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Testicular Mixed Yolk Sac Tumor and Teratoma with Seminoma

MedGen UID:
277815
•Concept ID:
C1336722
•
Neoplastic Process
Synonyms: Mixed Endodermal Sinus Neoplasm and Teratoma with Seminoma of Testis; Mixed Endodermal Sinus Neoplasm and Teratoma with Seminoma of the Testis; Mixed Endodermal Sinus Tumor and Teratoma with Seminoma of Testis; Mixed Endodermal Sinus Tumor and Teratoma with Seminoma of the Testis; Mixed Yolk Sac Neoplasm and Teratoma with Seminoma of Testis; Mixed Yolk Sac Neoplasm and Teratoma with Seminoma of the Testis; Mixed Yolk Sac Tumor and Teratoma with Seminoma of Testis; Mixed Yolk Sac Tumor and Teratoma with Seminoma of the Testis; Testicular Mixed Endodermal Sinus Neoplasm and Teratoma with Seminoma; Testicular Mixed Endodermal Sinus Tumor and Teratoma with Seminoma; Testicular Mixed Yolk Sac Neoplasm and Teratoma with Seminoma

Definition

A malignant germ cell tumor arising from the testis. It is characterized by a mixture of yolk sac, teratomatous, and seminomatous morphologic elements. Patients may present with painless or painful testicular swelling. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTesticular Mixed Yolk Sac Tumor and Teratoma with Seminoma

Professional guidelines

PubMed

Primary mediastinal germ cell tumours with high prevalence of somatic malignancy: An experience from a single tertiary care oncology centre.
Beg A, Kumar R, Sahay A, Janu A, Joshi A, Noronha V, Prabhash K, Karimundackal G, Jiwnani S, Agarwal JP, Pramesh CS
Ann Diagn Pathol 2021 Aug;53:151763. Epub 2021 May 26 doi: 10.1016/j.anndiagpath.2021.151763. PMID: 34111707
Role of HNF1β in the differential diagnosis of yolk sac tumor from other germ cell tumors.
Rougemont AL, Tille JC
Hum Pathol 2018 Nov;81:26-36. Epub 2018 May 16 doi: 10.1016/j.humpath.2018.04.025. PMID: 29753846
Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues.
Ulbright TM
Mod Pathol 2005 Feb;18 Suppl 2:S61-79. doi: 10.1038/modpathol.3800310. PMID: 15761467

Recent clinical studies

Etiology

Clinical Features and Survival Outcomes in Children and Adolescents With Malignant Mediastinal Germ Cell Tumors Based on Surveillance, Epidemiology, and End Results Database Analysis.
Wu P, Yang Y, Yu Z, Zhao L, Feng S
J Surg Res 2023 Aug;288:362-371. Epub 2023 Apr 14 doi: 10.1016/j.jss.2023.03.018. PMID: 37062232
Testicular Tumors: A Contemporary Update on Morphologic, Immunohistochemical and Molecular Features.
Al-Obaidy KI, Idrees MT
Adv Anat Pathol 2021 Jul 1;28(4):258-275. doi: 10.1097/PAP.0000000000000302. PMID: 33871428
Perspectives in Pediatric Pathology, Chapter 25. Testicular and Paratesticular Tumors in the Pediatric Age Group.
Nistal M, Paniagua R, González-Peramato P, Reyes-Múgica M
Pediatr Dev Pathol 2016 Nov/Dec;19(6):471-492. Epub 2016 Sep 14 doi: 10.2350/16-09-1829-PER.1. PMID: 27626837
Intratubular germ cell neoplasia of the testis: a brief review.
Al-Hussain T, Bakshi N, Akhtar M
Adv Anat Pathol 2015 May;22(3):202-12. doi: 10.1097/PAP.0000000000000066. PMID: 25844678
Germ cell neoplasms of the testis.
Ulbright TM
Am J Surg Pathol 1993 Nov;17(11):1075-91. doi: 10.1097/00000478-199311000-00001. PMID: 8214253

Diagnosis

Diagnostically misleading aberrant terminal deoxynucleotidyl transferase expression in germ cell tumors.
Pęksa R, Kunc M, Bieńkowski M, Popęda M, Biernat W
Pol J Pathol 2022;73(2):159-165. doi: 10.5114/pjp.2022.120098. PMID: 36345953
Testicular Tumors: A Contemporary Update on Morphologic, Immunohistochemical and Molecular Features.
Al-Obaidy KI, Idrees MT
Adv Anat Pathol 2021 Jul 1;28(4):258-275. doi: 10.1097/PAP.0000000000000302. PMID: 33871428
ZBTB16: a novel sensitive and specific biomarker for yolk sac tumor.
Xiao GQ, Li F, Unger PD, Katerji H, Yang Q, McMahon L, Burstein DE
Mod Pathol 2016 Jun;29(6):591-8. Epub 2016 Feb 26 doi: 10.1038/modpathol.2016.46. PMID: 26916077
Tumors of the Testis: Morphologic Features and Molecular Alterations.
Howitt BE, Berney DM
Surg Pathol Clin 2015 Dec;8(4):687-716. doi: 10.1016/j.path.2015.07.007. PMID: 26612222
Germ-cell tumors of the mediastinum.
Weidner N
Semin Diagn Pathol 1999 Feb;16(1):42-50. PMID: 10355653

Therapy

Pathologic findings and clinical outcomes in patients who required neoadjuvant chemotherapy before orchiectomy for testicular germ cell tumors.
Stump JA, Acosta AM, Whaley RD, Cheng L, Fang AM, Rais-Bahrami S, Gordetsky JB
Hum Pathol 2022 Oct;128:48-55. Epub 2022 Jul 9 doi: 10.1016/j.humpath.2022.06.026. PMID: 35817140

Prognosis

[(18)F]fluorodeoxyglucose positron emission tomography/computed tomography characteristics of primary mediastinal germ cell tumors.
Lee K, Kim YI, Oh JS, Seo SY, Yun JK, Lee GD, Choi S, Kim HR, Kim YH, Kim DK, Park SI, Ryu JS
Sci Rep 2023 Oct 17;13(1):17619. doi: 10.1038/s41598-023-44913-x. PMID: 37848723Free PMC Article
Age-incidence patterns of seminoma and nonseminoma among males and females in Germany and the United States, 2008-2016.
Stang A, Trocchi P, Kajüter H, Trabert B, Oosterhuis JW, McGlynn KA
Andrology 2023 Jan;11(1):65-72. Epub 2022 Sep 12 doi: 10.1111/andr.13282. PMID: 36059277
Perspectives in Pediatric Pathology, Chapter 25. Testicular and Paratesticular Tumors in the Pediatric Age Group.
Nistal M, Paniagua R, González-Peramato P, Reyes-Múgica M
Pediatr Dev Pathol 2016 Nov/Dec;19(6):471-492. Epub 2016 Sep 14 doi: 10.2350/16-09-1829-PER.1. PMID: 27626837
ZBTB16: a novel sensitive and specific biomarker for yolk sac tumor.
Xiao GQ, Li F, Unger PD, Katerji H, Yang Q, McMahon L, Burstein DE
Mod Pathol 2016 Jun;29(6):591-8. Epub 2016 Feb 26 doi: 10.1038/modpathol.2016.46. PMID: 26916077
Germ-cell tumors of the mediastinum.
Weidner N
Semin Diagn Pathol 1999 Feb;16(1):42-50. PMID: 10355653

Clinical prediction guides

Diagnostically misleading aberrant terminal deoxynucleotidyl transferase expression in germ cell tumors.
Pęksa R, Kunc M, Bieńkowski M, Popęda M, Biernat W
Pol J Pathol 2022;73(2):159-165. doi: 10.5114/pjp.2022.120098. PMID: 36345953
Perspectives in Pediatric Pathology, Chapter 25. Testicular and Paratesticular Tumors in the Pediatric Age Group.
Nistal M, Paniagua R, González-Peramato P, Reyes-Múgica M
Pediatr Dev Pathol 2016 Nov/Dec;19(6):471-492. Epub 2016 Sep 14 doi: 10.2350/16-09-1829-PER.1. PMID: 27626837
ZBTB16: a novel sensitive and specific biomarker for yolk sac tumor.
Xiao GQ, Li F, Unger PD, Katerji H, Yang Q, McMahon L, Burstein DE
Mod Pathol 2016 Jun;29(6):591-8. Epub 2016 Feb 26 doi: 10.1038/modpathol.2016.46. PMID: 26916077
CK19 is a sensitive marker for yolk sac tumours of the testis.
Bremmer F, Ströbel P, Jarry H, Strecker J, Gaisa N, Strauß A, Schweyer S, Radzun HJ, Behnes CL
Diagn Pathol 2015 Mar 24;10:7. doi: 10.1186/s13000-015-0243-y. PMID: 25889715Free PMC Article
An overview of testicular germ cell tumors.
Bahrami A, Ro JY, Ayala AG
Arch Pathol Lab Med 2007 Aug;131(8):1267-80. doi: 10.5858/2007-131-1267-AOOTGC. PMID: 17683189

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