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Small Intestinal Low Grade Intraepithelial Neoplasia

MedGen UID:
277654
•Concept ID:
C1336002
•
Neoplastic Process
Synonym: Small Intestinal Low-Grade Dysplasia

Definition

A precancerous neoplastic process that affects the small intestine. It is characterized by mild epithelial dysplasia and mild architectural alterations of the mucosal epithelium. There is no evidence of invasion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmall Intestinal Low Grade Intraepithelial Neoplasia

Professional guidelines

PubMed

A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article

Recent clinical studies

Etiology

Preneoplastic lesions in the liver: Molecular insights and relevance for clinical practice.
Desjonqueres E, Campani C, Marra F, Zucman-Rossi J, Nault JC
Liver Int 2022 Mar;42(3):492-506. Epub 2022 Jan 17 doi: 10.1111/liv.15152. PMID: 34982503
Pancreatic Intraepithelial Neoplasia (PanIN) as a Morphologic Marker of Pancreatobiliary Type of Ampullary Carcinoma.
Krishnamurthy K, Sriganeshan V
Pathol Oncol Res 2020 Jul;26(3):1735-1739. Epub 2019 Oct 22 doi: 10.1007/s12253-019-00754-6. PMID: 31642034
Short- and long-term outcomes of endoscopically treated superficial non-ampullary duodenal epithelial tumors.
Hara Y, Goda K, Dobashi A, Ohya TR, Kato M, Sumiyama K, Mitsuishi T, Hirooka S, Ikegami M, Tajiri H
World J Gastroenterol 2019 Feb 14;25(6):707-718. doi: 10.3748/wjg.v25.i6.707. PMID: 30783374Free PMC Article
A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article
Comparison between the location and the histomorphological/immunohistochemical characteristics of noninvasive neoplasms of the ampulla of Vater.
Yamamoto Y, Nemoto T, Okubo Y, Nihonyanagi Y, Ishiwatari T, Takuma K, Tochigi N, Okano N, Wakayama M, Igarashi Y, Shibuya K
Hum Pathol 2014 Sep;45(9):1910-7. Epub 2014 Jun 12 doi: 10.1016/j.humpath.2014.05.013. PMID: 25081540

Diagnosis

Preneoplastic lesions in the liver: Molecular insights and relevance for clinical practice.
Desjonqueres E, Campani C, Marra F, Zucman-Rossi J, Nault JC
Liver Int 2022 Mar;42(3):492-506. Epub 2022 Jan 17 doi: 10.1111/liv.15152. PMID: 34982503
Short- and long-term outcomes of endoscopically treated superficial non-ampullary duodenal epithelial tumors.
Hara Y, Goda K, Dobashi A, Ohya TR, Kato M, Sumiyama K, Mitsuishi T, Hirooka S, Ikegami M, Tajiri H
World J Gastroenterol 2019 Feb 14;25(6):707-718. doi: 10.3748/wjg.v25.i6.707. PMID: 30783374Free PMC Article
A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article
Expression of proliferative biomarkers in anal intraepithelial neoplasia of HIV-positive men.
Kreuter A, Jesse M, Potthoff A, Brockmeyer NH, Gambichler T, Stücker M, Bechara FG, Pfister H, Wieland U
J Am Acad Dermatol 2010 Sep;63(3):490-8. Epub 2009 Dec 16 doi: 10.1016/j.jaad.2009.08.043. PMID: 20006407
Diagnosis of esophagogastric tumors.
Moretó M
Endoscopy 2005 Jan;37(1):26-32. doi: 10.1055/s-2004-826095. PMID: 15657854

Therapy

Short- and long-term outcomes of endoscopically treated superficial non-ampullary duodenal epithelial tumors.
Hara Y, Goda K, Dobashi A, Ohya TR, Kato M, Sumiyama K, Mitsuishi T, Hirooka S, Ikegami M, Tajiri H
World J Gastroenterol 2019 Feb 14;25(6):707-718. doi: 10.3748/wjg.v25.i6.707. PMID: 30783374Free PMC Article
Clinical outcome of endoscopic resection for nonampullary duodenal tumors.
Nonaka S, Oda I, Tada K, Mori G, Sato Y, Abe S, Suzuki H, Yoshinaga S, Nakajima T, Matsuda T, Taniguchi H, Saito Y, Maetani I
Endoscopy 2015 Feb;47(2):129-35. Epub 2014 Oct 14 doi: 10.1055/s-0034-1390774. PMID: 25314330
Short-term results of 42 endoscopic ampullectomies: a single-center experience.
Jeanniard-Malet O, Caillol F, Pesenti C, Bories E, Monges G, Giovannini M
Scand J Gastroenterol 2011 Jul;46(7-8):1014-9. Epub 2011 Apr 15 doi: 10.3109/00365521.2011.571711. PMID: 21492053
Precancerous bile duct pathology in end-stage primary sclerosing cholangitis, with and without cholangiocarcinoma.
Lewis JT, Talwalkar JA, Rosen CB, Smyrk TC, Abraham SC
Am J Surg Pathol 2010 Jan;34(1):27-34. doi: 10.1097/PAS.0b013e3181bc96f9. PMID: 19898228

Prognosis

Significance of High-Mobility Group A Protein 2 Expression in Pancreatic Ductal Adenocarcinoma and Ampullary Adenocarcinoma.
Oflas D, Canaz F, Özer İ, Demir L, Çolak E
Turk J Gastroenterol 2023 Oct;34(10):1014-1024. doi: 10.5152/tjg.2023.22881. PMID: 37787719Free PMC Article
Pancreatic Intraepithelial Neoplasia (PanIN) as a Morphologic Marker of Pancreatobiliary Type of Ampullary Carcinoma.
Krishnamurthy K, Sriganeshan V
Pathol Oncol Res 2020 Jul;26(3):1735-1739. Epub 2019 Oct 22 doi: 10.1007/s12253-019-00754-6. PMID: 31642034
Initial and crucial genetic events in intestinal-type gastric intramucosal neoplasia.
Rokutan H, Abe H, Nakamura H, Ushiku T, Arakawa E, Hosoda F, Yachida S, Tsuji Y, Fujishiro M, Koike K, Totoki Y, Fukayama M, Shibata T
J Pathol 2019 Apr;247(4):494-504. Epub 2019 Jan 16 doi: 10.1002/path.5208. PMID: 30474112
A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article
Diagnosis of esophagogastric tumors.
Moretó M
Endoscopy 2005 Jan;37(1):26-32. doi: 10.1055/s-2004-826095. PMID: 15657854

Clinical prediction guides

Pancreatic Intraepithelial Neoplasia (PanIN) as a Morphologic Marker of Pancreatobiliary Type of Ampullary Carcinoma.
Krishnamurthy K, Sriganeshan V
Pathol Oncol Res 2020 Jul;26(3):1735-1739. Epub 2019 Oct 22 doi: 10.1007/s12253-019-00754-6. PMID: 31642034
Short- and long-term outcomes of endoscopically treated superficial non-ampullary duodenal epithelial tumors.
Hara Y, Goda K, Dobashi A, Ohya TR, Kato M, Sumiyama K, Mitsuishi T, Hirooka S, Ikegami M, Tajiri H
World J Gastroenterol 2019 Feb 14;25(6):707-718. doi: 10.3748/wjg.v25.i6.707. PMID: 30783374Free PMC Article
Initial and crucial genetic events in intestinal-type gastric intramucosal neoplasia.
Rokutan H, Abe H, Nakamura H, Ushiku T, Arakawa E, Hosoda F, Yachida S, Tsuji Y, Fujishiro M, Koike K, Totoki Y, Fukayama M, Shibata T
J Pathol 2019 Apr;247(4):494-504. Epub 2019 Jan 16 doi: 10.1002/path.5208. PMID: 30474112
A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article
Diagnosis of esophagogastric tumors.
Moretó M
Endoscopy 2005 Jan;37(1):26-32. doi: 10.1055/s-2004-826095. PMID: 15657854

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