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Atypical Parathyroid Gland Tumor

MedGen UID:
311105
•Concept ID:
C1709465
•
Neoplastic Process
Synonyms: Atypical Parathyroid Gland Neoplasm; Atypical Parathyroid Neoplasm; Atypical Parathyroid Tumor; Parathyroid Gland Tumor of Low/Uncertain Malignant Potential; Parathyroid Tumor of Low/Uncertain Malignant Potential

Definition

A parathyroid gland tumor that shares certain morphologic characteristics with parathyroid gland carcinomas (e.g. broad fibrous bands formation with or without hemosiderin deposition, presence of mitotic figures) but lacks unequivocal evidence of capsular or vascular invasion. It is considered a tumor of uncertain malignant potential. (WHO) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAtypical Parathyroid Gland Tumor

Professional guidelines

PubMed

Reticular fibre structure in the differential diagnosis of parathyroid neoplasms.
Hu X, He S, Jiang X, Wei P, Zhou X, Shi Z, Li X, Lu J, Zhao H, Wei B, Jin M
Diagn Pathol 2023 Jul 4;18(1):79. doi: 10.1186/s13000-023-01368-y. PMID: 37403167Free PMC Article
Editorial: Parathyroid atypical adenomas and carcinoma: An update on clinical management.
Gianotti L, Cetani F
Front Endocrinol (Lausanne) 2023;14:1163996. Epub 2023 Feb 24 doi: 10.3389/fendo.2023.1163996. PMID: 36909324Free PMC Article
Atypical parathyroid adenomas: challenging lesions in the differential diagnosis of endocrine tumors.
Cetani F, Marcocci C, Torregrossa L, Pardi E
Endocr Relat Cancer 2019 Jul;26(7):R441-R464. doi: 10.1530/ERC-19-0135. PMID: 31085770

Recent clinical studies

Etiology

Phenotypic Profiling and Molecular Mechanisms in Hyperparathyroidism-jaw Tumor Syndrome.
Tora R, Welch J, Sun J, Agarwal SK, Bell DA, Merino M, Weinstein LS, Simonds WF, Jha S
J Clin Endocrinol Metab 2023 Nov 17;108(12):3165-3177. doi: 10.1210/clinem/dgad368. PMID: 37339334Free PMC Article
Atypical parathyroid adenoma: clinical and anatomical pathologic features.
Galani A, Morandi R, Dimko M, Molfino S, Baronchelli C, Lai S, Gheza F, Cappelli C, Casella C
World J Surg Oncol 2021 Jan 20;19(1):19. doi: 10.1186/s12957-021-02123-7. PMID: 33472651Free PMC Article
Atypical parathyroid adenomas: challenging lesions in the differential diagnosis of endocrine tumors.
Cetani F, Marcocci C, Torregrossa L, Pardi E
Endocr Relat Cancer 2019 Jul;26(7):R441-R464. doi: 10.1530/ERC-19-0135. PMID: 31085770
Differentiating Atypical Parathyroid Neoplasm from Parathyroid Cancer.
Christakis I, Bussaidy N, Clarke C, Kwatampora LJ, Warneke CL, Silva AM, Williams MD, Grubbs EG, Lee JE, Perrier ND
Ann Surg Oncol 2016 Sep;23(9):2889-97. Epub 2016 May 9 doi: 10.1245/s10434-016-5248-6. PMID: 27160525
Parathyroid carcinoma: etiology, diagnosis, and treatment.
Okamoto T, Iihara M, Obara T, Tsukada T
World J Surg 2009 Nov;33(11):2343-54. doi: 10.1007/s00268-009-9999-0. PMID: 19350316

Diagnosis

Advances and Updates in Parathyroid Pathology.
Gokozan HN, Scognamiglio T
Adv Anat Pathol 2023 Jan 1;30(1):24-33. Epub 2022 Nov 1 doi: 10.1097/PAP.0000000000000379. PMID: 36315270
Overview of the 2022 WHO Classification of Parathyroid Tumors.
Erickson LA, Mete O, Juhlin CC, Perren A, Gill AJ
Endocr Pathol 2022 Mar;33(1):64-89. Epub 2022 Feb 17 doi: 10.1007/s12022-022-09709-1. PMID: 35175514
Parathyroid Tumors: Molecular Signatures.
Marini F, Giusti F, Iantomasi T, Brandi ML
Int J Mol Sci 2021 Oct 18;22(20) doi: 10.3390/ijms222011206. PMID: 34681865Free PMC Article
Atypical parathyroid adenomas: challenging lesions in the differential diagnosis of endocrine tumors.
Cetani F, Marcocci C, Torregrossa L, Pardi E
Endocr Relat Cancer 2019 Jul;26(7):R441-R464. doi: 10.1530/ERC-19-0135. PMID: 31085770
Immunohistochemistry in Diagnostic Parathyroid Pathology.
Erickson LA, Mete O
Endocr Pathol 2018 Jun;29(2):113-129. doi: 10.1007/s12022-018-9527-6. PMID: 29626276

Therapy

Phenotypic Profiling and Molecular Mechanisms in Hyperparathyroidism-jaw Tumor Syndrome.
Tora R, Welch J, Sun J, Agarwal SK, Bell DA, Merino M, Weinstein LS, Simonds WF, Jha S
J Clin Endocrinol Metab 2023 Nov 17;108(12):3165-3177. doi: 10.1210/clinem/dgad368. PMID: 37339334Free PMC Article
Histological alterations following fine-needle aspiration for parathyroid adenoma: Incidence and diagnostic problems.
Hirokawa M, Suzuki A, Higuchi M, Hayashi T, Kuma S, Miya A, Miyauchi A
Pathol Int 2021 Jun;71(6):400-405. Epub 2021 Mar 19 doi: 10.1111/pin.13091. PMID: 33740321Free PMC Article
Distinguishing Parathyromatosis, Atypical Parathyroid Adenomas, and Parathyroid Carcinomas Utilizing Histologic and Clinical Features.
Schulte JJ, Pease G, Taxy JB, Hall C, Cipriani NA
Head Neck Pathol 2021 Sep;15(3):727-736. Epub 2021 Jan 4 doi: 10.1007/s12105-020-01281-6. PMID: 33394375Free PMC Article
Atypical parathyroid adenoma.
Ramaswamy AS, Vijitha T, Kumarguru BN, Mahalingashetti PB
Indian J Pathol Microbiol 2017 Jan-Mar;60(1):99-101. doi: 10.4103/0377-4929.200055. PMID: 28195102
Biomarkers of parathyroid carcinoma.
Erovic BM, Harris L, Jamali M, Goldstein DP, Irish JC, Asa SL, Mete O
Endocr Pathol 2012 Dec;23(4):221-31. doi: 10.1007/s12022-012-9222-y. PMID: 23001705

Prognosis

Advances and Updates in Parathyroid Pathology.
Gokozan HN, Scognamiglio T
Adv Anat Pathol 2023 Jan 1;30(1):24-33. Epub 2022 Nov 1 doi: 10.1097/PAP.0000000000000379. PMID: 36315270
Atypical parathyroid adenoma: clinical and anatomical pathologic features.
Galani A, Morandi R, Dimko M, Molfino S, Baronchelli C, Lai S, Gheza F, Cappelli C, Casella C
World J Surg Oncol 2021 Jan 20;19(1):19. doi: 10.1186/s12957-021-02123-7. PMID: 33472651Free PMC Article
Genomics and Epigenomics in Parathyroid Neoplasia: from Bench to Surgical Pathology Practice.
Juhlin CC, Erickson LA
Endocr Pathol 2021 Mar;32(1):17-34. Epub 2020 Dec 2 doi: 10.1007/s12022-020-09656-9. PMID: 33269427Free PMC Article
Atypical parathyroid adenomas: challenging lesions in the differential diagnosis of endocrine tumors.
Cetani F, Marcocci C, Torregrossa L, Pardi E
Endocr Relat Cancer 2019 Jul;26(7):R441-R464. doi: 10.1530/ERC-19-0135. PMID: 31085770
Immunohistochemistry in Diagnostic Parathyroid Pathology.
Erickson LA, Mete O
Endocr Pathol 2018 Jun;29(2):113-129. doi: 10.1007/s12022-018-9527-6. PMID: 29626276

Clinical prediction guides

Filamin A and parafibromin expression in parathyroid carcinoma.
Storvall S, Leijon H, Ryhänen EM, Vesterinen T, Heiskanen I, Schalin-Jäntti C, Arola J
Eur J Endocrinol 2021 Oct 25;185(6):803-812. doi: 10.1530/EJE-21-0668. PMID: 34606470
Do Patients With Atypical Parathyroid Adenoma Need Close Follow-up?
Saponaro F, Pardi E, Mazoni L, Borsari S, Torregrossa L, Apicella M, Frustaci G, Materazzi G, Miccoli P, Basolo F, Marcocci C, Cetani F
J Clin Endocrinol Metab 2021 Oct 21;106(11):e4565-e4579. doi: 10.1210/clinem/dgab452. PMID: 34157106
Atypical parathyroid adenomas: challenging lesions in the differential diagnosis of endocrine tumors.
Cetani F, Marcocci C, Torregrossa L, Pardi E
Endocr Relat Cancer 2019 Jul;26(7):R441-R464. doi: 10.1530/ERC-19-0135. PMID: 31085770
Understanding the genetic basis of parathyroid carcinoma.
Gill AJ
Endocr Pathol 2014 Mar;25(1):30-4. doi: 10.1007/s12022-013-9294-3. PMID: 24402736
Parathyroid cytopathology.
Davey DD, Glant MD, Berger EK
Diagn Cytopathol 1986 Jan-Mar;2(1):76-80. doi: 10.1002/dc.2840020116. PMID: 2424691

Recent systematic reviews

Giant parathyroid tumours in primary hyperparathyroidism: a systematic review.
Wong HKG, Shipman K, Allan K, Ghabbour A, Borumandi F
Langenbecks Arch Surg 2022 Mar;407(2):501-516. Epub 2022 Jan 18 doi: 10.1007/s00423-021-02406-3. PMID: 35039921

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