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Testicular Mixed Choriocarcinoma and Teratoma

MedGen UID:
277811
•Concept ID:
C1336714
•
Neoplastic Process
Synonyms: Mixed Choriocarcinoma and Teratoma of Testis; Mixed Choriocarcinoma and Teratoma of the Testis

Definition

A malignant mixed germ cell tumor arising from the testis. It is characterized by the presence of a teratomatous component and malignant syncytiotrophoblastic cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTesticular Mixed Choriocarcinoma and Teratoma

Professional guidelines

PubMed

Role of HNF1β in the differential diagnosis of yolk sac tumor from other germ cell tumors.
Rougemont AL, Tille JC
Hum Pathol 2018 Nov;81:26-36. Epub 2018 May 16 doi: 10.1016/j.humpath.2018.04.025. PMID: 29753846
Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues.
Ulbright TM
Mod Pathol 2005 Feb;18 Suppl 2:S61-79. doi: 10.1038/modpathol.3800310. PMID: 15761467
The treatment of cranial germ cell tumours.
Brandes AA, Pasetto LM, Monfardini S
Cancer Treat Rev 2000 Aug;26(4):233-42. doi: 10.1053/ctrv.2000.0169. PMID: 10913379

Recent clinical studies

Etiology

Intratubular germ cell neoplasia of the testis: a brief review.
Al-Hussain T, Bakshi N, Akhtar M
Adv Anat Pathol 2015 May;22(3):202-12. doi: 10.1097/PAP.0000000000000066. PMID: 25844678
Testicular tumors: clinically relevant histological findings.
Ayala AG, Ro JY
Semin Urol Oncol 1998 May;16(2):72-81. PMID: 9649230
Pathology of testicular germ cell tumors.
Brodsky GL
Hematol Oncol Clin North Am 1991 Dec;5(6):1095-126. PMID: 1663935
Sequential excision of residual thoracic and retroperitoneal masses after chemotherapy for stage III germ cell tumors.
Tiffany P, Morse MJ, Bosl G, Vaughan ED Jr, Sogani PC, Herr HW, Whitmore WF Jr
Cancer 1986 Mar 1;57(5):978-83. doi: 10.1002/1097-0142(19860301)57:5<978::aid-cncr2820570517>3.0.co;2-9. PMID: 3002596
Sonographic detection of occult testicular neoplasms.
Glazer HS, Lee JK, Melson GL, McClennan BL
AJR Am J Roentgenol 1982 Apr;138(4):673-5. doi: 10.2214/ajr.138.4.673. PMID: 6978030

Diagnosis

Placental Site Trophoblastic Tumor in Mediastinal Recurrence of Mixed Germ Cell Tumor of the Testis: Report of a Case and Review of the Literature.
Budina A, Sharma T
Int J Surg Pathol 2023 Aug;31(5):585-591. Epub 2022 Jun 14 doi: 10.1177/10668969221105615. PMID: 35702046
Single synchronous pulmonary metastasis from placental site trophoblastic tumor and teratoma.
Billè A, Girelli L, Colecchia M, Pastorino U
Tumori 2015 Jun 25;101(3):e110-1. doi: 10.5301/tj.5000290. PMID: 25908040
Testicular tumors: clinically relevant histological findings.
Ayala AG, Ro JY
Semin Urol Oncol 1998 May;16(2):72-81. PMID: 9649230
Pathology of testicular germ cell tumors.
Brodsky GL
Hematol Oncol Clin North Am 1991 Dec;5(6):1095-126. PMID: 1663935
Germ-cell tumors of the mediastinum, postmortem findings.
Luna MA, Valenzuela-Tamariz J
Am J Clin Pathol 1976 Apr;65(4):450-4. doi: 10.1093/ajcp/65.4.450. PMID: 178171

Therapy

Role of High-Dose Chemotherapy With Autologous Stem-Cell Rescue in Men With Previously Treated Germ Cell Tumors.
Pagliaro LC
J Clin Oncol 2017 Apr 1;35(10):1036-1040. Epub 2016 Dec 19 doi: 10.1200/JCO.2016.70.6523. PMID: 27992270
Sequential excision of residual thoracic and retroperitoneal masses after chemotherapy for stage III germ cell tumors.
Tiffany P, Morse MJ, Bosl G, Vaughan ED Jr, Sogani PC, Herr HW, Whitmore WF Jr
Cancer 1986 Mar 1;57(5):978-83. doi: 10.1002/1097-0142(19860301)57:5<978::aid-cncr2820570517>3.0.co;2-9. PMID: 3002596
Characteristics and chemotherapeutic sensitivity of a human testicular cancer grown in artificially immunosuppressed mice.
Lapis P, Kopper L, Bodrogi I, Sugár J, Lapis K, Eckhardt S
Oncology 1985;42(2):112-8. doi: 10.1159/000226012. PMID: 2581199
Potential therapeutic and diagnostic applications of the growth of testicular cancer in soft agar.
Foster BJ, Javadpour N, Ozols RF
Int J Cell Cloning 1983 Apr;1(1):2-14. doi: 10.1002/stem.5530010103. PMID: 6201566

Prognosis

Germ-cell tumors of the mediastinum.
Weidner N
Semin Diagn Pathol 1999 Feb;16(1):42-50. PMID: 10355653
Testicular tumors: clinically relevant histological findings.
Ayala AG, Ro JY
Semin Urol Oncol 1998 May;16(2):72-81. PMID: 9649230
Pathology of testicular germ cell tumors.
Brodsky GL
Hematol Oncol Clin North Am 1991 Dec;5(6):1095-126. PMID: 1663935
Sequential excision of residual thoracic and retroperitoneal masses after chemotherapy for stage III germ cell tumors.
Tiffany P, Morse MJ, Bosl G, Vaughan ED Jr, Sogani PC, Herr HW, Whitmore WF Jr
Cancer 1986 Mar 1;57(5):978-83. doi: 10.1002/1097-0142(19860301)57:5<978::aid-cncr2820570517>3.0.co;2-9. PMID: 3002596
Immunohistological localization of AFP and HCG in uniformly classified testis tumors.
Wittekind C, Wichmann T, Von Kleist S
Anticancer Res 1983 Sep-Oct;3(5):327-30. PMID: 6197005

Clinical prediction guides

Diagnostically misleading aberrant terminal deoxynucleotidyl transferase expression in germ cell tumors.
Pęksa R, Kunc M, Bieńkowski M, Popęda M, Biernat W
Pol J Pathol 2022;73(2):159-165. doi: 10.5114/pjp.2022.120098. PMID: 36345953
ZBTB16: a novel sensitive and specific biomarker for yolk sac tumor.
Xiao GQ, Li F, Unger PD, Katerji H, Yang Q, McMahon L, Burstein DE
Mod Pathol 2016 Jun;29(6):591-8. Epub 2016 Feb 26 doi: 10.1038/modpathol.2016.46. PMID: 26916077
An overview of testicular germ cell tumors.
Bahrami A, Ro JY, Ayala AG
Arch Pathol Lab Med 2007 Aug;131(8):1267-80. doi: 10.5858/2007-131-1267-AOOTGC. PMID: 17683189
Testicular tumors: clinically relevant histological findings.
Ayala AG, Ro JY
Semin Urol Oncol 1998 May;16(2):72-81. PMID: 9649230
The ultrastructure and histogenesis of male germ neoplasia with emphasis on seminoma with early carcinomatous features.
Srigley JR, Mackay B, Toth P, Ayala A
Ultrastruct Pathol 1988 Jan-Feb;12(1):67-86. doi: 10.3109/01913128809048477. PMID: 2832992

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