Adenocarcinoma of skene gland origin

MedGen UID:: 282906
•Concept ID:: C1527427
•: Neoplastic Process

Synonyms:	Adenocarcinoma of Skene Gland; adenocarcinoma of Skene gland; Adenocarcinoma of Skene Gland Origin; adenocarcinoma of skene gland origin; adenocarcinoma of Skene gland origin; carcinoma of paraurethral gland; Carcinoma of Skene Gland; carcinoma of Skene gland; Carcinoma of Skene Glands; Carcinoma of Skene's Gland; carcinoma of Skene's gland; carcinoma of the paraurethral gland; paraurethral gland adenocarcinoma; paraurethral gland carcinoma; Skene gland carcinoma

Monarch Initiative:	MONDO:0004173

Definition

A rare adenocarcinoma arising from the Skene gland. It presents as a periurethral or anterior vaginal submucosal mass. It is characterized by morphological features similar to prostate adenocarcinoma. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAdenocarcinoma of skene gland origin

Pathological process
- Disease
  - Neoplasm
    - Epithelial neoplasm
      - Carcinoma
        Adenocarcinoma
        Adenocarcinoma of skene gland origin
        Skene Gland Adenocarcinoma of the Urethra
        Vaginal Adenocarcinoma of Skene Gland Origin

Recent clinical studies

Etiology

Management of Primary Female Urethral Adenocarcinoma: Two Rare Case Reports and Literature Review.

Tian J, Zhu T, Xu Z, Chen X, Wu Y, Fu G, Jin B
Medicina (Kaunas) 2023 Jan 4;59(1) doi: 10.3390/medicina59010109. PMID: 36676733 Free PMC Article

Primary adenocarcinomas of the vulva and related structures: An enigmatic and diverse group of tumors(✰).

Desouki MM, Fadare O
Semin Diagn Pathol 2021 Jan;38(1):71-84. Epub 2020 Sep 25 doi: 10.1053/j.semdp.2020.09.011. PMID: 33032903

Female urethral adenocarcinoma: evidence for more than one tissue of origin?

Dodson MK, Cliby WA, Pettavel PP, Keeney GL, Podratz KC
Gynecol Oncol 1995 Dec;59(3):352-7. doi: 10.1006/gyno.1995.9963. PMID: 8522254

See all (3)

Diagnosis

Management of Primary Female Urethral Adenocarcinoma: Two Rare Case Reports and Literature Review.

Tian J, Zhu T, Xu Z, Chen X, Wu Y, Fu G, Jin B
Medicina (Kaunas) 2023 Jan 4;59(1) doi: 10.3390/medicina59010109. PMID: 36676733 Free PMC Article

Skene's gland adenocarcinoma coexisting with infiltrating urothelial carcinoma of the urinary bladder.

Kunc M, Biernat W
Pol J Pathol 2021;72(2):170-173. doi: 10.5114/pjp.2021.109520. PMID: 34706525

First Molecular Genetic Characterization of Skene's Gland Adenocarcinoma.

Lenz J, Michal M, Michal M, Hes O, Konečná P, Lenz D
Int J Surg Pathol 2021 Jun;29(4):447-453. Epub 2020 Aug 14 doi: 10.1177/1066896920947808. PMID: 32795117

Skene's Glands Adenocarcinoma: A Series of 4 Cases.

Tregnago AC, Epstein JI
Am J Surg Pathol 2018 Nov;42(11):1513-1521. doi: 10.1097/PAS.0000000000001108. PMID: 29901570

Skene's gland adenocarcinoma resembling prostatic adenocarcinoma.

Pongtippan A, Malpica A, Levenback C, Deavers MT, Silva EG
Int J Gynecol Pathol 2004 Jan;23(1):71-4. doi: 10.1097/01.pgp.0000101144.79462.39. PMID: 14668555

See all (9)

Prognosis

First Molecular Genetic Characterization of Skene's Gland Adenocarcinoma.

Lenz J, Michal M, Michal M, Hes O, Konečná P, Lenz D
Int J Surg Pathol 2021 Jun;29(4):447-453. Epub 2020 Aug 14 doi: 10.1177/1066896920947808. PMID: 32795117

Adenoid cystic carcinoma of skene glands: a rare origin in the female genital tract and the characteristic clinical course.

Ueda Y, Mandai M, Matsumura N, Baba T, Suzuki A, Yoshioka Y, Kosaka K, Konishi I
Int J Gynecol Pathol 2012 Nov;31(6):596-600. doi: 10.1097/PGP.0b013e31824d357e. PMID: 23018210

Locally advanced female urethral adenocarcinoma of enteric origin: the role of adjuvant chemoradiation and brief review.

Chen LP, Lin SJ, Fu TY, Yu MS
Kaohsiung J Med Sci 2011 Apr;27(4):150-4. Epub 2011 Feb 16 doi: 10.1016/j.kjms.2010.12.009. PMID: 21463838

See all (3)