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Pulmonary type ovarian small cell carcinoma

MedGen UID:
309517
•Concept ID:
C1518737
•
Neoplastic Process
Synonyms: ovarian small cell carcinoma, pulmonary type; Ovarian Small Cell Carcinoma, Pulmonary-Type; Ovarian Small Cell NEC; Ovarian Small Cell Neuroendocrine Carcinoma; pulmonary type ovarian small cell carcinoma
 
Monarch Initiative: MONDO:0004318

Definition

An aggressive small cell neuroendocrine carcinoma that arises from the ovary. Morphologically, it resembles the small cell carcinoma that arises from the lung. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPulmonary type ovarian small cell carcinoma

Professional guidelines

PubMed

ROS1 protein-tyrosine kinase inhibitors in the treatment of ROS1 fusion protein-driven non-small cell lung cancers.
Roskoski R Jr
Pharmacol Res 2017 Jul;121:202-212. Epub 2017 Apr 30 doi: 10.1016/j.phrs.2017.04.022. PMID: 28465216
Incretin-based therapies in the treatment of type 2 diabetes--more than meets the eye?
Labuzek K, Kozłowski M, Szkudłapski D, Sikorska P, Kozłowska M, Okopień B
Eur J Intern Med 2013 Apr;24(3):207-12. Epub 2013 Jan 31 doi: 10.1016/j.ejim.2013.01.009. PMID: 23375875
The management of small-cell carcinomas of the gynecologic tract.
Cohen JG, Chan JK, Kapp DS
Curr Opin Oncol 2012 Sep;24(5):572-9. doi: 10.1097/CCO.0b013e3283565ed6. PMID: 22820410

Recent clinical studies

Etiology

Primary Ovarian Small Cell Carcinoma of Pulmonary Type: Analysis of 6 Cases and Review of 31 Cases in the Literatures.
Chen X, Liu HL, Wang JS, Zhao FH
Chin Med Sci J 2023 Jun 30;38(2):130-137. doi: 10.24920/004183. PMID: 37286512
Lymphadenectomy Benefits Small Cell Carcinoma of Ovary: A Population-Based Analysis.
Wang J, Ning Y, Du Y, Kang Y
Curr Oncol 2022 Oct 16;29(10):7802-7815. doi: 10.3390/curroncol29100617. PMID: 36290894Free PMC Article
Hereditary ovarian tumour syndromes: current update on genetics and imaging.
Shanbhogue KP, Prasad AS, Ucisik-Keser FE, Katabathina VS, Morani AC
Clin Radiol 2021 Apr;76(4):313.e15-313.e26. Epub 2021 Jan 19 doi: 10.1016/j.crad.2020.11.116. PMID: 33353730
Identification of Driver Mutations in Rare Cancers: The Role of SMARCA4 in Small Cell Carcinoma of the Ovary, Hypercalcemic Type (SCCOHT).
Lang JD, Hendricks WPD
Methods Mol Biol 2018;1706:367-379. doi: 10.1007/978-1-4939-7471-9_20. PMID: 29423809
The management of small-cell carcinomas of the gynecologic tract.
Cohen JG, Chan JK, Kapp DS
Curr Opin Oncol 2012 Sep;24(5):572-9. doi: 10.1097/CCO.0b013e3283565ed6. PMID: 22820410

Diagnosis

Hereditary ovarian tumour syndromes: current update on genetics and imaging.
Shanbhogue KP, Prasad AS, Ucisik-Keser FE, Katabathina VS, Morani AC
Clin Radiol 2021 Apr;76(4):313.e15-313.e26. Epub 2021 Jan 19 doi: 10.1016/j.crad.2020.11.116. PMID: 33353730
Ovarian pulmonary-type small cell carcinoma: case report and review of the literature.
Kurasaki A, Sakurai N, Yamamoto Y, Taoka H, Takahashi K, Kubushiro K
Int J Gynecol Pathol 2013 Sep;32(5):464-70. doi: 10.1097/PGP.0b013e31826d7ea8. PMID: 23896708
Use of immunohistochemistry in the diagnosis of problematic breast lesions.
Lee AH
J Clin Pathol 2013 Jun;66(6):471-7. Epub 2013 Mar 13 doi: 10.1136/jclinpath-2012-201109. PMID: 23486609
The management of small-cell carcinomas of the gynecologic tract.
Cohen JG, Chan JK, Kapp DS
Curr Opin Oncol 2012 Sep;24(5):572-9. doi: 10.1097/CCO.0b013e3283565ed6. PMID: 22820410
Small cell carcinoma of hypercalcemic type.
Scully RE
Int J Gynecol Pathol 1993 Apr;12(2):148-52. doi: 10.1097/00004347-199304000-00010. PMID: 8385068

Therapy

Collagen XI alpha 1 chain, a potential therapeutic target for cancer.
Liu Z, Lai J, Jiang H, Ma C, Huang H
FASEB J 2021 Jun;35(6):e21603. doi: 10.1096/fj.202100054RR. PMID: 33999448
Primary ovarian small cell carcinoma of pulmonary type with coexisting endometrial carcinoma in a breast cancer patient receiving tamoxifen: A case report and literature review.
Yin L, Li J, Wei Y, Ma D, Sun Y, Sun Y
Medicine (Baltimore) 2018 Jun;97(23):e10900. doi: 10.1097/MD.0000000000010900. PMID: 29879027Free PMC Article
Ovarian pulmonary-type small cell carcinoma: case report and review of the literature.
Kurasaki A, Sakurai N, Yamamoto Y, Taoka H, Takahashi K, Kubushiro K
Int J Gynecol Pathol 2013 Sep;32(5):464-70. doi: 10.1097/PGP.0b013e31826d7ea8. PMID: 23896708
Incretin-based therapies in the treatment of type 2 diabetes--more than meets the eye?
Labuzek K, Kozłowski M, Szkudłapski D, Sikorska P, Kozłowska M, Okopień B
Eur J Intern Med 2013 Apr;24(3):207-12. Epub 2013 Jan 31 doi: 10.1016/j.ejim.2013.01.009. PMID: 23375875
The management of small-cell carcinomas of the gynecologic tract.
Cohen JG, Chan JK, Kapp DS
Curr Opin Oncol 2012 Sep;24(5):572-9. doi: 10.1097/CCO.0b013e3283565ed6. PMID: 22820410

Prognosis

Lymphadenectomy Benefits Small Cell Carcinoma of Ovary: A Population-Based Analysis.
Wang J, Ning Y, Du Y, Kang Y
Curr Oncol 2022 Oct 16;29(10):7802-7815. doi: 10.3390/curroncol29100617. PMID: 36290894Free PMC Article
Collagen XI alpha 1 chain, a potential therapeutic target for cancer.
Liu Z, Lai J, Jiang H, Ma C, Huang H
FASEB J 2021 Jun;35(6):e21603. doi: 10.1096/fj.202100054RR. PMID: 33999448
Hereditary ovarian tumour syndromes: current update on genetics and imaging.
Shanbhogue KP, Prasad AS, Ucisik-Keser FE, Katabathina VS, Morani AC
Clin Radiol 2021 Apr;76(4):313.e15-313.e26. Epub 2021 Jan 19 doi: 10.1016/j.crad.2020.11.116. PMID: 33353730
The management of small-cell carcinomas of the gynecologic tract.
Cohen JG, Chan JK, Kapp DS
Curr Opin Oncol 2012 Sep;24(5):572-9. doi: 10.1097/CCO.0b013e3283565ed6. PMID: 22820410
Small cell carcinoma of hypercalcemic type.
Scully RE
Int J Gynecol Pathol 1993 Apr;12(2):148-52. doi: 10.1097/00004347-199304000-00010. PMID: 8385068

Clinical prediction guides

Lymphadenectomy Benefits Small Cell Carcinoma of Ovary: A Population-Based Analysis.
Wang J, Ning Y, Du Y, Kang Y
Curr Oncol 2022 Oct 16;29(10):7802-7815. doi: 10.3390/curroncol29100617. PMID: 36290894Free PMC Article
Spatial Mapping and Immunomodulatory Role of the OX40/OX40L Pathway in Human Non-Small Cell Lung Cancer.
Porciuncula A, Morgado M, Gupta R, Syrigos K, Meehan R, Zacharek SJ, Frederick JP, Schalper KA
Clin Cancer Res 2021 Nov 15;27(22):6174-6183. Epub 2021 Sep 13 doi: 10.1158/1078-0432.CCR-21-0987. PMID: 34518312Free PMC Article
Collagen XI alpha 1 chain, a potential therapeutic target for cancer.
Liu Z, Lai J, Jiang H, Ma C, Huang H
FASEB J 2021 Jun;35(6):e21603. doi: 10.1096/fj.202100054RR. PMID: 33999448
Neuroendocrine tumors of the ovary--a review.
Kupryjańczyk J
Verh Dtsch Ges Pathol 1997;81:253-9. PMID: 9474878
Small cell carcinoma of hypercalcemic type.
Scully RE
Int J Gynecol Pathol 1993 Apr;12(2):148-52. doi: 10.1097/00004347-199304000-00010. PMID: 8385068

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