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Testicular Mixed Yolk Sac Tumor and Teratoma

MedGen UID:
277814
Concept ID:
C1336721
Neoplastic Process
Synonyms: Mixed Endodermal Sinus Neoplasm and Teratoma of Testis; Mixed Endodermal Sinus Neoplasm and Teratoma of the Testis; Mixed Endodermal Sinus Tumor and Teratoma of Testis; Mixed Endodermal Sinus Tumor and Teratoma of the Testis; Mixed Yolk Sac Neoplasm and Teratoma of Testis; Mixed Yolk Sac Neoplasm and Teratoma of the Testis; Mixed Yolk Sac Tumor and Teratoma of Testis; Mixed Yolk Sac Tumor and Teratoma of the Testis; Testicular Mixed Endodermal Sinus Neoplasm and Teratoma; Testicular Mixed Endodermal Sinus Tumor and Teratoma; Testicular Mixed Yolk Sac Neoplasm and Teratoma

Definition

A malignant non-seminomatous germ cell tumor arising from the testis. It is characterized by a mixture of yolk sac and teratomatous morphologic elements. Patients may present with painless or painful testicular swelling. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTesticular Mixed Yolk Sac Tumor and Teratoma

Professional guidelines

PubMed

Rougemont AL, Tille JC
Hum Pathol 2018 Nov;81:26-36. Epub 2018 May 16 doi: 10.1016/j.humpath.2018.04.025. PMID: 29753846
Liu P, Li W, Song HC, Jiao LL, Zhang WP, Sun N
J Pediatr Urol 2018 Oct;14(5):443.e1-443.e7. Epub 2018 Apr 3 doi: 10.1016/j.jpurol.2018.02.030. PMID: 29705139
Brandes AA, Pasetto LM, Monfardini S
Cancer Treat Rev 2000 Aug;26(4):233-42. doi: 10.1053/ctrv.2000.0169. PMID: 10913379

Recent clinical studies

Etiology

Mohin M, Dey S, Ray R, Wasim Sk F, Das O, Chatterjee U
Fetal Pediatr Pathol 2024 Mar-Apr;43(2):182-187. Epub 2023 Nov 9 doi: 10.1080/15513815.2023.2279132. PMID: 37946365
Schraw JM, Sok P, Desrosiers TA, Janitz AE, Langlois PH, Canfield MA, Frazier AL, Plon SE, Lupo PJ, Poynter JN
Cancer 2023 Oct 15;129(20):3300-3308. Epub 2023 Jun 27 doi: 10.1002/cncr.34906. PMID: 37366624Free PMC Article
Wu P, Yang Y, Yu Z, Zhao L, Feng S
J Surg Res 2023 Aug;288:362-371. Epub 2023 Apr 14 doi: 10.1016/j.jss.2023.03.018. PMID: 37062232
Al-Obaidy KI, Idrees MT
Adv Anat Pathol 2021 Jul 1;28(4):258-275. doi: 10.1097/PAP.0000000000000302. PMID: 33871428
Al-Hussain T, Bakshi N, Akhtar M
Adv Anat Pathol 2015 May;22(3):202-12. doi: 10.1097/PAP.0000000000000066. PMID: 25844678

Diagnosis

Mohin M, Dey S, Ray R, Wasim Sk F, Das O, Chatterjee U
Fetal Pediatr Pathol 2024 Mar-Apr;43(2):182-187. Epub 2023 Nov 9 doi: 10.1080/15513815.2023.2279132. PMID: 37946365
Chiu CC, Jaing TH, Lai JY, Chen SH, Chang TY, Hsueh C, Wen YC, Tsay PK
Medicine (Baltimore) 2022 Jul 22;101(29):e29735. doi: 10.1097/MD.0000000000029735. PMID: 35866814Free PMC Article
Saini T, Kundu R, Rastogi P, Rohilla M, Gupta P, Gupta N, Srinivasan R, Dey P
Cytopathology 2022 Jul;33(4):493-498. Epub 2022 Apr 9 doi: 10.1111/cyt.13122. PMID: 35347771
Al-Obaidy KI, Idrees MT
Adv Anat Pathol 2021 Jul 1;28(4):258-275. doi: 10.1097/PAP.0000000000000302. PMID: 33871428
Howitt BE, Berney DM
Surg Pathol Clin 2015 Dec;8(4):687-716. doi: 10.1016/j.path.2015.07.007. PMID: 26612222

Therapy

Stump JA, Acosta AM, Whaley RD, Cheng L, Fang AM, Rais-Bahrami S, Gordetsky JB
Hum Pathol 2022 Oct;128:48-55. Epub 2022 Jul 9 doi: 10.1016/j.humpath.2022.06.026. PMID: 35817140
Newton C, Murali K, Ahmad A, Hockings H, Graham R, Liberale V, Sarker SJ, Ledermann J, Berney DM, Shamash J, Banerjee S, Stoneham S, Lockley M
Eur J Cancer 2019 May;113:19-27. Epub 2019 Apr 4 doi: 10.1016/j.ejca.2019.03.001. PMID: 30954883Free PMC Article
Wang X, Xu S, Tang D, Li M, Wu D, Huang Y
J Pediatr Surg 2012 Aug;47(8):1576-80. doi: 10.1016/j.jpedsurg.2011.11.005. PMID: 22901920
Calaminus G, Schneider DT, Weissbach L, Schönberger S, Okpanyi V, Leuschner I, Poremba C, Göbel U
Klin Padiatr 2009 May-Jun;221(3):136-40. Epub 2009 May 12 doi: 10.1055/s-0029-1220738. PMID: 19437360
Calaminus G, Schneider DT, Bökkerink JP, Gadner H, Harms D, Willers R, Göbel U
J Clin Oncol 2003 Mar 1;21(5):781-6. doi: 10.1200/JCO.2003.03.125. PMID: 12610174

Prognosis

Lee K, Kim YI, Oh JS, Seo SY, Yun JK, Lee GD, Choi S, Kim HR, Kim YH, Kim DK, Park SI, Ryu JS
Sci Rep 2023 Oct 17;13(1):17619. doi: 10.1038/s41598-023-44913-x. PMID: 37848723Free PMC Article
Wu P, Yang Y, Yu Z, Zhao L, Feng S
J Surg Res 2023 Aug;288:362-371. Epub 2023 Apr 14 doi: 10.1016/j.jss.2023.03.018. PMID: 37062232
Tabibi S, Kamanda S, Llosa N, Pratilas CA, Duncan BB, Esteves RS, Matoso A
Appl Immunohistochem Mol Morphol 2023 Jan 1;31(1):47-50. Epub 2022 Oct 26 doi: 10.1097/PAI.0000000000001081. PMID: 36476600Free PMC Article
Nistal M, Paniagua R, González-Peramato P, Reyes-Múgica M
Pediatr Dev Pathol 2016 Nov/Dec;19(6):471-492. Epub 2016 Sep 14 doi: 10.2350/16-09-1829-PER.1. PMID: 27626837
Xiao GQ, Li F, Unger PD, Katerji H, Yang Q, McMahon L, Burstein DE
Mod Pathol 2016 Jun;29(6):591-8. Epub 2016 Feb 26 doi: 10.1038/modpathol.2016.46. PMID: 26916077

Clinical prediction guides

Schraw JM, Sok P, Desrosiers TA, Janitz AE, Langlois PH, Canfield MA, Frazier AL, Plon SE, Lupo PJ, Poynter JN
Cancer 2023 Oct 15;129(20):3300-3308. Epub 2023 Jun 27 doi: 10.1002/cncr.34906. PMID: 37366624Free PMC Article
Miao X, Li Y, Zhou T, Lv M
Asian J Surg 2021 Dec;44(12):1503-1509. Epub 2021 Apr 21 doi: 10.1016/j.asjsur.2021.03.016. PMID: 33893031
Nistal M, Paniagua R, González-Peramato P, Reyes-Múgica M
Pediatr Dev Pathol 2016 Nov/Dec;19(6):471-492. Epub 2016 Sep 14 doi: 10.2350/16-09-1829-PER.1. PMID: 27626837
Xiao GQ, Li F, Unger PD, Katerji H, Yang Q, McMahon L, Burstein DE
Mod Pathol 2016 Jun;29(6):591-8. Epub 2016 Feb 26 doi: 10.1038/modpathol.2016.46. PMID: 26916077
Ulbright TM
Adv Anat Pathol 2004 Jan;11(1):10-23. doi: 10.1097/00125480-200401000-00002. PMID: 14676637

Recent systematic reviews

Miao X, Li Y, Zhou T, Lv M
Asian J Surg 2021 Dec;44(12):1503-1509. Epub 2021 Apr 21 doi: 10.1016/j.asjsur.2021.03.016. PMID: 33893031

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