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Malignant Mixed Tumor of the Minor Salivary Gland

MedGen UID:
277337
•Concept ID:
C1334605
•
Neoplastic Process
Synonyms: Malignant Minor Salivary Gland Mixed Neoplasm; Malignant Minor Salivary Gland Mixed Tumor; Malignant Mixed Neoplasm of Minor Salivary Gland; Malignant Mixed Neoplasm of the Minor Salivary Gland; Malignant Mixed Tumor of Minor Salivary Gland

Definition

A malignant tumor arising from the minor salivary glands. It includes carcinoma ex pleomorphic adenoma, a malignant epithelial tumor arising from a pre-existing pleomorphic adenoma and carcinosarcoma which is characterized by a mixture of malignant epithelial and sarcomatous elements. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Mixed Tumor of the Minor Salivary Gland

Professional guidelines

PubMed

Long-term treatment outcome of minor salivary gland carcinoma of the hard palate.
Li Q, Zhang XR, Liu XK, Liu ZM, Liu WW, Li H, Guo ZM
Oral Oncol 2012 May;48(5):456-62. Epub 2012 Jan 16 doi: 10.1016/j.oraloncology.2011.12.005. PMID: 22248739
Vinorelbine treatment of recurrent salivary gland carcinomas.
Airoldi M, Bumma C, Bertetto O, Gabriele P, Succo G, Pedani F
Bull Cancer 1998 Oct;85(10):892-4. PMID: 9835866
The use of radiation therapy in the management of minor salivary gland tumors.
Ellis ER, Million RR, Mendenhall WM, Parsons JT, Cassisi NJ
Int J Radiat Oncol Biol Phys 1988 Sep;15(3):613-7. doi: 10.1016/0360-3016(88)90302-1. PMID: 2843487

Recent clinical studies

Etiology

Long-term treatment outcome of minor salivary gland carcinoma of the hard palate.
Li Q, Zhang XR, Liu XK, Liu ZM, Liu WW, Li H, Guo ZM
Oral Oncol 2012 May;48(5):456-62. Epub 2012 Jan 16 doi: 10.1016/j.oraloncology.2011.12.005. PMID: 22248739
Factors predicting outcome in malignant minor salivary gland tumors of the oropharynx.
Iyer NG, Kim L, Nixon IJ, Palmer F, Kraus D, Shaha AR, Shah JP, Patel SG, Ganly I
Arch Otolaryngol Head Neck Surg 2010 Dec;136(12):1240-7. doi: 10.1001/archoto.2010.213. PMID: 21173374
First insights into the molecular basis of pleomorphic adenomas of the salivary glands.
Voz ML, Van de Ven WJ, Kas K
Adv Dent Res 2000 Dec;14:81-3. doi: 10.1177/08959374000140011301. PMID: 11842929
Atypical features in salivary gland mixed tumors: their relationship to malignant transformation.
Auclair PL, Ellis GL
Mod Pathol 1996 Jun;9(6):652-7. PMID: 8782203
The use of radiation therapy in the management of minor salivary gland tumors.
Ellis ER, Million RR, Mendenhall WM, Parsons JT, Cassisi NJ
Int J Radiat Oncol Biol Phys 1988 Sep;15(3):613-7. doi: 10.1016/0360-3016(88)90302-1. PMID: 2843487

Diagnosis

Adenoid cystic carcinoma of the Bartholin's gland is easily misdiagnosed: A case report and literature review.
Wang W, Chen H, Guo H, Chen L, Zhu M, Zhu Y
Medicine (Baltimore) 2022 Nov 11;101(45):e31744. doi: 10.1097/MD.0000000000031744. PMID: 36397326Free PMC Article
Immunohistochemical expression of cytokeratins 7 and 20 in malignant salivary gland tumors.
Nikitakis NG, Tosios KI, Papanikolaou VS, Rivera H, Papanicolaou SI, Ioffe OB
Mod Pathol 2004 Apr;17(4):407-15. doi: 10.1038/modpathol.3800064. PMID: 14976534
Atypical features in salivary gland mixed tumors: their relationship to malignant transformation.
Auclair PL, Ellis GL
Mod Pathol 1996 Jun;9(6):652-7. PMID: 8782203
Evaluation of the nucleolar organizer region associated proteins in minor salivary gland tumors.
van Heerden WF, Raubenheimer EJ
J Oral Pathol Med 1991 Jul;20(6):291-5. doi: 10.1111/j.1600-0714.1991.tb00930.x. PMID: 1716320
Malignant mixed tumors arising in salivary glands. I. Carcinomas arising in benign mixed tumors: a clinicopathologic study.
LiVolsi VA, Perzin KH
Cancer 1977 May;39(5):2209-30. doi: 10.1002/1097-0142(197705)39:5<2209::aid-cncr2820390540>3.0.co;2-8. PMID: 192443

Therapy

First insights into the molecular basis of pleomorphic adenomas of the salivary glands.
Voz ML, Van de Ven WJ, Kas K
Adv Dent Res 2000 Dec;14:81-3. doi: 10.1177/08959374000140011301. PMID: 11842929
Vinorelbine treatment of recurrent salivary gland carcinomas.
Airoldi M, Bumma C, Bertetto O, Gabriele P, Succo G, Pedani F
Bull Cancer 1998 Oct;85(10):892-4. PMID: 9835866
Immunohistochemical and ultrastructural study of malignant plasmacytoid myoepithelioma of the maxillary sinus.
Hsiao CH, Cheng CJ, Yeh KL
J Formos Med Assoc 1997 Mar;96(3):209-12. PMID: 9080761
Chemotherapy for recurrent salivary gland malignancies: experience of the ENT Department of Turin University.
Airoldi M, Brando V, Giordano C, Gabriele P, Bussi M, Cortesina G
ORL J Otorhinolaryngol Relat Spec 1994 Mar-Apr;56(2):105-11. doi: 10.1159/000276620. PMID: 8177583
Cisplatin, epirubicin and 5-fluorouracil combination chemotherapy for recurrent carcinoma of the salivary gland.
Airoldi M, Pedani F, Brando V, Gabriele P, Giordano C
Tumori 1989 Jun 30;75(3):252-6. doi: 10.1177/030089168907500312. PMID: 2475951

Prognosis

Long-term treatment outcome of minor salivary gland carcinoma of the hard palate.
Li Q, Zhang XR, Liu XK, Liu ZM, Liu WW, Li H, Guo ZM
Oral Oncol 2012 May;48(5):456-62. Epub 2012 Jan 16 doi: 10.1016/j.oraloncology.2011.12.005. PMID: 22248739
Factors predicting outcome in malignant minor salivary gland tumors of the oropharynx.
Iyer NG, Kim L, Nixon IJ, Palmer F, Kraus D, Shaha AR, Shah JP, Patel SG, Ganly I
Arch Otolaryngol Head Neck Surg 2010 Dec;136(12):1240-7. doi: 10.1001/archoto.2010.213. PMID: 21173374
Atypical features in salivary gland mixed tumors: their relationship to malignant transformation.
Auclair PL, Ellis GL
Mod Pathol 1996 Jun;9(6):652-7. PMID: 8782203
True malignant mixed tumor (carcinosarcoma) of palatal minor salivary gland origin.
Takeda Y
Ann Dent 1991 Summer;50(1):33-5. PMID: 1872589
Malignant mixed tumors arising in salivary glands. I. Carcinomas arising in benign mixed tumors: a clinicopathologic study.
LiVolsi VA, Perzin KH
Cancer 1977 May;39(5):2209-30. doi: 10.1002/1097-0142(197705)39:5<2209::aid-cncr2820390540>3.0.co;2-8. PMID: 192443

Clinical prediction guides

Adenoid cystic carcinoma of the Bartholin's gland is easily misdiagnosed: A case report and literature review.
Wang W, Chen H, Guo H, Chen L, Zhu M, Zhu Y
Medicine (Baltimore) 2022 Nov 11;101(45):e31744. doi: 10.1097/MD.0000000000031744. PMID: 36397326Free PMC Article
Glycoconjugate expression in adenoid cystic carcinoma of the salivary glands: up-regulation of L1 predicts fatal prognosis.
Dahl A, Teegen J, Altevogt P, Löning T, Schumacher U
Histopathology 2011 Aug;59(2):299-307. doi: 10.1111/j.1365-2559.2011.03895.x. PMID: 21884209
Factors predicting outcome in malignant minor salivary gland tumors of the oropharynx.
Iyer NG, Kim L, Nixon IJ, Palmer F, Kraus D, Shaha AR, Shah JP, Patel SG, Ganly I
Arch Otolaryngol Head Neck Surg 2010 Dec;136(12):1240-7. doi: 10.1001/archoto.2010.213. PMID: 21173374
First insights into the molecular basis of pleomorphic adenomas of the salivary glands.
Voz ML, Van de Ven WJ, Kas K
Adv Dent Res 2000 Dec;14:81-3. doi: 10.1177/08959374000140011301. PMID: 11842929
Malignant salivary tumors--analysis of prognostic factors and survival.
O'Brien CJ, Soong SJ, Herrera GA, Urist MM, Maddox WA
Head Neck Surg 1986 Nov-Dec;9(2):82-92. doi: 10.1002/hed.2890090204. PMID: 3623942

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