U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cervical adenosquamous carcinoma, glassy cell variant

MedGen UID:
308943
Concept ID:
C1516407
Neoplastic Process
Synonyms: Cervical Adenosquamous Carcinoma, Glassy Cell Variant; cervical adenosquamous carcinoma, glassy cell variant; Cervical Poorly Differentiated Adenosquamous Carcinoma; GCC of the cervix; glassy cell adenocarcinoma of the uterine cervix; glassy cell carcinoma of the cervix; glassy cell carcinoma of the cervix uteri; Glassy cell carcinoma of the cervix uteri; glassy cell variant cervical adenosquamous carcinoma
 
Monarch Initiative: MONDO:0004542
Orphanet: ORPHA213833

Definition

Glassy cell carcinoma of the cervix uteri is a rare cancer of the uterine cervix, composed of nests of large neoplastic cells with 'ground glass' cytoplasm, surrounded by a stroma with prominent eosinophilic infiltrates. It is a poorly differentiated, aggressive variant of adenosquamous carcinoma that usually affects young women and presents with dysfunctional vaginal bleeding and lower abdominal pain. Distant metastases to the lungs, liver spleen or bones are often present at the time of diagnosis. It is often associated with high-risk HPV-infection (types 18, 16 and 32). [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCervical adenosquamous carcinoma, glassy cell variant

Professional guidelines

PubMed

Young RH, Clement PB
Histopathology 2002 Sep;41(3):185-207. doi: 10.1046/j.1365-2559.2002.01462.x. PMID: 12207781

Recent clinical studies

Etiology

Randall ME, Kim JA, Mills SE, Hahn SS, Constable WC
Cancer 1986 Feb 15;57(4):816-22. doi: 10.1002/1097-0142(19860215)57:4<816::aid-cncr2820570423>3.0.co;2-z. PMID: 3002588

Diagnosis

Garg MM, Arora VK
Int J Gynecol Pathol 2012 May;31(3):294-6. doi: 10.1097/PGP.0b013e31823b6f37. PMID: 22498949
Deshpande AH, Kotwal MN, Bobhate SK
Indian J Cancer 2004 Apr-Jun;41(2):92-5. PMID: 15318016
Young RH, Clement PB
Histopathology 2002 Sep;41(3):185-207. doi: 10.1046/j.1365-2559.2002.01462.x. PMID: 12207781
Wang TY, Chen BF, Yang YC, Chen H, Wang Y, Cviko A, Quade BJ, Sun D, Yang A, McKeon FD, Crum CP
Hum Pathol 2001 May;32(5):479-86. doi: 10.1053/hupa.2001.24324. PMID: 11381365
Piura B, Rabinovich A, Meirovitz M, Yanai-Inbar I
J Surg Oncol 1999 Dec;72(4):206-10. doi: 10.1002/(sici)1096-9098(199912)72:4<206::aid-jso5>3.0.co;2-#. PMID: 10589035

Prognosis

Garg MM, Arora VK
Int J Gynecol Pathol 2012 May;31(3):294-6. doi: 10.1097/PGP.0b013e31823b6f37. PMID: 22498949
Deshpande AH, Kotwal MN, Bobhate SK
Indian J Cancer 2004 Apr-Jun;41(2):92-5. PMID: 15318016

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...