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Testicular Mixed Yolk Sac Tumor and Teratoma

MedGen UID:
277814
•Concept ID:
C1336721
•
Neoplastic Process
Synonyms: Mixed Endodermal Sinus Neoplasm and Teratoma of Testis; Mixed Endodermal Sinus Neoplasm and Teratoma of the Testis; Mixed Endodermal Sinus Tumor and Teratoma of Testis; Mixed Endodermal Sinus Tumor and Teratoma of the Testis; Mixed Yolk Sac Neoplasm and Teratoma of Testis; Mixed Yolk Sac Neoplasm and Teratoma of the Testis; Mixed Yolk Sac Tumor and Teratoma of Testis; Mixed Yolk Sac Tumor and Teratoma of the Testis; Testicular Mixed Endodermal Sinus Neoplasm and Teratoma; Testicular Mixed Endodermal Sinus Tumor and Teratoma; Testicular Mixed Yolk Sac Neoplasm and Teratoma

Definition

A malignant non-seminomatous germ cell tumor arising from the testis. It is characterized by a mixture of yolk sac and teratomatous morphologic elements. Patients may present with painless or painful testicular swelling. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTesticular Mixed Yolk Sac Tumor and Teratoma

Professional guidelines

PubMed

Primary Mediastinal Nonseminomas: A Population-Based Surveillance, Epidemiology, and End Results Analysis.
Yang X, Zhao K, Mei J, Wei S, Xia L, Pu Y, Liu L
J Surg Res 2021 Nov;267:25-36. Epub 2021 Jun 11 doi: 10.1016/j.jss.2021.04.022. PMID: 34126390
Characteristics, treatment decisions and outcomes of prepubertal testicular germ cell tumor: A descriptive analysis from a large Chinese center.
Liu P, Li W, Song HC, Jiao LL, Zhang WP, Sun N
J Pediatr Urol 2018 Oct;14(5):443.e1-443.e7. Epub 2018 Apr 3 doi: 10.1016/j.jpurol.2018.02.030. PMID: 29705139
The treatment of cranial germ cell tumours.
Brandes AA, Pasetto LM, Monfardini S
Cancer Treat Rev 2000 Aug;26(4):233-42. doi: 10.1053/ctrv.2000.0169. PMID: 10913379

Recent clinical studies

Etiology

Malignant testicular tumors in children: A single institution's 12-year experience.
Chiu CC, Jaing TH, Lai JY, Chen SH, Chang TY, Hsueh C, Wen YC, Tsay PK
Medicine (Baltimore) 2022 Jul 22;101(29):e29735. doi: 10.1097/MD.0000000000029735. PMID: 35866814Free PMC Article
Testicular Tumors: A Contemporary Update on Morphologic, Immunohistochemical and Molecular Features.
Al-Obaidy KI, Idrees MT
Adv Anat Pathol 2021 Jul 1;28(4):258-275. doi: 10.1097/PAP.0000000000000302. PMID: 33871428
Perspectives in Pediatric Pathology, Chapter 25. Testicular and Paratesticular Tumors in the Pediatric Age Group.
Nistal M, Paniagua R, González-Peramato P, Reyes-Múgica M
Pediatr Dev Pathol 2016 Nov/Dec;19(6):471-492. Epub 2016 Sep 14 doi: 10.2350/16-09-1829-PER.1. PMID: 27626837
Intratubular germ cell neoplasia of the testis: a brief review.
Al-Hussain T, Bakshi N, Akhtar M
Adv Anat Pathol 2015 May;22(3):202-12. doi: 10.1097/PAP.0000000000000066. PMID: 25844678
Germ cell neoplasms of the testis.
Ulbright TM
Am J Surg Pathol 1993 Nov;17(11):1075-91. doi: 10.1097/00000478-199311000-00001. PMID: 8214253

Diagnosis

Metastatic germ cell tumour in effusion cytology.
Saini T, Kundu R, Rastogi P, Rohilla M, Gupta P, Gupta N, Srinivasan R, Dey P
Cytopathology 2022 Jul;33(4):493-498. Epub 2022 Apr 9 doi: 10.1111/cyt.13122. PMID: 35347771
Testicular Tumors: A Contemporary Update on Morphologic, Immunohistochemical and Molecular Features.
Al-Obaidy KI, Idrees MT
Adv Anat Pathol 2021 Jul 1;28(4):258-275. doi: 10.1097/PAP.0000000000000302. PMID: 33871428
ZBTB16: a novel sensitive and specific biomarker for yolk sac tumor.
Xiao GQ, Li F, Unger PD, Katerji H, Yang Q, McMahon L, Burstein DE
Mod Pathol 2016 Jun;29(6):591-8. Epub 2016 Feb 26 doi: 10.1038/modpathol.2016.46. PMID: 26916077
Tumors of the Testis: Morphologic Features and Molecular Alterations.
Howitt BE, Berney DM
Surg Pathol Clin 2015 Dec;8(4):687-716. doi: 10.1016/j.path.2015.07.007. PMID: 26612222
Testicular tumors--some new and a few perennial problems.
Young RH
Arch Pathol Lab Med 2008 Apr;132(4):548-64. doi: 10.5858/2008-132-548-TTNAAF. PMID: 18384207

Therapy

Pathologic findings and clinical outcomes in patients who required neoadjuvant chemotherapy before orchiectomy for testicular germ cell tumors.
Stump JA, Acosta AM, Whaley RD, Cheng L, Fang AM, Rais-Bahrami S, Gordetsky JB
Hum Pathol 2022 Oct;128:48-55. Epub 2022 Jul 9 doi: 10.1016/j.humpath.2022.06.026. PMID: 35817140
Prepubertal testicular and paratesticular tumors in China: a single-center experience over a 10-year period.
Wang X, Xu S, Tang D, Li M, Wu D, Huang Y
J Pediatr Surg 2012 Aug;47(8):1576-80. doi: 10.1016/j.jpedsurg.2011.11.005. PMID: 22901920
Survival after an antiangiogenetic therapy and surgery in a wide spread growing teratoma originating from a testicular mixed malignant germ cell tumor.
Calaminus G, Schneider DT, Weissbach L, Schönberger S, Okpanyi V, Leuschner I, Poremba C, Göbel U
Klin Padiatr 2009 May-Jun;221(3):136-40. Epub 2009 May 12 doi: 10.1055/s-0029-1220738. PMID: 19437360
Prognostic value of tumor size, metastases, extension into bone, and increased tumor marker in children with malignant sacrococcygeal germ cell tumors: a prospective evaluation of 71 patients treated in the German cooperative protocols Maligne Keimzelltumoren (MAKEI) 83/86 and MAKEI 89.
Calaminus G, Schneider DT, Bökkerink JP, Gadner H, Harms D, Willers R, Göbel U
J Clin Oncol 2003 Mar 1;21(5):781-6. doi: 10.1200/JCO.2003.03.125. PMID: 12610174
Testicular and paratesticular tumours in children: 30 years' experience.
Sugita Y, Clarnette TD, Cooke-Yarborough C, Chow CW, Waters K, Hutson JM
Aust N Z J Surg 1999 Jul;69(7):505-8. doi: 10.1046/j.1440-1622.1999.01612.x. PMID: 10442922

Prognosis

Characteristics, treatment decisions and outcomes of prepubertal testicular germ cell tumor: A descriptive analysis from a large Chinese center.
Liu P, Li W, Song HC, Jiao LL, Zhang WP, Sun N
J Pediatr Urol 2018 Oct;14(5):443.e1-443.e7. Epub 2018 Apr 3 doi: 10.1016/j.jpurol.2018.02.030. PMID: 29705139
Perspectives in Pediatric Pathology, Chapter 25. Testicular and Paratesticular Tumors in the Pediatric Age Group.
Nistal M, Paniagua R, González-Peramato P, Reyes-Múgica M
Pediatr Dev Pathol 2016 Nov/Dec;19(6):471-492. Epub 2016 Sep 14 doi: 10.2350/16-09-1829-PER.1. PMID: 27626837
ZBTB16: a novel sensitive and specific biomarker for yolk sac tumor.
Xiao GQ, Li F, Unger PD, Katerji H, Yang Q, McMahon L, Burstein DE
Mod Pathol 2016 Jun;29(6):591-8. Epub 2016 Feb 26 doi: 10.1038/modpathol.2016.46. PMID: 26916077
Prepubertal testicular tumours and efficacy of testicular preserving surgery.
Bujons A, Sfulcini JC, Pascual M, Feu OA, Garat JM, Villavicencio H
BJU Int 2011 Jun;107(11):1812-6. Epub 2010 Oct 29 doi: 10.1111/j.1464-410X.2010.09796.x. PMID: 21040368
The treatment of cranial germ cell tumours.
Brandes AA, Pasetto LM, Monfardini S
Cancer Treat Rev 2000 Aug;26(4):233-42. doi: 10.1053/ctrv.2000.0169. PMID: 10913379

Clinical prediction guides

Testis-sparing surgery in children with testicular tumors: A systematic review and meta-analysis.
Miao X, Li Y, Zhou T, Lv M
Asian J Surg 2021 Dec;44(12):1503-1509. Epub 2021 Apr 21 doi: 10.1016/j.asjsur.2021.03.016. PMID: 33893031
Perspectives in Pediatric Pathology, Chapter 25. Testicular and Paratesticular Tumors in the Pediatric Age Group.
Nistal M, Paniagua R, González-Peramato P, Reyes-Múgica M
Pediatr Dev Pathol 2016 Nov/Dec;19(6):471-492. Epub 2016 Sep 14 doi: 10.2350/16-09-1829-PER.1. PMID: 27626837
ZBTB16: a novel sensitive and specific biomarker for yolk sac tumor.
Xiao GQ, Li F, Unger PD, Katerji H, Yang Q, McMahon L, Burstein DE
Mod Pathol 2016 Jun;29(6):591-8. Epub 2016 Feb 26 doi: 10.1038/modpathol.2016.46. PMID: 26916077
An overview of testicular germ cell tumors.
Bahrami A, Ro JY, Ayala AG
Arch Pathol Lab Med 2007 Aug;131(8):1267-80. doi: 10.5858/2007-131-1267-AOOTGC. PMID: 17683189
Gonadal teratomas: a review and speculation.
Ulbright TM
Adv Anat Pathol 2004 Jan;11(1):10-23. doi: 10.1097/00125480-200401000-00002. PMID: 14676637

Recent systematic reviews

Testis-sparing surgery in children with testicular tumors: A systematic review and meta-analysis.
Miao X, Li Y, Zhou T, Lv M
Asian J Surg 2021 Dec;44(12):1503-1509. Epub 2021 Apr 21 doi: 10.1016/j.asjsur.2021.03.016. PMID: 33893031

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