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Intraepithelial neoplasia

MedGen UID:
164203
Concept ID:
C0878500
Neoplastic Process
Synonyms: Intraepithelial Neoplasm; Intraepithelial Neoplasms; Neoplasm, Intraepithelial; Neoplasms, Intraepithelial
SNOMED CT: Epithelial dysplasia (61313004)
 
Monarch Initiative: MONDO:0024474

Definition

A precancerous neoplastic process that affects the squamous, glandular, or transitional cell epithelium without evidence of invasion. According to the degree of nuclear atypia, number of mitotic figures, and presence of architectural distortion, it is classified as low grade (mild dysplasia) or high grade (moderate or severe dysplasia). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIntraepithelial neoplasia

Professional guidelines

PubMed

Edwards SK, Bunker CB, van der Snoek EM, van der Meijden WI
J Eur Acad Dermatol Venereol 2023 Jun;37(6):1104-1117. Epub 2023 Mar 21 doi: 10.1111/jdv.18954. PMID: 36942977
Lebreton M, Carton I, Brousse S, Lavoué V, Body G, Levêque J, Nyangoh-Timoh K
J Gynecol Obstet Hum Reprod 2020 Nov;49(9):101801. Epub 2020 May 14 doi: 10.1016/j.jogoh.2020.101801. PMID: 32417455
McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695Free PMC Article

Recent clinical studies

Etiology

Borella F, Gallio N, Mangherini L, Cassoni P, Bertero L, Benedetto C, Preti M
J Med Virol 2023 Nov;95(11):e29238. doi: 10.1002/jmv.29238. PMID: 38009696
Dockery LE, Soper JT
Obstet Gynecol Surv 2021 Jan;76(1):55-62. doi: 10.1097/OGX.0000000000000857. PMID: 33506879
Curty G, de Carvalho PS, Soares MA
Int J Mol Sci 2019 Dec 28;21(1) doi: 10.3390/ijms21010222. PMID: 31905652Free PMC Article
Krajciova J, Vackova Z, Spicak J, Martinek J
Minerva Chir 2018 Aug;73(4):366-377. Epub 2018 May 25 doi: 10.23736/S0026-4733.18.07783-0. PMID: 29806757
Jarboe EA, Mutter GL
Semin Diagn Pathol 2010 Nov;27(4):215-25. doi: 10.1053/j.semdp.2010.09.007. PMID: 21309257

Diagnosis

Li Z, Liu P, Wang Z, Zhang Z, Chen Z, Chu R, Li G, Han Q, Zhao Y, Li L, Miao J, Kong B, Song K
Lancet Oncol 2023 Apr;24(4):403-414. Epub 2023 Mar 15 doi: 10.1016/S1470-2045(23)00066-9. PMID: 36933562
Cai Q, Shah RB
Surg Pathol Clin 2022 Dec;15(4):591-608. Epub 2022 Oct 13 doi: 10.1016/j.path.2022.07.001. PMID: 36344177
Dockery LE, Soper JT
Obstet Gynecol Surv 2021 Jan;76(1):55-62. doi: 10.1097/OGX.0000000000000857. PMID: 33506879
Curty G, de Carvalho PS, Soares MA
Int J Mol Sci 2019 Dec 28;21(1) doi: 10.3390/ijms21010222. PMID: 31905652Free PMC Article
Allbritton JI
Obstet Gynecol Clin North Am 2017 Sep;44(3):339-352. doi: 10.1016/j.ogc.2017.04.002. PMID: 28778635

Therapy

Grammatikopoulou MG, Gkiouras K, Papageorgiou SΤ, Myrogiannis I, Mykoniatis I, Papamitsou T, Bogdanos DP, Goulis DG
Nutrients 2020 Sep 29;12(10) doi: 10.3390/nu12102985. PMID: 33003518Free PMC Article
DeCensi A, Puntoni M, Guerrieri-Gonzaga A, Caviglia S, Avino F, Cortesi L, Taverniti C, Pacquola MG, Falcini F, Gulisano M, Digennaro M, Cariello A, Cagossi K, Pinotti G, Lazzeroni M, Serrano D, Branchi D, Campora S, Petrera M, Buttiron Webber T, Boni L, Bonanni B
J Clin Oncol 2019 Jul 1;37(19):1629-1637. Epub 2019 Apr 11 doi: 10.1200/JCO.18.01779. PMID: 30973790Free PMC Article
Santesso N, Mustafa RA, Wiercioch W, Kehar R, Gandhi S, Chen Y, Cheung A, Hopkins J, Khatib R, Ma B, Mustafa AA, Lloyd N, Wu D, Broutet N, Schünemann HJ
Int J Gynaecol Obstet 2016 Mar;132(3):266-71. Epub 2015 Nov 28 doi: 10.1016/j.ijgo.2015.07.026. PMID: 26643302
Joura EA, Giuliano AR, Iversen OE, Bouchard C, Mao C, Mehlsen J, Moreira ED Jr, Ngan Y, Petersen LK, Lazcano-Ponce E, Pitisuttithum P, Restrepo JA, Stuart G, Woelber L, Yang YC, Cuzick J, Garland SM, Huh W, Kjaer SK, Bautista OM, Chan IS, Chen J, Gesser R, Moeller E, Ritter M, Vuocolo S, Luxembourg A; Broad Spectrum HPV Vaccine Study
N Engl J Med 2015 Feb 19;372(8):711-23. doi: 10.1056/NEJMoa1405044. PMID: 25693011
Lippman SM, Hawk ET
Cancer Res 2009 Jul 1;69(13):5269-84. Epub 2009 Jun 2 doi: 10.1158/0008-5472.CAN-09-1750. PMID: 19491253

Prognosis

Kristiansen S, Torbrand C, Svensson Å, Forslund O, Bjartling C
BJU Int 2022 Jun;129(6):752-759. Epub 2022 Jan 24 doi: 10.1111/bju.15688. PMID: 35044047Free PMC Article
Kalliala I, Athanasiou A, Veroniki AA, Salanti G, Efthimiou O, Raftis N, Bowden S, Paraskevaidi M, Aro K, Arbyn M, Bennett P, Nieminen P, Paraskevaidis E, Kyrgiou M
Ann Oncol 2020 Feb;31(2):213-227. Epub 2020 Jan 3 doi: 10.1016/j.annonc.2019.11.004. PMID: 31959338Free PMC Article
DeCensi A, Puntoni M, Guerrieri-Gonzaga A, Caviglia S, Avino F, Cortesi L, Taverniti C, Pacquola MG, Falcini F, Gulisano M, Digennaro M, Cariello A, Cagossi K, Pinotti G, Lazzeroni M, Serrano D, Branchi D, Campora S, Petrera M, Buttiron Webber T, Boni L, Bonanni B
J Clin Oncol 2019 Jul 1;37(19):1629-1637. Epub 2019 Apr 11 doi: 10.1200/JCO.18.01779. PMID: 30973790Free PMC Article
McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695Free PMC Article
Joura EA, Garland SM, Paavonen J, Ferris DG, Perez G, Ault KA, Huh WK, Sings HL, James MK, Haupt RM; FUTURE I and II Study Group
BMJ 2012 Mar 27;344:e1401. doi: 10.1136/bmj.e1401. PMID: 22454089Free PMC Article

Clinical prediction guides

Epstein JI, Amin MB, Fine SW, Algaba F, Aron M, Baydar DE, Beltran AL, Brimo F, Cheville JC, Colecchia M, Comperat E, da Cunha IW, Delprado W, DeMarzo AM, Giannico GA, Gordetsky JB, Guo CC, Hansel DE, Hirsch MS, Huang J, Humphrey PA, Jimenez RE, Khani F, Kong Q, Kryvenko ON, Kunju LP, Lal P, Latour M, Lotan T, Maclean F, Magi-Galluzzi C, Mehra R, Menon S, Miyamoto H, Montironi R, Netto GJ, Nguyen JK, Osunkoya AO, Parwani A, Robinson BD, Rubin MA, Shah RB, So JS, Takahashi H, Tavora F, Tretiakova MS, True L, Wobker SE, Yang XJ, Zhou M, Zynger DL, Trpkov K
Arch Pathol Lab Med 2021 Apr 1;145(4):461-493. doi: 10.5858/arpa.2020-0015-RA. PMID: 32589068
Noë M, Brosens LA
Surg Pathol Clin 2016 Dec;9(4):561-580. Epub 2016 Oct 12 doi: 10.1016/j.path.2016.05.004. PMID: 27926360
Kato M
World J Gastroenterol 2015 Nov 28;21(44):12513-8. doi: 10.3748/wjg.v21.i44.12513. PMID: 26640329Free PMC Article
Frederiksen ME, Njor S, Lynge E, Rebolj M
Sex Transm Infect 2015 Jun;91(4):248-56. Epub 2014 Dec 15 doi: 10.1136/sextrans-2014-051754. PMID: 25512668
Palefsky JM
Sex Health 2012 Dec;9(6):580-6. doi: 10.1071/SH12045. PMID: 23380236

Recent systematic reviews

Kechagias KS, Kalliala I, Bowden SJ, Athanasiou A, Paraskevaidi M, Paraskevaidis E, Dillner J, Nieminen P, Strander B, Sasieni P, Veroniki AA, Kyrgiou M
BMJ 2022 Aug 3;378:e070135. doi: 10.1136/bmj-2022-070135. PMID: 35922074Free PMC Article
Arbyn M, Simon M, de Sanjosé S, Clarke MA, Poljak M, Rezhake R, Berkhof J, Nyaga V, Gultekin M, Canfell K, Wentzensen N
Lancet Oncol 2022 Jul;23(7):950-960. Epub 2022 Jun 13 doi: 10.1016/S1470-2045(22)00294-7. PMID: 35709810
Nees LK, Heublein S, Steinmacher S, Juhasz-Böss I, Brucker S, Tempfer CB, Wallwiener M
Arch Gynecol Obstet 2022 Aug;306(2):407-421. Epub 2022 Jan 10 doi: 10.1007/s00404-021-06380-5. PMID: 35001185Free PMC Article
Drolet M, Bénard É, Pérez N, Brisson M; HPV Vaccination Impact Study Group
Lancet 2019 Aug 10;394(10197):497-509. Epub 2019 Jun 26 doi: 10.1016/S0140-6736(19)30298-3. PMID: 31255301Free PMC Article
Tainio K, Athanasiou A, Tikkinen KAO, Aaltonen R, Cárdenas J, Hernándes, Glazer-Livson S, Jakobsson M, Joronen K, Kiviharju M, Louvanto K, Oksjoki S, Tähtinen R, Virtanen S, Nieminen P, Kyrgiou M, Kalliala I
BMJ 2018 Feb 27;360:k499. doi: 10.1136/bmj.k499. PMID: 29487049Free PMC Article

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