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Anterior Pituitary Gland Neoplasm

MedGen UID:
310471
•Concept ID:
C1706819
•
Neoplastic Process
Synonym: Neoplasm of the Anterior Lobe of the Pituitary Gland

Definition

A neoplasm arising from the anterior lobe of the pituitary gland. The vast majority are pituitary neuroendocrine tumors (formerly pituitary adenomas). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnterior Pituitary Gland Neoplasm

Professional guidelines

PubMed

Progress, challenges and perspectives in the management of hypopituitarism.
Boguszewski CL, Neggers S
Rev Endocr Metab Disord 2024 Jun;25(3):453-455. Epub 2024 May 27 doi: 10.1007/s11154-024-09889-7. PMID: 38801648
Diagnosis and Treatment of Parasellar Lesions.
Gatto F, Perez-Rivas LG, Olarescu NC, Khandeva P, Chachlaki K, Trivellin G, Gahete MD, Cuny T; on behalf of the ENEA Young Researchers Committee (EYRC)
Neuroendocrinology 2020;110(9-10):728-739. Epub 2020 Mar 4 doi: 10.1159/000506905. PMID: 32126547
Primary amenorrhea: diagnosis and management.
Marsh CA, Grimstad FW
Obstet Gynecol Surv 2014 Oct;69(10):603-12. doi: 10.1097/OGX.0000000000000111. PMID: 25336070

Recent clinical studies

Etiology

Pituitary metastases: a case series and scoping review.
Yang K, Begley SL, Lynch D, Ye V, Saini J, Gutierrez E, Vialet J, Millar BA, Conrad T, Laperriere N, Bernstein M, Zadeh G, Shultz DB, Kongkham PN
Pituitary 2023 Oct;26(5):538-550. Epub 2023 Sep 12 doi: 10.1007/s11102-023-01349-w. PMID: 37698666
Single-cell sequencing identifies differentiation-related markers for molecular classification and recurrence prediction of PitNET.
Zhang Q, Yao B, Long X, Chen Z, He M, Wu Y, Qiao N, Ma Z, Ye Z, Zhang Y, Yao S, Wang Y, Cheng H, Chen H, Ye H, Wang Y, Li Y, Chen J, Zhang Z, Guo F, Zhao Y
Cell Rep Med 2023 Feb 21;4(2):100934. Epub 2023 Feb 7 doi: 10.1016/j.xcrm.2023.100934. PMID: 36754052Free PMC Article
Overview of the 2022 WHO Classification of Pituitary Tumors.
Asa SL, Mete O, Perry A, Osamura RY
Endocr Pathol 2022 Mar;33(1):6-26. Epub 2022 Mar 15 doi: 10.1007/s12022-022-09703-7. PMID: 35291028
Clinical and Pathological Aspects of Silent Pituitary Adenomas.
Drummond J, Roncaroli F, Grossman AB, Korbonits M
J Clin Endocrinol Metab 2019 Jul 1;104(7):2473-2489. doi: 10.1210/jc.2018-00688. PMID: 30020466Free PMC Article
Hypopituitarism.
Higham CE, Johannsson G, Shalet SM
Lancet 2016 Nov 12;388(10058):2403-2415. Epub 2016 Mar 31 doi: 10.1016/S0140-6736(16)30053-8. PMID: 27041067

Diagnosis

Progress, challenges and perspectives in the management of hypopituitarism.
Boguszewski CL, Neggers S
Rev Endocr Metab Disord 2024 Jun;25(3):453-455. Epub 2024 May 27 doi: 10.1007/s11154-024-09889-7. PMID: 38801648
Aggressive corticotroph tumors and carcinomas.
Lasolle H, Vasiljevic A, Jouanneau E, Ilie MD, Raverot G
J Neuroendocrinol 2022 Aug;34(8):e13169. Epub 2022 Aug 18 doi: 10.1111/jne.13169. PMID: 35979732Free PMC Article
Overview of the 2022 WHO Classification of Pituitary Tumors.
Asa SL, Mete O, Perry A, Osamura RY
Endocr Pathol 2022 Mar;33(1):6-26. Epub 2022 Mar 15 doi: 10.1007/s12022-022-09703-7. PMID: 35291028
Clinical and Pathological Aspects of Silent Pituitary Adenomas.
Drummond J, Roncaroli F, Grossman AB, Korbonits M
J Clin Endocrinol Metab 2019 Jul 1;104(7):2473-2489. doi: 10.1210/jc.2018-00688. PMID: 30020466Free PMC Article
Hypopituitarism.
Higham CE, Johannsson G, Shalet SM
Lancet 2016 Nov 12;388(10058):2403-2415. Epub 2016 Mar 31 doi: 10.1016/S0140-6736(16)30053-8. PMID: 27041067

Therapy

Aggressive corticotroph tumors and carcinomas.
Lasolle H, Vasiljevic A, Jouanneau E, Ilie MD, Raverot G
J Neuroendocrinol 2022 Aug;34(8):e13169. Epub 2022 Aug 18 doi: 10.1111/jne.13169. PMID: 35979732Free PMC Article
Insights into non-classic and emerging causes of hypopituitarism.
Prodam F, Caputo M, Mele C, Marzullo P, Aimaretti G
Nat Rev Endocrinol 2021 Feb;17(2):114-129. Epub 2020 Nov 27 doi: 10.1038/s41574-020-00437-2. PMID: 33247226
Tumor-Directed Therapeutic Targets in Cushing Disease.
Theodoropoulou M, Reincke M
J Clin Endocrinol Metab 2019 Mar 1;104(3):925-933. doi: 10.1210/jc.2018-02080. PMID: 30535260
Hypopituitarism.
Higham CE, Johannsson G, Shalet SM
Lancet 2016 Nov 12;388(10058):2403-2415. Epub 2016 Mar 31 doi: 10.1016/S0140-6736(16)30053-8. PMID: 27041067
Resistant prolactinomas.
Vasilev V, Daly AF, Vroonen L, Zacharieva S, Beckers A
J Endocrinol Invest 2011 Apr;34(4):312-6. Epub 2011 Mar 15 doi: 10.1007/BF03347092. PMID: 21406957

Prognosis

Single-cell sequencing identifies differentiation-related markers for molecular classification and recurrence prediction of PitNET.
Zhang Q, Yao B, Long X, Chen Z, He M, Wu Y, Qiao N, Ma Z, Ye Z, Zhang Y, Yao S, Wang Y, Cheng H, Chen H, Ye H, Wang Y, Li Y, Chen J, Zhang Z, Guo F, Zhao Y
Cell Rep Med 2023 Feb 21;4(2):100934. Epub 2023 Feb 7 doi: 10.1016/j.xcrm.2023.100934. PMID: 36754052Free PMC Article
Aggressive corticotroph tumors and carcinomas.
Lasolle H, Vasiljevic A, Jouanneau E, Ilie MD, Raverot G
J Neuroendocrinol 2022 Aug;34(8):e13169. Epub 2022 Aug 18 doi: 10.1111/jne.13169. PMID: 35979732Free PMC Article
Clinical and Pathological Aspects of Silent Pituitary Adenomas.
Drummond J, Roncaroli F, Grossman AB, Korbonits M
J Clin Endocrinol Metab 2019 Jul 1;104(7):2473-2489. doi: 10.1210/jc.2018-00688. PMID: 30020466Free PMC Article
Gonadotrope Tumors.
Asa SL, Ezzat S
Prog Mol Biol Transl Sci 2016;143:187-210. Epub 2016 Sep 7 doi: 10.1016/bs.pmbts.2016.08.005. PMID: 27697203
Hypopituitarism.
Higham CE, Johannsson G, Shalet SM
Lancet 2016 Nov 12;388(10058):2403-2415. Epub 2016 Mar 31 doi: 10.1016/S0140-6736(16)30053-8. PMID: 27041067

Clinical prediction guides

Clinical and Molecular Characteristics of Gonadotroph Pituitary Tumors According to the WHO Classification.
Carbonara F, Feola T, Gianno F, Polidoro MA, Di Crescenzo RM, Arcella A, De Angelis M, Morace R, de Alcubierre D, Esposito V, Giangaspero F, Jaffrain-Rea ML
Endocr Pathol 2024 Mar;35(1):1-13. Epub 2023 Dec 14 doi: 10.1007/s12022-023-09794-w. PMID: 38095839Free PMC Article
Pituitary metastases: a case series and scoping review.
Yang K, Begley SL, Lynch D, Ye V, Saini J, Gutierrez E, Vialet J, Millar BA, Conrad T, Laperriere N, Bernstein M, Zadeh G, Shultz DB, Kongkham PN
Pituitary 2023 Oct;26(5):538-550. Epub 2023 Sep 12 doi: 10.1007/s11102-023-01349-w. PMID: 37698666
Single-cell sequencing identifies differentiation-related markers for molecular classification and recurrence prediction of PitNET.
Zhang Q, Yao B, Long X, Chen Z, He M, Wu Y, Qiao N, Ma Z, Ye Z, Zhang Y, Yao S, Wang Y, Cheng H, Chen H, Ye H, Wang Y, Li Y, Chen J, Zhang Z, Guo F, Zhao Y
Cell Rep Med 2023 Feb 21;4(2):100934. Epub 2023 Feb 7 doi: 10.1016/j.xcrm.2023.100934. PMID: 36754052Free PMC Article
MicroRNAs in pituitary tumors.
Wierinckx A, Roche M, Legras-Lachuer C, Trouillas J, Raverot G, Lachuer J
Mol Cell Endocrinol 2017 Nov 15;456:51-61. Epub 2017 Jan 13 doi: 10.1016/j.mce.2017.01.021. PMID: 28089822
Hypopituitarism.
Higham CE, Johannsson G, Shalet SM
Lancet 2016 Nov 12;388(10058):2403-2415. Epub 2016 Mar 31 doi: 10.1016/S0140-6736(16)30053-8. PMID: 27041067

Recent systematic reviews

The clinicopathological features and prognosis of silent corticotroph tumors: an updated systematic review and meta-analysis.
Vuong HG, Dunn IF
Endocrine 2023 Dec;82(3):527-535. Epub 2023 Jul 18 doi: 10.1007/s12020-023-03449-w. PMID: 37462809
The effect of endoscopic transsphenoidal somatotroph tumors resection on pituitary hormones: systematic review and meta-analysis.
Nie D, Fang Q, Wong W, Gui S, Zhao P, Li C, Zhang Y
World J Surg Oncol 2023 Mar 1;21(1):71. doi: 10.1186/s12957-023-02958-2. PMID: 36859291Free PMC Article
Post-operative surveillance for somatotroph, lactotroph and non-functional pituitary adenomas after curative resection: a systematic review.
Caulley L, Whelan J, Khoury M, Mavedatnia D, Sahlollbey N, Amrani L, Eid A, Doyle MA, Malcolm J, Alkherayf F, Ramsay T, Moher D, Johnson-Obaseki S, Schramm D, Hunink MGM, Kilty SJ
Pituitary 2023 Feb;26(1):73-93. Epub 2022 Nov 23 doi: 10.1007/s11102-022-01289-x. PMID: 36422846
Primary pituitary lymphoma: an update of the literature.
Tarabay A, Cossu G, Berhouma M, Levivier M, Daniel RT, Messerer M
J Neurooncol 2016 Dec;130(3):383-395. Epub 2016 Aug 31 doi: 10.1007/s11060-016-2249-z. PMID: 27581598
Metastatic involvement of the pituitary gland: a systematic review with pooled individual patient data analysis.
He W, Chen F, Dalm B, Kirby PA, Greenlee JD
Pituitary 2015 Feb;18(1):159-68. doi: 10.1007/s11102-014-0552-2. PMID: 24445565

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