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Borderline epithelial tumor of ovary

MedGen UID:
777110
•Concept ID:
C3665489
•
Neoplastic Process
Synonyms: Borderline epithelial neoplasm of ovary; Borderline Epithelial Neoplasm of Ovary; borderline epithelial neoplasm of ovary; Borderline Epithelial Neoplasm of the Ovary; borderline epithelial neoplasm of the ovary; Borderline Epithelial Tumor of Ovary; borderline epithelial tumor of ovary; Borderline Epithelial Tumor of the Ovary; borderline epithelial tumor of the ovary; borderline epithelial tumour of the ovary; Borderline Ovarian Epithelial Neoplasm; borderline ovarian epithelial neoplasm; Borderline Ovarian Epithelial Tumor; Borderline ovarian epithelial tumor; borderline ovarian epithelial tumor; borderline ovarian epithelial tumour; Borderline Ovarian Surface Epithelial-Stromal Tumor; borderline ovarian surface epithelial-stromal tumor; borderline ovarian surface epithelial-stromal tumour; Epithelial Neoplasm of Ovary of Borderline Malignancy; epithelial neoplasm of ovary of borderline malignancy; Epithelial Neoplasm of the Ovary of Borderline Malignancy; epithelial neoplasm of the ovary of borderline malignancy; Epithelial Ovarian Neoplasm of Borderline Malignancy; epithelial ovarian neoplasm of borderline malignancy; Epithelial Ovarian Tumor of Borderline Malignancy; epithelial ovarian tumor of borderline malignancy; epithelial ovarian tumour of borderline malignancy; Epithelial Tumor of Ovary of Borderline Malignancy; epithelial tumor of ovary of borderline malignancy; Epithelial Tumor of the Ovary of Borderline Malignancy; epithelial tumor of the ovary of borderline malignancy; epithelial tumour of ovary of borderline malignancy; epithelial tumour of the ovary of borderline malignancy; low malignant potential ovarian tumor; low malignant potential ovarian tumour; ovarian borderline malignant tumor; ovarian borderline malignant tumour; ovarian low malignant potential tumor; ovarian low malignant potential tumour; ovarian tum. of low malig. poten.; Ovarian tumor of low malignant potential; ovarian tumor of low malignant potential; ovarian tumors of low malignant potential; ovarian tumour of low malignant potential; ovarian tumours of low malignant potential
SNOMED CT: Borderline ovarian epithelial tumor (764791008); Borderline epithelial tumor of ovary (764791008); Borderline epithelial neoplasm of ovary (764791008)
 
Monarch Initiative: MONDO:0016093
Orphanet: ORPHA206473

Definition

An uncommon epithelial ovarian neoplasm, distinguished from ovarian carcinomas by the absence of destructive stromal invasion, generally characterised by indolent behaviour and excellent prognosis. Most patients are asymptomatic at the time of diagnosis, and the symptoms, if present, are often nonspecific and vague, such as pelvic pain, abdominal mass or, rarely, gastrointestinal problems including early satiety or bloating. Six histological subtypes are currently recognised, based on the epithelial cell type. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBorderline epithelial tumor of ovary

Professional guidelines

PubMed

Ovarian Cancer, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology.
Armstrong DK, Alvarez RD, Bakkum-Gamez JN, Barroilhet L, Behbakht K, Berchuck A, Chen LM, Cristea M, DeRosa M, Eisenhauer EL, Gershenson DM, Gray HJ, Grisham R, Hakam A, Jain A, Karam A, Konecny GE, Leath CA, Liu J, Mahdi H, Martin L, Matei D, McHale M, McLean K, Miller DS, O'Malley DM, Percac-Lima S, Ratner E, Remmenga SW, Vargas R, Werner TL, Zsiros E, Burns JL, Engh AM
J Natl Compr Canc Netw 2021 Feb 2;19(2):191-226. doi: 10.6004/jnccn.2021.0007. PMID: 33545690
Ovarian borderline tumors in the 2014 WHO classification: evolving concepts and diagnostic criteria.
Hauptmann S, Friedrich K, Redline R, Avril S
Virchows Arch 2017 Feb;470(2):125-142. Epub 2016 Dec 27 doi: 10.1007/s00428-016-2040-8. PMID: 28025670Free PMC Article
Clinical management of borderline ovarian tumors.
Trillsch F, Mahner S, Ruetzel J, Harter P, Ewald-Riegler N, Jaenicke F, du Bois A
Expert Rev Anticancer Ther 2010 Jul;10(7):1115-24. doi: 10.1586/era.10.90. PMID: 20645700

Recent clinical studies

Etiology

Trametinib versus standard of care in patients with recurrent low-grade serous ovarian cancer (GOG 281/LOGS): an international, randomised, open-label, multicentre, phase 2/3 trial.
Gershenson DM, Miller A, Brady WE, Paul J, Carty K, Rodgers W, Millan D, Coleman RL, Moore KN, Banerjee S, Connolly K, Secord AA, O'Malley DM, Dorigo O, Gaillard S, Gabra H, Slomovitz B, Hanjani P, Farley J, Churchman M, Ewing A, Hollis RL, Herrington CS, Huang HQ, Wenzel L, Gourley C
Lancet 2022 Feb 5;399(10324):541-553. doi: 10.1016/S0140-6736(21)02175-9. PMID: 35123694Free PMC Article
Brenner Borderline Ovarian Tumor: A Case Series and Literature Review.
Ricotta G, Maulard A, Genestie C, Pautier P, Leary A, Chargari C, Candiani M, Morice P, Gouy S
Ann Surg Oncol 2021 Oct;28(11):6714-6720. Epub 2021 Mar 25 doi: 10.1245/s10434-021-09879-y. PMID: 33768396
Low-grade serous ovarian cancer: State of the science.
Slomovitz B, Gourley C, Carey MS, Malpica A, Shih IM, Huntsman D, Fader AN, Grisham RN, Schlumbrecht M, Sun CC, Ludemann J, Cooney GA, Coleman R, Sood AK, Mahdi H, Wong KK, Covens A, O'Malley DM, Lecuru F, Cobb LP, Caputo TA, May T, Huang M, Siemon J, Fernández ML, Ray-Coquard I, Gershenson DM
Gynecol Oncol 2020 Mar;156(3):715-725. Epub 2020 Jan 20 doi: 10.1016/j.ygyno.2019.12.033. PMID: 31969252
Borderline Brenner Tumor: A Review of the Literature.
Zheng R, Heller DS
Arch Pathol Lab Med 2019 Oct;143(10):1278-1280. Epub 2019 Feb 19 doi: 10.5858/arpa.2018-0285-RS. PMID: 30779594
The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory.
Kurman RJ, Shih IeM
Am J Surg Pathol 2010 Mar;34(3):433-43. doi: 10.1097/PAS.0b013e3181cf3d79. PMID: 20154587Free PMC Article

Diagnosis

Trametinib versus standard of care in patients with recurrent low-grade serous ovarian cancer (GOG 281/LOGS): an international, randomised, open-label, multicentre, phase 2/3 trial.
Gershenson DM, Miller A, Brady WE, Paul J, Carty K, Rodgers W, Millan D, Coleman RL, Moore KN, Banerjee S, Connolly K, Secord AA, O'Malley DM, Dorigo O, Gaillard S, Gabra H, Slomovitz B, Hanjani P, Farley J, Churchman M, Ewing A, Hollis RL, Herrington CS, Huang HQ, Wenzel L, Gourley C
Lancet 2022 Feb 5;399(10324):541-553. doi: 10.1016/S0140-6736(21)02175-9. PMID: 35123694Free PMC Article
Ovarian Cancer, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology.
Armstrong DK, Alvarez RD, Bakkum-Gamez JN, Barroilhet L, Behbakht K, Berchuck A, Chen LM, Cristea M, DeRosa M, Eisenhauer EL, Gershenson DM, Gray HJ, Grisham R, Hakam A, Jain A, Karam A, Konecny GE, Leath CA, Liu J, Mahdi H, Martin L, Matei D, McHale M, McLean K, Miller DS, O'Malley DM, Percac-Lima S, Ratner E, Remmenga SW, Vargas R, Werner TL, Zsiros E, Burns JL, Engh AM
J Natl Compr Canc Netw 2021 Feb 2;19(2):191-226. doi: 10.6004/jnccn.2021.0007. PMID: 33545690
Low-grade serous ovarian cancer: State of the science.
Slomovitz B, Gourley C, Carey MS, Malpica A, Shih IM, Huntsman D, Fader AN, Grisham RN, Schlumbrecht M, Sun CC, Ludemann J, Cooney GA, Coleman R, Sood AK, Mahdi H, Wong KK, Covens A, O'Malley DM, Lecuru F, Cobb LP, Caputo TA, May T, Huang M, Siemon J, Fernández ML, Ray-Coquard I, Gershenson DM
Gynecol Oncol 2020 Mar;156(3):715-725. Epub 2020 Jan 20 doi: 10.1016/j.ygyno.2019.12.033. PMID: 31969252
Endometriosis-associated ovarian neoplasia.
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974
Ovarian borderline tumors in the 2014 WHO classification: evolving concepts and diagnostic criteria.
Hauptmann S, Friedrich K, Redline R, Avril S
Virchows Arch 2017 Feb;470(2):125-142. Epub 2016 Dec 27 doi: 10.1007/s00428-016-2040-8. PMID: 28025670Free PMC Article

Therapy

Advancements in Low-Grade Serous Carcinoma of the Ovary and Peritoneum.
Grisham RN, Chui MH
Curr Oncol Rep 2022 Nov;24(11):1549-1555. Epub 2022 Aug 13 doi: 10.1007/s11912-022-01315-y. PMID: 35962920Free PMC Article
Trametinib versus standard of care in patients with recurrent low-grade serous ovarian cancer (GOG 281/LOGS): an international, randomised, open-label, multicentre, phase 2/3 trial.
Gershenson DM, Miller A, Brady WE, Paul J, Carty K, Rodgers W, Millan D, Coleman RL, Moore KN, Banerjee S, Connolly K, Secord AA, O'Malley DM, Dorigo O, Gaillard S, Gabra H, Slomovitz B, Hanjani P, Farley J, Churchman M, Ewing A, Hollis RL, Herrington CS, Huang HQ, Wenzel L, Gourley C
Lancet 2022 Feb 5;399(10324):541-553. doi: 10.1016/S0140-6736(21)02175-9. PMID: 35123694Free PMC Article
Low-grade serous ovarian cancer: State of the science.
Slomovitz B, Gourley C, Carey MS, Malpica A, Shih IM, Huntsman D, Fader AN, Grisham RN, Schlumbrecht M, Sun CC, Ludemann J, Cooney GA, Coleman R, Sood AK, Mahdi H, Wong KK, Covens A, O'Malley DM, Lecuru F, Cobb LP, Caputo TA, May T, Huang M, Siemon J, Fernández ML, Ray-Coquard I, Gershenson DM
Gynecol Oncol 2020 Mar;156(3):715-725. Epub 2020 Jan 20 doi: 10.1016/j.ygyno.2019.12.033. PMID: 31969252
Mucinous epithelial ovarian carcinoma.
Perren TJ
Ann Oncol 2016 Apr;27 Suppl 1:i53-i57. doi: 10.1093/annonc/mdw087. PMID: 27141073
Mucinous tumors of the ovary: current thoughts on diagnosis and management.
Brown J, Frumovitz M
Curr Oncol Rep 2014 Jun;16(6):389. doi: 10.1007/s11912-014-0389-x. PMID: 24777667Free PMC Article

Prognosis

Advancements in Low-Grade Serous Carcinoma of the Ovary and Peritoneum.
Grisham RN, Chui MH
Curr Oncol Rep 2022 Nov;24(11):1549-1555. Epub 2022 Aug 13 doi: 10.1007/s11912-022-01315-y. PMID: 35962920Free PMC Article
Gynecologic cancer in pregnancy.
Korenaga TK, Tewari KS
Gynecol Oncol 2020 Jun;157(3):799-809. Epub 2020 Apr 5 doi: 10.1016/j.ygyno.2020.03.015. PMID: 32268951Free PMC Article
Pathology of Endometrioid and Clear Cell Carcinoma of the Ovary.
Fadare O, Parkash V
Surg Pathol Clin 2019 Jun;12(2):529-564. doi: 10.1016/j.path.2019.01.009. PMID: 31097114
Endometriosis-associated ovarian neoplasia.
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974
Ovarian borderline tumors in the 2014 WHO classification: evolving concepts and diagnostic criteria.
Hauptmann S, Friedrich K, Redline R, Avril S
Virchows Arch 2017 Feb;470(2):125-142. Epub 2016 Dec 27 doi: 10.1007/s00428-016-2040-8. PMID: 28025670Free PMC Article

Clinical prediction guides

Brenner Borderline Ovarian Tumor: A Case Series and Literature Review.
Ricotta G, Maulard A, Genestie C, Pautier P, Leary A, Chargari C, Candiani M, Morice P, Gouy S
Ann Surg Oncol 2021 Oct;28(11):6714-6720. Epub 2021 Mar 25 doi: 10.1245/s10434-021-09879-y. PMID: 33768396
Borderline ovarian tumors: Guidelines from the French national college of obstetricians and gynecologists (CNGOF).
Bourdel N, Huchon C, Abdel Wahab C, Azaïs H, Bendifallah S, Bolze PA, Brun JL, Canlorbe G, Chauvet P, Chereau E, Courbiere B, De La Motte Rouge T, Devouassoux-Shisheboran M, Eymerit-Morin C, Fauvet R, Gauroy E, Gauthier T, Grynberg M, Koskas M, Larouzee E, Lecointre L, Levêque J, Margueritte F, Mathieu D'argent E, Nyangoh-Timoh K, Ouldamer L, Raad J, Raimond E, Ramanah R, Rolland L, Rousset P, Rousset-Jablonski C, Thomassin-Naggara I, Uzan C, Zilliox M, Daraï E
Eur J Obstet Gynecol Reprod Biol 2021 Jan;256:492-501. Epub 2020 Nov 20 doi: 10.1016/j.ejogrb.2020.11.045. PMID: 33262005
Prognostic indicators in ovarian serous borderline tumours.
Malpica A, Longacre TA
Pathology 2018 Feb;50(2):205-213. Epub 2017 Dec 28 doi: 10.1016/j.pathol.2017.12.001. PMID: 29289348
Endometriosis-associated ovarian neoplasia.
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974
Ovarian borderline tumors in the 2014 WHO classification: evolving concepts and diagnostic criteria.
Hauptmann S, Friedrich K, Redline R, Avril S
Virchows Arch 2017 Feb;470(2):125-142. Epub 2016 Dec 27 doi: 10.1007/s00428-016-2040-8. PMID: 28025670Free PMC Article

Recent systematic reviews

Ovarian Strumal Carcinoid: Case Report, Systematic Literature Review and Pooled Analysis.
Turla A, Zamparini M, Milione M, Grisanti S, Amoroso V, Pedersini R, Cosentini D, Berruti A
Front Endocrinol (Lausanne) 2022;13:871210. Epub 2022 Apr 21 doi: 10.3389/fendo.2022.871210. PMID: 35528006Free PMC Article
Influence of lymph node involvement or lymphadenectomy on prognosis of patients with borderline ovarian tumors: A systematic review and meta-analysis.
Fan Y, Zhang YF, Wang MY, Mu Y, Mo SP, Li JK
Gynecol Oncol 2021 Sep;162(3):797-803. Epub 2021 Jun 10 doi: 10.1016/j.ygyno.2021.05.033. PMID: 34119365
Ovarian epithelial tumors and reproductive factors: a systematic review.
Schüler S, Ponnath M, Engel J, Ortmann O
Arch Gynecol Obstet 2013 Jun;287(6):1187-204. Epub 2013 Mar 17 doi: 10.1007/s00404-013-2784-1. PMID: 23503972

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