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Nasopharyngeal type undifferentiated carcinoma

MedGen UID:
87199
•Concept ID:
C0334254
•
Neoplastic Process
Synonyms: Lymphoepithelial carcinoma; Lymphoepithelial Carcinoma; lymphoepithelial carcinoma; Lymphoepithelial-like carcinoma; Lymphoepithelioma; lymphoepithelioma; Lymphoepithelioma-Like Carcinoma; Lymphoepithelioma-like carcinoma; lymphoepithelioma-like carcinoma; Nasopharyngeal Type Undifferentiated Carcinoma; nasopharyngeal type undifferentiated carcinoma; Nasopharyngeal-Type Undifferentiated Carcinoma; Schmincke Tumor; Schmincke tumor; Schmincke tumour; Schminke tumor; Schminke tumour
SNOMED CT: Lymphoepithelial carcinoma (7300000); Lymphoepithelioma (7300000); Schminke tumor (7300000); Lymphoepithelioma-like carcinoma (7300000); Lymphoepithelial carcinoma (764938007); Lymphoepithelial-like carcinoma (764938007)
 
Monarch Initiative: MONDO:0003572

Definition

A nonkeratinizing carcinoma which occurs predominantly in the nasopharynx but also in the tonsils and rarely in other anatomic sites. It is characterized by the presence of large malignant cells with vesicular nuclei, prominent nucleoli, syncytial growth pattern, and a lymphoplasmacytic infiltrate. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNasopharyngeal type undifferentiated carcinoma

Professional guidelines

PubMed

Biology and treatment of nasopharyngeal cancer.
Fandi A, Cvitkovic E
Curr Opin Oncol 1995 May;7(3):255-63. doi: 10.1097/00001622-199505000-00011. PMID: 7654828

Recent clinical studies

Diagnosis

Nasopharyngeal-type undifferentiated carcinoma (lymphoepithelioma) of paranasal sinuses: Rare case and literature review.
Hajiioannou JK, Kyrmizakis DE, Datseris G, Lachanas V, Karatzanis AK, George Velegrakis AA
J Otolaryngol 2006 Apr;35(2):147-51. doi: 10.2310/7070.2005.5012. PMID: 16527037
Sinonasal undifferentiated carcinoma, nasopharyngeal-type undifferentiated carcinoma, and keratinizing and nonkeratinizing squamous cell carcinoma express different cytokeratin patterns.
Franchi A, Moroni M, Massi D, Paglierani M, Santucci M
Am J Surg Pathol 2002 Dec;26(12):1597-604. doi: 10.1097/00000478-200212000-00007. PMID: 12459626
Biology and treatment of nasopharyngeal cancer.
Fandi A, Cvitkovic E
Curr Opin Oncol 1995 May;7(3):255-63. doi: 10.1097/00001622-199505000-00011. PMID: 7654828

Prognosis

Sinonasal undifferentiated carcinoma and nasopharyngeal-type undifferentiated carcinoma: two clinically, biologically, and histopathologically distinct entities.
Jeng YM, Sung MT, Fang CL, Huang HY, Mao TL, Cheng W, Hsiao CH
Am J Surg Pathol 2002 Mar;26(3):371-6. doi: 10.1097/00000478-200203000-00012. PMID: 11859210
Biology and treatment of nasopharyngeal cancer.
Fandi A, Cvitkovic E
Curr Opin Oncol 1995 May;7(3):255-63. doi: 10.1097/00001622-199505000-00011. PMID: 7654828

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