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Small Intestinal Anastomotic Leakage

MedGen UID:
306413
•Concept ID:
C1698195
•
Pathologic Function

Definition

Leakage due to breakdown of a small intestinal anastomosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmall Intestinal Anastomotic Leakage

Professional guidelines

PubMed

Treatment of esophagojejunal anastomosis leakage: a systematic review from the last two decades.
Aurello P, Magistri P, D'Angelo F, Valabrega S, Sirimarco D, Tierno SM, Nava AK, Ramacciato G
Am Surg 2015 May;81(5):450-3. PMID: 25975326
Treatment of anastomotic leak.
Heisler KA
J Am Coll Surg 2014 Sep;219(3):592. doi: 10.1016/j.jamcollsurg.2014.06.004. PMID: 25151351
Management of anastomotic leakage in a nationwide cohort of colonic cancer patients.
Krarup PM, Jorgensen LN, Harling H; Danish Colorectal Cancer Group
J Am Coll Surg 2014 May;218(5):940-9. Epub 2014 Feb 18 doi: 10.1016/j.jamcollsurg.2014.01.051. PMID: 24745566

Recent clinical studies

Etiology

Anastomotic Leakage after Gastrectomy for Gastric Cancer.
Seicean RI, Puscasu D, Gheorghiu A, Pojoga C, Seicean A, Dindelegan G
J Gastrointestin Liver Dis 2023 Dec 22;32(4):526-535. doi: 10.15403/jgld-5238. PMID: 38147605
Factors associated with dehiscence of intestinal anastomosis.
Álvarez-Villaseñor AS, Prado-Rico SDC, Morales-Alvarado JI, Reyes-Aguirre LL, Fuentes-Orozco C, González-Ojeda A
Cir Cir 2021;89(2):233-242. doi: 10.24875/CIRU.20000018. PMID: 33784278
The role of Kono-S anastomosis and mesenteric resection in reducing recurrence after surgery for Crohn's disease: a systematic review.
Alshantti A, Hind D, Hancock L, Brown SR
Colorectal Dis 2021 Jan;23(1):7-17. Epub 2020 Jun 11 doi: 10.1111/codi.15136. PMID: 32418300
Esophagojejunal anastomotic leakage following gastrectomy for gastric cancer.
Makuuchi R, Irino T, Tanizawa Y, Bando E, Kawamura T, Terashima M
Surg Today 2019 Mar;49(3):187-196. Epub 2018 Oct 13 doi: 10.1007/s00595-018-1726-8. PMID: 30317492
Complications of biliary-enteric anastomoses.
Kadaba RS, Bowers KA, Khorsandi S, Hutchins RR, Abraham AT, Sarker SJ, Bhattacharya S, Kocher HM
Ann R Coll Surg Engl 2017 Mar;99(3):210-215. Epub 2016 Sep 23 doi: 10.1308/rcsann.2016.0293. PMID: 27659373Free PMC Article

Diagnosis

Mesenteric Cyst in 22 Cases.
Yavuz Y, Varman A, Şentürk ÜM, Kafadar MT
J Gastrointest Cancer 2021 Sep;52(3):993-996. Epub 2020 Sep 24 doi: 10.1007/s12029-020-00522-9. PMID: 32970308
Esophagojejunal anastomotic leakage following gastrectomy for gastric cancer.
Makuuchi R, Irino T, Tanizawa Y, Bando E, Kawamura T, Terashima M
Surg Today 2019 Mar;49(3):187-196. Epub 2018 Oct 13 doi: 10.1007/s00595-018-1726-8. PMID: 30317492
Reconstruction after esophagectomy for esophageal cancer patients with a history of gastrectomy.
Watanabe M, Mine S, Nishida K, Kurogochi T, Okamura A, Imamura Y
Gen Thorac Cardiovasc Surg 2016 Aug;64(8):457-63. Epub 2016 May 27 doi: 10.1007/s11748-016-0661-0. PMID: 27234222
Treatment with corticosteroids and the risk of anastomotic leakage following lower gastrointestinal surgery: a literature survey.
Eriksen TF, Lassen CB, Gögenur I
Colorectal Dis 2014 May;16(5):O154-60. doi: 10.1111/codi.12490. PMID: 24215329
Current management of acute malignant large bowel obstruction: a systematic review.
Frago R, Ramirez E, Millan M, Kreisler E, del Valle E, Biondo S
Am J Surg 2014 Jan;207(1):127-38. Epub 2013 Oct 12 doi: 10.1016/j.amjsurg.2013.07.027. PMID: 24124659

Therapy

Anastomotic Leakage after Gastrectomy for Gastric Cancer.
Seicean RI, Puscasu D, Gheorghiu A, Pojoga C, Seicean A, Dindelegan G
J Gastrointestin Liver Dis 2023 Dec 22;32(4):526-535. doi: 10.15403/jgld-5238. PMID: 38147605
The role of Kono-S anastomosis and mesenteric resection in reducing recurrence after surgery for Crohn's disease: a systematic review.
Alshantti A, Hind D, Hancock L, Brown SR
Colorectal Dis 2021 Jan;23(1):7-17. Epub 2020 Jun 11 doi: 10.1111/codi.15136. PMID: 32418300
Long-Term Impact of Iatrogenic Bile Duct Injury.
Schreuder AM, Busch OR, Besselink MG, Ignatavicius P, Gulbinas A, Barauskas G, Gouma DJ, van Gulik TM
Dig Surg 2020;37(1):10-21. Epub 2019 Jan 17 doi: 10.1159/000496432. PMID: 30654363Free PMC Article
Which is the best pancreatic anastomosis?
Fiorentini G, Tamburrino D, Belfiori G, Crippa S, Partelli S, Falconi M
Minerva Chir 2019 Jun;74(3):241-252. Epub 2019 Jan 18 doi: 10.23736/S0026-4733.19.07997-5. PMID: 30665292
Esophagojejunal anastomotic leakage following gastrectomy for gastric cancer.
Makuuchi R, Irino T, Tanizawa Y, Bando E, Kawamura T, Terashima M
Surg Today 2019 Mar;49(3):187-196. Epub 2018 Oct 13 doi: 10.1007/s00595-018-1726-8. PMID: 30317492

Prognosis

Oral Budesonide and low serum albumin levels at surgery are associated with a higher risk of postoperative intra-abdominal septic complications after primary ileocaecal resection for Crohn's disease: A retrospective analysis of 853 consecutive patients.
Dajti G, Cardelli S, Calini G, Rizzello F, Gionchetti P, Flacco ME, Poggioli G, Rottoli M
Dig Liver Dis 2024 Sep;56(9):1497-1502. Epub 2024 Apr 14 doi: 10.1016/j.dld.2024.03.014. PMID: 38616140
Long-Term Impact of Iatrogenic Bile Duct Injury.
Schreuder AM, Busch OR, Besselink MG, Ignatavicius P, Gulbinas A, Barauskas G, Gouma DJ, van Gulik TM
Dig Surg 2020;37(1):10-21. Epub 2019 Jan 17 doi: 10.1159/000496432. PMID: 30654363Free PMC Article
Esophagojejunal anastomotic leakage following gastrectomy for gastric cancer.
Makuuchi R, Irino T, Tanizawa Y, Bando E, Kawamura T, Terashima M
Surg Today 2019 Mar;49(3):187-196. Epub 2018 Oct 13 doi: 10.1007/s00595-018-1726-8. PMID: 30317492
Complications of biliary-enteric anastomoses.
Kadaba RS, Bowers KA, Khorsandi S, Hutchins RR, Abraham AT, Sarker SJ, Bhattacharya S, Kocher HM
Ann R Coll Surg Engl 2017 Mar;99(3):210-215. Epub 2016 Sep 23 doi: 10.1308/rcsann.2016.0293. PMID: 27659373Free PMC Article
Intracorporeal ileocolic anastomosis: a review.
Tarta C, Bishawi M, Bergamaschi R
Tech Coloproctol 2013 Oct;17(5):479-85. Epub 2013 Mar 22 doi: 10.1007/s10151-013-0998-7. PMID: 23519986

Clinical prediction guides

Oral Budesonide and low serum albumin levels at surgery are associated with a higher risk of postoperative intra-abdominal septic complications after primary ileocaecal resection for Crohn's disease: A retrospective analysis of 853 consecutive patients.
Dajti G, Cardelli S, Calini G, Rizzello F, Gionchetti P, Flacco ME, Poggioli G, Rottoli M
Dig Liver Dis 2024 Sep;56(9):1497-1502. Epub 2024 Apr 14 doi: 10.1016/j.dld.2024.03.014. PMID: 38616140
Safety and Feasibility of Indocyanine Green Fluorescence Angiography in Pediatric Gastrointestinal Surgery: A Systematic Review.
Breuking EA, van Varsseveld OC, Harms M, Tytgat SHAJ, Hulscher JBF, Ruiterkamp J
J Pediatr Surg 2023 Aug;58(8):1534-1542. Epub 2022 Oct 24 doi: 10.1016/j.jpedsurg.2022.10.045. PMID: 36404183
Improved anastomotic technique for esophagojejunal anastomosis using circular stapler.
Niihara M, Hiki N, Hosoda K, Sakuraya M, Washio M, Chuman M, Yamashita K
Langenbecks Arch Surg 2022 Feb;407(1):353-356. Epub 2022 Jan 24 doi: 10.1007/s00423-021-02417-0. PMID: 35072779
Modified Single-Loop Reconstruction for Pancreaticoduodenectomy.
Luu AM, Aghalarov I, Braumann C, Uhl W, Belyaev O
J Vis Exp 2019 Sep 28;(151) doi: 10.3791/59319. PMID: 31609317
Anastomotic Location Predicts Anastomotic Leakage After Elective Colonic Resection for Cancer.
Voron T, Bruzzi M, Ragot E, Zinzindohoue F, Chevallier JM, Douard R, Berger A
J Gastrointest Surg 2019 Feb;23(2):339-347. Epub 2018 Aug 3 doi: 10.1007/s11605-018-3891-x. PMID: 30076589

Recent systematic reviews

A systematic review of outcomes and quality of life after ileorectal anastomosis for ulcerative colitis.
Al-Rashedy M, Mukherjee T, Askari A, Gurjar S
Arab J Gastroenterol 2023 May;24(2):79-84. Epub 2023 Feb 20 doi: 10.1016/j.ajg.2023.01.007. PMID: 36813579
The role of Kono-S anastomosis and mesenteric resection in reducing recurrence after surgery for Crohn's disease: a systematic review.
Alshantti A, Hind D, Hancock L, Brown SR
Colorectal Dis 2021 Jan;23(1):7-17. Epub 2020 Jun 11 doi: 10.1111/codi.15136. PMID: 32418300
Long-Term Impact of Iatrogenic Bile Duct Injury.
Schreuder AM, Busch OR, Besselink MG, Ignatavicius P, Gulbinas A, Barauskas G, Gouma DJ, van Gulik TM
Dig Surg 2020;37(1):10-21. Epub 2019 Jan 17 doi: 10.1159/000496432. PMID: 30654363Free PMC Article
Pancreaticojejunostomy Versus Pancreaticogastrostomy After Pancreaticoduodenectomy: An Up-to-date Meta-Analysis.
Guerrini GP, Soliani P, D'Amico G, Di Benedetto F, Negri M, Piccoli M, Ruffo G, Orti-Rodriguez RJ, Pissanou T, Fusai G
J Invest Surg 2016 Jun;29(3):175-84. Epub 2015 Dec 18 doi: 10.3109/08941939.2015.1093047. PMID: 26682701
Treatment with corticosteroids and the risk of anastomotic leakage following lower gastrointestinal surgery: a literature survey.
Eriksen TF, Lassen CB, Gögenur I
Colorectal Dis 2014 May;16(5):O154-60. doi: 10.1111/codi.12490. PMID: 24215329

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