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Salivary Gland Intraductal Papilloma

MedGen UID:
277629
•Concept ID:
C1335901
•
Neoplastic Process

Definition

An intraluminal papillary proliferation that causes unicystic dilatation of the duct and may have features in common with papillary cystadenoma. It is quite rare, and involves almost exclusively the excretory ducts of intraoral minor salivary glands. It presents as an asymptomatic submucosal swelling. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSalivary Gland Intraductal Papilloma

Professional guidelines

PubMed

Histopathological evaluation of minor salivary gland papillary-cystic tumours: focus on genetic alterations in sialadenoma papilliferum and intraductal papillary mucinous neoplasm.
Nakaguro M, Urano M, Ogawa I, Hirai H, Yamamoto Y, Yamaguchi H, Tanigawa M, Matsubayashi J, Hirano H, Shibahara J, Tada Y, Tsuzuki T, Okada Y, Sato Y, Ikeda K, Sukeda A, Honda Y, Mikami Y, Nagao T
Histopathology 2020 Feb;76(3):411-422. Epub 2019 Dec 1 doi: 10.1111/his.13990. PMID: 31505033

Recent clinical studies

Etiology

Papillary Neoplasms of the Salivary Duct System: A Review.
Agaimy A
Surg Pathol Clin 2021 Mar;14(1):53-65. Epub 2020 Dec 15 doi: 10.1016/j.path.2020.09.007. PMID: 33526223
Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours.
Hellquist H, Paiva-Correia A, Vander Poorten V, Quer M, Hernandez-Prera JC, Andreasen S, Zbären P, Skalova A, Rinaldo A, Ferlito A
Adv Ther 2019 Aug;36(8):1950-1974. Epub 2019 Jun 17 doi: 10.1007/s12325-019-01007-3. PMID: 31209701Free PMC Article
CD44 expression in intraoral salivary ductal papillomas and oral papillary squamous cell carcinoma.
Fitzpatrick SG, Montague LJ, Cohen DM, Bhattacharyya I
Head Neck Pathol 2013 Jun;7(2):122-8. Epub 2012 Nov 13 doi: 10.1007/s12105-012-0407-y. PMID: 23143465Free PMC Article
Ductal papillomas of salivary gland origin: A report of 19 cases and a review of the literature.
Brannon RB, Sciubba JJ, Giulani M
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001 Jul;92(1):68-77. doi: 10.1067/moe.2001.115978. PMID: 11458248

Diagnosis

Intraductal Papilloma Arising From the Minor Salivary Glands of the Larynx: A Case Report.
Hara S, Ohba S, Arakawa A, Matsumoto F, Ito S, Fujimaki M, Kojima M, Ikeda K
Ear Nose Throat J 2022 Feb;101(2):NP73-NP77. Epub 2020 Aug 3 doi: 10.1177/0145561320944638. PMID: 32744904
Papillary Neoplasms of the Salivary Duct System: A Review.
Agaimy A
Surg Pathol Clin 2021 Mar;14(1):53-65. Epub 2020 Dec 15 doi: 10.1016/j.path.2020.09.007. PMID: 33526223
Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours.
Hellquist H, Paiva-Correia A, Vander Poorten V, Quer M, Hernandez-Prera JC, Andreasen S, Zbären P, Skalova A, Rinaldo A, Ferlito A
Adv Ther 2019 Aug;36(8):1950-1974. Epub 2019 Jun 17 doi: 10.1007/s12325-019-01007-3. PMID: 31209701Free PMC Article
Intraductal papilloma arising from the accessory parotid gland: A case report and literature review.
Sun S, Wang P, Wang Y, Su W, Wang F, Yang H
Medicine (Baltimore) 2018 May;97(20):e10761. doi: 10.1097/MD.0000000000010761. PMID: 29768362Free PMC Article
Ductal papillomas of salivary gland origin: A report of 19 cases and a review of the literature.
Brannon RB, Sciubba JJ, Giulani M
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001 Jul;92(1):68-77. doi: 10.1067/moe.2001.115978. PMID: 11458248

Prognosis

Papillary Neoplasms of the Salivary Duct System: A Review.
Agaimy A
Surg Pathol Clin 2021 Mar;14(1):53-65. Epub 2020 Dec 15 doi: 10.1016/j.path.2020.09.007. PMID: 33526223
Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours.
Hellquist H, Paiva-Correia A, Vander Poorten V, Quer M, Hernandez-Prera JC, Andreasen S, Zbären P, Skalova A, Rinaldo A, Ferlito A
Adv Ther 2019 Aug;36(8):1950-1974. Epub 2019 Jun 17 doi: 10.1007/s12325-019-01007-3. PMID: 31209701Free PMC Article
Ductal papillomas of salivary gland origin: A report of 19 cases and a review of the literature.
Brannon RB, Sciubba JJ, Giulani M
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001 Jul;92(1):68-77. doi: 10.1067/moe.2001.115978. PMID: 11458248

Clinical prediction guides

Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours.
Hellquist H, Paiva-Correia A, Vander Poorten V, Quer M, Hernandez-Prera JC, Andreasen S, Zbären P, Skalova A, Rinaldo A, Ferlito A
Adv Ther 2019 Aug;36(8):1950-1974. Epub 2019 Jun 17 doi: 10.1007/s12325-019-01007-3. PMID: 31209701Free PMC Article
Intraductal Papillary Mucinous Neoplasms of Minor Salivary Glands With AKT1 p.Glu17Lys Mutation.
Agaimy A, Mueller SK, Bumm K, Iro H, Moskalev EA, Hartmann A, Stoehr R, Haller F
Am J Surg Pathol 2018 Aug;42(8):1076-1082. doi: 10.1097/PAS.0000000000001080. PMID: 29738361
Intraductal papilloma arising from sublingual minor salivary gland: case report and immunohistochemical study.
Aikawa T, Kishino M, Masuda T, Isomura ET, Tanaka S, Namikawa M, Iida S
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009 May;107(5):e34-7. doi: 10.1016/j.tripleo.2009.01.019. PMID: 19426904
Solitary intraductal papilloma of the minor salivary glands.
Abbey LM
Oral Surg Oral Med Oral Pathol 1975 Jul;40(1):135-40. doi: 10.1016/0030-4220(75)90357-6. PMID: 1057130

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