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Salivary Gland Lymphoepithelial Carcinoma

MedGen UID:
277304
•Concept ID:
C1334461
•
Neoplastic Process
Synonym: Lymphoepithelial Salivary Gland Carcinoma

Definition

A rare carcinoma that arises from the salivary glands, most often the parotid gland. It is characterized by the presence of an undifferentiated carcinomatous component associated with a prominent reactive lymphoplasmacytic infiltrate. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSalivary Gland Lymphoepithelial Carcinoma

Professional guidelines

PubMed

The differential diagnosis of lymphoepithelial lesion of the salivary gland.
Urano M, Nakaguro M
Semin Diagn Pathol 2024 Jul;41(4):190-196. Epub 2024 May 1 doi: 10.1053/j.semdp.2024.04.004. PMID: 38734484
Could definitive radiotherapy be a treatment option for lymphoepithelial carcinoma of major salivary gland: Comparison of clinical outcomes of upfront surgery and upfront chemoradiotherapy.
Qiu Z, Wu Z, Zhou X, Lin F, Lyu S, Su Y, Tao Y
Oral Oncol 2023 Aug;143:106443. Epub 2023 Jun 7 doi: 10.1016/j.oraloncology.2023.106443. PMID: 37295063
Is postoperative radiotherapy an essential treatment for nonmetastatic lymphoepithelial carcinoma of the salivary gland?
Niu X, Liu P, Zhou X, Wang X, Hu C
Radiother Oncol 2022 Jul;172:76-82. Epub 2022 May 11 doi: 10.1016/j.radonc.2022.05.008. PMID: 35568285

Recent clinical studies

Etiology

Clinical analysis of 12 patients with primary lymphoepithelial carcinoma of the parotid gland.
Deng DF, Zhou Q, Ye ZM, Xu Z, Shen L
Eur Arch Otorhinolaryngol 2022 Apr;279(4):2003-2008. Epub 2021 Aug 11 doi: 10.1007/s00405-021-06947-7. PMID: 34379180
Lymphoepithelial carcinoma of salivary glands: CT and MR imaging findings.
Wang P, Yang J, Yu Q
Dentomaxillofac Radiol 2017 Dec;46(8):20170053. Epub 2017 Oct 3 doi: 10.1259/dmfr.20170053. PMID: 28707954Free PMC Article
Lymphoepithelial carcinoma of the salivary gland: morphologic patterns and imaging features on CT and MRI.
Ban X, Wu J, Mo Y, Yang Q, Liu X, Xie C, Zhang R
AJNR Am J Neuroradiol 2014 Sep;35(9):1813-9. Epub 2014 May 15 doi: 10.3174/ajnr.A3940. PMID: 24831594Free PMC Article
CT features and pathologic characteristics of lymphoepithelial carcinoma of salivary glands.
Zhang G, Tang J, Pan Y, Zhuang Q, Wu C
Int J Clin Exp Pathol 2014;7(3):1004-11. Epub 2014 Feb 15 PMID: 24696717Free PMC Article

Diagnosis

Clinical analysis of 12 patients with primary lymphoepithelial carcinoma of the parotid gland.
Deng DF, Zhou Q, Ye ZM, Xu Z, Shen L
Eur Arch Otorhinolaryngol 2022 Apr;279(4):2003-2008. Epub 2021 Aug 11 doi: 10.1007/s00405-021-06947-7. PMID: 34379180
Lymphoepithelial carcinoma of salivary glands: CT and MR imaging findings.
Wang P, Yang J, Yu Q
Dentomaxillofac Radiol 2017 Dec;46(8):20170053. Epub 2017 Oct 3 doi: 10.1259/dmfr.20170053. PMID: 28707954Free PMC Article
Lymphoepithelial carcinoma of the salivary gland: morphologic patterns and imaging features on CT and MRI.
Ban X, Wu J, Mo Y, Yang Q, Liu X, Xie C, Zhang R
AJNR Am J Neuroradiol 2014 Sep;35(9):1813-9. Epub 2014 May 15 doi: 10.3174/ajnr.A3940. PMID: 24831594Free PMC Article
CT features and pathologic characteristics of lymphoepithelial carcinoma of salivary glands.
Zhang G, Tang J, Pan Y, Zhuang Q, Wu C
Int J Clin Exp Pathol 2014;7(3):1004-11. Epub 2014 Feb 15 PMID: 24696717Free PMC Article

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