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Gastrointestinal anastomotic leak

MedGen UID:
87421
•Concept ID:
C0341562
•
Finding
Synonyms: Digestive System Anastomotic Leakage; Gastrointestinal System Anastomotic Leakage; Leaking gastrointestinal anastomosis
SNOMED CT: Leaking gastrointestinal anastomosis (236085004); Gastrointestinal anastomotic leak (236085004)

Definition

Leakage due to breakdown of a gastrointestinal anastomosis. [from NCI]

Professional guidelines

PubMed

Endoscopic management of surgical complications.
Goyal M, Bains A, Singh Y, Deepali F, Singh A, Sood S, Buttar NS
Best Pract Res Clin Gastroenterol 2024 Mar;69:101898. Epub 2024 Mar 6 doi: 10.1016/j.bpg.2024.101898. PMID: 38749577
Endoscopic management of gastrointestinal leaks and fistulae: What option do we have?
Cereatti F, Grassia R, Drago A, Conti CB, Donatelli G
World J Gastroenterol 2020 Aug 7;26(29):4198-4217. doi: 10.3748/wjg.v26.i29.4198. PMID: 32848329Free PMC Article
Anastomotic leakage after gastrointestinal surgery: diagnosis and management.
Girard E, Messager M, Sauvanet A, Benoist S, Piessen G, Mabrut JY, Mariette C
J Visc Surg 2014 Dec;151(6):441-50. Epub 2014 Oct 22 doi: 10.1016/j.jviscsurg.2014.10.004. PMID: 25455960

Recent clinical studies

Etiology

The risk factors for gastrointestinal anastomotic leak after cytoreduction with hyperthermic intraperitoneal chemotherapy.
Bisgin T, Sökmen S, Arslan NC, Ozkardesler S, Barlik Obuz F
Ulus Travma Acil Cerrahi Derg 2023 Mar;29(3):370-378. doi: 10.14744/tjtes.2023.52358. PMID: 36880628Free PMC Article
The importance of presepsin value in detection of gastrointestinal anastomotic leak: a pilot study.
Cikot M, Kasapoglu P, Isiksacan N, Binboga S, Kones O, Gemici E, Kartal B, Alis H
J Surg Res 2018 Aug;228:100-106. Epub 2018 Mar 31 doi: 10.1016/j.jss.2018.02.059. PMID: 29907197
Epidural Local Anesthetics Versus Opioid-Based Analgesic Regimens for Postoperative Gastrointestinal Paralysis, Vomiting, and Pain After Abdominal Surgery: A Cochrane Review.
Guay J, Nishimori M, Kopp SL
Anesth Analg 2016 Dec;123(6):1591-1602. doi: 10.1213/ANE.0000000000001628. PMID: 27870743
Risk factors for failure of percutaneous drainage and need for reoperation following symptomatic gastrointestinal anastomotic leak.
Felder SI, Barmparas G, Murrell Z, Fleshner P
Am J Surg 2014 Jul;208(1):58-64. Epub 2014 Jan 4 doi: 10.1016/j.amjsurg.2013.08.050. PMID: 24476970
Anastomotic leaks: what is the best diagnostic imaging study?
Nicksa GA, Dring RV, Johnson KH, Sardella WV, Vignati PV, Cohen JL
Dis Colon Rectum 2007 Feb;50(2):197-203. doi: 10.1007/s10350-006-0708-x. PMID: 17164970

Diagnosis

The risk factors for gastrointestinal anastomotic leak after cytoreduction with hyperthermic intraperitoneal chemotherapy.
Bisgin T, Sökmen S, Arslan NC, Ozkardesler S, Barlik Obuz F
Ulus Travma Acil Cerrahi Derg 2023 Mar;29(3):370-378. doi: 10.14744/tjtes.2023.52358. PMID: 36880628Free PMC Article
The importance of presepsin value in detection of gastrointestinal anastomotic leak: a pilot study.
Cikot M, Kasapoglu P, Isiksacan N, Binboga S, Kones O, Gemici E, Kartal B, Alis H
J Surg Res 2018 Aug;228:100-106. Epub 2018 Mar 31 doi: 10.1016/j.jss.2018.02.059. PMID: 29907197
Systematic review of methods to predict and detect anastomotic leakage in colorectal surgery.
Hirst NA, Tiernan JP, Millner PA, Jayne DG
Colorectal Dis 2014 Feb;16(2):95-109. doi: 10.1111/codi.12411. PMID: 23992097
Anastomotic leaks: what is the best diagnostic imaging study?
Nicksa GA, Dring RV, Johnson KH, Sardella WV, Vignati PV, Cohen JL
Dis Colon Rectum 2007 Feb;50(2):197-203. doi: 10.1007/s10350-006-0708-x. PMID: 17164970

Therapy

The risk factors for gastrointestinal anastomotic leak after cytoreduction with hyperthermic intraperitoneal chemotherapy.
Bisgin T, Sökmen S, Arslan NC, Ozkardesler S, Barlik Obuz F
Ulus Travma Acil Cerrahi Derg 2023 Mar;29(3):370-378. doi: 10.14744/tjtes.2023.52358. PMID: 36880628Free PMC Article
The importance of presepsin value in detection of gastrointestinal anastomotic leak: a pilot study.
Cikot M, Kasapoglu P, Isiksacan N, Binboga S, Kones O, Gemici E, Kartal B, Alis H
J Surg Res 2018 Aug;228:100-106. Epub 2018 Mar 31 doi: 10.1016/j.jss.2018.02.059. PMID: 29907197
Epidural Local Anesthetics Versus Opioid-Based Analgesic Regimens for Postoperative Gastrointestinal Paralysis, Vomiting, and Pain After Abdominal Surgery: A Cochrane Review.
Guay J, Nishimori M, Kopp SL
Anesth Analg 2016 Dec;123(6):1591-1602. doi: 10.1213/ANE.0000000000001628. PMID: 27870743
Epidural local anaesthetics versus opioid-based analgesic regimens for postoperative gastrointestinal paralysis, vomiting and pain after abdominal surgery.
Guay J, Nishimori M, Kopp S
Cochrane Database Syst Rev 2016 Jul 16;7(7):CD001893. doi: 10.1002/14651858.CD001893.pub2. PMID: 27419911Free PMC Article
Endoscopic treatment of a large upper gastrointestinal anastomotic leak using a prolene plug and cyanoacrylate.
Disibeyaz S, Parlak E, Koksal AS, Cicek B, Koc U, Sahin B
Endoscopy 2005 Oct;37(10):1032-3. doi: 10.1055/s-2005-870439. PMID: 16189781

Prognosis

The risk factors for gastrointestinal anastomotic leak after cytoreduction with hyperthermic intraperitoneal chemotherapy.
Bisgin T, Sökmen S, Arslan NC, Ozkardesler S, Barlik Obuz F
Ulus Travma Acil Cerrahi Derg 2023 Mar;29(3):370-378. doi: 10.14744/tjtes.2023.52358. PMID: 36880628Free PMC Article
The importance of presepsin value in detection of gastrointestinal anastomotic leak: a pilot study.
Cikot M, Kasapoglu P, Isiksacan N, Binboga S, Kones O, Gemici E, Kartal B, Alis H
J Surg Res 2018 Aug;228:100-106. Epub 2018 Mar 31 doi: 10.1016/j.jss.2018.02.059. PMID: 29907197
Image-guided percutaneous drainage vs. surgical repair of gastrointestinal anastomotic leaks: is there a difference in hospital course or hospitalization cost?
Burke LM, Bashir MR, Gardner CS, Parsee AA, Marin D, Vermess D, Bhattacharya SD, Thacker JK, Jaffe TA
Abdom Imaging 2015 Jun;40(5):1279-84. doi: 10.1007/s00261-014-0265-z. PMID: 25294007
Risk factors for failure of percutaneous drainage and need for reoperation following symptomatic gastrointestinal anastomotic leak.
Felder SI, Barmparas G, Murrell Z, Fleshner P
Am J Surg 2014 Jul;208(1):58-64. Epub 2014 Jan 4 doi: 10.1016/j.amjsurg.2013.08.050. PMID: 24476970
Systematic review of methods to predict and detect anastomotic leakage in colorectal surgery.
Hirst NA, Tiernan JP, Millner PA, Jayne DG
Colorectal Dis 2014 Feb;16(2):95-109. doi: 10.1111/codi.12411. PMID: 23992097

Clinical prediction guides

The risk factors for gastrointestinal anastomotic leak after cytoreduction with hyperthermic intraperitoneal chemotherapy.
Bisgin T, Sökmen S, Arslan NC, Ozkardesler S, Barlik Obuz F
Ulus Travma Acil Cerrahi Derg 2023 Mar;29(3):370-378. doi: 10.14744/tjtes.2023.52358. PMID: 36880628Free PMC Article
Epidural Local Anesthetics Versus Opioid-Based Analgesic Regimens for Postoperative Gastrointestinal Paralysis, Vomiting, and Pain After Abdominal Surgery: A Cochrane Review.
Guay J, Nishimori M, Kopp SL
Anesth Analg 2016 Dec;123(6):1591-1602. doi: 10.1213/ANE.0000000000001628. PMID: 27870743
Image-guided percutaneous drainage vs. surgical repair of gastrointestinal anastomotic leaks: is there a difference in hospital course or hospitalization cost?
Burke LM, Bashir MR, Gardner CS, Parsee AA, Marin D, Vermess D, Bhattacharya SD, Thacker JK, Jaffe TA
Abdom Imaging 2015 Jun;40(5):1279-84. doi: 10.1007/s00261-014-0265-z. PMID: 25294007
Risk factors for failure of percutaneous drainage and need for reoperation following symptomatic gastrointestinal anastomotic leak.
Felder SI, Barmparas G, Murrell Z, Fleshner P
Am J Surg 2014 Jul;208(1):58-64. Epub 2014 Jan 4 doi: 10.1016/j.amjsurg.2013.08.050. PMID: 24476970
Systematic review of methods to predict and detect anastomotic leakage in colorectal surgery.
Hirst NA, Tiernan JP, Millner PA, Jayne DG
Colorectal Dis 2014 Feb;16(2):95-109. doi: 10.1111/codi.12411. PMID: 23992097

Recent systematic reviews

Epidural local anaesthetics versus opioid-based analgesic regimens for postoperative gastrointestinal paralysis, vomiting and pain after abdominal surgery.
Guay J, Nishimori M, Kopp S
Cochrane Database Syst Rev 2016 Jul 16;7(7):CD001893. doi: 10.1002/14651858.CD001893.pub2. PMID: 27419911Free PMC Article
Systematic review of methods to predict and detect anastomotic leakage in colorectal surgery.
Hirst NA, Tiernan JP, Millner PA, Jayne DG
Colorectal Dis 2014 Feb;16(2):95-109. doi: 10.1111/codi.12411. PMID: 23992097

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