lerwill MF, Siriaunkgul S, Suprasert P, Pojchamarnwiputh S, Chiangmai WN, Young RH
Int J Gynecol Pathol 2008 Jul;27(3):366-79. doi: 10.1097/PGP.0b013e31815d6903. PMID: 18580314
From Krukenberg to today: the ever present problems posed by metastatic tumors in the ovary. Part II.
Young RH
Adv Anat Pathol 2007 May;14(3):149-77. doi: 10.1097/PAP.0b013e3180504abf. PMID: 17452813
Intrahepatic cholangiocarcinomas associated with nonbiliary cirrhosis. A clinicopathologic study.
Terada T, Kida T, Nakanuma Y, Kurumaya H, Doishita K, Takayanagi N
J Clin Gastroenterol 1994 Jun;18(4):335-42. doi: 10.1097/00004836-199406000-00016. PMID: 8071522

Diagnosis

Rare histotypes of epithelial biliary tract tumors: A literature review.
Sapuppo E, Brunetti O, Tessitore D, Brandi G, Di Giovanni N, Fadda G, Luchini C, Martini M, Quaresmini D, Russo A, Santarpia M, Scarpa A, Scartozzi M, Tuccari G, Franchina T, Silvestris N
Crit Rev Oncol Hematol 2023 Jan;181:103892. Epub 2022 Dec 5 doi: 10.1016/j.critrevonc.2022.103892. PMID: 36481306
Genomic analysis of an aggressive case with metastatic intrahepatic mucinous cholangiocarcinoma.
Masaki Y, Akutsu N, Adachi Y, Ishigami K, Iwata N, Endo T, Ishii Y, Sasaki Y, Nagayama M, Kimura Y, Nakase H
Clin J Gastroenterol 2022 Aug;15(4):809-817. Epub 2022 Jun 14 doi: 10.1007/s12328-022-01649-x. PMID: 35699889
Prediction of mismatch repair deficient biliary tract cancer: Role of morphological features and host immune response detected by routine hematoxylin-eosin staining.
Suda R, Sakai N, Matsushita K, Ishige T, Kawasaki Y, Shiko Y, Furukawa K, Mishima T, Nakadai E, Ohtsuka M
J Hepatobiliary Pancreat Sci 2021 Aug;28(8):680-691. Epub 2021 Jun 5 doi: 10.1002/jhbp.988. PMID: 33998775
Digestive tract neoplasms in young individuals: Demographics, staging and risk factors.
Tasneem AA, Luck NH
Cancer Rep (Hoboken) 2021 Apr;4(2):e1319. Epub 2020 Dec 9 doi: 10.1002/cnr2.1319. PMID: 33295088Free PMC Article
Occurrence of signet-ring cell carcinoma with cholangiocarcinoma 25 years after choledochal cyst excision: A case report.
Zhang C, Zhou J, Kou K, Liu S, We F, Wang G
Medicine (Baltimore) 2018 Feb;97(8):e9956. doi: 10.1097/MD.0000000000009956. PMID: 29465585Free PMC Article

Therapy

Feasibility study of postoperative adjuvant chemotherapy with S-1 in patients with biliary tract cancer.
Nakachi K, Konishi M, Ikeda M, Shimada K, Okusaka T, Saiura A, Ishii H, Sugiyama M, Furuse J, Sakamoto H, Shimamura T, Ohta T
Int J Clin Oncol 2018 Oct;23(5):894-899. Epub 2018 Apr 28 doi: 10.1007/s10147-018-1283-6. PMID: 29705976
Occurrence of signet-ring cell carcinoma with cholangiocarcinoma 25 years after choledochal cyst excision: A case report.
Zhang C, Zhou J, Kou K, Liu S, We F, Wang G
Medicine (Baltimore) 2018 Feb;97(8):e9956. doi: 10.1097/MD.0000000000009956. PMID: 29465585Free PMC Article

Prognosis

Prediction of mismatch repair deficient biliary tract cancer: Role of morphological features and host immune response detected by routine hematoxylin-eosin staining.
Suda R, Sakai N, Matsushita K, Ishige T, Kawasaki Y, Shiko Y, Furukawa K, Mishima T, Nakadai E, Ohtsuka M
J Hepatobiliary Pancreat Sci 2021 Aug;28(8):680-691. Epub 2021 Jun 5 doi: 10.1002/jhbp.988. PMID: 33998775
Feasibility study of postoperative adjuvant chemotherapy with S-1 in patients with biliary tract cancer.
Nakachi K, Konishi M, Ikeda M, Shimada K, Okusaka T, Saiura A, Ishii H, Sugiyama M, Furuse J, Sakamoto H, Shimamura T, Ohta T
Int J Clin Oncol 2018 Oct;23(5):894-899. Epub 2018 Apr 28 doi: 10.1007/s10147-018-1283-6. PMID: 29705976
Rapidly Progressing Primary Extrahepatic Bile Duct Signet-Ring Cell Carcinoma in a Caucasian Woman.
Welsh JL, Jaber O, Ivanovic M, Johlin FC, El Abiad RG, Clamon GH, Smith MC, Chan CHF
J Gastrointest Cancer 2018 Mar;49(1):63-66. doi: 10.1007/s12029-016-9843-3. PMID: 27270710
Immunohistochemical staining in the diagnosis of pancreatobiliary and ampulla of Vater adenocarcinoma: application of CDX2, CK17, MUC1, and MUC2.
Chu PG, Schwarz RE, Lau SK, Yen Y, Weiss LM
Am J Surg Pathol 2005 Mar;29(3):359-67. doi: 10.1097/01.pas.0000149708.12335.6a. PMID: 15725805
Pathological and immunohistochemical findings in a case of mucinous cholangiocarcinoma.
Sasaki M, Nakanuma Y, Shimizu K, Izumi R
Pathol Int 1995 Oct;45(10):781-6. doi: 10.1111/j.1440-1827.1995.tb03397.x. PMID: 8563941

Clinical prediction guides

Prediction of mismatch repair deficient biliary tract cancer: Role of morphological features and host immune response detected by routine hematoxylin-eosin staining.
Suda R, Sakai N, Matsushita K, Ishige T, Kawasaki Y, Shiko Y, Furukawa K, Mishima T, Nakadai E, Ohtsuka M
J Hepatobiliary Pancreat Sci 2021 Aug;28(8):680-691. Epub 2021 Jun 5 doi: 10.1002/jhbp.988. PMID: 33998775
Feasibility study of postoperative adjuvant chemotherapy with S-1 in patients with biliary tract cancer.
Nakachi K, Konishi M, Ikeda M, Shimada K, Okusaka T, Saiura A, Ishii H, Sugiyama M, Furuse J, Sakamoto H, Shimamura T, Ohta T
Int J Clin Oncol 2018 Oct;23(5):894-899. Epub 2018 Apr 28 doi: 10.1007/s10147-018-1283-6. PMID: 29705976
Carcinoma of extrahepatic bile ducts and gallbladder metastatic to the ovary: a report of 16 cases.
Khunamornpong S, Lerwill MF, Siriaunkgul S, Suprasert P, Pojchamarnwiputh S, Chiangmai WN, Young RH
Int J Gynecol Pathol 2008 Jul;27(3):366-79. doi: 10.1097/PGP.0b013e31815d6903. PMID: 18580314
Immunohistochemical staining in the diagnosis of pancreatobiliary and ampulla of Vater adenocarcinoma: application of CDX2, CK17, MUC1, and MUC2.
Chu PG, Schwarz RE, Lau SK, Yen Y, Weiss LM
Am J Surg Pathol 2005 Mar;29(3):359-67. doi: 10.1097/01.pas.0000149708.12335.6a. PMID: 15725805
Hep par 1 antibody stain for the differential diagnosis of hepatocellular carcinoma: 676 tumors tested using tissue microarrays and conventional tissue sections.
Fan Z, van de Rijn M, Montgomery K, Rouse RV
Mod Pathol 2003 Feb;16(2):137-44. doi: 10.1097/01.MP.0000052103.13730.20. PMID: 12591966

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