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Atypical Parathyroid Gland Tumor

MedGen UID:
311105
Concept ID:
C1709465
Neoplastic Process
Synonyms: Atypical Parathyroid Gland Neoplasm; Atypical Parathyroid Neoplasm; Atypical Parathyroid Tumor; Parathyroid Gland Tumor of Low/Uncertain Malignant Potential; Parathyroid Tumor of Low/Uncertain Malignant Potential

Definition

A parathyroid gland tumor that shares certain morphologic characteristics with parathyroid gland carcinomas (e.g. broad fibrous bands formation with or without hemosiderin deposition, presence of mitotic figures) but lacks unequivocal evidence of capsular or vascular invasion. It is considered a tumor of uncertain malignant potential. (WHO) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAtypical Parathyroid Gland Tumor

Professional guidelines

PubMed

Gianotti L, Cetani F
Front Endocrinol (Lausanne) 2023;14:1163996. Epub 2023 Feb 24 doi: 10.3389/fendo.2023.1163996. PMID: 36909324Free PMC Article
Cetani F, Marcocci C, Torregrossa L, Pardi E
Endocr Relat Cancer 2019 Jul;26(7):R441-R464. doi: 10.1530/ERC-19-0135. PMID: 31085770
Okamoto T, Iihara M, Obara T, Tsukada T
World J Surg 2009 Nov;33(11):2343-54. doi: 10.1007/s00268-009-9999-0. PMID: 19350316

Recent clinical studies

Etiology

Hu X, He S, Jiang X, Wei P, Zhou X, Shi Z, Li X, Lu J, Zhao H, Wei B, Jin M
Diagn Pathol 2023 Jul 4;18(1):79. doi: 10.1186/s13000-023-01368-y. PMID: 37403167Free PMC Article
Tora R, Welch J, Sun J, Agarwal SK, Bell DA, Merino M, Weinstein LS, Simonds WF, Jha S
J Clin Endocrinol Metab 2023 Nov 17;108(12):3165-3177. doi: 10.1210/clinem/dgad368. PMID: 37339334Free PMC Article
Steen S, Hysek M, Zedenius J, Falhammar H, Juhlin CC
Diagn Cytopathol 2022 Feb;50(2):75-83. Epub 2021 Dec 27 doi: 10.1002/dc.24923. PMID: 34962106
Gill AJ
Endocr Pathol 2014 Mar;25(1):30-4. doi: 10.1007/s12022-013-9294-3. PMID: 24402736
Okamoto T, Iihara M, Obara T, Tsukada T
World J Surg 2009 Nov;33(11):2343-54. doi: 10.1007/s00268-009-9999-0. PMID: 19350316

Diagnosis

Hu X, He S, Jiang X, Wei P, Zhou X, Shi Z, Li X, Lu J, Zhao H, Wei B, Jin M
Diagn Pathol 2023 Jul 4;18(1):79. doi: 10.1186/s13000-023-01368-y. PMID: 37403167Free PMC Article
Uljanovs R, Sinkarevs S, Strumfs B, Vidusa L, Merkurjeva K, Strumfa I
Int J Mol Sci 2022 Jun 23;23(13) doi: 10.3390/ijms23136981. PMID: 35805976Free PMC Article
Erickson LA, Mete O, Juhlin CC, Perren A, Gill AJ
Endocr Pathol 2022 Mar;33(1):64-89. Epub 2022 Feb 17 doi: 10.1007/s12022-022-09709-1. PMID: 35175514
Gill AJ
Endocr Pathol 2014 Mar;25(1):30-4. doi: 10.1007/s12022-013-9294-3. PMID: 24402736
Okamoto T, Iihara M, Obara T, Tsukada T
World J Surg 2009 Nov;33(11):2343-54. doi: 10.1007/s00268-009-9999-0. PMID: 19350316

Therapy

Tora R, Welch J, Sun J, Agarwal SK, Bell DA, Merino M, Weinstein LS, Simonds WF, Jha S
J Clin Endocrinol Metab 2023 Nov 17;108(12):3165-3177. doi: 10.1210/clinem/dgad368. PMID: 37339334Free PMC Article
Schulte JJ, Pease G, Taxy JB, Hall C, Cipriani NA
Head Neck Pathol 2021 Sep;15(3):727-736. Epub 2021 Jan 4 doi: 10.1007/s12105-020-01281-6. PMID: 33394375Free PMC Article
Abdel-Aziz TE, Gleeson F, Sadler G, Mihai R
J Surg Res 2019 May;237:56-60. Epub 2019 Jan 25 doi: 10.1016/j.jss.2018.12.021. PMID: 30694792
Ramaswamy AS, Vijitha T, Kumarguru BN, Mahalingashetti PB
Indian J Pathol Microbiol 2017 Jan-Mar;60(1):99-101. doi: 10.4103/0377-4929.200055. PMID: 28195102
Erovic BM, Harris L, Jamali M, Goldstein DP, Irish JC, Asa SL, Mete O
Endocr Pathol 2012 Dec;23(4):221-31. doi: 10.1007/s12022-012-9222-y. PMID: 23001705

Prognosis

Gokozan HN, Scognamiglio T
Adv Anat Pathol 2023 Jan 1;30(1):24-33. Epub 2022 Nov 1 doi: 10.1097/PAP.0000000000000379. PMID: 36315270
Uljanovs R, Sinkarevs S, Strumfs B, Vidusa L, Merkurjeva K, Strumfa I
Int J Mol Sci 2022 Jun 23;23(13) doi: 10.3390/ijms23136981. PMID: 35805976Free PMC Article
Erickson LA, Mete O
Endocr Pathol 2018 Jun;29(2):113-129. doi: 10.1007/s12022-018-9527-6. PMID: 29626276
Gill AJ
Endocr Pathol 2014 Mar;25(1):30-4. doi: 10.1007/s12022-013-9294-3. PMID: 24402736
Okamoto T, Iihara M, Obara T, Tsukada T
World J Surg 2009 Nov;33(11):2343-54. doi: 10.1007/s00268-009-9999-0. PMID: 19350316

Clinical prediction guides

Juhlin CC, Nilsson IL, Falhammar H, Zedenius J
Pathology 2021 Dec;53(7):852-859. Epub 2021 May 14 doi: 10.1016/j.pathol.2021.02.011. PMID: 33994174
Li Y, Zhang J, Adikaram PR, Welch J, Guan B, Weinstein LS, Chen H, Simonds WF
Endocr Relat Cancer 2020 Sep;27(9):483-494. doi: 10.1530/ERC-20-0149. PMID: 32590342Free PMC Article
Gill AJ
Endocr Pathol 2014 Mar;25(1):30-4. doi: 10.1007/s12022-013-9294-3. PMID: 24402736
Sulaiman L, Haglund F, Hashemi J, Obara T, Nordenström J, Larsson C, Juhlin CC
PLoS One 2012;7(9):e46325. Epub 2012 Sep 28 doi: 10.1371/journal.pone.0046325. PMID: 23029479Free PMC Article
Davey DD, Glant MD, Berger EK
Diagn Cytopathol 1986 Jan-Mar;2(1):76-80. doi: 10.1002/dc.2840020116. PMID: 2424691

Recent systematic reviews

Wong HKG, Shipman K, Allan K, Ghabbour A, Borumandi F
Langenbecks Arch Surg 2022 Mar;407(2):501-516. Epub 2022 Jan 18 doi: 10.1007/s00423-021-02406-3. PMID: 35039921

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