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Osteoblastic osteosarcoma

MedGen UID:
312376
•Concept ID:
C1704328
•
Neoplastic Process
Synonyms: Osteoblastic Osteosarcoma; osteoblastic osteosarcoma
 
Monarch Initiative: MONDO:0020660

Definition

A conventional osteosarcoma characterized by the predominance of osteoid matrix. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Osteoblastic osteosarcoma

Professional guidelines

PubMed

KPNA2 expression is a potential marker for differential diagnosis between osteosarcomas and other malignant bone tumor mimics.
Jiang L, Liu J, Wei Q, Wang Y
Diagn Pathol 2020 Nov 11;15(1):135. doi: 10.1186/s13000-020-01051-6. PMID: 33176814Free PMC Article
Osteoblastic osteosarcoma: cytomorphologic characteristics and differential diagnosis on fine-needle aspiration.
Sathiyamoorthy S, Ali SZ
Acta Cytol 2012;56(5):481-6. Epub 2012 Sep 27 doi: 10.1159/000339196. PMID: 23075887
Osteosarcoma with cytokeratin expression: a clinicopathological study of six cases with an emphasis on differential diagnosis from metastatic cancer.
Okada K, Hasegawa T, Yokoyama R, Beppu Y, Itoi E
J Clin Pathol 2003 Oct;56(10):742-6. doi: 10.1136/jcp.56.10.742. PMID: 14514776Free PMC Article

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Bone Cancer, 2023

Recent clinical studies

Etiology

Characterization of the tumour microenvironment phenotypes in malignant tissues and pleural effusion from advanced osteoblastic osteosarcoma patients.
Zhang Z, Ji W, Huang J, Zhang Y, Zhou Y, Zhang J, Dong Y, Yuan T, Yang Q, Ding X, Tang L, Li H, Yin J, Wang Y, Ji T, Fei J, Zhang B, Chen P, Hu H
Clin Transl Med 2022 Nov;12(11):e1072. doi: 10.1002/ctm2.1072. PMID: 36305631Free PMC Article
Avicularin Reduces the Expression of Mediators of Inflammation and Oxidative Stress in Bradykinin-Treated MG-63 Human Osteoblastic Osteosarcoma Cells.
Zhang Z, Lv G, Du L
Med Sci Monit 2020 May 28;26:e921957. doi: 10.12659/MSM.921957. PMID: 32463805Free PMC Article
Survival analysis of osteosarcoma patients: A 15-year experience.
Yasin NF, Abdul Rashid ML, Ajit Singh V
J Orthop Surg (Hong Kong) 2020 Jan-Apr;28(1):2309499019896662. doi: 10.1177/2309499019896662. PMID: 32077796
PIK3CA and AKT gene polymorphisms in susceptibility to osteosarcoma in a Chinese population.
He ML, Wu Y, Zhao JM, Wang Z, Chen YB
Asian Pac J Cancer Prev 2013;14(9):5117-22. doi: 10.7314/apjcp.2013.14.9.5117. PMID: 24175786
Osteoblastic osteosarcoma: cytomorphologic characteristics and differential diagnosis on fine-needle aspiration.
Sathiyamoorthy S, Ali SZ
Acta Cytol 2012;56(5):481-6. Epub 2012 Sep 27 doi: 10.1159/000339196. PMID: 23075887

Diagnosis

Metachronous Osteosarcoma, A Differential Diagnosis to be Considered in Children With Osteosarcoma: A Review of Literature and a Case From Our Center.
Gotta J, Bochennek K, Klingebiel T, Bielack S, Wild PJ, Demes MC, Gradhand E
J Pediatr Hematol Oncol 2023 Apr 1;45(3):105-110. Epub 2022 Oct 17 doi: 10.1097/MPH.0000000000002560. PMID: 36251795Free PMC Article
Primary meningeal osteoblastic osteosarcoma containing fibroblast osteosarcoma: clinicopathological analysis and literature review.
Qiu YQ, Chen YL
Osteoporos Int 2021 May;32(5):1007-1012. Epub 2020 Oct 12 doi: 10.1007/s00198-020-05675-8. PMID: 33047193
Cutaneous Osteoblastic Osteosarcoma: Report of 2 New Cases Integrated With SATB2 Immunohistochemistry and Review of the Literature.
Falconieri G, Cataldi P, Kavalar R, Štitič V, Luzar B
Am J Dermatopathol 2016 Nov;38(11):824-831. doi: 10.1097/DAD.0000000000000555. PMID: 27043339
Bone-seeking radiopharmaceuticals as targeted agents of osteosarcoma: samarium-153-EDTMP and radium-223.
Anderson PM, Subbiah V, Rohren E
Adv Exp Med Biol 2014;804:291-304. doi: 10.1007/978-3-319-04843-7_16. PMID: 24924181
Osteoblastic osteosarcoma: cytomorphologic characteristics and differential diagnosis on fine-needle aspiration.
Sathiyamoorthy S, Ali SZ
Acta Cytol 2012;56(5):481-6. Epub 2012 Sep 27 doi: 10.1159/000339196. PMID: 23075887

Therapy

A case report of apatinib in treating osteosarcoma with pulmonary metastases.
Zhou Y, Zhang W, Tang F, Luo Y, Min L, Zhang W, Shi R, Duan H, Tu C
Medicine (Baltimore) 2017 Apr;96(15):e6578. doi: 10.1097/MD.0000000000006578. PMID: 28403086Free PMC Article
Bone-seeking radiopharmaceuticals as targeted agents of osteosarcoma: samarium-153-EDTMP and radium-223.
Anderson PM, Subbiah V, Rohren E
Adv Exp Med Biol 2014;804:291-304. doi: 10.1007/978-3-319-04843-7_16. PMID: 24924181
Dedifferentiated parosteal osteosarcoma: the experience of the Rizzoli Institute.
Bertoni F, Bacchini P, Staals EL, Davidovitz P
Cancer 2005 Jun 1;103(11):2373-82. doi: 10.1002/cncr.21039. PMID: 15852358
Second messenger signaling of c-fos gene induction by parathyroid hormone (PTH) and PTH-related peptide in osteoblastic osteosarcoma cells: its role in osteoblast proliferation and osteoclast-like cell formation.
Kano J, Sugimoto T, Kanatani M, Kuroki Y, Tsukamoto T, Fukase M, Chihara K
J Cell Physiol 1994 Nov;161(2):358-66. doi: 10.1002/jcp.1041610221. PMID: 7962120
Radiation-induced osteosarcoma of the calvaria--case report.
Sugita Y, Shigemori M, Miyagi J, Ochiai S, Lee S, Watanabe T, Abe H, Morimatsu M
Neurol Med Chir (Tokyo) 1992 Jan;32(1):32-5. doi: 10.2176/nmc.32.32. PMID: 1375983

Prognosis

Characterization of the tumour microenvironment phenotypes in malignant tissues and pleural effusion from advanced osteoblastic osteosarcoma patients.
Zhang Z, Ji W, Huang J, Zhang Y, Zhou Y, Zhang J, Dong Y, Yuan T, Yang Q, Ding X, Tang L, Li H, Yin J, Wang Y, Ji T, Fei J, Zhang B, Chen P, Hu H
Clin Transl Med 2022 Nov;12(11):e1072. doi: 10.1002/ctm2.1072. PMID: 36305631Free PMC Article
Primary meningeal osteoblastic osteosarcoma containing fibroblast osteosarcoma: clinicopathological analysis and literature review.
Qiu YQ, Chen YL
Osteoporos Int 2021 May;32(5):1007-1012. Epub 2020 Oct 12 doi: 10.1007/s00198-020-05675-8. PMID: 33047193
Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma.
Zhou Y, Yang D, Yang Q, Lv X, Huang W, Zhou Z, Wang Y, Zhang Z, Yuan T, Ding X, Tang L, Zhang J, Yin J, Huang Y, Yu W, Wang Y, Zhou C, Su Y, He A, Sun Y, Shen Z, Qian B, Meng W, Fei J, Yao Y, Pan X, Chen P, Hu H
Nat Commun 2020 Dec 10;11(1):6322. doi: 10.1038/s41467-020-20059-6. PMID: 33303760Free PMC Article
PLK2 modulation of enriched TAp73 affects osteogenic differentiation and prognosis in human osteosarcoma.
Li W, Zhang X, Xi X, Li Y, Quan H, Liu S, Wu L, Wu P, Lan W, Shao Y, Li H, Chen K, Hu Z
Cancer Med 2020 Jun;9(12):4371-4385. Epub 2020 Apr 29 doi: 10.1002/cam4.3066. PMID: 32349184Free PMC Article
Osteoblastic osteosarcoma: cytomorphologic characteristics and differential diagnosis on fine-needle aspiration.
Sathiyamoorthy S, Ali SZ
Acta Cytol 2012;56(5):481-6. Epub 2012 Sep 27 doi: 10.1159/000339196. PMID: 23075887

Clinical prediction guides

Giant cell-rich osteosarcoma: A match pair analysis of 11 new cases and literature review of 56 patients.
Karczewski D, Gonzalez MR, Bedi A, Ready JE, Anderson ME, Lozano-Calderon SA
J Surg Oncol 2023 Oct;128(5):877-890. Epub 2023 Jun 9 doi: 10.1002/jso.27368. PMID: 37292033
Treatment of Osteosarcoma of the Talus With a 3D-Printed Talar Prosthesis.
Huang J, Xie F, Tan X, Xing W, Zheng Y, Zeng C
J Foot Ankle Surg 2021 Jan-Feb;60(1):194-198. Epub 2020 Sep 2 doi: 10.1053/j.jfas.2020.01.012. PMID: 33162293
Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma.
Zhou Y, Yang D, Yang Q, Lv X, Huang W, Zhou Z, Wang Y, Zhang Z, Yuan T, Ding X, Tang L, Zhang J, Yin J, Huang Y, Yu W, Wang Y, Zhou C, Su Y, He A, Sun Y, Shen Z, Qian B, Meng W, Fei J, Yao Y, Pan X, Chen P, Hu H
Nat Commun 2020 Dec 10;11(1):6322. doi: 10.1038/s41467-020-20059-6. PMID: 33303760Free PMC Article
Cutaneous Osteoblastic Osteosarcoma: Report of 2 New Cases Integrated With SATB2 Immunohistochemistry and Review of the Literature.
Falconieri G, Cataldi P, Kavalar R, Štitič V, Luzar B
Am J Dermatopathol 2016 Nov;38(11):824-831. doi: 10.1097/DAD.0000000000000555. PMID: 27043339
Proliferative activity of osteosarcoma cells: comparison of osteoblastic and nonosteoblastic regions.
Sakayama K, Fujibuchi T, Kidani T, Miyazaki T, Yamamoto H
J Orthop Sci 2003;8(5):678-82. doi: 10.1007/s00776-003-0694-y. PMID: 14557934

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    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Bone Cancer, 2023

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