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DNA Crosslinking

MedGen UID:
307393
•Concept ID:
C1511665
•
Cell or Molecular Dysfunction
Synonym: DNA Crosslink

Definition

DNA Crosslinking involves the formation of a covalent bond between two bases on DNA. (NCI) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDNA Crosslinking

Professional guidelines

PubMed

Inhibition of MAPKAPK2/MK2 facilitates DNA replication upon cancer cell treatment with gemcitabine but not cisplatin.
Li Y, Köpper F, Dobbelstein M
Cancer Lett 2018 Aug 1;428:45-54. Epub 2018 Apr 25 doi: 10.1016/j.canlet.2018.04.030. PMID: 29704518
ATR mediates cisplatin resistance in a p53 genotype-specific manner.
Sangster-Guity N, Conrad BH, Papadopoulos N, Bunz F
Oncogene 2011 Jun 2;30(22):2526-33. Epub 2011 Jan 24 doi: 10.1038/onc.2010.624. PMID: 21258400Free PMC Article
Inactivation of the Fanconi anemia/BRCA pathway in lung and oral cancers: implications for treatment and survival.
Marsit CJ, Liu M, Nelson HH, Posner M, Suzuki M, Kelsey KT
Oncogene 2004 Jan 29;23(4):1000-4. doi: 10.1038/sj.onc.1207256. PMID: 14647419

Recent clinical studies

Etiology

Sequence-Dependent Diastereospecific and Diastereodivergent Crosslinking of DNA by Decarbamoylmitomycin C.
Aguilar W, Paz MM, Vargas A, Clement CC, Cheng SY, Champeil E
Chemistry 2018 Apr 20;24(23):6030-6035. Epub 2018 Mar 27 doi: 10.1002/chem.201705771. PMID: 29504661Free PMC Article
Regulation of FANCD2 and FANCI monoubiquitination by their interaction and by DNA.
Longerich S, Kwon Y, Tsai MS, Hlaing AS, Kupfer GM, Sung P
Nucleic Acids Res 2014 May;42(9):5657-70. Epub 2014 Mar 12 doi: 10.1093/nar/gku198. PMID: 24623813Free PMC Article
Secondary mutations of BRCA1/2 and drug resistance.
Dhillon KK, Swisher EM, Taniguchi T
Cancer Sci 2011 Apr;102(4):663-9. Epub 2011 Jan 30 doi: 10.1111/j.1349-7006.2010.01840.x. PMID: 21205087Free PMC Article
The Fanconi anemia pathway and ubiquitin.
Jacquemont C, Taniguchi T
BMC Biochem 2007 Nov 22;8 Suppl 1(Suppl 1):S10. doi: 10.1186/1471-2091-8-S1-S10. PMID: 18047734Free PMC Article
The Fanconi anaemia/BRCA pathway.
D'Andrea AD, Grompe M
Nat Rev Cancer 2003 Jan;3(1):23-34. doi: 10.1038/nrc970. PMID: 12509764

Diagnosis

FBL promotes cancer cell resistance to DNA damage and BRCA1 transcription via YBX1.
Sun X, Gao C, Xu X, Li M, Zhao X, Wang Y, Wang Y, Zhang S, Yan Z, Liu X, Wu C
EMBO Rep 2023 Sep 6;24(9):e56230. Epub 2023 Jul 25 doi: 10.15252/embr.202256230. PMID: 37489617Free PMC Article
UVA photosensitization of thiopurines and skin cancer in organ transplant recipients.
Attard NR, Karran P
Photochem Photobiol Sci 2012 Jan;11(1):62-8. Epub 2011 Aug 23 doi: 10.1039/c1pp05194f. PMID: 21860872
Secondary mutations of BRCA1/2 and drug resistance.
Dhillon KK, Swisher EM, Taniguchi T
Cancer Sci 2011 Apr;102(4):663-9. Epub 2011 Jan 30 doi: 10.1111/j.1349-7006.2010.01840.x. PMID: 21205087Free PMC Article
Fanconi anemia and its diagnosis.
Auerbach AD
Mutat Res 2009 Jul 31;668(1-2):4-10. Epub 2009 Feb 28 doi: 10.1016/j.mrfmmm.2009.01.013. PMID: 19622403Free PMC Article
The Fanconi anaemia/BRCA pathway.
D'Andrea AD, Grompe M
Nat Rev Cancer 2003 Jan;3(1):23-34. doi: 10.1038/nrc970. PMID: 12509764

Therapy

FBL promotes cancer cell resistance to DNA damage and BRCA1 transcription via YBX1.
Sun X, Gao C, Xu X, Li M, Zhao X, Wang Y, Wang Y, Zhang S, Yan Z, Liu X, Wu C
EMBO Rep 2023 Sep 6;24(9):e56230. Epub 2023 Jul 25 doi: 10.15252/embr.202256230. PMID: 37489617Free PMC Article
Genomic signature of Fanconi anaemia DNA repair pathway deficiency in cancer.
Webster ALH, Sanders MA, Patel K, Dietrich R, Noonan RJ, Lach FP, White RR, Goldfarb A, Hadi K, Edwards MM, Donovan FX, Hoogenboezem RM, Jung M, Sridhar S, Wiley TF, Fedrigo O, Tian H, Rosiene J, Heineman T, Kennedy JA, Bean L, Rosti RO, Tryon R, Gonzalez AM, Rosenberg A, Luo JD, Carroll TS, Shroff S, Beaumont M, Velleuer E, Rastatter JC, Wells SI, Surrallés J, Bagby G, MacMillan ML, Wagner JE, Cancio M, Boulad F, Scognamiglio T, Vaughan R, Beaumont KG, Koren A, Imielinski M, Chandrasekharappa SC, Auerbach AD, Singh B, Kutler DI, Campbell PJ, Smogorzewska A
Nature 2022 Dec;612(7940):495-502. Epub 2022 Nov 30 doi: 10.1038/s41586-022-05253-4. PMID: 36450981Free PMC Article
Melphalan Flufenamide (Melflufen): First Approval.
Dhillon S
Drugs 2021 Jun;81(8):963-969. doi: 10.1007/s40265-021-01522-0. PMID: 33961277
The evolving role of DNA inter-strand crosslinks in chemotherapy.
Rycenga HB, Long DT
Curr Opin Pharmacol 2018 Aug;41:20-26. Epub 2018 Apr 18 doi: 10.1016/j.coph.2018.04.004. PMID: 29679802Free PMC Article
Epigenetic deregulation of DNA repair and its potential for therapy.
Hegi ME, Sciuscio D, Murat A, Levivier M, Stupp R
Clin Cancer Res 2009 Aug 15;15(16):5026-31. Epub 2009 Aug 11 doi: 10.1158/1078-0432.CCR-08-1169. PMID: 19671858

Prognosis

ML216-Induced BLM Helicase Inhibition Sensitizes PCa Cells to the DNA-Crosslinking Agent Cisplatin.
Ma XY, Zhao JF, Ruan Y, Zhang WM, Zhang LQ, Cai ZD, Xu HQ
Molecules 2022 Dec 12;27(24) doi: 10.3390/molecules27248790. PMID: 36557923Free PMC Article
Centipeda minima extract sensitizes lung cancer cells to DNA-crosslinking agents via targeting Fanconi anemia pathway.
Fan XZ, Chen YF, Zhang SB, He DH, Wei SF, Wang Q, Pan HF, Liu YQ
Phytomedicine 2021 Oct;91:153689. Epub 2021 Aug 6 doi: 10.1016/j.phymed.2021.153689. PMID: 34446320
Drug Sensitivity Prediction Models Reveal a Link between DNA Repair Defects and Poor Prognosis in HNSCC.
Essers PBM, van der Heijden M, Verhagen CVM, Ploeg EM, de Roest RH, Leemans CR, Brakenhoff RH, van den Brekel MWM, Bartelink H, Verheij M, Vens C
Cancer Res 2019 Nov 1;79(21):5597-5611. Epub 2019 Sep 12 doi: 10.1158/0008-5472.CAN-18-3388. PMID: 31515237
Molecular pathogenesis of Fanconi anemia: recent progress.
Taniguchi T, D'Andrea AD
Blood 2006 Jun 1;107(11):4223-33. Epub 2006 Feb 21 doi: 10.1182/blood-2005-10-4240. PMID: 16493006
Chlorambucil in chronic lymphocytic leukemia: mechanism of action.
Begleiter A, Mowat M, Israels LG, Johnston JB
Leuk Lymphoma 1996 Oct;23(3-4):187-201. doi: 10.3109/10428199609054821. PMID: 9031099

Clinical prediction guides

DNA crosslinking and recombination-activating genes 1/2 (RAG1/2) are required for oncogenic splicing in acute lymphoblastic leukemia.
Zhang H, Cheng N, Li Z, Bai L, Fang C, Li Y, Zhang W, Dong X, Jiang M, Liang Y, Zhang S, Mi J, Zhu J, Zhang Y, Chen SJ, Zhao Y, Weng XQ, Hu W, Chen Z, Huang J, Meng G
Cancer Commun (Lond) 2021 Nov;41(11):1116-1136. Epub 2021 Oct 26 doi: 10.1002/cac2.12234. PMID: 34699692Free PMC Article
A possible approach for stem cell gene therapy of Fanconi anemia.
Song L
Curr Gene Ther 2009 Feb;9(1):26-32. doi: 10.2174/156652309787354667. PMID: 19275569
The Fanconi anemia pathway and ubiquitin.
Jacquemont C, Taniguchi T
BMC Biochem 2007 Nov 22;8 Suppl 1(Suppl 1):S10. doi: 10.1186/1471-2091-8-S1-S10. PMID: 18047734Free PMC Article
Fanconi anaemia genes and susceptibility to cancer.
Mathew CG
Oncogene 2006 Sep 25;25(43):5875-84. doi: 10.1038/sj.onc.1209878. PMID: 16998502
Molecular pathogenesis of Fanconi anemia: recent progress.
Taniguchi T, D'Andrea AD
Blood 2006 Jun 1;107(11):4223-33. Epub 2006 Feb 21 doi: 10.1182/blood-2005-10-4240. PMID: 16493006

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