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Non-Neoplastic Laryngeal Disorder

MedGen UID:
277426
•Concept ID:
C1335018
•
Disease or Syndrome
Synonym: Non-Neoplastic Laryngeal Disease

Definition

A non-neoplastic pathologic process that affects the larynx. Representative examples include laryngitis, vocal cord nodule, and laryngeal cleft. [from NCI]

Professional guidelines

PubMed

Benign tracheal and laryngotracheal stenosis: surgical treatment and results.
Rea F, Callegaro D, Loy M, Zuin A, Narne S, Gobbi T, Grapeggia M, Sartori F
Eur J Cardiothorac Surg 2002 Sep;22(3):352-6. doi: 10.1016/s1010-7940(02)00342-1. PMID: 12204722

Recent clinical studies

Etiology

Serum concentration of total sialic acids in patients with primary laryngeal carcinoma.
Bronikowska I, Świętochowska E, Morawski R, Ścierski W, Czecior E
Otolaryngol Pol 2022 Nov 24;77(2):1-5. doi: 10.5604/01.3001.0016.1094. PMID: 36804774
Post-thyroidectomy complications in southwestern Saudi Arabia: a retrospective study of a 6-year period.
Bawa D, Alghamdi A, Albishi H, Al-Tufail N, Sharma SP, Khalifa YM, Khan S, Alhajmohammed MA
Ann Saudi Med 2021 Nov-Dec;41(6):369-375. Epub 2021 Dec 2 doi: 10.5144/0256-4947.2021.369. PMID: 34873936Free PMC Article
Effectiveness of narrow band imaging in the detection of premalignant and malignant lesions of the larynx: validation of a new endoscopic clinical classification.
Bertino G, Cacciola S, Fernandes WB Jr, Fernandes CM, Occhini A, Tinelli C, Benazzo M
Head Neck 2015 Feb;37(2):215-22. Epub 2014 Apr 19 doi: 10.1002/hed.23582. PMID: 24375619
General primer-mediated polymerase chain reaction for simultaneous detection and typing of human papillomavirus DNA in laryngeal squamous cell carcinomas.
Salam MA, Rockett J, Morris A
Clin Otolaryngol Allied Sci 1995 Feb;20(1):84-8. doi: 10.1111/j.1365-2273.1995.tb00019.x. PMID: 7788942
Acute phase reactant proteins--an aid to monitoring surgical treatment of laryngeal carcinoma.
Krecicki T, Leluk M
J Laryngol Otol 1992 Jul;106(7):613-5. doi: 10.1017/s002221510012033x. PMID: 1382109

Diagnosis

Tyrosine-Like Crystalloids Localize to Non-Neoplastic True Vocal Cord and Attachments.
Dababneh MN, Farris AB, Steward-Tharp SM, Viswanathan K, Lubin D, Saeed F, Magliocca KR
Head Neck Pathol 2024 Aug 23;18(1):81. doi: 10.1007/s12105-024-01691-w. PMID: 39177813Free PMC Article
Cystic metastasis versus brain abscess: role of MR imaging in accurate diagnosis and implications on treatment.
Shetty P, Moiyadi A, Pantvaidya G, Arya S
J Cancer Res Ther 2010 Jul-Sep;6(3):356-8. doi: 10.4103/0973-1482.73368. PMID: 21119276
Imaging of the larynx and hypopharynx.
Becker M, Burkhardt K, Dulguerov P, Allal A
Eur J Radiol 2008 Jun;66(3):460-79. Epub 2008 May 20 doi: 10.1016/j.ejrad.2008.03.027. PMID: 18495402
Postcricoid hemangioma: an overlooked cause of dysphagia in infants?-a case report.
Desuter GR, El Makhloufi K, François GJ, Godding VM, Saint-Martin C, Buts JP, Hamoir MF
Dysphagia 2004 Winter;19(1):48-51. doi: 10.1007/s00455-003-0028-4. PMID: 14745646
An immunocytochemical study of the distribution of epithelial membrane antigen in normal and disordered squamous epithelium.
Sloane JP, Ormerod MG, Carter RL, Gusterson BA, Foster CS
Diagn Histopathol 1982 Jan-Mar;5(1):11-7. PMID: 7040004

Therapy

Post-thyroidectomy complications in southwestern Saudi Arabia: a retrospective study of a 6-year period.
Bawa D, Alghamdi A, Albishi H, Al-Tufail N, Sharma SP, Khalifa YM, Khan S, Alhajmohammed MA
Ann Saudi Med 2021 Nov-Dec;41(6):369-375. Epub 2021 Dec 2 doi: 10.5144/0256-4947.2021.369. PMID: 34873936Free PMC Article
Long-term control of laryngeal plasma cell mucositis with systemic immunosuppression.
Triplett J, Hee G, McLean-Tooke A, Lucas M
BMJ Case Rep 2018 Jun 20;2018 doi: 10.1136/bcr-2017-221333. PMID: 29930164Free PMC Article
Laryngeal cancer: smoking is not the only risk factor.
Vassileiou A, Vlastarakos PV, Kandiloros D, Delicha E, Ferekidis E, Tzagaroulakis A, Nikolopoulos TP
B-ENT 2012;8(4):273-8. PMID: 23409557
Micronutrients and laryngeal cancer risk in Italy and Switzerland: a case-control study.
Bidoli E, Bosetti C, La Vecchia C, Levi F, Parpinel M, Talamini R, Negri E, Maso LD, Franceschi S
Cancer Causes Control 2003 Jun;14(5):477-84. doi: 10.1023/a:1024991618398. PMID: 12946043
Delayed multiorgan non-neoplastic damage after exposure to radiotherapy in infancy.
Olivieri O, Girelli D, Russo C, Nardelli E, Corrocher R
Eur J Med 1993 Jan;2(1):58-9. PMID: 8258008

Prognosis

Nuclear EGFR Expression Is Associated With Poor Survival in Laryngeal Carcinoma.
Marijić B, Braut T, Babarović E, Krstulja M, Maržić D, Avirović M, Kujundžić M, Hadžisejdić I
Appl Immunohistochem Mol Morphol 2021 Sep 1;29(8):576-584. doi: 10.1097/PAI.0000000000000932. PMID: 33758141
Expression and prognostic significance of YAP, TAZ, TEAD4 and p73 in human laryngeal cancer.
Tsinias G, Nikou S, Mastronikolis N, Bravou V, Papadaki H
Histol Histopathol 2020 Sep;35(9):983-995. Epub 2020 May 7 doi: 10.14670/HH-18-228. PMID: 32378727
Increased expression of lncRNA FTH1P3 predicts a poor prognosis and promotes aggressive phenotypes of laryngeal squamous cell carcinoma.
Yuan H, Jiang H, Wang Y, Dong Y
Biosci Rep 2019 Jun 28;39(6) Epub 2019 Jun 18 doi: 10.1042/BSR20181644. PMID: 31142627Free PMC Article
Effectiveness of narrow band imaging in the detection of premalignant and malignant lesions of the larynx: validation of a new endoscopic clinical classification.
Bertino G, Cacciola S, Fernandes WB Jr, Fernandes CM, Occhini A, Tinelli C, Benazzo M
Head Neck 2015 Feb;37(2):215-22. Epub 2014 Apr 19 doi: 10.1002/hed.23582. PMID: 24375619
Acute phase reactant proteins--an aid to monitoring surgical treatment of laryngeal carcinoma.
Krecicki T, Leluk M
J Laryngol Otol 1992 Jul;106(7):613-5. doi: 10.1017/s002221510012033x. PMID: 1382109

Clinical prediction guides

Laryngeal nodular fasciitis in a 75-year-old man: a rare case report and review of the literature.
Wen Y, Ye S, Liu C, Zhu Y
J Int Med Res 2024 Aug;52(8):3000605241259764. doi: 10.1177/03000605241259764. PMID: 39142703Free PMC Article
Expression and prognostic significance of YAP, TAZ, TEAD4 and p73 in human laryngeal cancer.
Tsinias G, Nikou S, Mastronikolis N, Bravou V, Papadaki H
Histol Histopathol 2020 Sep;35(9):983-995. Epub 2020 May 7 doi: 10.14670/HH-18-228. PMID: 32378727
Effectiveness of narrow band imaging in the detection of premalignant and malignant lesions of the larynx: validation of a new endoscopic clinical classification.
Bertino G, Cacciola S, Fernandes WB Jr, Fernandes CM, Occhini A, Tinelli C, Benazzo M
Head Neck 2015 Feb;37(2):215-22. Epub 2014 Apr 19 doi: 10.1002/hed.23582. PMID: 24375619
Quality-of-life impact of non-neoplastic voice disorders: a meta-analysis.
Cohen SM, Dupont WD, Courey MS
Ann Otol Rhinol Laryngol 2006 Feb;115(2):128-34. doi: 10.1177/000348940611500209. PMID: 16514796
Laryngotracheal reconstruction in subglottic stenosis: an ancient problem still present.
Peña J, Cicero R, Marín J, Ramírez M, Cruz S, Navarro F
Otolaryngol Head Neck Surg 2001 Oct;125(4):397-400. doi: 10.1067/mhn.2001.117372. PMID: 11593179

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