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Malignant vaginal mixed epithelial and mesenchymal neoplasm

MedGen UID:
307683
•Concept ID:
C1512974
•
Neoplastic Process
Synonyms: Malignant Vaginal Mixed Epithelial and Mesenchymal Neoplasm; malignant vaginal mixed epithelial and mesenchymal neoplasm; Malignant Vaginal Mixed Epithelial and Mesenchymal Tumor; malignant vaginal mixed epithelial and mesenchymal tumor; malignant vaginal mixed epithelial and mesenchymal tumour
 
Monarch Initiative: MONDO:0037746

Definition

A malignant neoplasm that arises from the vagina and is characterized by the presence of an epithelial and a mesenchymal component. This category includes adenosarcoma, carcinosarcoma, and malignant mixed tumor resembling synovial sarcoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant vaginal mixed epithelial and mesenchymal neoplasm

Professional guidelines

PubMed

Mixed tumors of the vagina: an immunohistochemical study of 13 cases with emphasis on the cell of origin and potential aid in differential diagnosis.
Oliva E, Gonzalez L, Dionigi A, Young RH
Mod Pathol 2004 Oct;17(10):1243-50. doi: 10.1038/modpathol.3800173. PMID: 15154010

Recent clinical studies

Etiology

Review literature on uterine carcinosarcoma.
Singh R
J Cancer Res Ther 2014 Jul-Sep;10(3):461-8. doi: 10.4103/0973-1482.138197. PMID: 25313723
Synchronous uterine carcinosarcoma and contralateral breast cancer after tamoxifen therapy: a case report.
Shen L, Hong L, Zhang G, Mai R
Int J Clin Exp Pathol 2014;7(8):5295-301. Epub 2014 Jul 15 PMID: 25197413Free PMC Article
Mesonephric carcinosarcoma of the uterine cervix: a case report.
Lopez-Chardi L, González-Bosquet E, Rovira Zurriaga C, Laïlla Vicens JM
Eur J Gynaecol Oncol 2013;34(4):336-8. PMID: 24020142
Adenofibroma of the endometrium protruding into the vaginal cavity: findings on transvaginal ultrasonography, MRI and CT.
Konishi Y, Sato H, Fujimoto T, Tanaka H, Takahashi O, Tanaka T
J Obstet Gynaecol Res 2006 Dec;32(6):623-7. doi: 10.1111/j.1447-0756.2006.00467.x. PMID: 17100829
Benign mixed tumor of the vagina: case report with expanded immunohistochemical profile.
Murdoch F, Sharma R, Al-Nafussi A
Int J Gynecol Cancer 2003 Jul-Aug;13(4):543-7. doi: 10.1046/j.1525-1438.2003.13309.x. PMID: 12911736

Diagnosis

Two Components of Variant Profiles in Primary Vaginal Carcinosarcoma via Next-Generation Sequencing and a Literature Review.
Kotoku R, Yanazume S, Kuroda T, Kobayashi Y, Kitazono I, Akahane T, Tanimoto A, Kobayashi H
Int J Surg Pathol 2022 May;30(3):288-294. Epub 2021 Aug 31 doi: 10.1177/10668969211037915. PMID: 34463147
Metastasizing uterine mullerian adenosarcoma in a young female: Diagnostic enigma.
Patnayak R, Rukmangadha N, Architha P, Reddy GS, Lakshmi AY, Kannan T, Jena A
Indian J Pathol Microbiol 2018 Jul-Sep;61(3):440-442. doi: 10.4103/IJPM.IJPM_1_18. PMID: 30004077
Review literature on uterine carcinosarcoma.
Singh R
J Cancer Res Ther 2014 Jul-Sep;10(3):461-8. doi: 10.4103/0973-1482.138197. PMID: 25313723
Tumor rupture as an initial manifestation of malignant mesonephric mixed tumor: a case report and review of the literature.
Tseng CE, Chen CH, Chen SJ, Chi CL
Int J Clin Exp Pathol 2014;7(3):1212-7. Epub 2014 Feb 15 PMID: 24696739Free PMC Article
Vaginal adenosarcoma arising from endometriosis.
Judson PL, Temple AM, Fowler WC Jr, Novotny DB, Funkhouser WK Jr
Gynecol Oncol 2000 Jan;76(1):123-5. doi: 10.1006/gyno.1999.5617. PMID: 10620454

Therapy

Metastasizing uterine mullerian adenosarcoma in a young female: Diagnostic enigma.
Patnayak R, Rukmangadha N, Architha P, Reddy GS, Lakshmi AY, Kannan T, Jena A
Indian J Pathol Microbiol 2018 Jul-Sep;61(3):440-442. doi: 10.4103/IJPM.IJPM_1_18. PMID: 30004077
Synchronous uterine carcinosarcoma and contralateral breast cancer after tamoxifen therapy: a case report.
Shen L, Hong L, Zhang G, Mai R
Int J Clin Exp Pathol 2014;7(8):5295-301. Epub 2014 Jul 15 PMID: 25197413Free PMC Article

Prognosis

Review literature on uterine carcinosarcoma.
Singh R
J Cancer Res Ther 2014 Jul-Sep;10(3):461-8. doi: 10.4103/0973-1482.138197. PMID: 25313723
Tumor rupture as an initial manifestation of malignant mesonephric mixed tumor: a case report and review of the literature.
Tseng CE, Chen CH, Chen SJ, Chi CL
Int J Clin Exp Pathol 2014;7(3):1212-7. Epub 2014 Feb 15 PMID: 24696739Free PMC Article
Case of uterine cervical carcinosarcoma.
Iida T, Yasuda M, Kajiwara H, Minematsu T, Osamura RY, Itoh J, Inomo A, Hirasawa T, Muramatsu T, Murakami M
J Obstet Gynaecol Res 2005 Oct;31(5):404-8. doi: 10.1111/j.1447-0756.2005.00310.x. PMID: 16176508
Benign mixed tumor of the vagina: case report with expanded immunohistochemical profile.
Murdoch F, Sharma R, Al-Nafussi A
Int J Gynecol Cancer 2003 Jul-Aug;13(4):543-7. doi: 10.1046/j.1525-1438.2003.13309.x. PMID: 12911736
Vaginal adenosarcoma arising from endometriosis.
Judson PL, Temple AM, Fowler WC Jr, Novotny DB, Funkhouser WK Jr
Gynecol Oncol 2000 Jan;76(1):123-5. doi: 10.1006/gyno.1999.5617. PMID: 10620454

Clinical prediction guides

Malignant mixed Müllerian tumor with an extensive squamous-cell carcinomatous component: a potential pitfall in liquid-based cervical cytology.
Bongiovanni M, Vitale VA, Grassi P, Mazzucchelli L
Acta Cytol 2014;58(4):413-8. Epub 2014 Jul 18 doi: 10.1159/000364851. PMID: 25059755

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