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Testicular Mixed Embryonal Carcinoma and Yolk Sac Tumor with Seminoma

MedGen UID:
277377
•Concept ID:
C1334783
•
Neoplastic Process
Synonyms: Mixed Embryonal Carcinoma and Endodermal Sinus Neoplasm with Seminoma of Testis; Mixed Embryonal Carcinoma and Endodermal Sinus Neoplasm with Seminoma of the Testis; Mixed Embryonal Carcinoma and Endodermal Sinus Tumor with Seminoma of Testis; Mixed Embryonal Carcinoma and Endodermal Sinus Tumor with Seminoma of the Testis; Mixed Embryonal Carcinoma and Yolk Sac Neoplasm with Seminoma of Testis; Mixed Embryonal Carcinoma and Yolk Sac Neoplasm with Seminoma of the Testis; Mixed Embryonal Carcinoma and Yolk Sac Tumor with Seminoma of Testis; Mixed Embryonal Carcinoma and Yolk Sac Tumor with Seminoma of the Testis; Testicular Mixed Embryonal Carcinoma and Endodermal Sinus Tumor with Seminoma; Testicular Mixed Embryonal Carcinoma and Yolk Sac Neoplasm with Seminoma

Definition

A malignant germ cell tumor arising from the testis. It is characterized by a mixture of embryonal carcinoma, yolk sac, and seminomatous morphologic elements. Patients may present with painless or painful testicular swelling. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTesticular Mixed Embryonal Carcinoma and Yolk Sac Tumor with Seminoma

Professional guidelines

PubMed

Role of HNF1β in the differential diagnosis of yolk sac tumor from other germ cell tumors.
Rougemont AL, Tille JC
Hum Pathol 2018 Nov;81:26-36. Epub 2018 May 16 doi: 10.1016/j.humpath.2018.04.025. PMID: 29753846
D2-40 immunohistochemistry in the differential diagnosis of seminoma and embryonal carcinoma: a comparative immunohistochemical study with KIT (CD117) and CD30.
Lau SK, Weiss LM, Chu PG
Mod Pathol 2007 Mar;20(3):320-5. Epub 2007 Feb 2 doi: 10.1038/modpathol.3800749. PMID: 17277761
Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues.
Ulbright TM
Mod Pathol 2005 Feb;18 Suppl 2:S61-79. doi: 10.1038/modpathol.3800310. PMID: 15761467

Recent clinical studies

Etiology

Cytological spectrum of testicular malignancies with histopathological correlation: A retrospective analysis.
Kerkar A, Kundu R, Kaur A, Rohilla M, Gupta P, Gupta N, Srinivasan R, Kakkar N, Dey P
Diagn Cytopathol 2023 Oct;51(10):646-653. Epub 2023 Jul 14 doi: 10.1002/dc.25194. PMID: 37452481
Clinical Features and Survival Outcomes in Children and Adolescents With Malignant Mediastinal Germ Cell Tumors Based on Surveillance, Epidemiology, and End Results Database Analysis.
Wu P, Yang Y, Yu Z, Zhao L, Feng S
J Surg Res 2023 Aug;288:362-371. Epub 2023 Apr 14 doi: 10.1016/j.jss.2023.03.018. PMID: 37062232
Intratubular germ cell neoplasia of the testis: a brief review.
Al-Hussain T, Bakshi N, Akhtar M
Adv Anat Pathol 2015 May;22(3):202-12. doi: 10.1097/PAP.0000000000000066. PMID: 25844678
Pathology of germ cell tumors of the testis.
Sesterhenn IA, Davis CJ Jr
Cancer Control 2004 Nov-Dec;11(6):374-87. doi: 10.1177/107327480401100605. PMID: 15625525
Germ cell neoplasms of the testis.
Ulbright TM
Am J Surg Pathol 1993 Nov;17(11):1075-91. doi: 10.1097/00000478-199311000-00001. PMID: 8214253

Diagnosis

Cytological spectrum of testicular malignancies with histopathological correlation: A retrospective analysis.
Kerkar A, Kundu R, Kaur A, Rohilla M, Gupta P, Gupta N, Srinivasan R, Kakkar N, Dey P
Diagn Cytopathol 2023 Oct;51(10):646-653. Epub 2023 Jul 14 doi: 10.1002/dc.25194. PMID: 37452481
Diagnostically misleading aberrant terminal deoxynucleotidyl transferase expression in germ cell tumors.
Pęksa R, Kunc M, Bieńkowski M, Popęda M, Biernat W
Pol J Pathol 2022;73(2):159-165. doi: 10.5114/pjp.2022.120098. PMID: 36345953
ZBTB16: a novel sensitive and specific biomarker for yolk sac tumor.
Xiao GQ, Li F, Unger PD, Katerji H, Yang Q, McMahon L, Burstein DE
Mod Pathol 2016 Jun;29(6):591-8. Epub 2016 Feb 26 doi: 10.1038/modpathol.2016.46. PMID: 26916077
Testicular embryonal carcinoma: a morphologic study of 180 cases highlighting unusual and unemphasized aspects.
Kao CS, Ulbright TM, Young RH, Idrees MT
Am J Surg Pathol 2014 May;38(5):689-97. doi: 10.1097/PAS.0000000000000171. PMID: 24503753
Germ-cell tumors of the mediastinum.
Weidner N
Semin Diagn Pathol 1999 Feb;16(1):42-50. PMID: 10355653

Therapy

Poor prognosis of retroperitoneal mixed extragonadal germ cell tumors in an HIV-infected man with severe immunosuppression and bilateral cryptorchidism: a case report.
Li R, Li H
BMC Cancer 2019 Mar 18;19(1):244. doi: 10.1186/s12885-019-5456-0. PMID: 30885154Free PMC Article
Metastatic mixed germ-cell neoplasm presenting as retinal detachment.
Phelps PO, Kapadia AA, Chennuri R, Mehta DG
J Clin Oncol 2012 May 1;30(13):e133-6. Epub 2012 Mar 5 doi: 10.1200/JCO.2011.38.2093. PMID: 22393102
Histologically pure seminoma with elevated alpha-fetoprotein: a clinicopathologic study of ten cases.
Nazeer T, Ro JY, Amato RJ, Park YW, Ordonez NG, Ayala AG
Oncol Rep 1998 Nov-Dec;5(6):1425-9. doi: 10.3892/or.5.6.1425. PMID: 9769381

Prognosis

Clinical Features and Survival Outcomes in Children and Adolescents With Malignant Mediastinal Germ Cell Tumors Based on Surveillance, Epidemiology, and End Results Database Analysis.
Wu P, Yang Y, Yu Z, Zhao L, Feng S
J Surg Res 2023 Aug;288:362-371. Epub 2023 Apr 14 doi: 10.1016/j.jss.2023.03.018. PMID: 37062232
Age-incidence patterns of seminoma and nonseminoma among males and females in Germany and the United States, 2008-2016.
Stang A, Trocchi P, Kajüter H, Trabert B, Oosterhuis JW, McGlynn KA
Andrology 2023 Jan;11(1):65-72. Epub 2022 Sep 12 doi: 10.1111/andr.13282. PMID: 36059277
ZBTB16: a novel sensitive and specific biomarker for yolk sac tumor.
Xiao GQ, Li F, Unger PD, Katerji H, Yang Q, McMahon L, Burstein DE
Mod Pathol 2016 Jun;29(6):591-8. Epub 2016 Feb 26 doi: 10.1038/modpathol.2016.46. PMID: 26916077
Metastatic mixed germ-cell neoplasm presenting as retinal detachment.
Phelps PO, Kapadia AA, Chennuri R, Mehta DG
J Clin Oncol 2012 May 1;30(13):e133-6. Epub 2012 Mar 5 doi: 10.1200/JCO.2011.38.2093. PMID: 22393102
Germ-cell tumors of the mediastinum.
Weidner N
Semin Diagn Pathol 1999 Feb;16(1):42-50. PMID: 10355653

Clinical prediction guides

Diagnostically misleading aberrant terminal deoxynucleotidyl transferase expression in germ cell tumors.
Pęksa R, Kunc M, Bieńkowski M, Popęda M, Biernat W
Pol J Pathol 2022;73(2):159-165. doi: 10.5114/pjp.2022.120098. PMID: 36345953
Role of HNF1β in the differential diagnosis of yolk sac tumor from other germ cell tumors.
Rougemont AL, Tille JC
Hum Pathol 2018 Nov;81:26-36. Epub 2018 May 16 doi: 10.1016/j.humpath.2018.04.025. PMID: 29753846
ZBTB16: a novel sensitive and specific biomarker for yolk sac tumor.
Xiao GQ, Li F, Unger PD, Katerji H, Yang Q, McMahon L, Burstein DE
Mod Pathol 2016 Jun;29(6):591-8. Epub 2016 Feb 26 doi: 10.1038/modpathol.2016.46. PMID: 26916077
An overview of testicular germ cell tumors.
Bahrami A, Ro JY, Ayala AG
Arch Pathol Lab Med 2007 Aug;131(8):1267-80. doi: 10.5858/2007-131-1267-AOOTGC. PMID: 17683189
From the archives of the AFIP: tumors and tumorlike lesions of the testis: radiologic-pathologic correlation.
Woodward PJ, Sohaey R, O'Donoghue MJ, Green DE
Radiographics 2002 Jan-Feb;22(1):189-216. doi: 10.1148/radiographics.22.1.g02ja14189. PMID: 11796908

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