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ATIC-ALK Fusion Protein Expression

MedGen UID:
307162
•Concept ID:
C1510696
•
Cell or Molecular Dysfunction

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVATIC-ALK Fusion Protein Expression

Professional guidelines

PubMed

Molecular Screening in Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma: Anaplastic Lymphoma Kinase Analysis, Next-Generation Sequencing Fusion Gene Detection, and T-Cell Receptor Immunoprofiling.
Kalinova M, Mrhalova M, Kabickova E, Svaton M, Skotnicova A, Prouzova Z, Krenova Z, Kolenova A, Divoka M, Fronkova E, Kodet R
Mod Pathol 2024 Mar;37(3):100428. Epub 2024 Jan 23 doi: 10.1016/j.modpat.2024.100428. PMID: 38266918

Recent clinical studies

Etiology

Variant ALK-fusion positive anaplastic large cell lymphoma (ALCL): A population-based paediatric study of the NHL-BFM study group.
Luedersen J, Stadt UZ, Richter J, Oschlies I, Klapper W, Rosenwald A, Kalinova M, Simonitsch-Klupp I, Siebert R, Zimmermann M, Qi M, Nakel J, Scheinemann K, Knörr F, Attarbaschi A, Kabickova E, Woessmann W, Damm-Welk C
Br J Haematol 2024 May;204(5):1894-1898. Epub 2024 Jan 26 doi: 10.1111/bjh.19308. PMID: 38279625
Pathobiology of NPM-ALK and variant fusion genes in anaplastic large cell lymphoma and other lymphomas.
Drexler HG, Gignac SM, von Wasielewski R, Werner M, Dirks WG
Leukemia 2000 Sep;14(9):1533-59. doi: 10.1038/sj.leu.2401878. PMID: 10994999
A new variant anaplastic lymphoma kinase (ALK)-fusion protein (ATIC-ALK) in a case of ALK-positive anaplastic large cell lymphoma.
Trinei M, Lanfrancone L, Campo E, Pulford K, Mason DY, Pelicci PG, Falini B
Cancer Res 2000 Feb 15;60(4):793-8. PMID: 10706082

Diagnosis

Variant ALK-fusion positive anaplastic large cell lymphoma (ALCL): A population-based paediatric study of the NHL-BFM study group.
Luedersen J, Stadt UZ, Richter J, Oschlies I, Klapper W, Rosenwald A, Kalinova M, Simonitsch-Klupp I, Siebert R, Zimmermann M, Qi M, Nakel J, Scheinemann K, Knörr F, Attarbaschi A, Kabickova E, Woessmann W, Damm-Welk C
Br J Haematol 2024 May;204(5):1894-1898. Epub 2024 Jan 26 doi: 10.1111/bjh.19308. PMID: 38279625
Molecular Screening in Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma: Anaplastic Lymphoma Kinase Analysis, Next-Generation Sequencing Fusion Gene Detection, and T-Cell Receptor Immunoprofiling.
Kalinova M, Mrhalova M, Kabickova E, Svaton M, Skotnicova A, Prouzova Z, Krenova Z, Kolenova A, Divoka M, Fronkova E, Kodet R
Mod Pathol 2024 Mar;37(3):100428. Epub 2024 Jan 23 doi: 10.1016/j.modpat.2024.100428. PMID: 38266918
Anaplastic lymphoma kinase-positive anaplastic large cell lymphoma with the variant RNF213-, ATIC- and TPM3-ALK fusions is characterized by copy number gain of the rearranged ALK gene.
van der Krogt JA, Bempt MV, Ferreiro JF, Mentens N, Jacobs K, Pluys U, Doms K, Geerdens E, Uyttebroeck A, Pierre P, Michaux L, Devos T, Vandenberghe P, Tousseyn T, Cools J, Wlodarska I
Haematologica 2017 Sep;102(9):1605-1616. Epub 2017 Jun 28 doi: 10.3324/haematol.2016.146571. PMID: 28659337Free PMC Article
Prognostic significance of NPM-ALK fusion transcript overexpression in ALK-positive anaplastic large-cell lymphoma.
Li C, Takino H, Eimoto T, Ishida T, Inagaki A, Ueda R, Suzuki R, Yoshino T, Nakagawa A, Nakamura S, Inagaki H
Mod Pathol 2007 Jun;20(6):648-55. Epub 2007 Apr 20 doi: 10.1038/modpathol.3800781. PMID: 17464320
Pathobiology of NPM-ALK and variant fusion genes in anaplastic large cell lymphoma and other lymphomas.
Drexler HG, Gignac SM, von Wasielewski R, Werner M, Dirks WG
Leukemia 2000 Sep;14(9):1533-59. doi: 10.1038/sj.leu.2401878. PMID: 10994999

Prognosis

Variant ALK-fusion positive anaplastic large cell lymphoma (ALCL): A population-based paediatric study of the NHL-BFM study group.
Luedersen J, Stadt UZ, Richter J, Oschlies I, Klapper W, Rosenwald A, Kalinova M, Simonitsch-Klupp I, Siebert R, Zimmermann M, Qi M, Nakel J, Scheinemann K, Knörr F, Attarbaschi A, Kabickova E, Woessmann W, Damm-Welk C
Br J Haematol 2024 May;204(5):1894-1898. Epub 2024 Jan 26 doi: 10.1111/bjh.19308. PMID: 38279625
ALK-positive primary cutaneous T-cell-lymphoma (CTCL) with unusual clinical presentation and aggressive course.
Wehkamp U, Oschlies I, Nagel I, Brasch J, Kneba M, Günther A, Klapper W, Weichenthal M
J Cutan Pathol 2015 Nov;42(11):870-7. Epub 2015 Jun 25 doi: 10.1111/cup.12547. PMID: 26053561
Prognostic significance of NPM-ALK fusion transcript overexpression in ALK-positive anaplastic large-cell lymphoma.
Li C, Takino H, Eimoto T, Ishida T, Inagaki A, Ueda R, Suzuki R, Yoshino T, Nakagawa A, Nakamura S, Inagaki H
Mod Pathol 2007 Jun;20(6):648-55. Epub 2007 Apr 20 doi: 10.1038/modpathol.3800781. PMID: 17464320
Pathobiology of NPM-ALK and variant fusion genes in anaplastic large cell lymphoma and other lymphomas.
Drexler HG, Gignac SM, von Wasielewski R, Werner M, Dirks WG
Leukemia 2000 Sep;14(9):1533-59. doi: 10.1038/sj.leu.2401878. PMID: 10994999
ATIC-ALK: A novel variant ALK gene fusion in anaplastic large cell lymphoma resulting from the recurrent cryptic chromosomal inversion, inv(2)(p23q35).
Colleoni GW, Bridge JA, Garicochea B, Liu J, Filippa DA, Ladanyi M
Am J Pathol 2000 Mar;156(3):781-9. doi: 10.1016/S0002-9440(10)64945-0. PMID: 10702393Free PMC Article

Clinical prediction guides

Molecular Screening in Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma: Anaplastic Lymphoma Kinase Analysis, Next-Generation Sequencing Fusion Gene Detection, and T-Cell Receptor Immunoprofiling.
Kalinova M, Mrhalova M, Kabickova E, Svaton M, Skotnicova A, Prouzova Z, Krenova Z, Kolenova A, Divoka M, Fronkova E, Kodet R
Mod Pathol 2024 Mar;37(3):100428. Epub 2024 Jan 23 doi: 10.1016/j.modpat.2024.100428. PMID: 38266918
Anaplastic lymphoma kinase-positive anaplastic large cell lymphoma with the variant RNF213-, ATIC- and TPM3-ALK fusions is characterized by copy number gain of the rearranged ALK gene.
van der Krogt JA, Bempt MV, Ferreiro JF, Mentens N, Jacobs K, Pluys U, Doms K, Geerdens E, Uyttebroeck A, Pierre P, Michaux L, Devos T, Vandenberghe P, Tousseyn T, Cools J, Wlodarska I
Haematologica 2017 Sep;102(9):1605-1616. Epub 2017 Jun 28 doi: 10.3324/haematol.2016.146571. PMID: 28659337Free PMC Article
Prognostic significance of NPM-ALK fusion transcript overexpression in ALK-positive anaplastic large-cell lymphoma.
Li C, Takino H, Eimoto T, Ishida T, Inagaki A, Ueda R, Suzuki R, Yoshino T, Nakagawa A, Nakamura S, Inagaki H
Mod Pathol 2007 Jun;20(6):648-55. Epub 2007 Apr 20 doi: 10.1038/modpathol.3800781. PMID: 17464320

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