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Intraductal papilloma

MedGen UID:: 61667
•Concept ID:: C0206713
•: Neoplastic Process

Synonyms:	Intraductal Papilloma; Intraductal Papillomas; Papilloma, Intraductal; Papillomas, Intraductal
SNOMED CT:	Intraductal papilloma (5244003); Ductal papilloma (5244003); Duct adenoma (5244003)

Monarch Initiative:	MONDO:0002060

Definition

An intraluminal papillary epithelial neoplasm arising within the ducts. Representative examples are the intraductal breast papilloma and the salivary gland intraductal papilloma. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVIntraductal papilloma

Pathological process
- Disease
  - Neoplasm
    - Neoplasms by Histologic Type
      - Neoplasms, Glandular and Epithelial
        Neoplasms, Ductal, Lobular, and Medullary
        Intraductal papilloma
        Intraductal breast papilloma
        Atypical breast papilloma
        Central breast papilloma
        Intraductal breast papillomatosis
        Juvenile breast papillomatosis
        Microscopic breast papilloma
        Sclerosing breast papilloma
        Salivary Gland Intraductal Papilloma

Professional guidelines

PubMed

Differential Diagnosis of Benign and Malignant Breast Papillary Neoplasms on MRI With Non-mass Enhancement.

Zhou J, Li M, Liu D, Sheng F, Cai J
Acad Radiol 2023 Sep;30 Suppl 2:S127-S132. Epub 2023 Mar 9 doi: 10.1016/j.acra.2023.02.010. PMID: 36906443

Papillary neoplasms of the breast including upgrade rates and management of intraductal papilloma without atypia diagnosed at core needle biopsy.

Brogi E, Krystel-Whittemore M
Mod Pathol 2021 Jan;34(Suppl 1):78-93. Epub 2020 Oct 26 doi: 10.1038/s41379-020-00706-5. PMID: 33106592

Pathological criteria and practical issues in papillary lesions of the breast - a review.

Ni YB, Tse GM
Histopathology 2016 Jan;68(1):22-32. doi: 10.1111/his.12866. PMID: 26768027

See all (27)

Recent clinical studies

Etiology

Intraductal Papillomas.

Tierney SN
Surg Clin North Am 2022 Dec;102(6):965-972. doi: 10.1016/j.suc.2022.08.011. PMID: 36335931

Intraductal Papilloma on Breast Biopsy: Upstaging Rate and Implications for Practice Guidelines.

Jee Y, Bakht A, Burner JM, Coldren DL, Howard-McNatt M, Chiba A
Am Surg 2022 Jul;88(7):1467-1470. Epub 2022 Apr 14 doi: 10.1177/00031348221082276. PMID: 35420506

Papillary neoplasms of the breast including upgrade rates and management of intraductal papilloma without atypia diagnosed at core needle biopsy.

Brogi E, Krystel-Whittemore M
Mod Pathol 2021 Jan;34(Suppl 1):78-93. Epub 2020 Oct 26 doi: 10.1038/s41379-020-00706-5. PMID: 33106592

International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas.

Tanaka M, Fernández-del Castillo C, Adsay V, Chari S, Falconi M, Jang JY, Kimura W, Levy P, Pitman MB, Schmidt CM, Shimizu M, Wolfgang CL, Yamaguchi K, Yamao K; International Association of Pancreatology
Pancreatology 2012 May-Jun;12(3):183-97. Epub 2012 Apr 16 doi: 10.1016/j.pan.2012.04.004. PMID: 22687371

International consensus guidelines for management of intraductal papillary mucinous neoplasms and mucinous cystic neoplasms of the pancreas.

Tanaka M, Chari S, Adsay V, Fernandez-del Castillo C, Falconi M, Shimizu M, Yamaguchi K, Yamao K, Matsuno S; International Association of Pancreatology
Pancreatology 2006;6(1-2):17-32. doi: 10.1159/000090023. PMID: 16327281

See all (249)

Diagnosis

Intraductal Papillomas.

Tierney SN
Surg Clin North Am 2022 Dec;102(6):965-972. doi: 10.1016/j.suc.2022.08.011. PMID: 36335931

Papillary neoplasms of the breast-reviewing the spectrum.

Tay TKY, Tan PH
Mod Pathol 2021 Jun;34(6):1044-1061. Epub 2021 Jan 18 doi: 10.1038/s41379-020-00732-3. PMID: 33462367

Papillary neoplasms of the breast including upgrade rates and management of intraductal papilloma without atypia diagnosed at core needle biopsy.

Brogi E, Krystel-Whittemore M
Mod Pathol 2021 Jan;34(Suppl 1):78-93. Epub 2020 Oct 26 doi: 10.1038/s41379-020-00706-5. PMID: 33106592

Papillary Lesions of the Breast: An Update.

Wei S
Arch Pathol Lab Med 2016 Jul;140(7):628-43. doi: 10.5858/arpa.2015-0092-RA. PMID: 27362568

International consensus guidelines for management of intraductal papillary mucinous neoplasms and mucinous cystic neoplasms of the pancreas.

See all (438)

Therapy

Unusual recurrent metastasizing benign breast papilloma: a case report.

Jain AL, Mullins J, Smith JR, Valasareddy P, Miller E, Chaudhry A, Ryder J, Hare F, Ranganath H, Berry M, Robins D, Schwartzberg L, Vidal GA
J Med Case Rep 2020 Feb 19;14(1):33. doi: 10.1186/s13256-020-2354-7. PMID: 32070435 Free PMC Article

Underestimation of breast cancer in intraductal papillomas treated with vacuum-assisted core needle biopsy.

Hodorowicz-Zaniewska D, Siarkiewicz B, Brzuszkiewicz K, Szpor J
Ginekol Pol 2019;90(3):122-127. doi: 10.5603/GP.2019.0022. PMID: 30950000

Liver abscess with Citrobacter koseri bacteremia.

Kanzawa Y, Ishimaru N, Seto H, Tsutsumi T, Kinami S
Infez Med 2018 Sep 1;26(3):266-269. PMID: 30246771

Epithelial displacement in breast lesions: a papillary phenomenon.

Nagi C, Bleiweiss I, Jaffer S
Arch Pathol Lab Med 2005 Nov;129(11):1465-9. doi: 10.5858/2005-129-1465-EDIBLA. PMID: 16253028

Diagnosis and fine needle aspiration of intraductal papillary mucinous tumor by endoscopic ultrasound.

Bounds BC
Gastrointest Endosc Clin N Am 2002 Oct;12(4):735-45, vii. doi: 10.1016/s1052-5157(02)00031-4. PMID: 12607783

See all (31)

Prognosis

Intraductal papillary neoplasm of the bile duct: The new frontier of biliary pathology.

Mocchegiani F, Vincenzi P, Conte G, Nicolini D, Rossi R, Cacciaguerra AB, Vivarelli M
World J Gastroenterol 2023 Oct 14;29(38):5361-5373. doi: 10.3748/wjg.v29.i38.5361. PMID: 37900587 Free PMC Article

Upgrade rates of intraductal papilloma with and without atypia diagnosed on core needle biopsy and clinicopathologic predictors.

Corbin H, Bomeisl P, Amin AL, Marshall HN, Gilmore H, Harbhajanka A
Hum Pathol 2022 Oct;128:90-100. Epub 2022 Jul 19 doi: 10.1016/j.humpath.2022.07.012. PMID: 35863513

Papillary Neoplasms of the Salivary Duct System: A Review.

Agaimy A
Surg Pathol Clin 2021 Mar;14(1):53-65. Epub 2020 Dec 15 doi: 10.1016/j.path.2020.09.007. PMID: 33526223

Papillary neoplasms of the breast-reviewing the spectrum.

Tay TKY, Tan PH
Mod Pathol 2021 Jun;34(6):1044-1061. Epub 2021 Jan 18 doi: 10.1038/s41379-020-00732-3. PMID: 33462367

Mammary and extramammary Paget's disease.

Lopes Filho LL, Lopes IM, Lopes LR, Enokihara MM, Michalany AO, Matsunaga N
An Bras Dermatol 2015 Mar-Apr;90(2):225-31. doi: 10.1590/abd1806-4841.20153189. PMID: 25830993 Free PMC Article

See all (163)

Clinical prediction guides

Upgrade rates of intraductal papilloma with and without atypia diagnosed on core needle biopsy and clinicopathologic predictors.

Corbin H, Bomeisl P, Amin AL, Marshall HN, Gilmore H, Harbhajanka A
Hum Pathol 2022 Oct;128:90-100. Epub 2022 Jul 19 doi: 10.1016/j.humpath.2022.07.012. PMID: 35863513

A retrospective observational study of intraductal breast papilloma and its coexisting lesions: A real-world experience.

Li X, Wang H, Sun Z, Fan C, Jin F, Mao X
Cancer Med 2020 Oct;9(20):7751-7762. Epub 2020 Aug 21 doi: 10.1002/cam4.3308. PMID: 32822113 Free PMC Article

Papillary lesions of the breast: To excise or observe?

Khan S, Diaz A, Archer KJ, Lehman RR, Mullins T, Cardenosa G, Bear HD
Breast J 2018 May;24(3):350-355. Epub 2017 Aug 27 doi: 10.1111/tbj.12907. PMID: 28845569

MRI characteristics of intraductal papilloma.

Wang W, Ding J, Yang W, Li Y, Zhou L, Zhang S, Zhu H, Mao J, Tang J, Gu Y, Peng W
Acta Radiol 2015 Mar;56(3):276-83. Epub 2014 Apr 2 doi: 10.1177/0284185114526590. PMID: 24696194

Intraductal papillary lesions of the breast: clinical and pathological correlation.

Shouhed D, Amersi FF, Spurrier R, Dang C, Astvatsaturyan K, Bose S, Phillips E
Am Surg 2012 Oct;78(10):1161-5. PMID: 23025963

See all (168)