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t(11;14)(q13;q32)

MedGen UID:
308363
•Concept ID:
C1515705
•
Cell or Molecular Dysfunction

Definition

A cytogenetic abnormality that refers to the translocation of the long arm (q13) of chromosome 11 and the long arm (q32) of chromosome 14. It results in up-regulation of cyclin D1 and is the most common translocation detected in multiple myeloma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVt(11;14)(q13;q32)

Professional guidelines

PubMed

Mantle cell lymphoma: A clinical review of the changing treatment paradigms with the advent of novel therapies, and an insight into Indian data.
Radhakrishnan VS, Lokireddy P, Parihar M, Prakash PS, Menon H
Cancer Rep (Hoboken) 2022 Jul;5(7):e1590. Epub 2021 Nov 24 doi: 10.1002/cnr2.1590. PMID: 34821081Free PMC Article
Leukemic Non-nodal Mantle Cell Lymphoma: Diagnosis and Treatment.
Jain AG, Chang CC, Ahmad S, Mori S
Curr Treat Options Oncol 2019 Nov 27;20(12):85. doi: 10.1007/s11864-019-0684-8. PMID: 31776787
Update on the molecular pathogenesis and clinical treatment of mantle cell lymphoma: report of the 11th annual conference of the European Mantle Cell Lymphoma Network.
Dreyling M, Kluin-Nelemans HC, Beà S, Klapper W, Vogt N, Delfau-Larue MH, Hutter G, Cheah C, Chiappella A, Cortelazzo S, Pott C, Hess G, Visco C, Vitolo U, Klener P, Aurer I, Unterhalt M, Ribrag V, Hoster E, Hermine O; European MCL Network
Leuk Lymphoma 2013 Apr;54(4):699-707. Epub 2012 Nov 21 doi: 10.3109/10428194.2012.733882. PMID: 23020649

Recent clinical studies

Etiology

Imaging flow cytometry-based multiplex FISH for three IGH translocations in multiple myeloma.
Tsukamoto T, Kinoshita M, Yamada K, Ito H, Yamaguchi T, Chinen Y, Mizutani S, Fujino T, Kobayashi T, Shimura Y, Inazawa J, Kuroda J
J Hum Genet 2023 Jul;68(7):507-514. Epub 2023 Mar 8 doi: 10.1038/s10038-023-01136-2. PMID: 36882509Free PMC Article
The pathologic diagnosis of mantle cell lymphoma.
Li S, Xu J, You MJ
Histol Histopathol 2021 Oct;36(10):1037-1051. Epub 2021 Jun 11 doi: 10.14670/HH-18-351. PMID: 34114641
Immunophenotypic and laboratory features of t(11;14)(q13;q32)-positive plasma cell neoplasms.
Shi M, Ternus JA, Ketterling RP, Jevremovic D, McPhail ED
Leuk Lymphoma 2018 Aug;59(8):1913-1919. Epub 2017 Dec 7 doi: 10.1080/10428194.2017.1410885. PMID: 29214874
Recurrent Cytogenetic Abnormalities in Non-Hodgkin's Lymphoma and Chronic Lymphocytic Leukemia.
Ma ES
Methods Mol Biol 2017;1541:279-293. doi: 10.1007/978-1-4939-6703-2_22. PMID: 27910030
Impact of t(11;14)(q13;q32) on the outcome of autologous hematopoietic cell transplantation in multiple myeloma.
Sasaki K, Lu G, Saliba RM, Bashir Q, Hosing C, Popat U, Shah N, Parmar S, Dinh Y, Ahmed S, Shpall EJ, Kebriaei P, Shah JJ, Orlowski RZ, Champlin R, Qazilbash MH
Biol Blood Marrow Transplant 2013 Aug;19(8):1227-32. Epub 2013 May 31 doi: 10.1016/j.bbmt.2013.05.017. PMID: 23733001Free PMC Article

Diagnosis

Imaging flow cytometry-based multiplex FISH for three IGH translocations in multiple myeloma.
Tsukamoto T, Kinoshita M, Yamada K, Ito H, Yamaguchi T, Chinen Y, Mizutani S, Fujino T, Kobayashi T, Shimura Y, Inazawa J, Kuroda J
J Hum Genet 2023 Jul;68(7):507-514. Epub 2023 Mar 8 doi: 10.1038/s10038-023-01136-2. PMID: 36882509Free PMC Article
The pathologic diagnosis of mantle cell lymphoma.
Li S, Xu J, You MJ
Histol Histopathol 2021 Oct;36(10):1037-1051. Epub 2021 Jun 11 doi: 10.14670/HH-18-351. PMID: 34114641
Leukemic Non-nodal Mantle Cell Lymphoma: Diagnosis and Treatment.
Jain AG, Chang CC, Ahmad S, Mori S
Curr Treat Options Oncol 2019 Nov 27;20(12):85. doi: 10.1007/s11864-019-0684-8. PMID: 31776787
Immunophenotypic and laboratory features of t(11;14)(q13;q32)-positive plasma cell neoplasms.
Shi M, Ternus JA, Ketterling RP, Jevremovic D, McPhail ED
Leuk Lymphoma 2018 Aug;59(8):1913-1919. Epub 2017 Dec 7 doi: 10.1080/10428194.2017.1410885. PMID: 29214874
Mantle cell lymphoma.
Hankin RC, Hunter SV
Arch Pathol Lab Med 1999 Dec;123(12):1182-8. doi: 10.5858/1999-123-1182-MCL. PMID: 10583923

Therapy

Mantle cell lymphoma: a Turkish Multi-Center Study.
Okay M, Meletli O, Kelkitli E, Malkan UY, Turgut M, Buyukasik Y, Tekin F, Demiroglu H, Goker H
J BUON 2019 Sep-Oct;24(5):2084-2089. PMID: 31786879
Mantle cell lymphoma: biology, clinical presentation, and therapeutic approaches.
Dreyling M; European Mantle Cell Lymphoma Network
Am Soc Clin Oncol Educ Book 2014:191-8. doi: 10.14694/EdBook_AM.2014.34.191. PMID: 24857076
Radioimmunotherapy in mantle cell lymphoma.
Skarbnik AP, Smith MR
Best Pract Res Clin Haematol 2012 Jun;25(2):201-10. Epub 2012 May 9 doi: 10.1016/j.beha.2012.04.004. PMID: 22687456Free PMC Article
Myeloma and the t(11;14)(q13;q32); evidence for a biologically defined unique subset of patients.
Fonseca R, Blood EA, Oken MM, Kyle RA, Dewald GW, Bailey RJ, Van Wier SA, Henderson KJ, Hoyer JD, Harrington D, Kay NE, Van Ness B, Greipp PR
Blood 2002 May 15;99(10):3735-41. doi: 10.1182/blood.v99.10.3735. PMID: 11986230
Multiple myeloma and the translocation t(11;14)(q13;q32): a report on 13 cases.
Fonseca R, Witzig TE, Gertz MA, Kyle RA, Hoyer JD, Jalal SM, Greipp PR
Br J Haematol 1998 May;101(2):296-301. doi: 10.1046/j.1365-2141.1998.00700.x. PMID: 9609525

Prognosis

Imaging flow cytometry-based multiplex FISH for three IGH translocations in multiple myeloma.
Tsukamoto T, Kinoshita M, Yamada K, Ito H, Yamaguchi T, Chinen Y, Mizutani S, Fujino T, Kobayashi T, Shimura Y, Inazawa J, Kuroda J
J Hum Genet 2023 Jul;68(7):507-514. Epub 2023 Mar 8 doi: 10.1038/s10038-023-01136-2. PMID: 36882509Free PMC Article
The pathologic diagnosis of mantle cell lymphoma.
Li S, Xu J, You MJ
Histol Histopathol 2021 Oct;36(10):1037-1051. Epub 2021 Jun 11 doi: 10.14670/HH-18-351. PMID: 34114641
Leukemic Non-nodal Mantle Cell Lymphoma: Diagnosis and Treatment.
Jain AG, Chang CC, Ahmad S, Mori S
Curr Treat Options Oncol 2019 Nov 27;20(12):85. doi: 10.1007/s11864-019-0684-8. PMID: 31776787
Recurrent Cytogenetic Abnormalities in Non-Hodgkin's Lymphoma and Chronic Lymphocytic Leukemia.
Ma ES
Methods Mol Biol 2017;1541:279-293. doi: 10.1007/978-1-4939-6703-2_22. PMID: 27910030
Mantle cell lymphoma.
Hankin RC, Hunter SV
Arch Pathol Lab Med 1999 Dec;123(12):1182-8. doi: 10.5858/1999-123-1182-MCL. PMID: 10583923

Clinical prediction guides

Recurrent Cytogenetic Abnormalities in Non-Hodgkin's Lymphoma and Chronic Lymphocytic Leukemia.
Ma ES
Methods Mol Biol 2017;1541:279-293. doi: 10.1007/978-1-4939-6703-2_22. PMID: 27910030
The complex landscape of genetic alterations in mantle cell lymphoma.
Royo C, Salaverria I, Hartmann EM, Rosenwald A, Campo E, Beà S
Semin Cancer Biol 2011 Nov;21(5):322-34. Epub 2011 Sep 18 doi: 10.1016/j.semcancer.2011.09.007. PMID: 21945515
Advances in the understanding of mantle cell lymphoma.
Jares P, Campo E
Br J Haematol 2008 Jun;142(2):149-65. Epub 2008 Apr 10 doi: 10.1111/j.1365-2141.2008.07124.x. PMID: 18410453
Translocation t(11;14)(q13;q32) is the hallmark of IgM, IgE, and nonsecretory multiple myeloma variants.
Avet-Loiseau H, Garand R, Lodé L, Harousseau JL, Bataille R; Intergroupe Francophone du Myélome
Blood 2003 Feb 15;101(4):1570-1. Epub 2002 Oct 3 doi: 10.1182/blood-2002-08-2436. PMID: 12393502
Multiple myeloma and the translocation t(11;14)(q13;q32): a report on 13 cases.
Fonseca R, Witzig TE, Gertz MA, Kyle RA, Hoyer JD, Jalal SM, Greipp PR
Br J Haematol 1998 May;101(2):296-301. doi: 10.1046/j.1365-2141.1998.00700.x. PMID: 9609525

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