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Acute Myelomonocytic Leukemia without Abnormal Eosinophils

MedGen UID:
310448
•Concept ID:
C1706708
•
Neoplastic Process

Definition

Acute myelomonocytic leukemia without an abnormal eosinophilic component in the bone marrow. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute Myelomonocytic Leukemia without Abnormal Eosinophils

Recent clinical studies

Etiology

Systemic mastocytosis in the elderly.
Butterfield JH, Weiler CR
Am J Hematol 2013 May;88(5):406-8. Epub 2013 Mar 27 doi: 10.1002/ajh.23426. PMID: 23436294
Acute myeloid leukemia with t(6;9) (p23;q34): association with myelodysplasia, basophilia, and initial CD34 negative immunophenotype.
Alsabeh R, Brynes RK, Slovak ML, Arber DA
Am J Clin Pathol 1997 Apr;107(4):430-7. doi: 10.1093/ajcp/107.4.430. PMID: 9124211
Acquired inversions in human leucocytes.
Aurias A, Dutrillaux B
Ann Genet 1986;29(3):203-6. PMID: 3491576
Abnormalities of chromosome 16 in association with acute myelomonocytic leukemia and dysplastic bone marrow eosinophils.
Hogge DE, Misawa S, Parsa NZ, Pollak A, Testa JR
J Clin Oncol 1984 Jun;2(6):550-7. doi: 10.1200/JCO.1984.2.6.550. PMID: 6587018
A morphologic and cytochemical study of acute myelomonocytic leukemia with abnormal marrow eosinophils associated with inv(16)(p13q22).
Bitter MA, Le Beau MM, Larson RA, Rosner MC, Golomb HM, Rowley JD, Vardiman JW
Am J Clin Pathol 1984 Jun;81(6):733-41. doi: 10.1093/ajcp/81.6.733. PMID: 6203400

Diagnosis

Systemic mastocytosis in the elderly.
Butterfield JH, Weiler CR
Am J Hematol 2013 May;88(5):406-8. Epub 2013 Mar 27 doi: 10.1002/ajh.23426. PMID: 23436294
Acute myelomonocytic leukemia with abnormal eosinophils: a case report with multi-modality diagnostic work-up.
Chang ST, Hsieh YC, Lee LP, Tzeng CC, Chuang SS
Chang Gung Med J 2006 Sep-Oct;29(5):532-7. PMID: 17214400
Acute myelomonocytic leukemia with abnormal eosinophils presenting as an ovarian mass: a report of two cases and a review of the literature.
Drinkard LC, Waggoner S, Stein RN, Byrne RA, Larson RA
Gynecol Oncol 1995 Feb;56(2):307-11. doi: 10.1006/gyno.1995.1052. PMID: 7896204
Acute nonlymphocytic leukemia with marrow eosinophilia and chromosome 16 abnormality: a report of 18 cases.
Bernard P, Dachary D, Reiffers J, Marit G, Wen Z, Jonveaux P, David B, Lacombe F, Broustet A
Leukemia 1989 Oct;3(10):740-5. PMID: 2779289
Acute myelomonocytic leukemia with abnormal eosinophils and inv(16) or t(16;16) has a favorable prognosis.
Larson RA, Williams SF, Le Beau MM, Bitter MA, Vardiman JW, Rowley JD
Blood 1986 Dec;68(6):1242-9. PMID: 3465376

Therapy

B-lymphoblastic leukemia/lymphoma associated with t(8;13)(p11;q12)/ ZMYM2 (ZNF198)-FGFR1 : rare case and review of the literature.
Trimaldi J, Carballido EM, Bowers JW, Anguiano AL, Zhang ZJ, Shah BD, Bruno S, List AF, Moscinski LC, Grady T, Agosti SJ, Kang L, Zhang L
Acta Haematol 2013;130(3):127-34. Epub 2013 Apr 16 doi: 10.1159/000347030. PMID: 23594707
The biological significance of the multidrug resistance gene MRP in inversion 16 leukemias.
Kuss BJ, Deeley RG, Cole SP, Willman CL, Kopecky KJ, Wolman SR, Eyre HJ, Callen DF
Leuk Lymphoma 1996 Feb;20(5-6):357-64. doi: 10.3109/10428199609052416. PMID: 8833390
Clinical aspects of acute myeloid leukemias of the FAB types M3 and M4Eo. The AML Cooperative Group.
Haferlach T, Gassmann W, Löffler H, Jürgensen C, Noak J, Ludwig WD, Thiel E, Haase D, Fonatsch C, Becher R
Ann Hematol 1993 Apr;66(4):165-70. doi: 10.1007/BF01703230. PMID: 8485203
Acute lysis pneumopathy after chemotherapy for acute myelomonocytic leukemia with abnormal marrow eosinophils.
Dombret H, Hunault M, Faucher C, Dombret MC, Degos L
Cancer 1992 Mar 15;69(6):1356-61. doi: 10.1002/1097-0142(19920315)69:6<1356::aid-cncr2820690609>3.0.co;2-b. PMID: 1540873
Syndromes of acute nonlymphocytic leukemia.
Koeffler HP
Ann Intern Med 1987 Nov;107(5):748-58. doi: 10.7326/0003-4819-107-5-748. PMID: 3310797

Prognosis

Systemic mastocytosis in the elderly.
Butterfield JH, Weiler CR
Am J Hematol 2013 May;88(5):406-8. Epub 2013 Mar 27 doi: 10.1002/ajh.23426. PMID: 23436294
Acute myelomonocytic leukemia with abnormal eosinophils: a case report with multi-modality diagnostic work-up.
Chang ST, Hsieh YC, Lee LP, Tzeng CC, Chuang SS
Chang Gung Med J 2006 Sep-Oct;29(5):532-7. PMID: 17214400
Acute myelomonocytic leukemia with abnormal eosinophils presenting as an ovarian mass: a report of two cases and a review of the literature.
Drinkard LC, Waggoner S, Stein RN, Byrne RA, Larson RA
Gynecol Oncol 1995 Feb;56(2):307-11. doi: 10.1006/gyno.1995.1052. PMID: 7896204
Acute nonlymphocytic leukemia with marrow eosinophilia and chromosome 16 abnormality: a report of 18 cases.
Bernard P, Dachary D, Reiffers J, Marit G, Wen Z, Jonveaux P, David B, Lacombe F, Broustet A
Leukemia 1989 Oct;3(10):740-5. PMID: 2779289
Acute myelomonocytic leukemia with abnormal eosinophils and inv(16) or t(16;16) has a favorable prognosis.
Larson RA, Williams SF, Le Beau MM, Bitter MA, Vardiman JW, Rowley JD
Blood 1986 Dec;68(6):1242-9. PMID: 3465376

Clinical prediction guides

Systemic mastocytosis in the elderly.
Butterfield JH, Weiler CR
Am J Hematol 2013 May;88(5):406-8. Epub 2013 Mar 27 doi: 10.1002/ajh.23426. PMID: 23436294
Detection of CBFbeta/MYH11 fusion transcripts in acute myeloid leukemia: heterogeneity of cytological and molecular characteristics.
Costello R, Sainty D, Lecine P, Cusenier A, Mozziconacci MJ, Arnoulet C, Maraninchi D, Gastaut JA, Imbert J, Lafage-Pochitaloff M, Gabert J
Leukemia 1997 May;11(5):644-50. doi: 10.1038/sj.leu.2400629. PMID: 9180286
The abnormal eosinophils are part of the leukemic cell population in acute myelomonocytic leukemia with abnormal eosinophils (AML M4Eo) and carry the pericentric inversion 16: a combination of May-Grünwald-Giemsa staining and fluorescence in situ hybridization.
Haferlach T, Winkemann M, Löffler H, Schoch R, Gassmann W, Fonatsch C, Schoch C, Poetsch M, Weber-Matthiesen K, Schlegelberger B
Blood 1996 Mar 15;87(6):2459-63. PMID: 8630411
Acquired inversions in human leucocytes.
Aurias A, Dutrillaux B
Ann Genet 1986;29(3):203-6. PMID: 3491576
Acute myelomonocytic leukemia with abnormal eosinophils and inv(16) or t(16;16) has a favorable prognosis.
Larson RA, Williams SF, Le Beau MM, Bitter MA, Vardiman JW, Rowley JD
Blood 1986 Dec;68(6):1242-9. PMID: 3465376

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