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Gastric diffuse large B-cell lymphoma

MedGen UID:
277530
•Concept ID:
C1335483
•
Neoplastic Process
Synonyms: Gastric Diffuse Large B-Cell Lymphoma; gastric diffuse large B-cell lymphoma; Primary Diffuse Large B-Cell Gastric Lymphoma; primary diffuse large B-cell gastric lymphoma; Primary Diffuse Large B-Cell Lymphoma of Stomach; primary diffuse large B-cell lymphoma of stomach; Primary Diffuse Large B-Cell Lymphoma of the Stomach; primary diffuse large B-cell lymphoma of the stomach; Primary Gastric Diffuse Large B-Cell Lymphoma; primary gastric diffuse large B-cell lymphoma
 
Monarch Initiative: MONDO:0006223

Definition

An extranodal diffuse large B-cell lymphoma that arises from the stomach with the bulk of the mass located in the stomach. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGastric diffuse large B-cell lymphoma

Professional guidelines

PubMed

Pattern of failure and optimal treatment strategy for primary gastric diffuse large B-cell lymphoma treated with R-CHOP chemotherapy.
Kang HJ, Lee HH, Jung SE, Park KS, O JH, Jeon YW, Choi BO, Cho SG
PLoS One 2020;15(9):e0238807. Epub 2020 Sep 22 doi: 10.1371/journal.pone.0238807. PMID: 32960887Free PMC Article
Increased risk of gastric adenocarcinoma after treatment of primary gastric diffuse large B-cell lymphoma.
Inaba K, Kushima R, Murakami N, Kuroda Y, Harada K, Kitaguchi M, Yoshio K, Sekii S, Takahashi K, Morota M, Mayahara H, Ito Y, Sumi M, Uno T, Itami J
BMC Cancer 2013 Oct 26;13:499. doi: 10.1186/1471-2407-13-499. PMID: 24159918Free PMC Article
Rituximab in treatment of primary gastric diffuse large B-cell lymphoma.
Zhang J, Li G, Yang H, Liu X, Cao J
Leuk Lymphoma 2012 Nov;53(11):2175-81. Epub 2012 Apr 19 doi: 10.3109/10428194.2012.680451. PMID: 22462613

Recent clinical studies

Etiology

miR-155-regulated mTOR and Toll-like receptor 5 in gastric diffuse large B-cell lymphoma.
Huang WT, Kuo SH, Kuo YC, Lin CW
Cancer Med 2022 Feb;11(3):555-570. Epub 2021 Dec 16 doi: 10.1002/cam4.4466. PMID: 34913612Free PMC Article
Primary Gastric Diffuse Large B-Cell Lymphoma: Prognostic Factors in the Immuno-Oncology Therapeutics Era.
Bai Z, Li Z, Guan T, Wang L, Wang J, Wu S, Su L
Turk J Haematol 2020 Aug 28;37(3):193-202. Epub 2020 Mar 12 doi: 10.4274/tjh.galenos.2020.2019.0332. PMID: 32160735Free PMC Article
Complications and outcomes in diffuse large B-cell lymphoma with gastric lesions treated with R-CHOP.
Kadota T, Seo S, Fuse H, Ishii G, Itoh K, Yano T, Kaneko K, Tsukasaki K
Cancer Med 2019 Mar;8(3):982-989. Epub 2019 Feb 7 doi: 10.1002/cam4.1982. PMID: 30730104Free PMC Article
Primary gastric diffuse large B-cell lymphoma: The role of dose-dense chemotherapy.
Avilés A, Nambo MJ, Neri N
J Oncol Pharm Pract 2019 Oct;25(7):1682-1686. Epub 2018 Oct 28 doi: 10.1177/1078155218809458. PMID: 30370804
Gastrointestinal lymphoma.
Bierman PJ
Curr Treat Options Oncol 2003 Oct;4(5):421-30. doi: 10.1007/s11864-003-0043-6. PMID: 12941202

Diagnosis

miR-155-regulated mTOR and Toll-like receptor 5 in gastric diffuse large B-cell lymphoma.
Huang WT, Kuo SH, Kuo YC, Lin CW
Cancer Med 2022 Feb;11(3):555-570. Epub 2021 Dec 16 doi: 10.1002/cam4.4466. PMID: 34913612Free PMC Article
Primary Gastric Diffuse Large B-Cell Lymphoma: Prognostic Factors in the Immuno-Oncology Therapeutics Era.
Bai Z, Li Z, Guan T, Wang L, Wang J, Wu S, Su L
Turk J Haematol 2020 Aug 28;37(3):193-202. Epub 2020 Mar 12 doi: 10.4274/tjh.galenos.2020.2019.0332. PMID: 32160735Free PMC Article
Complications and outcomes in diffuse large B-cell lymphoma with gastric lesions treated with R-CHOP.
Kadota T, Seo S, Fuse H, Ishii G, Itoh K, Yano T, Kaneko K, Tsukasaki K
Cancer Med 2019 Mar;8(3):982-989. Epub 2019 Feb 7 doi: 10.1002/cam4.1982. PMID: 30730104Free PMC Article
Primary gastric diffuse large B-cell lymphoma: The role of dose-dense chemotherapy.
Avilés A, Nambo MJ, Neri N
J Oncol Pharm Pract 2019 Oct;25(7):1682-1686. Epub 2018 Oct 28 doi: 10.1177/1078155218809458. PMID: 30370804
Helicobacter pylori eradication in gastric diffuse large B cell lymphoma.
Paydas S
World J Gastroenterol 2015 Apr 7;21(13):3773-6. doi: 10.3748/wjg.v21.i13.3773. PMID: 25852262Free PMC Article

Therapy

Primary Gastric Diffuse Large B-Cell Lymphoma: Prognostic Factors in the Immuno-Oncology Therapeutics Era.
Bai Z, Li Z, Guan T, Wang L, Wang J, Wu S, Su L
Turk J Haematol 2020 Aug 28;37(3):193-202. Epub 2020 Mar 12 doi: 10.4274/tjh.galenos.2020.2019.0332. PMID: 32160735Free PMC Article
Complications and outcomes in diffuse large B-cell lymphoma with gastric lesions treated with R-CHOP.
Kadota T, Seo S, Fuse H, Ishii G, Itoh K, Yano T, Kaneko K, Tsukasaki K
Cancer Med 2019 Mar;8(3):982-989. Epub 2019 Feb 7 doi: 10.1002/cam4.1982. PMID: 30730104Free PMC Article
Primary gastric diffuse large B-cell lymphoma: The role of dose-dense chemotherapy.
Avilés A, Nambo MJ, Neri N
J Oncol Pharm Pract 2019 Oct;25(7):1682-1686. Epub 2018 Oct 28 doi: 10.1177/1078155218809458. PMID: 30370804
Helicobacter pylori eradication in gastric diffuse large B cell lymphoma.
Paydas S
World J Gastroenterol 2015 Apr 7;21(13):3773-6. doi: 10.3748/wjg.v21.i13.3773. PMID: 25852262Free PMC Article
De-escalating therapy in gastric aggressive lymphoma.
Cuccurullo R, Govi S, Ferreri AJ
World J Gastroenterol 2014 Jul 21;20(27):8993-7. doi: 10.3748/wjg.v20.i27.8993. PMID: 25083073Free PMC Article

Prognosis

miR-155-regulated mTOR and Toll-like receptor 5 in gastric diffuse large B-cell lymphoma.
Huang WT, Kuo SH, Kuo YC, Lin CW
Cancer Med 2022 Feb;11(3):555-570. Epub 2021 Dec 16 doi: 10.1002/cam4.4466. PMID: 34913612Free PMC Article
Primary Gastric Diffuse Large B-Cell Lymphoma: Prognostic Factors in the Immuno-Oncology Therapeutics Era.
Bai Z, Li Z, Guan T, Wang L, Wang J, Wu S, Su L
Turk J Haematol 2020 Aug 28;37(3):193-202. Epub 2020 Mar 12 doi: 10.4274/tjh.galenos.2020.2019.0332. PMID: 32160735Free PMC Article
Complications and outcomes in diffuse large B-cell lymphoma with gastric lesions treated with R-CHOP.
Kadota T, Seo S, Fuse H, Ishii G, Itoh K, Yano T, Kaneko K, Tsukasaki K
Cancer Med 2019 Mar;8(3):982-989. Epub 2019 Feb 7 doi: 10.1002/cam4.1982. PMID: 30730104Free PMC Article
Primary gastric diffuse large B-cell lymphoma: The role of dose-dense chemotherapy.
Avilés A, Nambo MJ, Neri N
J Oncol Pharm Pract 2019 Oct;25(7):1682-1686. Epub 2018 Oct 28 doi: 10.1177/1078155218809458. PMID: 30370804
Gastrointestinal lymphoma.
Bierman PJ
Curr Treat Options Oncol 2003 Oct;4(5):421-30. doi: 10.1007/s11864-003-0043-6. PMID: 12941202

Clinical prediction guides

Evaluation of clinical and prognostic factors for primary gastric diffuse large B-cell lymphoma: Single-center experience.
Bardakci M, Esmer DD, Hafizoglu E, Karaman K, Kuzu OF, Karakas H, Gungorer B, Uncu D
J Cancer Res Ther 2023 Apr-Jun;19(3):778-782. doi: 10.4103/jcrt.jcrt_2111_21. PMID: 37470610
miR-155-regulated mTOR and Toll-like receptor 5 in gastric diffuse large B-cell lymphoma.
Huang WT, Kuo SH, Kuo YC, Lin CW
Cancer Med 2022 Feb;11(3):555-570. Epub 2021 Dec 16 doi: 10.1002/cam4.4466. PMID: 34913612Free PMC Article
Prognostic significance of helicobacter pylori-infection in gastric diffuse large B-cell lymphoma.
Cheng Y, Xiao Y, Zhou R, Liao Y, Zhou J, Ma X
BMC Cancer 2019 Aug 28;19(1):842. doi: 10.1186/s12885-019-6067-5. PMID: 31455250Free PMC Article
Primary gastric diffuse large B-cell lymphoma: The role of dose-dense chemotherapy.
Avilés A, Nambo MJ, Neri N
J Oncol Pharm Pract 2019 Oct;25(7):1682-1686. Epub 2018 Oct 28 doi: 10.1177/1078155218809458. PMID: 30370804
Helicobacter pylori eradication in gastric diffuse large B cell lymphoma.
Paydas S
World J Gastroenterol 2015 Apr 7;21(13):3773-6. doi: 10.3748/wjg.v21.i13.3773. PMID: 25852262Free PMC Article

Recent systematic reviews

A systematic review of primary gastric diffuse large B-cell lymphoma: Clinical diagnosis, staging, treatment and prognostic factors.
Bai Z, Zhou Y
Leuk Res 2021 Dec;111:106716. Epub 2021 Oct 1 doi: 10.1016/j.leukres.2021.106716. PMID: 34627052

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