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Adrenal Cortical Oncocytic Adenoma

MedGen UID:
310452
•Concept ID:
C1706724
•
Neoplastic Process
Synonyms: Adrenal Cortex Oncocytic Adenoma; Adrenal Gland Oncocytic Adenoma

Definition

A usually non-functioning variant of adrenal cortex adenoma, composed of large cells with abundant granular eosinophilic cytoplasm. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdrenal Cortical Oncocytic Adenoma

Professional guidelines

PubMed

Differential diagnosis of renal tumors with clear cytoplasm: clinical relevance of renal tumor subclassification in the era of targeted therapies and personalized medicine.
Goyal R, Gersbach E, Yang XJ, Rohan SM
Arch Pathol Lab Med 2013 Apr;137(4):467-80. doi: 10.5858/arpa.2012-0085-RA. PMID: 23544936

Recent clinical studies

Etiology

Overview of the 2022 WHO Classification of Adrenal Cortical Tumors.
Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG
Endocr Pathol 2022 Mar;33(1):155-196. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09710-8. PMID: 35288842Free PMC Article
Testosterone- and Cortisol-secreting Oncocytic Adrenocortical Adenoma in the Pediatric Age-group.
Al Badi MK, Al-Alwan I, Al-Dubayee M, Al-Anzi A, Al Turki MS, Aloudah N, Alsaad KO
Pediatr Dev Pathol 2018 Nov-Dec;21(6):568-573. Epub 2018 Feb 9 doi: 10.1177/1093526617753045. PMID: 29426273
Oncocytic Adreno Cortical Tumors: Pathological Features of 16 Cases and Review of the Literature.
Ertan Y, Argon A, Özdemir M, Yürekli BPS, Dökümcü Z, Makay Ö
J Environ Pathol Toxicol Oncol 2017;36(3):237-244. doi: 10.1615/JEnvironPatholToxicolOncol.2017021895. PMID: 29283337
Update on Adrenal Tumours in 2017 World Health Organization (WHO) of Endocrine Tumours.
Lam AK
Endocr Pathol 2017 Sep;28(3):213-227. doi: 10.1007/s12022-017-9484-5. PMID: 28477311
Adrenal Pathology in the Adult: A Urological Pathologist's Perspective.
Hansel DE, Reuter VE
Adv Anat Pathol 2016 Sep;23(5):273-84. doi: 10.1097/PAP.0000000000000120. PMID: 27438375

Diagnosis

Overview of the 2022 WHO Classification of Adrenal Cortical Tumors.
Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG
Endocr Pathol 2022 Mar;33(1):155-196. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09710-8. PMID: 35288842Free PMC Article
Unravelling Adrenal Oncocytic Neoplasm.
Virarkar M, Patnana M, Vikram R, Bhargava P, Birkenfeld E, Sagebiel T
Clin Genitourin Cancer 2019 Feb;17(1):e216-e220. Epub 2018 Oct 26 doi: 10.1016/j.clgc.2018.10.011. PMID: 30454970
Challenges in surgical pathology of adrenocortical tumours.
Erickson LA
Histopathology 2018 Jan;72(1):82-96. doi: 10.1111/his.13255. PMID: 29239032
Oncocytic Adreno Cortical Tumors: Pathological Features of 16 Cases and Review of the Literature.
Ertan Y, Argon A, Özdemir M, Yürekli BPS, Dökümcü Z, Makay Ö
J Environ Pathol Toxicol Oncol 2017;36(3):237-244. doi: 10.1615/JEnvironPatholToxicolOncol.2017021895. PMID: 29283337
Adrenal Pathology in the Adult: A Urological Pathologist's Perspective.
Hansel DE, Reuter VE
Adv Anat Pathol 2016 Sep;23(5):273-84. doi: 10.1097/PAP.0000000000000120. PMID: 27438375

Therapy

Cushing's syndrome associated with an adrenocortical oncocytoma.
Calderón Vicente DM, Ronquillo Rubio A, Yunta Abarca P, Quílez Toboso R, Aranda Regules J
Endocrinol Nutr 2015 Oct;62(8):416-8. Epub 2015 Jun 9 doi: 10.1016/j.endonu.2015.04.002. PMID: 26066092
The use of immunohistochemical expression of SF-1 and EMA in distinguishing adrenocortical tumors from renal neoplasms.
Enriquez ML, Lal P, Ziober A, Wang L, Tomaszewski JE, Bing Z
Appl Immunohistochem Mol Morphol 2012 Mar;20(2):141-5. doi: 10.1097/pai.0b013e31823605e7. PMID: 22553814
Bilateral adrenocortical oncocytoma with bilateral myelolipomatous metaplasia.
Shastri C, Rana C, Kumari N, Agarwal G, Krishnani N
Endocr Pathol 2012 Jun;23(2):112-4. doi: 10.1007/s12022-012-9198-7. PMID: 22350762
Aldosterone-producing adrenal cortical adenoma with oncocytic change and cytoplasmic eosinophilic globular inclusions.
Mete O, Asa SL
Endocr Pathol 2009 Fall;20(3):182-5. doi: 10.1007/s12022-009-9082-2. PMID: 19462261
The unique case of adrenocortical malignant and functioning oncocytic tumour.
Gołkowski F, Buziak-Bereza M, Huszno B, Bałdys-Waligórska A, Stefańska A, Budzyński A, Okoń K, Chrzan R, Urbanik A
Exp Clin Endocrinol Diabetes 2007 Jun;115(6):401-4. doi: 10.1055/s-2007-967083. PMID: 17701888

Prognosis

Overview of the 2022 WHO Classification of Adrenal Cortical Tumors.
Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG
Endocr Pathol 2022 Mar;33(1):155-196. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09710-8. PMID: 35288842Free PMC Article
Unravelling Adrenal Oncocytic Neoplasm.
Virarkar M, Patnana M, Vikram R, Bhargava P, Birkenfeld E, Sagebiel T
Clin Genitourin Cancer 2019 Feb;17(1):e216-e220. Epub 2018 Oct 26 doi: 10.1016/j.clgc.2018.10.011. PMID: 30454970
Challenges in surgical pathology of adrenocortical tumours.
Erickson LA
Histopathology 2018 Jan;72(1):82-96. doi: 10.1111/his.13255. PMID: 29239032
Adrenal Pathology in the Adult: A Urological Pathologist's Perspective.
Hansel DE, Reuter VE
Adv Anat Pathol 2016 Sep;23(5):273-84. doi: 10.1097/PAP.0000000000000120. PMID: 27438375
Adrenal oncocytic neoplasm: a systematic review.
Mearini L, Del Sordo R, Costantini E, Nunzi E, Porena M
Urol Int 2013;91(2):125-33. Epub 2012 Nov 8 doi: 10.1159/000345141. PMID: 23147196

Clinical prediction guides

Overview of the 2022 WHO Classification of Adrenal Cortical Tumors.
Mete O, Erickson LA, Juhlin CC, de Krijger RR, Sasano H, Volante M, Papotti MG
Endocr Pathol 2022 Mar;33(1):155-196. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09710-8. PMID: 35288842Free PMC Article
Challenges in surgical pathology of adrenocortical tumours.
Erickson LA
Histopathology 2018 Jan;72(1):82-96. doi: 10.1111/his.13255. PMID: 29239032
Oncocytic Adreno Cortical Tumors: Pathological Features of 16 Cases and Review of the Literature.
Ertan Y, Argon A, Özdemir M, Yürekli BPS, Dökümcü Z, Makay Ö
J Environ Pathol Toxicol Oncol 2017;36(3):237-244. doi: 10.1615/JEnvironPatholToxicolOncol.2017021895. PMID: 29283337
Update on Adrenal Tumours in 2017 World Health Organization (WHO) of Endocrine Tumours.
Lam AK
Endocr Pathol 2017 Sep;28(3):213-227. doi: 10.1007/s12022-017-9484-5. PMID: 28477311
Adrenal Pathology in the Adult: A Urological Pathologist's Perspective.
Hansel DE, Reuter VE
Adv Anat Pathol 2016 Sep;23(5):273-84. doi: 10.1097/PAP.0000000000000120. PMID: 27438375

Recent systematic reviews

Adrenal oncocytic neoplasm: a systematic review.
Mearini L, Del Sordo R, Costantini E, Nunzi E, Porena M
Urol Int 2013;91(2):125-33. Epub 2012 Nov 8 doi: 10.1159/000345141. PMID: 23147196

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