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ALK Fusion Protein Expression

MedGen UID:
414759
•Concept ID:
C2825844
•
Cell or Molecular Dysfunction
Synonyms: ALK Fusion Protein Positive; ALK Tyrosine Kinase Receptor Fusion Protein Expression; Anaplastic Lymphoma Kinase Fusion Protein Expression; CD246 Antigen Fusion Protein Expression

Definition

Expression of fusion protein transcripts resulting from genetic alterations of the anaplastic lymphoma kinase (ALK) gene. [from NCI]

Professional guidelines

PubMed

Multi-omic and functional analysis for classification and treatment of sarcomas with FUS-TFCP2 or EWSR1-TFCP2 fusions.
Schöpf J, Uhrig S, Heilig CE, Lee KS, Walther T, Carazzato A, Dobberkau AM, Weichenhan D, Plass C, Hartmann M, Diwan GD, Carrero ZI, Ball CR, Hohl T, Kindler T, Rudolph-Hähnel P, Helm D, Schneider M, Nilsson A, Øra I, Imle R, Banito A, Russell RB, Jones BC, Lipka DB, Glimm H, Hübschmann D, Hartmann W, Fröhling S, Scholl C
Nat Commun 2024 Jan 2;15(1):51. doi: 10.1038/s41467-023-44360-2. PMID: 38168093Free PMC Article
Driver Fusions and Their Implications in the Development and Treatment of Human Cancers.
Gao Q, Liang WW, Foltz SM, Mutharasu G, Jayasinghe RG, Cao S, Liao WW, Reynolds SM, Wyczalkowski MA, Yao L, Yu L, Sun SQ; Fusion Analysis Working Group; Cancer Genome Atlas Research Network, Chen K, Lazar AJ, Fields RC, Wendl MC, Van Tine BA, Vij R, Chen F, Nykter M, Shmulevich I, Ding L
Cell Rep 2018 Apr 3;23(1):227-238.e3. doi: 10.1016/j.celrep.2018.03.050. PMID: 29617662Free PMC Article
Anaplastic lymphoma kinase (ALK) inhibitors in the treatment of ALK-driven lung cancers.
Roskoski R Jr
Pharmacol Res 2017 Mar;117:343-356. Epub 2017 Jan 8 doi: 10.1016/j.phrs.2017.01.007. PMID: 28077299

Recent clinical studies

Etiology

Anaplastic lymphoma kinase fusion protein expression is associated with a favorable prognosis in resected invasive mucinous lung adenocarcinoma: A retrospective study from two Chinese tertiary hospitals.
Wang J, Wei P, Liu J, Su P, Xing A, Jing H, Hao J
J Cancer Res Ther 2022 Apr;18(2):445-451. doi: 10.4103/jcrt.jcrt_2334_21. PMID: 35645113

Diagnosis

Anaplastic lymphoma kinase fusion protein expression is associated with a favorable prognosis in resected invasive mucinous lung adenocarcinoma: A retrospective study from two Chinese tertiary hospitals.
Wang J, Wei P, Liu J, Su P, Xing A, Jing H, Hao J
J Cancer Res Ther 2022 Apr;18(2):445-451. doi: 10.4103/jcrt.jcrt_2334_21. PMID: 35645113

Prognosis

Anaplastic lymphoma kinase fusion protein expression is associated with a favorable prognosis in resected invasive mucinous lung adenocarcinoma: A retrospective study from two Chinese tertiary hospitals.
Wang J, Wei P, Liu J, Su P, Xing A, Jing H, Hao J
J Cancer Res Ther 2022 Apr;18(2):445-451. doi: 10.4103/jcrt.jcrt_2334_21. PMID: 35645113

Clinical prediction guides

Anaplastic lymphoma kinase fusion protein expression is associated with a favorable prognosis in resected invasive mucinous lung adenocarcinoma: A retrospective study from two Chinese tertiary hospitals.
Wang J, Wei P, Liu J, Su P, Xing A, Jing H, Hao J
J Cancer Res Ther 2022 Apr;18(2):445-451. doi: 10.4103/jcrt.jcrt_2334_21. PMID: 35645113
MiR-29a down-regulation in ALK-positive anaplastic large cell lymphomas contributes to apoptosis blockade through MCL-1 overexpression.
Desjobert C, Renalier MH, Bergalet J, Dejean E, Joseph N, Kruczynski A, Soulier J, Espinos E, Meggetto F, Cavaillé J, Delsol G, Lamant L
Blood 2011 Jun 16;117(24):6627-37. Epub 2011 Apr 6 doi: 10.1182/blood-2010-09-301994. PMID: 21471522

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