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Skin Carcinogenesis

MedGen UID:
276822
•Concept ID:
C1519346
•
Neoplastic Process

Definition

The process by which normal skin cells are transformed into cancer cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSkin Carcinogenesis

Professional guidelines

PubMed

The Use of Retinoids for the Prevention and Treatment of Skin Cancers: An Updated Review.
Ramchatesingh B, Martínez Villarreal A, Arcuri D, Lagacé F, Setah SA, Touma F, Al-Badarin F, Litvinov IV
Int J Mol Sci 2022 Oct 20;23(20) doi: 10.3390/ijms232012622. PMID: 36293471Free PMC Article
How to prevent skin damage from air pollution part 2: Current treatment options.
Damevska K, Simeonovski V, Darlenski R, Damevska S
Dermatol Ther 2021 Nov;34(6):e15132. Epub 2021 Sep 23 doi: 10.1111/dth.15132. PMID: 34528361
The relevance of piroxicam for the prevention and treatment of nonmelanoma skin cancer and its precursors.
Campione E, Paternò EJ, Candi E, Falconi M, Costanza G, Diluvio L, Terrinoni A, Bianchi L, Orlandi A
Drug Des Devel Ther 2015;9:5843-50. Epub 2015 Oct 29 doi: 10.2147/DDDT.S84849. PMID: 26604686Free PMC Article

Recent clinical studies

Etiology

The Use of Retinoids for the Prevention and Treatment of Skin Cancers: An Updated Review.
Ramchatesingh B, Martínez Villarreal A, Arcuri D, Lagacé F, Setah SA, Touma F, Al-Badarin F, Litvinov IV
Int J Mol Sci 2022 Oct 20;23(20) doi: 10.3390/ijms232012622. PMID: 36293471Free PMC Article
Human Papillomaviruses and Skin Cancer.
Smola S
Adv Exp Med Biol 2020;1268:195-209. doi: 10.1007/978-3-030-46227-7_10. PMID: 32918220
Beta human papillomaviruses infection and skin carcinogenesis.
Bandolin L, Borsetto D, Fussey J, Da Mosto MC, Nicolai P, Menegaldo A, Calabrese L, Tommasino M, Boscolo-Rizzo P
Rev Med Virol 2020 Jul;30(4):e2104. Epub 2020 Mar 30 doi: 10.1002/rmv.2104. PMID: 32232924
Randomized trial of calcipotriol combined with 5-fluorouracil for skin cancer precursor immunotherapy.
Cunningham TJ, Tabacchi M, Eliane JP, Tuchayi SM, Manivasagam S, Mirzaalian H, Turkoz A, Kopan R, Schaffer A, Saavedra AP, Wallendorf M, Cornelius LA, Demehri S
J Clin Invest 2017 Jan 3;127(1):106-116. Epub 2016 Nov 21 doi: 10.1172/JCI89820. PMID: 27869649Free PMC Article
HPV-associated skin disease.
Akgül B, Cooke JC, Storey A
J Pathol 2006 Jan;208(2):165-75. doi: 10.1002/path.1893. PMID: 16362995

Diagnosis

Neoplastic Multifocal Skin Lesions: Biology, Etiology, and Targeted Therapies for Nonmelanoma Skin Cancers.
Fernandes AR, Santos AC, Sanchez-Lopez E, Kovačević AB, Espina M, Calpena AC, Veiga FJ, Garcia ML, Souto EB
Skin Pharmacol Physiol 2018;31(2):59-73. Epub 2017 Dec 21 doi: 10.1159/000479529. PMID: 29262420
Immunopathogenesis of HPV-Associated Cancers and Prospects for Immunotherapy.
Smola S
Viruses 2017 Sep 12;9(9) doi: 10.3390/v9090254. PMID: 28895886Free PMC Article
Research Techniques Made Simple: Skin Carcinogenesis Models: Xenotransplantation Techniques.
Mollo MR, Antonini D, Cirillo L, Missero C
J Invest Dermatol 2016 Feb;136(2):e13-e17. doi: 10.1016/j.jid.2015.12.015. PMID: 26802242
Vitamin D and skin cancer.
Burns EM, Elmets CA, Yusuf N
Photochem Photobiol 2015 Jan-Feb;91(1):201-9. Epub 2014 Dec 8 doi: 10.1111/php.12382. PMID: 25378147Free PMC Article
IκB kinase alpha and cancer.
Liu S, Chen Z, Zhu F, Hu Y
J Interferon Cytokine Res 2012 Apr;32(4):152-8. Epub 2011 Dec 7 doi: 10.1089/jir.2011.0107. PMID: 22149351Free PMC Article

Therapy

The Use of Retinoids for the Prevention and Treatment of Skin Cancers: An Updated Review.
Ramchatesingh B, Martínez Villarreal A, Arcuri D, Lagacé F, Setah SA, Touma F, Al-Badarin F, Litvinov IV
Int J Mol Sci 2022 Oct 20;23(20) doi: 10.3390/ijms232012622. PMID: 36293471Free PMC Article
Human Papillomaviruses and Skin Cancer.
Smola S
Adv Exp Med Biol 2020;1268:195-209. doi: 10.1007/978-3-030-46227-7_10. PMID: 32918220
Beta human papillomaviruses infection and skin carcinogenesis.
Bandolin L, Borsetto D, Fussey J, Da Mosto MC, Nicolai P, Menegaldo A, Calabrese L, Tommasino M, Boscolo-Rizzo P
Rev Med Virol 2020 Jul;30(4):e2104. Epub 2020 Mar 30 doi: 10.1002/rmv.2104. PMID: 32232924
Randomized trial of calcipotriol combined with 5-fluorouracil for skin cancer precursor immunotherapy.
Cunningham TJ, Tabacchi M, Eliane JP, Tuchayi SM, Manivasagam S, Mirzaalian H, Turkoz A, Kopan R, Schaffer A, Saavedra AP, Wallendorf M, Cornelius LA, Demehri S
J Clin Invest 2017 Jan 3;127(1):106-116. Epub 2016 Nov 21 doi: 10.1172/JCI89820. PMID: 27869649Free PMC Article
HPV-associated skin disease.
Akgül B, Cooke JC, Storey A
J Pathol 2006 Jan;208(2):165-75. doi: 10.1002/path.1893. PMID: 16362995

Prognosis

Is diet related to skin condition? A Mendelian randomization study.
Wang Q, Qiu Z, Cheng L, Xu S, Li H, Guo J, Zhang X
Arch Dermatol Res 2024 Jun 1;316(6):328. doi: 10.1007/s00403-024-03103-z. PMID: 38824251
Syringic acid prevents skin carcinogenesis via regulation of NoX and EGFR signaling.
Ha SJ, Lee J, Park J, Kim YH, Lee NH, Kim YE, Song KM, Chang PS, Jeong CH, Jung SK
Biochem Pharmacol 2018 Aug;154:435-445. Epub 2018 Jun 7 doi: 10.1016/j.bcp.2018.06.007. PMID: 29886055
Skin Cancers as Contraindication to Organ Transplantation.
Imko-Walczuk B, Kiełbowicz M, Dębska-Ślizień A, Rutkowski B
Transplant Proc 2015 Jul-Aug;47(6):1547-52. doi: 10.1016/j.transproceed.2015.03.047. PMID: 26293011
Modeling cutaneous squamous carcinoma development in the mouse.
Huang PY, Balmain A
Cold Spring Harb Perspect Med 2014 Sep 2;4(9):a013623. doi: 10.1101/cshperspect.a013623. PMID: 25183851Free PMC Article
Modelling melanoma in mice.
Walker GJ, Soyer HP, Terzian T, Box NF
Pigment Cell Melanoma Res 2011 Dec;24(6):1158-76. Epub 2011 Nov 2 doi: 10.1111/j.1755-148X.2011.00923.x. PMID: 21985222

Clinical prediction guides

Is diet related to skin condition? A Mendelian randomization study.
Wang Q, Qiu Z, Cheng L, Xu S, Li H, Guo J, Zhang X
Arch Dermatol Res 2024 Jun 1;316(6):328. doi: 10.1007/s00403-024-03103-z. PMID: 38824251
C3 Drives Inflammatory Skin Carcinogenesis Independently of C5.
Jackson WD, Gulino A, Fossati-Jimack L, Castro Seoane R, Tian K, Best K, Köhl J, Belmonte B, Strid J, Botto M
J Invest Dermatol 2021 Feb;141(2):404-414.e6. Epub 2020 Jul 16 doi: 10.1016/j.jid.2020.06.025. PMID: 32682912Free PMC Article
Skin Cancers as Contraindication to Organ Transplantation.
Imko-Walczuk B, Kiełbowicz M, Dębska-Ślizień A, Rutkowski B
Transplant Proc 2015 Jul-Aug;47(6):1547-52. doi: 10.1016/j.transproceed.2015.03.047. PMID: 26293011
Wnt/β-Catenin Signaling Pathway in Skin Carcinogenesis and Therapy.
Li J, Ji L, Chen J, Zhang W, Ye Z
Biomed Res Int 2015;2015:964842. Epub 2015 May 19 doi: 10.1155/2015/964842. PMID: 26078973Free PMC Article
Modelling melanoma in mice.
Walker GJ, Soyer HP, Terzian T, Box NF
Pigment Cell Melanoma Res 2011 Dec;24(6):1158-76. Epub 2011 Nov 2 doi: 10.1111/j.1755-148X.2011.00923.x. PMID: 21985222

Recent systematic reviews

Sirtuin 1 and Skin: Implications in Intrinsic and Extrinsic Aging-A Systematic Review.
Bielach-Bazyluk A, Zbroch E, Mysliwiec H, Rydzewska-Rosolowska A, Kakareko K, Flisiak I, Hryszko T
Cells 2021 Apr 6;10(4) doi: 10.3390/cells10040813. PMID: 33917352Free PMC Article
Carcinogenic risks of psoralen UV-A therapy and narrowband UV-B therapy in chronic plaque psoriasis: a systematic literature review.
Archier E, Devaux S, Castela E, Gallini A, Aubin F, Le Maître M, Aractingi S, Bachelez H, Cribier B, Joly P, Jullien D, Misery L, Paul C, Ortonne JP, Richard MA
J Eur Acad Dermatol Venereol 2012 May;26 Suppl 3:22-31. doi: 10.1111/j.1468-3083.2012.04520.x. PMID: 22512677

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