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Cementoma

MedGen UID:
2942
Concept ID:
C0007659
Neoplastic Process
Synonyms: Cemento Ossifying Fibroma; Cemento-Ossifying Fibroma; Cemento-Ossifying Fibromas; Cementomas; Dysplasia, Periapical Fibrous; Fibroma, Cemento-Ossifying; Fibrous Dysplasia, Periapical; Fibrous Dysplasias, Periapical; Periapical Fibrous Dysplasia; Periapical Fibrous Dysplasias
SNOMED CT: Benign cementoblastoma (23255001); True cementoma (23255001); Cementoblastoma (23255001); Cementoblastoma, benign (23255001); Cementoma (37258009); Periapical cemental dysplasia (37258009); Periapical cemento-osseous dysplasia (37258009); Periradicular cemental dysplasia (37258009)
 
HPO: HP:0012328

Definition

An odontogenic tumor of the cementum of tooth. [from HPO]

Term Hierarchy

Conditions with this feature

Gigantiform cementoma
MedGen UID:
501159
Concept ID:
C3495361
Neoplastic Process
Familial gigantiform cementoma (FGC) is a rare autosomal dominant tumor that is benign but can result in disfigurement of the facial skeleton. Onset of symptoms usually occurs in adolescence, with rapid growth causing expansion of the maxilla and mandible, resulting in significant facial deformity and malocclusion. Radiologic examination defines 3 stages of the lesions: osteolytic, with well-defined radiolucent areas; cementoblastic, in which cementum is formed within the fibrous tissue, represented by radiopacities within the radiolucent zones; and mature, in which the fibrous tissue is almost completely replaced by cementum, represented by a large radioopaque area surrounded by a radiolucent space separating the tumor from normal bone. Histologic examination shows confluent sclerotic avascular cementum, with distinct areas of lamellar bone in some cases. Examination under polarized light reveals a varied birefringent pattern typical of cementum (summary by Finical et al., 1999). Affected individuals may develop osteopenia and sustain long bone fractures after minor trauma (Moshref et al., 2008; Wang et al., 2015).

Professional guidelines

PubMed

Mainville GN, Turgeon DP, Kauzman A
Oral Dis 2017 May;23(4):440-450. Epub 2016 Aug 1 doi: 10.1111/odi.12531. PMID: 27387498
Panders AK
Radiol Clin Biol 1968;37(1):53-6. PMID: 5667687

Recent clinical studies

Etiology

Rezende DDSDM, Souza LL, Uchôa DCC, Fernandes LA, Lemos JGR, Santos-Silva AR, Lopes MA, Arboleda LPA, Rocha AC, Gonçalves FLN, Pontes FSC, Fonseca FP, Pontes HAR
Braz Oral Res 2023;37:e011. Epub 2023 Feb 13 doi: 10.1590/1807-3107bor-2023.vol37.0011. PMID: 36790252
Hameed M, Horvai AE, Jordan RCK
Head Neck Pathol 2020 Mar;14(1):70-82. Epub 2020 Jan 16 doi: 10.1007/s12105-019-01094-2. PMID: 31950477Free PMC Article
Li X, Peng Z, Latif M, Kumar A, Chen W, Zhang Z
BMC Musculoskelet Disord 2017 Mar 14;18(1):103. doi: 10.1186/s12891-017-1460-1. PMID: 28288612Free PMC Article
Mainville GN, Turgeon DP, Kauzman A
Oral Dis 2017 May;23(4):440-450. Epub 2016 Aug 1 doi: 10.1111/odi.12531. PMID: 27387498
Macdonald-Jankowski DS
Dentomaxillofac Radiol 2008 Sep;37(6):350-60. doi: 10.1259/dmfr/31641295. PMID: 18757721

Diagnosis

Hameed M, Horvai AE, Jordan RCK
Head Neck Pathol 2020 Mar;14(1):70-82. Epub 2020 Jan 16 doi: 10.1007/s12105-019-01094-2. PMID: 31950477Free PMC Article
Li X, Peng Z, Latif M, Kumar A, Chen W, Zhang Z
BMC Musculoskelet Disord 2017 Mar 14;18(1):103. doi: 10.1186/s12891-017-1460-1. PMID: 28288612Free PMC Article
Mainville GN, Turgeon DP, Kauzman A
Oral Dis 2017 May;23(4):440-450. Epub 2016 Aug 1 doi: 10.1111/odi.12531. PMID: 27387498
Deshmukh J, Shrivastava R, Bharath KP, Mallikarjuna R
BMJ Case Rep 2014 May 2;2014 doi: 10.1136/bcr-2014-203678. PMID: 24792022Free PMC Article
Ahluwalia J, Ly JQ, Norman E, Costello RF Jr, Beall DP
Clin Imaging 2007 Jan-Feb;31(1):67-9. doi: 10.1016/j.clinimag.2006.07.003. PMID: 17189853

Therapy

Zhang W, Chen M, Yang C, Han Z, Wei W, Chai Y
J Craniofac Surg 2018 Mar;29(2):e155-e158. doi: 10.1097/SCS.0000000000004237. PMID: 29303851
Baghdady MT, Carnahan H, Lam EW, Woods NN
J Dent Educ 2013 Jun;77(6):757-63. PMID: 23740912
Martini MZ, de Carvalho Júnior JP, Soares HA
Minerva Stomatol 2006 Sep;55(9):515-21. PMID: 17146430
Smith S, Patel K, Hoskinson AE
Br Dent J 1998 Aug 8;185(3):122-3. doi: 10.1038/sj.bdj.4809747. PMID: 9744236
Hamner JE 3rd, Scofield HH, Cornyn J
Cancer 1968 Oct;22(4):861-78. doi: 10.1002/1097-0142(196810)22:4<861::aid-cncr2820220425>3.0.co;2-c. PMID: 5212309

Prognosis

Nelson BL, Phillips BJ
Head Neck Pathol 2019 Sep;13(3):466-475. Epub 2019 Mar 18 doi: 10.1007/s12105-018-0992-5. PMID: 30887390Free PMC Article
Li X, Peng Z, Latif M, Kumar A, Chen W, Zhang Z
BMC Musculoskelet Disord 2017 Mar 14;18(1):103. doi: 10.1186/s12891-017-1460-1. PMID: 28288612Free PMC Article
Neelakandan RS, Deshpande A, Krithika C, Bhargava D
Oral Maxillofac Surg 2012 Mar;16(1):119-21. Epub 2011 Mar 16 doi: 10.1007/s10006-011-0267-8. PMID: 21409396
Waldron CA
J Oral Maxillofac Surg 1993 Aug;51(8):828-35. doi: 10.1016/s0278-2391(10)80097-7. PMID: 8336219
Vindenes H, Nilsen R, Gilhuus-Moe O
Int J Oral Surg 1979 Aug;8(4):318-24. doi: 10.1016/s0300-9785(79)80055-1. PMID: 120336

Clinical prediction guides

Soluk-Tekkesin M, Sinanoglu A, Selvi F, Cakir Karabas H, Aksakalli N
J Stomatol Oral Maxillofac Surg 2022 Jun;123(3):364-371. Epub 2021 Apr 18 doi: 10.1016/j.jormas.2021.04.008. PMID: 33878496
Kato CNAO, Nunes LFM, Chalub LLFH, Etges A, Silva TA, Mesquita RA
J Oral Maxillofac Surg 2018 Nov;76(11):2348-2359. Epub 2018 May 10 doi: 10.1016/j.joms.2018.04.037. PMID: 29859157
Humagain M , Dawadi A , Srii R , Poudel P
Kathmandu Univ Med J (KUMJ) 2017 Jul-Sept.;15(59):261-264. PMID: 30353905
Chrcanovic BR, Gomez RS
J Craniomaxillofac Surg 2017 Oct;45(10):1759-1766. Epub 2017 Aug 8 doi: 10.1016/j.jcms.2017.08.002. PMID: 28869132
Waldron CA
J Oral Maxillofac Surg 1993 Aug;51(8):828-35. doi: 10.1016/s0278-2391(10)80097-7. PMID: 8336219

Recent systematic reviews

Wang HW, Ma CY, Qin XJ, Zhang CP
Medicine (Baltimore) 2017 Dec;96(50):e9138. doi: 10.1097/MD.0000000000009138. PMID: 29390315Free PMC Article
Macdonald-Jankowski DS
Dentomaxillofac Radiol 2008 Sep;37(6):350-60. doi: 10.1259/dmfr/31641295. PMID: 18757721
MacDonald-Jankowski DS
Dentomaxillofac Radiol 2003 May;32(3):141-9. doi: 10.1259/dmfr/32988764. PMID: 12917278

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