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Borderline Fallopian Tube Endometrioid Tumor

MedGen UID:
307296
•Concept ID:
C1511254
•
Neoplastic Process
Synonym: Borderline Fallopian Tube Endometrioid Neoplasm

Definition

A neoplasm of low malignant potential arising from the fallopian tube. It is characterized by the presence of glandular or cystic spaces which contain atypical glandular epithelial cells resembling endometrial cells. There is no evidence of stromal invasion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBorderline Fallopian Tube Endometrioid Tumor

Professional guidelines

PubMed

Ovarian Cancer, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology.
Armstrong DK, Alvarez RD, Bakkum-Gamez JN, Barroilhet L, Behbakht K, Berchuck A, Chen LM, Cristea M, DeRosa M, Eisenhauer EL, Gershenson DM, Gray HJ, Grisham R, Hakam A, Jain A, Karam A, Konecny GE, Leath CA, Liu J, Mahdi H, Martin L, Matei D, McHale M, McLean K, Miller DS, O'Malley DM, Percac-Lima S, Ratner E, Remmenga SW, Vargas R, Werner TL, Zsiros E, Burns JL, Engh AM
J Natl Compr Canc Netw 2021 Feb 2;19(2):191-226. doi: 10.6004/jnccn.2021.0007. PMID: 33545690
Optimal primary management of bulky stage IIIC ovarian, fallopian tube and peritoneal carcinoma: Are the only options complete gross resection at primary debulking surgery or neoadjuvant chemotherapy?
Sioulas VD, Schiavone MB, Kadouri D, Zivanovic O, Roche KL, O'Cearbhaill R, Abu-Rustum NR, Levine DA, Sonoda Y, Gardner GJ, Leitao MM Jr, Chi DS
Gynecol Oncol 2017 Apr;145(1):15-20. Epub 2017 Feb 21 doi: 10.1016/j.ygyno.2017.02.023. PMID: 28238354Free PMC Article

Recent clinical studies

Etiology

Atypical Endometriosis: Comprehensive Characterization of Clinicopathologic, Immunohistochemical, and Molecular Features.
Wepy C, Nucci MR, Parra-Herran C
Int J Gynecol Pathol 2024 Jan 1;43(1):70-77. Epub 2023 Mar 13 doi: 10.1097/PGP.0000000000000952. PMID: 37043650
Primary tumor types and origins in positive abdominopelvic washing cytology, a single institution experience.
Hou Y, Bruehl FK, McHugh KE, Reynolds JP
J Am Soc Cytopathol 2020 Mar-Apr;9(2):89-94. Epub 2019 Oct 14 doi: 10.1016/j.jasc.2019.10.001. PMID: 31734259
New insights in the pathophysiology of ovarian cancer and implications for screening and prevention.
Nezhat FR, Apostol R, Nezhat C, Pejovic T
Am J Obstet Gynecol 2015 Sep;213(3):262-7. Epub 2015 Mar 25 doi: 10.1016/j.ajog.2015.03.044. PMID: 25818671
Recent concepts of ovarian carcinogenesis: type I and type II.
Koshiyama M, Matsumura N, Konishi I
Biomed Res Int 2014;2014:934261. Epub 2014 Apr 23 doi: 10.1155/2014/934261. PMID: 24868556Free PMC Article
The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory.
Kurman RJ, Shih IeM
Am J Surg Pathol 2010 Mar;34(3):433-43. doi: 10.1097/PAS.0b013e3181cf3d79. PMID: 20154587Free PMC Article

Diagnosis

Atypical Endometriosis: Comprehensive Characterization of Clinicopathologic, Immunohistochemical, and Molecular Features.
Wepy C, Nucci MR, Parra-Herran C
Int J Gynecol Pathol 2024 Jan 1;43(1):70-77. Epub 2023 Mar 13 doi: 10.1097/PGP.0000000000000952. PMID: 37043650
WT1 Positive Ovarian Endometrioid Tumors: Observations From Consult Cases and Strategies for Distinguishing From Serous Neoplasms.
Rajendran S, McCluggage WG
Int J Gynecol Pathol 2022 Mar 1;41(2):191-202. doi: 10.1097/PGP.0000000000000788. PMID: 33782345
Ovarian Cancer, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology.
Armstrong DK, Alvarez RD, Bakkum-Gamez JN, Barroilhet L, Behbakht K, Berchuck A, Chen LM, Cristea M, DeRosa M, Eisenhauer EL, Gershenson DM, Gray HJ, Grisham R, Hakam A, Jain A, Karam A, Konecny GE, Leath CA, Liu J, Mahdi H, Martin L, Matei D, McHale M, McLean K, Miller DS, O'Malley DM, Percac-Lima S, Ratner E, Remmenga SW, Vargas R, Werner TL, Zsiros E, Burns JL, Engh AM
J Natl Compr Canc Netw 2021 Feb 2;19(2):191-226. doi: 10.6004/jnccn.2021.0007. PMID: 33545690
Multimodality Imaging Approach to Ovarian Neoplasms with Pathologic Correlation.
Taylor EC, Irshaid L, Mathur M
Radiographics 2021 Jan-Feb;41(1):289-315. Epub 2020 Nov 13 doi: 10.1148/rg.2021200086. PMID: 33186060
Primary tumor types and origins in positive abdominopelvic washing cytology, a single institution experience.
Hou Y, Bruehl FK, McHugh KE, Reynolds JP
J Am Soc Cytopathol 2020 Mar-Apr;9(2):89-94. Epub 2019 Oct 14 doi: 10.1016/j.jasc.2019.10.001. PMID: 31734259

Therapy

Optimal primary management of bulky stage IIIC ovarian, fallopian tube and peritoneal carcinoma: Are the only options complete gross resection at primary debulking surgery or neoadjuvant chemotherapy?
Sioulas VD, Schiavone MB, Kadouri D, Zivanovic O, Roche KL, O'Cearbhaill R, Abu-Rustum NR, Levine DA, Sonoda Y, Gardner GJ, Leitao MM Jr, Chi DS
Gynecol Oncol 2017 Apr;145(1):15-20. Epub 2017 Feb 21 doi: 10.1016/j.ygyno.2017.02.023. PMID: 28238354Free PMC Article
Impact of levonorgestrel-releasing intrauterine system use on the cancer risk of the ovary and fallopian tube.
Soini T, Hurskainen R, Grénman S, Mäenpää J, Paavonen J, Pukkala E
Acta Oncol 2016 Nov;55(11):1281-1284. Epub 2016 May 5 doi: 10.1080/0284186X.2016.1175660. PMID: 27148621
Cancerous ovarian stem cells: obscure targets for therapy but relevant to chemoresistance.
Ahmed N, Abubaker K, Findlay J, Quinn M
J Cell Biochem 2013 Jan;114(1):21-34. doi: 10.1002/jcb.24317. PMID: 22887554
Body size and risk of epithelial ovarian and related cancers: a population-based case-control study.
Olsen CM, Nagle CM, Whiteman DC, Purdie DM, Green AC, Webb PM
Int J Cancer 2008 Jul 15;123(2):450-456. doi: 10.1002/ijc.23509. PMID: 18449887
Pathogenesis of ovarian cancer: lessons from morphology and molecular biology and their clinical implications.
Kurman RJ, Shih IeM
Int J Gynecol Pathol 2008 Apr;27(2):151-60. doi: 10.1097/PGP.0b013e318161e4f5. PMID: 18317228Free PMC Article

Prognosis

Primary tumor types and origins in positive abdominopelvic washing cytology, a single institution experience.
Hou Y, Bruehl FK, McHugh KE, Reynolds JP
J Am Soc Cytopathol 2020 Mar-Apr;9(2):89-94. Epub 2019 Oct 14 doi: 10.1016/j.jasc.2019.10.001. PMID: 31734259
The new WHO classification of ovarian, fallopian tube, and primary peritoneal cancer and its clinical implications.
Meinhold-Heerlein I, Fotopoulou C, Harter P, Kurzeder C, Mustea A, Wimberger P, Hauptmann S, Sehouli J
Arch Gynecol Obstet 2016 Apr;293(4):695-700. Epub 2016 Feb 19 doi: 10.1007/s00404-016-4035-8. PMID: 26894303
Recent concepts of ovarian carcinogenesis: type I and type II.
Koshiyama M, Matsumura N, Konishi I
Biomed Res Int 2014;2014:934261. Epub 2014 Apr 23 doi: 10.1155/2014/934261. PMID: 24868556Free PMC Article
Precursors and pathogenesis of ovarian carcinoma.
Lim D, Oliva E
Pathology 2013 Apr;45(3):229-42. doi: 10.1097/PAT.0b013e32835f2264. PMID: 23478230
Morphological subtypes of ovarian carcinoma: a review with emphasis on new developments and pathogenesis.
McCluggage WG
Pathology 2011 Aug;43(5):420-32. doi: 10.1097/PAT.0b013e328348a6e7. PMID: 21716157

Clinical prediction guides

Ciliated Cells in Ovarian Cancer Decrease with Increasing Tumor Grade and Disease Progression.
Richardson MT, Recouvreux MS, Karlan BY, Walts AE, Orsulic S
Cells 2022 Dec 11;11(24) doi: 10.3390/cells11244009. PMID: 36552773Free PMC Article
Differential epithelial and stromal LGR5 expression in ovarian carcinogenesis.
Kim H, Lee DH, Park E, Myung JK, Park JH, Kim DI, Kim SI, Lee M, Kim Y, Park CM, Hyun CL, Maeng YH, Lee C, Jang B
Sci Rep 2022 Jul 1;12(1):11200. doi: 10.1038/s41598-022-15234-2. PMID: 35778589Free PMC Article
WT1 Positive Ovarian Endometrioid Tumors: Observations From Consult Cases and Strategies for Distinguishing From Serous Neoplasms.
Rajendran S, McCluggage WG
Int J Gynecol Pathol 2022 Mar 1;41(2):191-202. doi: 10.1097/PGP.0000000000000788. PMID: 33782345
Immunohistochemical localization of HE4 in benign, borderline, and malignant lesions of the ovary.
Georgakopoulos P, Mehmood S, Akalin A, Shroyer KR
Int J Gynecol Pathol 2012 Nov;31(6):517-23. doi: 10.1097/PGP.0b013e31824fe269. PMID: 23018214
Histopathological characteristics of BRCA1- and BRCA2-associated intraperitoneal cancer: a clinic-based study.
Piek JM, Torrenga B, Hermsen B, Verheijen RH, Zweemer RP, Gille JJ, Kenemans P, van Diest PJ, Menko FH
Fam Cancer 2003;2(2):73-8. doi: 10.1023/a:1025700807451. PMID: 14574155

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